Publications by authors named "Karamatollah Rahmanian"

11 Publications

  • Page 1 of 1

Association of obesity and pulse pressure with hypertension in an Iranian urban population.

J Family Med Prim Care 2020 Sep 30;9(9):4705-4711. Epub 2020 Sep 30.

Research Center for Noncommunicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran.

Objective: Nowadays, obesity is an important health problem and pulse pressure (PP) is a good predictor of cardiovascular events. The aim of study was to determine the association of obesity and PP with hypertension (HTN) in individuals aged 30 years or older in the urban population of Jahrom, Iran.

Materials And Methods: In this study, we used a multistage stratified sampling method to select participants among the urban population aged 30 years or older. Height, weight, and blood pressure were obtained by a trained physician. Obesity was defined according to the World Health Organization classification. Angina was assessed with reliable and validate Rose questionnaire. Data were record by SPSS-16. Categorical and continues variables analyzed by Chi-squared, independent -test, and one-way ANOVA test. Binary logistic regression analysis method was used for the association of PP and obesity with HTN and Rose angina that adjusted for age, gender, education class, marital status, smoking, total cholesterol, triglyceride, low-density lipoprotein, and high-density lipoprotein. A < 0.05 was considered as statistical significance.

Results: The prevalence of obesity was 18.1% that was greater in women (24.8% vs. 9.9%, < 0.001). The prevalence of Rose angina and HTN in obese individuals were more than in normal weight individuals (24.8% vs. 16.4%, = 0.027) and (42.0% vs. 31.1%, < 0.001), respectively. Furthermore, patients in higher PP groups were older, were more possible to had HTN and had greater diastolic blood pressure (DBP), systolic blood pressure (SBP), and mean arterial pressure (MAP) in compared to individuals in the lower PP group. The individuals with HTN had greater DBP, SBP, MAP, PP, and body mass index (BMI) than individuals without HTN. However, individuals who had Rose angina, only had higher PP and BMI in compared to ones without Rose angina. The obese individuals had 1.97 (1.22-3.17, = 0.005) fold for HTN risk than individuals with normal weight. In addition, PP weakly increased the risk of HTN about 1.09 fold (1.07-1.10, < 0.001). However, Rose angina was associated only to overweight status (odds ratio = 1.51, confidence interval 95%: 1.03-2.20), = 0.035) than individuals in normal weight group.

Conclusion: Obesity and PP were higher in hypertensive individuals and overweight in individuals with Rose angina. It is time to pay more attention to abnormal BMI.
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http://dx.doi.org/10.4103/jfmpc.jfmpc_723_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652129PMC
September 2020

Relation of health-related quality of life with abnormal weight: A cross-sectional study prior to the weight reduction intervention.

J Family Med Prim Care 2020 Sep 30;9(9):4662-4666. Epub 2020 Sep 30.

Research Center for Noncommunicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran.

Objective: Obesity is a major health issue that is well-documented association with morbidity and mortality. The aim of this study was to investigate the associations between health-related quality of life (HRQOL) and abnormal body mass index (BMI) levels.

Materials And Methods: This descriptive study assessed 134 healthy individuals with abnormal BMI aged 18-39 years, clustered into three weight categories. The Short-form (SF)-36 Questionnaire was used for measuring of HRQOL.

Results: Linear-regression analyses discovered the negative correlation between BMI and the general health element of HRQL, however, a positive relation to role emotional dimension. But BMI was not associated with other six dimensions, and also with physical and mental component summary and with total health quality of life.

Conclusion: BMI was an important detriment factor for the general health dimension of HRQL with regression analysis. The higher grade of abnormal BMI had a negative influence on general health and positive effect on the role emotional dimension of HRQOL.
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http://dx.doi.org/10.4103/jfmpc.jfmpc_667_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652151PMC
September 2020

Seroprevalence of toxoplasma gondii infection: An umbrella review of updated systematic reviews and meta-analyses.

J Family Med Prim Care 2020 Aug 25;9(8):3848-3855. Epub 2020 Aug 25.

Epidemiology and Zoonosis Division, Department of Food Hygiene, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

Objectives: Toxoplasmosis is one of the neglected parasitic disease in humans and animals that produced via toxoplasma gondii. This study we implemented an umbrella review of all existing systematic reviews, meta-analyzing studies to apprise, and summarize seroprevalence of human toxoplasmosis in worldwide.

Methods: The search was carried out in databases including: Pub Med, Google Scholar, Science Direct, Scopus, Web of Science, Cochrane, and global health from their start dates until December 2018 in Persian and English language. A total of 21 systematics review and meta-analysis met the inclusion criteria of umbrella review. The Q test and the I statistic were used to evaluate heterogeneities. Quality assessment were performed and made use of the AMSTAR tool.

Results: The estimated pooled seroprevalence of T. gondii infection in blood donors, Immunocompromised patients, childbearing age women, general population, newborns and children, pregnant women and overall was 33% (95% CI, 29.0-38.0%), 42.0% (95 CI, 34.0-49.0%), 32.0% (CI, 26.0-38.0%), 42.0% (CI, 38.0-45.0%), 4.0% (CI, 2.0-5.0%), 40.0% (CI,37.0-44.0%), and 36% (CI, 24.0-48.0%), respectively.

Conclusion: The results of our umbrella review show a higher seroprevalence of T. gondii infection in immunocompromised patients, general population, pregnant women, blood donors, childbearing age women, and newborn groups, respectively. Routine serologic screening test and health education by primary care physicians for Toxoplasmosis is recommended to be conducted in high-risk groups in the endemic region.
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http://dx.doi.org/10.4103/jfmpc.jfmpc_753_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586519PMC
August 2020

Prevalence and clinical characteristics of metabolically unhealthy obesity in an Iranian adult population.

Diabetes Metab Syndr Obes 2019 13;12:1387-1395. Epub 2019 Aug 13.

Research Center for Non-communicable Diseases, Internal Diseases Department, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.

Purpose: The incidence of obesity is globally increasing and it is a predisposing factor for morbidity and mortality. This study assessed the prevalence of metabolically unhealthy (MU) individuals and its determinants according to body mass index (BMI).

Materials And Method: In our cross-sectional study, 891 persons aged 30 years or older participated. Participants were classified as obese (BMI ≥30 kg/m), overweight (BMI 25-<30 kg/m and normal weight (BMI <25 kg/m). Metabolic health status was defined using four existing cardio-metabolic abnormalities (elevated blood pressure, elevated serum concentrations of triglyceride and fasting glucose and a low serum concentration of high density lipoprotein cholesterol). Then, two phenotypes were defined: healthy (existence of 0-1 cardio-metabolic abnormalities) and unhealthy (presence of 2 or more cardio-metabolic abnormalities).

Result: Overall, 10.9% (95% confidence interval (CI): 8.8-13.0) and 7.2% (95% CI: 5.5-8.9) of participants were MU obese and metabolically healthy obese, respectively. The prevalence of MU was higher in overweight (55.6%; 95% CI: 50.6-60.6, <0.001) and obese (60.2%; 95% CI: 52.8-67.6, =0.001) subjects than in individuals with a normal weight (37.5%; 95% CI: 29.4-42.6). Multiple logistic regression analysis showed an association of a MU state with age and dyslipidaemia in the BMI subgroups and with female sex in the normal weight individuals.

Conclusion: The prevalence of a MU state increased with increasing BMI. Ageing and dyslipidaemia were associated with an unhealthy metabolic state in normal weight, overweight and obese subjects and with the female sex in normal weight subjects.
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http://dx.doi.org/10.2147/DMSO.S197476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698163PMC
August 2019

The Association Between Pre-Diabetes With Body Mass Index and Marital Status in an Iranian Urban Population.

Glob J Health Sci 2015 Jul 31;8(4):95-101. Epub 2015 Jul 31.

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Pre-diabetes increased the development of diabetes mellitus (type 2). The aim of study was to determine the association of body weight, education and marital status with pre-diabetes in an Iranian urban population.A sample of 788 subjects (360 men and 428 women) between the ages 30-85 years participated in our study and anthropometric measurements, educational level and fasting blood sugar of participants were recorded. The t and Chi square tests were used for continuous and categorical variables. The association of age, BMI categories, educational level and marital status to pre-diabetes was assessed by estimating the odds ratio. A p-value ≤ 0.05 were considered significant. The analysis was done using SPSS version 11.5. Our study showed that pre-diabetic subjects were older and low educated than normoglycemic subjects. Mean BMI and educational level were associated to pre-diabetes only in women. The odds of being pre-diabetes also were higher in obese women than in normal BMI women. No relationship was found between education and marital status with pre-diabetes in both men and women. Based on our finding, it is possible that advancing age and obesity has increased in pre-diabetes. This highlights the importance of population based survey to monitor blood glucose for effective prevention and control.
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http://dx.doi.org/10.5539/gjhs.v8n4p95DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873576PMC
July 2015

Effect of Palm Pollen on Sperm Parameters of Infertile Man.

Pak J Biol Sci 2015 Apr;18(4):196-9

There is a rapidly growing trend in the consumption of herbal remedies in the developing countries. The aim of this study was to determine the effects of orally administered Date Palm Pollen (DPP) on the results of semen analysis in adult infertile men. Forty infertile men participated in our study. They were treated by Pollen powder 120 mg kg(-1) in gelatinous capsules every other day, for two months. Before and at the end of therapy, the semen was collected after masturbation and sperm numbers, motility and morphology were determined. Our findings revealed that consumption of DPP improved the sperm count. The treatment was significantly increased sperm motility, morphology and forward progressive motility. Date palm pollen seems to cure male infertility by improving the quality of sperm parameters.
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http://dx.doi.org/10.3923/pjbs.2015.196.199DOI Listing
April 2015

Immunity to tetanus in major beta thalassemia patients.

Clin Exp Vaccine Res 2015 Jul 29;4(2):184-8. Epub 2015 Jul 29.

Research Center for Social Determinants of Health, Jahrom University of Medical Sciences, Jahrom, Iran.

Purpose: Patients with beta thalassemia major are at increased risk for bacterial infections specially splenectomized patients. The aim of this study was to determine the anti-tetanus antibody concentration among patients with beta thalassemia major.

Materials And Methods: The anti-tetanus antibody concentration was investigated in 224 patients with thalassemia major and 224 healthy subjects matched for age and gender. Tetanus antibody and ferritin serum level were determined by enzyme-linked immunosorbent assay method using commercial kits. Subjects who had antibody level ≥ 0.1 IU/mL was defined as complete protection, 0.01 to < 0.1 IU/mL as partial protection and < 0.01 IU/mL as no protection. For the analysis, we used SPSS version 11.5 software. A two-sided p-value less 0.05 was considered statistically significant.

Results: In patients with beta thalassemia major, antibody level against tetanus was inversely dependent about 29.3% to serum ferritin level. Thus, when serum ferritin increased 1 ng/mL, serum antibody against tetanus decreased 0.002 IU/mL. Mean anti-tetanus (IgG) antibody titers was lower in thalassemia patients compared to healthy subjects (1.53 ± 1.71 vs. 2.02 ± 2.05, p = 0.007) that was no significantly associated to age and gender in both study groups. All of participants had serum antibody level 0.01 IU/mL or greater. The complete protective level of anti-tetanus antibody was lower in thalassemia subjects in compare to healthy persons (71% vs. 87.9%, p < 0.001).

Conclusion: Patients with thalassemia had lower anti-tetanus antibody level than healthy subjects. Thus the vaccine recommendation seems essential for patients with beta thalassemia major.
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http://dx.doi.org/10.7774/cevr.2015.4.2.184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524903PMC
July 2015

Natural immunity against Haemophilus influenza type B in splenectomised Beta-thalassaemia children.

Pak J Biol Sci 2014 Nov;17(11):1190-4

Patients with beta-thalassaemia major and asplenia have an increased risk of encapsulated bacterial infections. The aim of this study was to determine the Haemophilus influenza type b (Hib) antibody concentrations in beta-thalassaemia patients with or without spleens. The Hib antibody concentrations were investigated in 850 patients with thalassaemia major, of whom 437 had undergone splenectomy. Hib antibody levels equal or greater than 1.0 μg mL(-1) were classified as long-term protection, those between 0.15 and less than 1.0 μg mL(-1) as short-term protection and those less than 0.15 μg mL(-1) as no protection. The mean Hib antibody level was lower in asplenic subjects than in non splenectomised subjects (0.39 ± 0.5 vs. 1.08 ± 0.55 μg mL(-1), p < 0.001). The protective antibody level prevalence in asplenic patients was significantly lower than that in patients with spleens (32.3% vs. 85.7%, p < 0.001). Protection against Hib decreased as the time interval after splenectomy increased from 57.2% at a less than 60 months interval to 10.8% at a greater than 120 months interval (p = 0.001). Nearly 30% of the 437 splenectomised subjects had long-term protection against Hib, whereas 64.4% of the 413 non splenectomised subjects had long-term protection (p < 0.001). Asplenic subjects had lower Hib antibody levels than non splenectomised subjects. Additionally, the antibody levels decreased as the time interval increased after splenectomy. A Hib vaccine recommendation for splenectomised thalassaemia major seems essential.
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http://dx.doi.org/10.3923/pjbs.2014.1190.1194DOI Listing
November 2014

Relation of type 2 diabetes mellitus with gender, education, and marital status in an Iranian urban population.

Rep Biochem Mol Biol 2013 Apr;1(2):64-8

Department of Immunology, Jahrom University of Medical Sciences, Jahrom, Iran.

Background: Type 2 diabetes mellitus is one of the most important cardiovascular risk factors.

Objectives: This study was performed to assess the relationship of diabetes with gender, education, and marital status in an Iranian urban population.

Methods: A total of 892 men and women aged 30-85 were recruited using a cluster-stratified sampling method from an urban population. Using a questionnaire, demographical data including gender, education, and marital status were collected. A blood sample after fasting for at least eight hours was collected from each subject. Associations of type 2 diabetes mellitus and studied variables were tested for significance.

Results: The prevalence of diabetes mellitus was 11.6%; 11.1% in men and 12.1% in women with no significant difference between them. Diabetes mellitus was most prevalent in the oldest age (age more than 60 years, 22.9%) and low education groups (17.9%, P < 0.001). Marital status was not significantly related to diabetes mellitus (P= 0.37).

Conclusion: The prevalence of diabetes mellitus is related to education within the Iranian population. Thus preventive strategies should be based on the affective factors.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757057PMC
April 2013

Natural immunity to hemophilus influenza type b in children, south of Iran: need for vaccination.

Pak J Biol Sci 2012 Feb;15(3):160-3

Department of Immunology, Jahrom University of Medical Sciences, Jahrom, Iran.

Hemophilus influenza type b (Hib) infection has a high morbidity and mortality rate especially in children less than 5 years of age. The incidence of Hib disease in Iran is not known and Hib vaccine is not included in the National Immunization Program. The aim of the present study was to investigate the level of antibody to Hib of children five years or younger living in Jahrom, Iran. Three hundred eighty six children 5 years or younger were selected by random sampling method. A blood samples were taken from those children. Anti-Hib IgG antibody (anti-PRP) level was determined in the serum by using anti-Hemophilus influenza IgG EIA kit (IBL, Germany). An anti-PRP antibody levels of 0.15 microg mL(-1) and over were accepted as the natural immunity. The mean concentration of Hib antibody was 0.94 +/- 0.480 microg mL(-1). Natural immunity was determined in three hundred and twenty six (84.5%) of the children. The proportion of natural immunity was increased from 64.9% among children = 12 month old to 95.2% in children aged 49-60 month (p < 0.001). The exposure rate of children with Hib was higher than expected, even in children who were just a few months old. Present data revealed need to be introducing Hib conjugate vaccine in the National Immunization Programs.
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http://dx.doi.org/10.3923/pjbs.2012.160.163DOI Listing
February 2012

The prevalence of pre-hypertension and its association to established cardiovascular risk factors in south of Iran.

BMC Res Notes 2012 Jul 28;5:386. Epub 2012 Jul 28.

Department of Social Medicine, Jahom University of Medical Sciences, Jahrom, Iran.

Background: Pre-hypertension is associated with an increased risk of the development of hypertension and subsequent cardiovascular disease and raises mortality risk. The aim of this study was to determine the prevalence of pre-hypertension and to explore the associations between pre-hypertension and established cardiovascular risk factors in a population-based sample of Iranian adults.

Methods: In this cross-sectional study a representative sample of 892 participants aged ≥ 30 years was selected using a multistage cluster sampling method. After completion of a detailed demographic and medical questionnaire (gender, age, history of diabetes mellitus and hypertension, taking antihypertensive or hypoglycemic agents and history of smoking), all participants were subjected to physical examination, blood lipid profile, blood glucose, anthropometric and smoking assessments, during the years 2009 and 2010. Variables were considered significant at a p-value ≤ 0.05. Statistical analysis was performed using SPSS version 11.5 software.

Results: Pre-hypertension was observed among 300 (33.7%) subjects, 36.4% for men and 31.4% for women (p > 0.05). The pre-hypertensive group had higher levels of blood glucose and triglycerides, higher body mass index and lower percentage of smoking than did the normotensive group. Multivariate logistic regression analysis showed that obesity and overweight were the strongest predictors of pre-hypertension [odds ratio, 2.74: 95% CI (Confidence Interval), 1.62 to 4.62 p < 0.001; odds ratio, 2.56, 95% CI, 1.74 to 3.77, p < 0.001 respectively].

Conclusions: Overweight and obesity are major determinants of the high prevalence rate of pre-hypertension detected in Iranian population. Therefore, primary prevention strategies should concentrate on reducing overweight and obesity if the increased prevalence of pre-hypertension is to be diminished in Iranian adults.
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http://dx.doi.org/10.1186/1756-0500-5-386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506467PMC
July 2012