Publications by authors named "Kapil Bharti"

59Publications

Regulatory considerations for developing a phase I investigational new drug application for autologous induced pluripotent stem cells-based therapy product.

Stem Cells Transl Med 2020 Sep 18. Epub 2020 Sep 18.

Ocular and Stem Cell Translational Research Section, Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.

View Article and Find Full Text PDF
September 2020

CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and RPE disorganization.

Elife 2020 Apr 1;9. Epub 2020 Apr 1.

Section on Neuron-Glia Interactions in Retinal Disease, National Eye Institute, National Institutes of Health, Bethesda, United States.

View Article and Find Full Text PDF
April 2020

A biofabricated vascularized skin model of atopic dermatitis for preclinical studies.

Biofabrication 2020 04 9;12(3):035002. Epub 2020 Apr 9.

National Center for Advancing Translational Sciences, National Institute of Health, Rockville, MD, United States of America.

View Article and Find Full Text PDF
April 2020

Retinal Pigment Epithelium Replacement Therapy for Age-Related Macular Degeneration: Are We There Yet?

Annu Rev Pharmacol Toxicol 2020 01;60:553-572

Unit on Ocular and Stem Cell Translational Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA; email:

View Article and Find Full Text PDF
January 2020

The Homeodomain Transcription Factors Vax1 and Six6 Are Required for SCN Development and Function.

Mol Neurobiol 2020 Feb 9;57(2):1217-1232. Epub 2019 Nov 9.

Department of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.

View Article and Find Full Text PDF
February 2020

High-yield, automated intracellular electrophysiology in retinal pigment epithelia.

J Neurosci Methods 2019 12 25;328:108442. Epub 2019 Sep 25.

Georgia Institute of Technology, G.W. Woodruff School of Mechanical Engineering, Atlanta, GA 30332, USA.

View Article and Find Full Text PDF
December 2019

Retinal stem cell transplantation: Balancing safety and potential.

Prog Retin Eye Res 2020 03 5;75:100779. Epub 2019 Sep 5.

National Eye Institute, National Institutes of Health, Bethesda, MD, 90892, USA.

View Article and Find Full Text PDF
March 2020

A strategic road map to filing a Biologics License Application for a pluripotent stem cell derived therapeutic product.

Biologicals 2019 May 30;59:68-71. Epub 2019 Apr 30.

International Alliance for Biological Standardization (IABS), Geneva, Switzerland.

View Article and Find Full Text PDF
May 2019

Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice.

Invest Ophthalmol Vis Sci 2018 12;59(15):6067-6073

Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Insitutes of Health, Bethesda, Maryland, United States.

View Article and Find Full Text PDF
December 2018

Generation of an inducible RPE-specific Cre transgenic-mouse line.

PLoS One 2018 15;13(11):e0207222. Epub 2018 Nov 15.

Institute of Molecular Physiology, Johannes-Gutenberg University, Mainz, Germany.

View Article and Find Full Text PDF
April 2019

Identifying core biological processes distinguishing human eye tissues with precise systems-level gene expression analyses and weighted correlation networks.

Hum Mol Genet 2018 10;27(19):3325-3339

Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.

View Article and Find Full Text PDF
October 2018

Validation of iPS Cell-Derived RPE Tissue in Animal Models.

Adv Exp Med Biol 2018 ;1074:633-640

Section on Epithelial and Retinal Physiology and Disease, National Eye Institute, Bethesda, MD, USA.

View Article and Find Full Text PDF
May 2019

Allogeneic iPSC-Derived RPE Cell Graft Failure Following Transplantation Into the Subretinal Space in Nonhuman Primates.

Invest Ophthalmol Vis Sci 2018 03;59(3):1374-1383

Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States.

View Article and Find Full Text PDF
March 2018