Publications by authors named "Kaoutar Znati"

53 Publications

A swollen thumb.

JAAD Case Rep 2021 Aug 10;14:46-48. Epub 2021 Jun 10.

Department of Dermatology, Mohammed V University in Rabat, Ibn Sina University Hospital, Rabat, Morocco.

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http://dx.doi.org/10.1016/j.jdcr.2021.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256003PMC
August 2021

Kaposi sarcoma of the adrenal gland: A report of two cases with a review of the literature.

J Cancer Res Ther 2021 Apr-Jun;17(2):606-608

Department of Pathology, Ibn Sina Teaching Hospital, Rabat, Morocco.

Kaposi sarcoma (KS) is a low-grade vascular neoplasm commonly involving mucocutaneous sites, while adrenal gland involvement is exceptional. The anaplastic variant is a rare entity characterized by marked cellular pleomorphism, increased mitosis, worse prognosis, and an increased metastatic potential. The diagnosis remains on histology and immunohistochemistry. We describe two cases of primary adrenal KS to report on this exceptional presentation of KS: the first case is a 67-year-old female with anaplastic KS wit fatal outcome. The second case is a 56-year-old male who presented a classic KS of the adrenal gland. Until now, no standard efficient treatment regimens have been clearly identified. There is a need for a further understanding of anaplastic KS's biology, and collecting a sizable patient cohort remains essential to review treatment outcome.
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http://dx.doi.org/10.4103/jcrt.JCRT_670_20DOI Listing
June 2021

Leiomyosarcoma of the Renal Vein Mimicking a Primitive Renal Cell Carcinoma: Case Report of an Unusual Presentation.

Case Rep Pathol 2021 12;2021:6637533. Epub 2021 May 12.

Department of Pathology, Ibn Sina University Hospital Center, Rabat, Morocco.

Primary leiomyosarcomas (LMS) of vascular origin are rare tumors, and more than half of the cases arise in the inferior vena cava (IVC). Primary LMS of the renal vein are extremely rare tumors with only a few cases reported in the literature. Their diagnosis is made only by pathological features. Histologically, they are made of atypical spindle-shaped cells arranged in long intersecting fascicles. Tumor cells stain positive for myogenic markers in immunohistochemistry. Standard treatment consists of radical nephrectomy followed by chemotherapy and/or radiotherapy. Because of insufficient histological data and follow-up, the prognosis factors are not well identified. Overall prognosis of renal vein LMS is poor. We report here an exceptional case of a huge LMS of the right renal vein mimicking a primitive renal cell carcinoma, occurring in a 56-year-old male patient.
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http://dx.doi.org/10.1155/2021/6637533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133846PMC
May 2021

Primary Hodgkin lymphoma of the ulnar nerve: the first case report with review of the literature.

J Surg Case Rep 2021 May 20;2021(5):rjab185. Epub 2021 May 20.

Department of Pathology, Ibn Sina Teaching Hospital, Abderrahim Bouabid Avenue, Rabat 12000, Morocco.

Hodgkin lymphoma is a lymphoid malignancy characterized by minority population of neoplastic cells (Reed-Sternberg cells and its variants) within a reactive inflammatory background. It encompasses two entities: classical HL (∼95% of cases) and nodular lymphocyte predominant HL (∼5% of cases). Primary lymphoma of peripheral nerves (PLPN) represent a very rare condition, since only 19 cases have been reported in the English literature to date, all of which are of a non-HL phenotype. A 20-year-old female presented an intramural mass of the ulnar nerve. Histological analysis revealed a Classical Hodgkin lymphoma. Further investigations failed to reveal nodal or extranodal involvement. PLPN is a very rare entity. There is a need for further understanding of this unusual lymphoma presentation.
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http://dx.doi.org/10.1093/jscr/rjab185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136864PMC
May 2021

Comedonal plaque on the scalp.

JAAD Case Rep 2021 May 25;11:90-92. Epub 2021 Mar 25.

Department of Dermatology, Mohammed V University in Rabat, Ibn Sina University Hospital, Rabat, Morocco.

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http://dx.doi.org/10.1016/j.jdcr.2021.03.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079957PMC
May 2021

Dermoscopy of a hyperkeratotic pigmented lesion on the pubis.

JAAD Case Rep 2021 May 13;11:26-28. Epub 2021 Mar 13.

Department of Dermatology, Mohammed V University in Rabat, Ibn Sina University Hospital, Rabat, Morocco.

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http://dx.doi.org/10.1016/j.jdcr.2021.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058609PMC
May 2021

A polymorphous cutaneous tuberculosis.

Int J Mycobacteriol 2021 Jan-Mar;10(1):85-88

Department of Dermatology, CHU Ibn Sina, Mohamed V University of Rabat, Rabat, Morocco.

Cutaneous tuberculosis is uncommon, comprising 1%-2% of all extrapulmonary manifestations. It has a wide clinical spectrum. The clinical presentation depends on the route of the infection, the pathogenicity of the bacteria, and the immune status of the host. Association of multiple forms in a same patient is uncommon. We report a case of disseminated tuberculosis with polymorphous cutaneous lesions in an immunocompetent woman, combining scrofuloderma, gummas, and sporotrichoid lesions, along with tuberculous adenitis and bone tuberculosis.
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http://dx.doi.org/10.4103/ijmy.ijmy_224_20DOI Listing
March 2021

Dermoscopy of collision tumor arising in nevus sebaceus of Jadassohn.

JAAD Case Rep 2021 Feb 17;8:74-76. Epub 2020 Dec 17.

Department of Dermatology, Mohammed V University in Rabat, Ibn Sina University Hospital, Rabat, Morocco.

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http://dx.doi.org/10.1016/j.jdcr.2020.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822779PMC
February 2021

Retroperitoneal leiomyoma of gynecologic type: a case report and review of the litterature.

J Surg Case Rep 2020 Dec 24;2020(12):rjaa489. Epub 2020 Dec 24.

Department of Pathology, Ibn Sina Teaching Hospital, Rabat, Morocco.

Retroperitoneal leiomyomas are rare benign tumors with smooth muscle differentiation, with only ~1001 cases reported in the English literature to date. Because of its scarcity and non-specific presentation, the preoperative diagnosis might be challenging. On histology, these neoplasms share the same macroscopic, morphological and phenotypic features with uterine leiomyoma; thus, they are referred to as leiomyoma of gynecologic type. Herein, we describe a case of a voluminous retroperitoneal leiomyoma in a 51-year-old woman with a history of total hysterectomy to raise awareness about this condition, as its differential diagnosis might be challenging.
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http://dx.doi.org/10.1093/jscr/rjaa489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758995PMC
December 2020

Adrenocortical sarcomatoid carcinoma: a case report and review of the literature.

J Surg Case Rep 2020 Jul 16;2020(7):rjaa211. Epub 2020 Jul 16.

Department of Pathology, Ibn Sina Teaching Hospital, Rabat, Morocco.

Adrenal sarcomatoid carcinoma (ASC) is a very rare aggressive variant of adrenocortical carcinoma showing carcinomatous and sarcomatous differentiation. It is a poorly differentiated carcinoma with poor prognosis. The diagnosis requires careful histological and immunohistochemical investigation. We describe a new case of ASC to raise awareness on this extremely rare entity. A 27-year-old woman presented with a right flank pain. Imaging revealed a tissular mass of the right adrenal gland without metastases. After adrenalectomy, histology revealed sheets of epithelioid cells that stained for synaptophysin and Melan-A; and spindled cells staining for S-100. We have reported the clinical and histopathological features of ACS's case; as it is an extremely rare cancer with a challenging diagnosis. There is a need for a further understanding of ASC's biology to improve it poor prognosis.
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http://dx.doi.org/10.1093/jscr/rjaa211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371253PMC
July 2020

[Pseudo-tumoral cutaneous tertiary syphilis].

Presse Med 2019 Nov 11;48(11 Pt 1):1347-1348. Epub 2019 Nov 11.

Université Mohammed V, centre hospitalier universitaire Ibn Sina, service de dermatologie et de vénérologie, 10170 Rabat, Maroc.

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http://dx.doi.org/10.1016/j.lpm.2019.09.047DOI Listing
November 2019

Erythromelanosis follicularis faciei et colli: Dermoscopy and dermatopathology correlates.

JAAD Case Rep 2019 Jun 8;5(6):535-536. Epub 2019 Jun 8.

Department of Dermatology-Venereology, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.

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http://dx.doi.org/10.1016/j.jdcr.2019.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558350PMC
June 2019

[Recurrence of pseudomyxoma peritonei with liver and splenic metastases: about a case and literature review].

Pan Afr Med J 2018 25;30:225. Epub 2018 Jul 25.

Laboratoire d'Anatomie Pathologique, Centre Hospitalier Universitaire Avicenne, Rabat, Maroc.

Pseudomyxoma peritonei (PMP) is a clinicopathologic syndrome characterized by mucinous ascites and pools of mucin resulting in neoplastic mucinous epithelium in the peritoneal cavity. PMP is uncommon and it is characterized by clinical and unusual pathologic manifestations posing diagnostic and therapeutic problems. Involvement of abdominal viscera and lymph node metastases are rare and sporadic cases have been reported in the literature. We here report the case of a 56-year old patient who had undergone two operations for PMP of appendicular origin presenting with progressive abdominal pain five years after his last treatment. Scanner objectified a recurrence of peritoneal pseudo-myxoma with liver and splenic intraparenchymatous lesions. Anatomopathological examination showed intrasplenic and hepatic recurrence of low-grade peritoneal pseudo-myxoma confirming the metastases.
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http://dx.doi.org/10.11604/pamj.2018.30.225.15484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295300PMC
January 2019

[Pneumoblastoma in adults: a new case report and literature review].

Pan Afr Med J 2017 2;28:198. Epub 2017 Nov 2.

Labaoratoire d'Anatomie Pathologique/Hopital Militaire Mohamed V, Rabat, Maroc.

Pulmonary blastoma is a rare tumor which has been mainly reported in children. It accounts for 0.25-0.5% of all pulmonary tumors, with a very serious prognosis. Histologically, it is a tumor composed of two components: an epithelial component and a mesenchymal component. Clinically, it usually manifests as chest pain, cough, hemoptysis and dyspnea, but it is asymptomatic in approximately 40% of cases. We report the case of a 25 year old woman, with no previous medical history, who complained of dyspnoea, cough and left basithoracic pain. Radiological evaluation showed large basithoracic mass in the left lung. A biopsy was performed which only showed necrotic material. The surgical specimen was largely necrotic. The viable tissue was examined with the miroscope which showed biphasic pattern composed of malignant epithelial tissue associated with malignant mesenchymal tissue, typical of biphasic pneumoblastoma. The patient underwent chemotherapy and radiation therapy. Follow-up examination showed a recurrence, thus the patient underwent second line chemotherapy.
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http://dx.doi.org/10.11604/pamj.2017.28.198.13907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878848PMC
May 2018

A rare presentation of hepatocellular carcinoma in non-cirrhotic liver.

Pan Afr Med J 2017 22;28:69. Epub 2017 Sep 22.

Faculty of medicine, mohammed V Souissi University Rabat Morocco.

Hepatocellular carcinoma is the most frequent type of liver malignancy. Most cases of hepatocellular carcinoma are secondary to either viral hepatitis (hepatitis B, C) or alcoholic cirrhosis. Liver cirrhosis due to any other causes is considered as a risk factor for development of hepatocellular carcinoma; however, hepatocellular carcinoma in non cirrhotic livers remains a rare condition. The present case report describes a 59-year-old woman patient admitted to explore right hypochondriac and epigastric pain, with no evidence of pre-existing liver disease and with a good general condition. The computed tomography was very suggestive of a gastro-intestinal stromal tumor. But, at laparotomy, a huge hepatic tumor was discovered. Histopathological study confirmed the presence of primary hepatocellular carcinoma. Hepatocellular carcinoma occurs more frequently on a cirrhotic liver. However, it can occur on a non cirrhotic liver and remains and extremely rare case.
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http://dx.doi.org/10.11604/pamj.2017.28.69.13512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724728PMC
December 2017

HPV and cofactors for invasive cervical cancer in Morocco: a multicentre case-control study.

BMC Cancer 2017 Jun 20;17(1):435. Epub 2017 Jun 20.

Laboratory of Epidemiology, Clinical Research and Community Health, Faculty of Medicine and Pharmacy, University Sidi Mohammed Benabdellah, BP.1893, Km 2.2 Route Sidi Harazem, Fez, Morocco.

Background: Limited national information is available in Morocco on the prevalence and distribution of HPV-sub-types of cervical cancer and the role of other risk factors. The aim was to determine the frequency of HPV-sub-types of cervical cancer in Morocco and investigate risk factors for this disease.

Methods: Between November 2009 and April 2012 a multicentre case-control study was carried out. A total of 144 cases of cervical cancer and 288 age-matched controls were included. Odds-ratios and corresponding confidence-intervals were computed by conditional logistic regression models.

Results: Current HPV infection was detected in 92.5% of cases and 13.9% of controls. HPV16 was the most common type for both cases and controls. Very strong associations between HPV-sub-types and cervical cancer were observed: total-HPV (OR = 39), HPV16 (OR = 49), HPV18 (OR = 31), and multiple infections (OR = 13). Education, high parity, sexual intercourse during menstruation, history of sexually transmitted infections, and husband's multiple sexual partners were also significantly associated with cervical cancer in the multivariate analysis.

Conclusions: Our results could be used to establish a primary prevention program and to prioritize limited screening to women who have specific characteristics that may put them at an increased risk of cervical cancer.
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http://dx.doi.org/10.1186/s12885-017-3425-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479029PMC
June 2017

Severe pemphigoid gestationis associated with acute disseminated encephalomyelitis in the setting of a systemic disorder.

Australas J Dermatol 2018 May 19;59(2):e123-e126. Epub 2017 May 19.

Department of Neurology, Mohammed V. Rabat Military Hospital, Rabat, Morocco.

Pemphigoid gestationis is a skin-specific autoimmune disorder that can sometimes present as the cutaneous manifestation of a multiorgan disease due to potentially common pathogenic mechanisms. We report a severe form of pemphigoid gestationis in a 32-year-old primigravida woman, who presented at 22 weeks of gestation with headaches and blurred vision, later developing encephalitis, intrauterine fetal demise and dilated cardiomyopathy.
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http://dx.doi.org/10.1111/ajd.12656DOI Listing
May 2018

[Primary mediastinal large B-cell lymphoma in women: about five cases].

Pan Afr Med J 2016 30;24:181. Epub 2016 Jun 30.

Service de Pneumologie, Hôpital Ibn Sina, CHU Rabat, Maroc.

Primary mediastinal large B-cell lymphoma (PMBL) is a lymphoma occurring in the anterior mediastinum starting from the cells B of the thymique medullary zone. This is a rare entity characterized by epidemiological, clinical and evolutionary peculiarities as well as by pathological and immunohistochemical peculiarities. We report a case series of 5 patients with diagnosed PMBL hospitalized in Pulmonology Department of Ibn Sina Hospital between January 2012 and May 2016. The average age was 34 years, the median of consultation time was 2 months. Reported symptoms were dyspnea, chest pain, dry cough; two patients suffered from superior vena cava syndrome. LDH level was high in 4 patients. Thoracic imaging showed an anterior mediastinal tissue processing in 5 patients. Histological diagnosis was based on ultrasound-guided transparietal puncture biopsy in 5 patients. The contribution of immunohistochemistry was decisive in all cases. Patients were sent to the National Institute of Oncology for therapeutic management. PMBL prognosis is reserved, it most commonly occurs in young women, which increases the need of aggressive therapy to improve survival rate.
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http://dx.doi.org/10.11604/pamj.2016.24.181.9906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072861PMC
March 2017

External ear nodule revealing a disseminated Kaposi disease.

Dermatol Online J 2016 Aug 15;22(8). Epub 2016 Aug 15.

Department of dermatology, Ibn Sina hospital, Rabat, Morocco.

Kaposi disease (KD) is an angiogenetic tumor process, characterized by its various clinical aspects. Its pathogenesis is multifactorial and it was attributed to HHV-8 infection. We report an original case of disseminated KD revealed by solitary lesion of external ear in a patient treated by corticosteroids for bullous pemphigoid.
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August 2016

[Papules on the feet].

Presse Med 2016 Jun 12;45(6 Pt 1):607-8. Epub 2016 May 12.

CHU Ibn Sina, université Mohammed V, faculté de médecine et de pharmacie, service de dermatologie-vénérologie, Rabat, Maroc.

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http://dx.doi.org/10.1016/j.lpm.2016.04.003DOI Listing
June 2016

[Unusual cause of intussusception in adult].

Ann Pathol 2016 Apr 12;36(2):143-5. Epub 2015 Nov 12.

Service central d'anatomie pathologique, CHU Ibn Sina, Rabat, Maroc; Central Department of Pathology, Ibn Sina university hospital, Rabat, Maroc.

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http://dx.doi.org/10.1016/j.annpat.2015.08.013DOI Listing
April 2016

Cutaneous neuromas following a burn injury.

Int J Dermatol 2016 Mar 13;55(3):e161-2. Epub 2015 Nov 13.

Department of Pathology, Ibn Sina Hospital, Mohammed V University, Rabat, Morocco.

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http://dx.doi.org/10.1111/ijd.13058DOI Listing
March 2016

Synchronous adenomyomas of the ileum in an adult-an exceptional cause of intussusception.

Clin Case Rep 2015 Jul 20;3(7):578-81. Epub 2015 May 20.

Department of Pathology, Ibn Sina University Hospital Rabat, Morocco.

In this article, we report a case of two synchronous ileal adenomyomas leading to intussusception. This rare occurrence has never been reported in the literature. Our case is noteworthy, because the lesion is rare and should be considered in the differential diagnosis of intussusception in adults.
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http://dx.doi.org/10.1002/ccr3.290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527800PMC
July 2015

[Extragenital lichen sclerosus atrophicus].

Presse Med 2015 Nov 9;44(11):1208-10. Epub 2015 Jun 9.

CHU Ibn-Sina, université Mohamed V, service de dermatologie-vénéréologie, 10000 Rabat, Maroc.

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http://dx.doi.org/10.1016/j.lpm.2015.03.018DOI Listing
November 2015

Malignant renal epithelioid angiomyolipoma associated with abdominopelvic hydatid cysts: a case report.

J Med Case Rep 2015 Apr 10;9:80. Epub 2015 Apr 10.

Department of Pathology, Ibn Sina University Hospital, Ahmed Balafrej Avenue, 10000, Rabat, Morocco.

Introduction: The World Health Organization defines epithelioid angiomyolipoma as a potentially malignant mesenchymal neoplasm characterized by proliferation of predominantly epithelioid cells and as closely related to the triphasic (classic) angiomyolipoma. It can be benign, potentially aggressive or malignant. The pathologist's role is crucial in making a positive diagnosis, providing appropriate patient management and assessing prognosis. In this report, we present a case of a patient with an epithelioid angiomyolipoma and hydatid cyst association. To the best of our knowledge, such an association has not been reported previously in the literature.

Case Presentation: A 70-year-old Arabian woman presented to our hospital with a 6-month history of a right lumbago and weight loss. Computed tomography objectified a mid-right renal tumor, several locoregional lymph nodes and four abdominopelvic cystic formations. The patient underwent a right nephroureterectomy and removal of abdominal and pelvic masses. Histologically, the tumor corresponded to a proliferation of large eosinophil cells, polygonal or ovoid, with epithelial appearance, and associated with thickened, hyalinized vessel walls, fat cells and bundles of smooth muscle cells. Mitoses were estimated at 2 per 50 high-power fields. In immunohistochemical study, epithelioid tumor cells expressed S-100 protein and Melan-A. The diagnosis of malignant epithelioid angiomyolipoma was made. The wall of the abdominopelvic cysts was eosinophilic and lamellar, corresponding to the cuticular membrane of hydatid cysts.

Conclusion: In our patient, careful histological examination and immunohistochemical study allowed us to make the correct diagnosis of angiomyolipoma in its malignant form. The association with hydatid cysts is what makes our case original.
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http://dx.doi.org/10.1186/s13256-015-0556-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395905PMC
April 2015

[Not Available].

Can Urol Assoc J 2014 Sep;8(9-10):E733-8

Service d'Urologie « A » Centre hospitalier universitaire Ibn Sina Rabat, Morocco.

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http://dx.doi.org/10.5489/cuaj.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216307PMC
September 2014

Combined myoepithelial carcinoma and myoepithelioma in soft tissue: a case report and review of the literature.

J Med Case Rep 2014 Sep 24;8:317. Epub 2014 Sep 24.

Department of Pathology, Ibn Sina University Hospital, Rabat, Morocco.

Introduction: Soft tissue myoepithelial carcinoma and myoepithelioma are rare entities, part of myoepithelial tumors. They were incorporated into the World Health Organization classification of soft tissue tumors in 2002. Here we present an exceptional case of myoepithelial carcinoma and myoepithelioma association. To the best of our knowledge, such an association has never been reported in the literature.

Case Presentation: We report a case of myoepithelial carcinoma combined with myoepithelioma occurring in the soft tissue of the right forearm of an 84-year-old Arabian man. We describe the clinical, radiological and pathological features dominated by histological polymorphism. We will also describe the proposed histological criteria of malignancy and the major role of immunohistochemistry in positive and differential diagnosis. We finally mention the therapeutic arsenal available.

Conclusion: Through this work, we report that myoepithelioma of soft tissue can progress to malignant myoepithelioma.
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http://dx.doi.org/10.1186/1752-1947-8-317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181467PMC
September 2014