Kannan Gunasekaran

Kannan Gunasekaran

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Kannan Gunasekaran

Kannan Gunasekaran

Publications by authors named "Kannan Gunasekaran"

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Engineering an IgG Scaffold Lacking Effector Function with Optimized Developability.

J Biol Chem 2017 02 19;292(5):1865-1875. Epub 2016 Dec 19.

From the Biologics Optimization-Therapeutic Discovery, Clinical Immunology, and Process Development, Amgen Inc., Thousand Oaks, California 91320

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http://dx.doi.org/10.1074/jbc.M116.748525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290958PMC
February 2017

Pancreatic lipoma: a pancreatic incidentaloma; diagnosis with ultrasound, computed tomography and magnetic resonance imaging.

BJR Case Rep 2016 2;2(4):20150507. Epub 2016 Nov 2.

Department of Radiodiagnosis, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

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http://dx.doi.org/10.1259/bjrcr.20150507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243312PMC
November 2016

Discovery and bio-optimization of human antibody therapeutics using the XenoMouse® transgenic mouse platform.

Immunol Rev 2016 Mar;270(1):51-64

Amgen British Columbia, Burnaby, BC, Canada.

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http://dx.doi.org/10.1111/imr.12409DOI Listing
March 2016

Imaging in Lhermitte: Duclos disease.

South Asian J Cancer 2013 Jul;2(3):131

Department of Radiology and Imaging, P. S. G. Institute of Medical Sciences and Research, Peelamedu, Coimbatore, Tamilnadu, India.

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http://dx.doi.org/10.4103/2278-330X.114114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892528PMC
July 2013

IgG2 disulfide isoform conversion kinetics.

Mol Immunol 2013 Jun 2;54(2):217-26. Epub 2013 Jan 2.

Department of Process and Product Development, Amgen Inc., Thousand Oaks, CA 91320, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S016158901200480
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http://dx.doi.org/10.1016/j.molimm.2012.12.005DOI Listing
June 2013

Characterization of a unique IgG1 mAb CEX profile by limited Lys-C proteolysis/CEX separation coupled with mass spectrometry and structural analysis.

J Chromatogr B Analyt Technol Biomed Life Sci 2010 Jul 1;878(22):1973-81. Epub 2010 Jun 1.

Department of Analytical & Formulation Sciences, 1201 Amgen Court West, Seattle, WA 98119-3105, USA.

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http://dx.doi.org/10.1016/j.jchromb.2010.05.032DOI Listing
July 2010

Histidine residue mediates radical-induced hinge cleavage of human IgG1.

J Biol Chem 2010 Jun 19;285(24):18662-71. Epub 2010 Mar 19.

Department of Analytical and Formulation Science, Amgen Inc., Seattle, Washington 98119, USA.

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http://dx.doi.org/10.1074/jbc.M110.108597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881791PMC
June 2010

Structural and thermodynamic effects of ANS binding to human interleukin-1 receptor antagonist.

Protein Sci 2008 Apr 27;17(4):652-63. Epub 2008 Feb 27.

Department of Pharmaceutics, Amgen Inc., Seattle, Washington 98119-3105, USA.

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http://dx.doi.org/10.1110/ps.073332408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2271160PMC
April 2008

How different are structurally flexible and rigid binding sites? Sequence and structural features discriminating proteins that do and do not undergo conformational change upon ligand binding.

J Mol Biol 2007 Jan 29;365(1):257-73. Epub 2006 Sep 29.

Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, NCI-Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.jmb.2006.09.062DOI Listing
January 2007

Sequence and structure analysis of parallel beta helices: implication for constructing amyloid structural models.

Structure 2006 Jun;14(6):1059-72

Department of Chemistry, National Central University, Chung-Li 32001, Taiwan.

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http://linkinghub.elsevier.com/retrieve/pii/S096921260600216
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http://dx.doi.org/10.1016/j.str.2006.03.015DOI Listing
June 2006

Computational study of the fibril organization of polyglutamine repeats reveals a common motif identified in beta-helices.

J Mol Biol 2006 Apr 9;358(1):330-45. Epub 2006 Feb 9.

Department of Chemical Engineering, E.T.S.E.I.B.-U.P.C., Av. Diagonal 647, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.jmb.2006.01.070DOI Listing
April 2006

Fibril modelling by sequence and structure conservation analysis combined with protein docking techniques: beta(2)-microglobulin amyloidosis.

Biochim Biophys Acta 2005 Nov 2;1753(1):121-30. Epub 2005 Aug 2.

Bioinformatics Unit, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.

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http://dx.doi.org/10.1016/j.bbapap.2005.07.012DOI Listing
November 2005

Structural features differentiate the mechanisms between 2S (2 state) and 3S (3 state) folding homodimers.

Bioinformation 2005 Sep 2;1(2):42-9. Epub 2005 Sep 2.

School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891634PMC
September 2005

Energy landscape of amyloidogenic peptide oligomerization by parallel-tempering molecular dynamics simulation: significant role of Asn ladder.

Proc Natl Acad Sci U S A 2005 Jun 27;102(23):8174-9. Epub 2005 May 27.

Basic Research Program, SAIC-Frederick, Inc., Laboratory of Experimental and Computational Biology, National Cancer Institute, Building 469, Room 145, Frederick, MD 21702, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0408653102
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http://dx.doi.org/10.1073/pnas.0408653102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1149403PMC
June 2005

Analysis of ordered and disordered protein complexes reveals structural features discriminating between stable and unstable monomers.

J Mol Biol 2004 Aug;341(5):1327-41

Laboratory of Experimental and Computational Biology, Basic Research Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.jmb.2004.07.002DOI Listing
August 2004

The stability and dynamics of the human calcitonin amyloid peptide DFNKF.

Biophys J 2004 Jul;87(1):146-58

Basic Research Program, Science Applications International Corporation-Frederick, Laboratory of Experimental and Computational Biology, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1529/biophysj.104.040352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1304338PMC
July 2004

Side chain interactions determine the amyloid organization: a single layer beta-sheet molecular structure of the calcitonin peptide segment 15-19.

Phys Biol 2004 Jun;1(1-2):89-99

Laboratory of Experimental and Computational Biology, NCI-Frederick, Bldg 469, Rm 151, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1088/1478-3967/1/2/005DOI Listing
June 2004

Sequence and structural analysis of cellular retinoic acid-binding proteins reveals a network of conserved hydrophobic interactions.

Proteins 2004 Feb;54(2):179-94

Department of Biochemistry, University of Massachusetts, Amherst 01003, USA.

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http://dx.doi.org/10.1002/prot.10520DOI Listing
February 2004

Modulating functional loop movements: the role of highly conserved residues in the correlated loop motions.

Chembiochem 2004 Feb;5(2):224-30

Basic Research Program, SAIC-Frederick, Inc Laboratory of Experimental and Computational Biology, NCI-Frederick, building 469, room 151, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1002/cbic.200300732DOI Listing
February 2004

Using DelPhi to compute electrostatic potentials and assess their contribution to interactions.

Curr Protoc Bioinformatics 2003 Aug;Chapter 8:Unit 8.4

Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1002/0471250953.bi0804s02DOI Listing
August 2003

Extended disordered proteins: targeting function with less scaffold.

Trends Biochem Sci 2003 Feb;28(2):81-5

Laboratory of Experimental and Computational Biology, NCI- Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/S0968-0004(03)00003-3DOI Listing
February 2003