Publications by authors named "Kamran Shamsi"

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Conifer Green Needle Complex in Patients with Precancerous Gastric Lesions: An Observational Pilot Study.

Evid Based Complement Alternat Med 2016 28;2016:3848409. Epub 2016 Nov 28.

Solagran Limited, Biotechnology Company, 98-106 Moray St., South Melbourne, VIC 3205, Australia; Saint Petersburg State Forest Technical Academy, Saint Petersburg, Russia.

. infection is common and can lead to precancerous gastric lesions. Standard antibiotic therapy has a failure rate of more than 25% from antibiotic resistance. The primary aim of this observational pilot study was to test the feasibility of a large-scale clinical trial of Conifer Green Needle Complex (CGNC) to treat precancerous gastric lesions. Secondary aims were to investigate infection, stomach function, and histopathology of the gastric mucosa. . A tablet form of CGNC (extracted from and (L) Karst) was prescribed to 26 patients with precancerous gastric lesions (two tablets, 100 mg CGNC/tablet, three times per day for six months). Another 24 patients received no treatment. Compared with control patients, CGNC-treated patients showed total or partial regression (using the quantitative Rome III diagnostic criteria) of dyspeptic symptoms (92.3%, < 0.0001), eradication of infection (57.1%, < 0.03), a reduction in endoscopic signs of gastritis (92.3%, < 0.001), an increase of pepsinogen-pepsin in the gastric juice (57.7%, < 0.05), and total regression or reduction in the degree of intestinal metaplasia (46.2%, < 0.05) and lymphoplasmacytic infiltration (53.8%, < 0.05). This study justifies a randomised-controlled trial with CGNC in patients with atrophic gastritis.
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http://dx.doi.org/10.1155/2016/3848409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5149685PMC
November 2016
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