Publications by authors named "Kamel Khalili"

100Publications

Potential Role for Herpesviruses in Alzheimer's Disease.

J Alzheimers Dis 2020 Oct 13. Epub 2020 Oct 13.

Department of Neuroscience and Center for Neurovirology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.3233/JAD-200814DOI Listing
October 2020

Cross-talk between lipid homeostasis and endoplasmic reticulum stress in neurodegeneration: insights for HIV-1 associated neurocognitive disorders (HAND).

Neurochem Int 2020 Oct 13:104880. Epub 2020 Oct 13.

Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500, N. Broad Street, Philadelphia, PA. Electronic address:

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http://dx.doi.org/10.1016/j.neuint.2020.104880DOI Listing
October 2020

The lncRNA LOC102549805 (U1) modulates neurotoxicity of HIV-1 Tat protein.

Cell Death Dis 2020 Oct 8;11(10):835. Epub 2020 Oct 8.

Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500 North Broad Street, Philadelphia, PA, 19140, USA.

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http://dx.doi.org/10.1038/s41419-020-03033-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546609PMC
October 2020

Novel BAG3 Variants in African American Patients With Cardiomyopathy: Reduced β-Adrenergic Responsiveness in Excitation-Contraction.

J Card Fail 2020 Sep 18. Epub 2020 Sep 18.

Department of Medicine, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania; Center for Translational Medicine, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.cardfail.2020.09.009DOI Listing
September 2020

Amplification of Replication Competent HIV-1 by Adoptive Transfer of Human Cells From Infected Humanized Mice.

Front Cell Infect Microbiol 2020 11;10:38. Epub 2020 Feb 11.

Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, United States.

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http://dx.doi.org/10.3389/fcimb.2020.00038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026001PMC
February 2020

Suppression of Zika Virus Infection in the Brain by the Antiretroviral Drug Rilpivirine.

Mol Ther 2019 12 11;27(12):2067-2079. Epub 2019 Oct 11.

Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, Philadelphia, PA 19140, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904669PMC
December 2019

Age-related neurodegenerative diseases.

J Cell Physiol 2020 Apr 25;235(4):3131-3141. Epub 2019 Sep 25.

Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/jcp.29248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029396PMC
April 2020

Perturbation of synapsins homeostasis through HIV-1 Tat-mediated suppression of BAG3 in primary neuronal cells.

Cell Death Dis 2019 06 17;10(7):473. Epub 2019 Jun 17.

Department of Neuroscience Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500N. Broad Street, Philadelphia, PA, 19140, USA.

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http://dx.doi.org/10.1038/s41419-019-1702-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572798PMC
June 2019

Role of Bcl2-associated Athanogene 3 in Turnover of Gap Junction Protein, Connexin 43, in Neonatal Cardiomyocytes.

Sci Rep 2019 05 21;9(1):7658. Epub 2019 May 21.

Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/s41598-019-44139-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529437PMC
May 2019

Evidence for the impact of BAG3 on electrophysiological activity of primary culture of neonatal cardiomyocytes.

J Cell Physiol 2019 08 1;234(10):18371-18381. Epub 2019 Apr 1.

Department of Neuroscience, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/jcp.28471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830737PMC
August 2019

Magnetically guided non-invasive CRISPR-Cas9/gRNA delivery across blood-brain barrier to eradicate latent HIV-1 infection.

Sci Rep 2019 03 8;9(1):3928. Epub 2019 Mar 8.

Department of Immunology and Nano-Medicine, Center for Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.

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http://dx.doi.org/10.1038/s41598-019-40222-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408460PMC
March 2019

Surface-engineered multimodal magnetic nanoparticles to manage CNS diseases.

Drug Discov Today 2019 03 17;24(3):873-882. Epub 2019 Jan 17.

Department of Immunology and Nano-Medicine, Institute of NeuroImmune Pharmacology, Centre for Personalized Nanomedicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2019.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405805PMC
March 2019

Lamin B is a target for selective nuclear PQC by BAG3: implication for nuclear envelopathies.

Cell Death Dis 2019 01 10;10(1):23. Epub 2019 Jan 10.

Department of Neuroscience, Center for Neurovirology, Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.

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http://www.nature.com/articles/s41419-018-1255-9
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http://dx.doi.org/10.1038/s41419-018-1255-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328609PMC
January 2019

Gene Editing of HIV-1 Co-receptors to Prevent and/or Cure Virus Infection.

Front Microbiol 2018 17;9:2940. Epub 2018 Dec 17.

Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States.

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https://www.frontiersin.org/article/10.3389/fmicb.2018.02940
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http://dx.doi.org/10.3389/fmicb.2018.02940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304358PMC
December 2018

Toward the Cure of HIV-1 Infection: Lessons Learned and Yet to be Learned as New Strategies are Developed.

AIDS Rev 2018 ;20(4):220-225

Department of Neuroscience, Center for Translational AIDS Research, Philadelphia, USA.

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http://www.aidsreviews.com/resumen.php?id=1450
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http://dx.doi.org/10.24875/AIDSRev.18000027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810680PMC
May 2019

Mitochondrial quality control in cardiac cells: Mechanisms and role in cardiac cell injury and disease.

J Cell Physiol 2019 06 11;234(6):8122-8133. Epub 2018 Nov 11.

Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/jcp.27597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395499PMC
June 2019

Dysregulation of Neuronal Cholesterol Homeostasis upon Exposure to HIV-1 Tat and Cocaine Revealed by RNA-Sequencing.

Sci Rep 2018 11 2;8(1):16300. Epub 2018 Nov 2.

Department of Neuroscience, Center for Neurovirology, Comprehensive NeuroAIDS Center, Lewis Katz School of Medicine at Temple University, 3500N. Broad Street, Philadelphia, PA, 19140, USA.

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http://www.nature.com/articles/s41598-018-34539-9
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http://dx.doi.org/10.1038/s41598-018-34539-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215004PMC
November 2018

Removal of HIV DNA by CRISPR from Patient Blood Engrafts in Humanized Mice.

Mol Ther Nucleic Acids 2018 Sep 19;12:275-282. Epub 2018 Jun 19.

Center for Neurovirology, Department of Neuroscience, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA; Center for AIDS Translational Research, Department of Neuroscience, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2018.05.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011019PMC
September 2018

Network analysis of hippocampal neurons by microelectrode array in the presence of HIV-1 Tat and cocaine.

J Cell Physiol 2018 12 22;233(12):9299-9311. Epub 2018 Jun 22.

Department of Neuroscience, Center for Neurovirology and Comprehensive NeuroAIDS Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/jcp.26322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988922PMC
December 2018

HIV-1 Nef-induced cardiotoxicity through dysregulation of autophagy.

Sci Rep 2017 08 17;7(1):8572. Epub 2017 Aug 17.

Department of Neuroscience, Center for Neurovirology and Comprehensive NeuroAIDS Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41598-017-08736-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561171PMC
August 2017

Precision Medicine for Heart Failure: Lessons From Oncology.

Circ Heart Fail 2017 06;10(6)

From the Departments of Medicine (A.M.F., J.Y.C.), Genetics and Molecular Biochemistry (G.S.G.), and Neuroscience (K.K.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; Division of Cardiology, Duke University School of Medicine, Durham, NC (C.D.K.); and Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC (J.M.M.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643024PMC
June 2017

Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes.

J Cell Physiol 2018 Feb 31;233(2):748-758. Epub 2017 Jul 31.

Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/jcp.26002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673531PMC
February 2018

CRISPR Editing Technology in Biological and Biomedical Investigation.

J Cell Biochem 2017 11 4;118(11):3586-3594. Epub 2017 Jul 4.

Center for Neurovirology and Comprehensive NeuroAIDS Center, Department of Neuroscience, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, Philadelphia, Pennsylvania, 19140.

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http://dx.doi.org/10.1002/jcb.26099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682924PMC
November 2017

In Vivo Excision of HIV-1 Provirus by saCas9 and Multiplex Single-Guide RNAs in Animal Models.

Mol Ther 2017 05 30;25(5):1168-1186. Epub 2017 Mar 30.

Department of Neuroscience, Center for Neurovirology and the Comprehensive NeuroAIDS Center, Temple University Lewis Katz School of Medicine, 3500 N. Broad Street, Philadelphia, PA 19140, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15250016173011
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http://dx.doi.org/10.1016/j.ymthe.2017.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417847PMC
May 2017

Novel AIDS therapies based on gene editing.

Cell Mol Life Sci 2017 07 16;74(13):2439-2450. Epub 2017 Feb 16.

Department of Neuroscience, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, 7th Floor, Philadelphia, PA, 19140, USA.

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http://dx.doi.org/10.1007/s00018-017-2479-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474186PMC
July 2017

HIV-1 Nef is released in extracellular vesicles derived from astrocytes: evidence for Nef-mediated neurotoxicity.

Cell Death Dis 2017 01 12;8(1):e2542. Epub 2017 Jan 12.

Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine, Temple University, Philadelphia, 19140 PA, USA.

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http://dx.doi.org/10.1038/cddis.2016.467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386374PMC
January 2017

Gene Editing Approaches against Viral Infections and Strategy to Prevent Occurrence of Viral Escape.

PLoS Pathog 2016 12 8;12(12):e1005953. Epub 2016 Dec 8.

Department of Neuroscience, Center for Neurovirology and Comprehensive NeuroAIDS Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145235PMC
December 2016

Negative Feedback Regulation of HIV-1 by Gene Editing Strategy.

Sci Rep 2016 08 16;6:31527. Epub 2016 Aug 16.

Department of Neuroscience Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, 7th Floor Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1038/srep31527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985742PMC
August 2016

Zika virus: An emergent neuropathological agent.

Ann Neurol 2016 Oct 10;80(4):479-89. Epub 2016 Aug 10.

Department of Neuroscience, Center for Neurovirology, Comprehensive NeuroAIDS Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086418PMC
http://dx.doi.org/10.1002/ana.24748DOI Listing
October 2016

Evidence for the Role of BAG3 in Mitochondrial Quality Control in Cardiomyocytes.

J Cell Physiol 2017 Apr 19;232(4):797-805. Epub 2016 Jul 19.

Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/jcp.25476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663276PMC
April 2017

Glutamate metabolism in HIV-1 infected macrophages: Role of HIV-1 Vpr.

Cell Cycle 2016 Sep 31;15(17):2288-98. Epub 2016 May 31.

a Department of Neuroscience and Comprehensive NeuroAIDS Center , Lewis Katz School of Medicine at Temple University , Philadelphia , PA , USA.

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http://dx.doi.org/10.1080/15384101.2016.1190054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004675PMC
September 2016

Gene Editing for Treatment of Neurological Infections.

Neurotherapeutics 2016 07;13(3):547-54

Department of Neuroscience, Center for Neurovirology, Comprehensive NeuroAIDS Center, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, 7th Floor, Philadelphia, PA, 19140, USA.

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http://dx.doi.org/10.1007/s13311-016-0439-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965407PMC
July 2016

Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers.

Sci Rep 2016 05 4;6:25309. Epub 2016 May 4.

Center for Personalized Nanomedicine, Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Miami, FL-33199, USA.

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http://dx.doi.org/10.1038/srep25309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855156PMC
May 2016

UBC9-Mediated Sumoylation Favorably Impacts Cardiac Function in Compromised Hearts.

Circ Res 2016 06 3;118(12):1894-905. Epub 2016 May 3.

From the Department of Neuroscience, Temple University, Philadelphia, PA (M.K.G., K.K.); and Department of Pediatrics, The Heart Institute, The Cincinnati Children's Hospital Medical Center, Cincinnati, OH (P.M.M., J.G., J.J, J.R.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.308268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902739PMC
June 2016

Inhibition of HSV-1 Replication by Gene Editing Strategy.

Sci Rep 2016 Apr 11;6:23146. Epub 2016 Apr 11.

Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, 3500 N. Broad Street, Philadelphia, 19140 PA, USA.

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http://dx.doi.org/10.1038/srep23146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827394PMC
April 2016

HIV-1 Tat and Cocaine Impair Survival of Cultured Primary Neuronal Cells via a Mitochondrial Pathway.

J Neuroimmune Pharmacol 2016 06 31;11(2):358-68. Epub 2016 Mar 31.

Department of Neuroscience, Center for Neurovirology and Comprehensive NeuroAIDS Center, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, Philadelphia, PA, 19140, USA.

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http://dx.doi.org/10.1007/s11481-016-9669-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215880PMC
June 2016

HIV-1 Latency and Eradication: Past, Present and Future.

Curr HIV Res 2016 ;14(5):431-441

Department of Neuroscience, Center for Neurovirology and Comprehensive NeuroAIDS Center, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, 7th Floor, Philadelphia, PA 19140, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157928PMC
http://dx.doi.org/10.2174/1570162x14666160324125536DOI Listing
August 2017

Functional screening of guide RNAs targeting the regulatory and structural HIV-1 viral genome for a cure of AIDS.

AIDS 2016 05;30(8):1163-74

aDepartment of Neuroscience, Center for Neurovirology and The Comprehensive NeuroAIDS Center, Temple University School of Medicine, Philadelphia bDepartment of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. *Kamel Khalili, Wenhui Hu and Yonggang Zhang are senior authors and have equally contributed to this manuscript.

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http://dx.doi.org/10.1097/QAD.0000000000001079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851589PMC
May 2016

Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing.

Sci Rep 2016 Mar 4;6:22555. Epub 2016 Mar 4.

Department of Neuroscience/Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, 7th Floor, Philadelphia, PA 19140 USA.

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http://dx.doi.org/10.1038/srep22555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778041PMC
March 2016

CRISPR/Cas9 and cancer targets: future possibilities and present challenges.

Oncotarget 2016 Mar;7(11):12305-17

Department of Neuroscience, Center for Neurovirology and Comprehensive Neuroaids Center, Temple University School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.18632/oncotarget.7104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914286PMC
March 2016

BAG3 regulates contractility and Ca(2+) homeostasis in adult mouse ventricular myocytes.

J Mol Cell Cardiol 2016 Mar 19;92:10-20. Epub 2016 Jan 19.

Center of Translational Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA; Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2016.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789075PMC
March 2016

GRP78 Interacting Partner Bag5 Responds to ER Stress and Protects Cardiomyocytes From ER Stress-Induced Apoptosis.

J Cell Biochem 2016 08 21;117(8):1813-21. Epub 2016 Jan 21.

Department of Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/jcb.25481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909508PMC
August 2016

Diagnostic assays for polyomavirus JC and progressive multifocal leukoencephalopathy.

Rev Med Virol 2016 Mar 14;26(2):102-14. Epub 2015 Dec 14.

Department of Neuroscience, Center for Neurovirology and Comprehensive NeuroAIDS Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/rmv.1866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883008PMC
March 2016

Morphine-induced MOR-1X and ASF/SF2 Expressions Are Independent of Transcriptional Regulation: Implications for MOR-1X Signaling.

J Cell Physiol 2016 Jul 28;231(7):1542-53. Epub 2015 Dec 28.

Department of Neuroscience and Center for Neurovirology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/jcp.25246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801751PMC
July 2016

CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs.

Sci Rep 2015 Nov 5;5:16277. Epub 2015 Nov 5.

Department of Neuroscience, Center for Neurovirology and The Comprehensive NeuroAIDS Center, Temple University School of Medicine, 3500 N Broad Street, Philadelphia, PA 19140.

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http://dx.doi.org/10.1038/srep16277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633726PMC
November 2015

Regulation and Functional Implications of Opioid Receptor Splicing in Opioid Pharmacology and HIV Pathogenesis.

J Cell Physiol 2016 May 24;231(5):976-85. Epub 2015 Nov 24.

Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/jcp.25237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728022PMC
May 2016

TNF-α/TNFR2 Regulatory Axis Stimulates EphB2-Mediated Neuroregeneration Via Activation of NF-κB.

J Cell Physiol 2016 Jun 4;231(6):1237-48. Epub 2015 Nov 4.

Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/jcp.25219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755888PMC
June 2016

CRISPR/Cas9 System as an Agent for Eliminating Polyomavirus JC Infection.

PLoS One 2015 11;10(9):e0136046. Epub 2015 Sep 11.

Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA, 19122, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136046PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567079PMC
May 2016

Cardiac Dysfunction in HIV-1 Transgenic Mouse: Role of Stress and BAG3.

Clin Transl Sci 2015 Aug 24;8(4):305-10. Epub 2015 Aug 24.

Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1111/cts.12331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841629PMC
August 2015

Dysregulation of autophagy by HIV-1 Nef in human astrocytes.

Cell Cycle 2015 15;14(18):2899-904. Epub 2015 Jul 15.

a Department of Neuroscience Center for Neurovirology ; Temple University School of Medicine ; Philadelphia , PA USA.

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http://dx.doi.org/10.1080/15384101.2015.1069927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825552PMC
August 2016

Animal Models for Progressive Multifocal Leukoencephalopathy.

J Cell Physiol 2015 Dec;230(12):2869-74

Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/jcp.25047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549183PMC
December 2015

The CRISPR/Cas9 genome editing methodology as a weapon against human viruses.

Discov Med 2015 Apr;19(105):255-62

Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445958PMC
April 2015

BAG3: a new player in the heart failure paradigm.

Heart Fail Rev 2015 Jul;20(4):423-34

Department of Neuroscience, Temple University School of Medicine, 3500 N. Broad Street, Suite 1150, Philadelphia, PA, 19140, USA.

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http://link.springer.com/content/pdf/10.1007%2Fs10741-015-94
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http://link.springer.com/10.1007/s10741-015-9487-6
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http://dx.doi.org/10.1007/s10741-015-9487-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463985PMC
July 2015

Epigenetic regulation of polyomavirus JC involves acetylation of specific lysine residues in NF-κB p65.

J Neurovirol 2015 Dec 20;21(6):679-87. Epub 2015 Mar 20.

Center for Neurovirology, Department of Neuroscience, Temple University School of Medicine, Room 756 MERB, 3500 N. Broad Street, Philadelphia, PA, 19140, USA.

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http://dx.doi.org/10.1007/s13365-015-0326-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575817PMC
December 2015

Genome editing strategies: potential tools for eradicating HIV-1/AIDS.

J Neurovirol 2015 Jun 26;21(3):310-21. Epub 2015 Feb 26.

Department of Neuroscience, Center for Neurovirology and the Comprehensive NeuroAIDS Center, Temple University School of Medicine, Philadelphia, PA, 19140, USA,

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http://dx.doi.org/10.1007/s13365-014-0308-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433555PMC
June 2015

Persistence and pathogenesis of the neurotropic polyomavirus JC.

Ann Neurol 2015 Apr 6;77(4):560-70. Epub 2015 Mar 6.

Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA.

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http://doi.wiley.com/10.1002/ana.24371
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376594PMC
April 2015

Role of hexokinase-1 in the survival of HIV-1-infected macrophages.

Cell Cycle 2015 ;14(7):980-9

a Department of Biology ; College of Science and Technology ; Temple University ; Philadelphia , PA USA.

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http://dx.doi.org/10.1080/15384101.2015.1006971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612415PMC
December 2015

Rad51 activates polyomavirus JC early transcription.

PLoS One 2014 13;9(10):e110122. Epub 2014 Oct 13.

Center for Neurovirology, Department of Neuroscience, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195707PMC
September 2015

WW domain of BAG3 is required for the induction of autophagy in glioma cells.

J Cell Physiol 2015 Apr;230(4):831-41

Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/jcp.24811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373658PMC
April 2015

The agnoprotein of polyomavirus JC is released by infected cells: evidence for its cellular uptake by uninfected neighboring cells.

Virology 2014 Nov 23;468-470:88-95. Epub 2014 Aug 23.

Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, 3500 North Broad Street, 7th Floor, Philadelphia, PA 19140 USA. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2014.07.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254181PMC
November 2014

RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection.

Proc Natl Acad Sci U S A 2014 Aug 21;111(31):11461-6. Epub 2014 Jul 21.

Department of Neuroscience, Center for Neurovirology and The Comprehensive NeuroAIDS Center, Temple University School of Medicine, Philadelphia, PA 19140;

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http://dx.doi.org/10.1073/pnas.1405186111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128125PMC
August 2014

Viruses and human cancers: a long road of discovery of molecular paradigms.

Clin Microbiol Rev 2014 Jul;27(3):463-81

Department of Neuroscience, Temple University School of Medicine, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/CMR.00124-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135891PMC
July 2014

Interplay of Rad51 with NF-κB pathway stimulates expression of HIV-1.

PLoS One 2014 21;9(5):e98304. Epub 2014 May 21.

Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029908PMC
January 2015

Polyamines: Predictive Biomarker for HIV-Associated Neurocognitive Disorders.

J AIDS Clin Res 2014;5(6):1000312

Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.4172/2155-6113.1000312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397651PMC
January 2014

TNF-α/NF-κB signaling in the CNS: possible connection to EPHB2.

J Neuroimmune Pharmacol 2014 Mar 27;9(2):133-41. Epub 2013 Nov 27.

Center for Neurovirology, Department of Neuroscience, Temple University School of Medicine, Room 741 MERB, 3500N. Broad Street, Philadelphia, PA, 19140, USA.

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http://dx.doi.org/10.1007/s11481-013-9517-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959244PMC
March 2014

Compartmentalized neuronal cultures.

Methods Mol Biol 2013 ;1078:147-52

Department of Pathology, The Mount Sinai Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1007/978-1-62703-640-5_13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987660PMC
March 2014

Epigenetic regulation of polyomavirus JC.

Virol J 2013 Aug 23;10:264. Epub 2013 Aug 23.

Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, 3500 N Broad Street, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1186/1743-422X-10-264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765676PMC
August 2013

Neuroprotective activity of pDING in response to HIV-1 Tat.

J Cell Physiol 2014 Feb;229(2):153-61

Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/jcp.24392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204488PMC
February 2014

The role of AEG-1/MTDH/LYRIC in the pathogenesis of central nervous system disease.

Adv Cancer Res 2013 ;120:159-92

Department of Neurology and Neuroscience, Weill-Cornell Medical Center-New York Presbyterian Hospital, New York, NY, USA.

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https://linkinghub.elsevier.com/retrieve/pii/B97801240167670
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204483PMC
March 2014

HIV-1 Vpr modulates macrophage metabolic pathways: a SILAC-based quantitative analysis.

PLoS One 2013 12;8(7):e68376. Epub 2013 Jul 12.

Department of Biochemistry, Temple University School of Medicine, Fels Institute, Philadelphia, Pennsylvania, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709966PMC
February 2014

Neural Crest Cells Isolated from the Bone Marrow of Transgenic Mice Express JCV T-Antigen.

PLoS One 2013 21;8(6):e65947. Epub 2013 Jun 21.

Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689770PMC
October 2017

The rapidly expanding family of human polyomaviruses: recent developments in understanding their life cycle and role in human pathology.

PLoS Pathog 2013 Mar 14;9(3):e1003206. Epub 2013 Mar 14.

Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1371/journal.ppat.1003206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597531PMC
March 2013

Polyomavirus JC infection inhibits differentiation of oligodendrocyte progenitor cells.

J Neurosci Res 2013 Jan 22;91(1):116-27. Epub 2012 Oct 22.

Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

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http://dx.doi.org/10.1002/jnr.23135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641310PMC
January 2013

Inhibition of NF-κB activity by HIV-1 Vpr is dependent on Vpr binding protein.

J Cell Physiol 2013 Apr;228(4):781-90

Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

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http://dx.doi.org/10.1002/jcp.24226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604695PMC
April 2013

Bag3-induced autophagy is associated with degradation of JCV oncoprotein, T-Ag.

PLoS One 2012 12;7(9):e45000. Epub 2012 Sep 12.

Department of Neuroscience and Center for Neurovirology Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440322PMC
March 2013

Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain.

Clin Microbiol Rev 2012 Jul;25(3):471-506

Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1128/CMR.05031-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416490PMC
July 2012

Cooperative roles of NF-κB and NFAT4 in polyomavirus JC regulation at the KB control element.

Virology 2012 Oct 30;432(1):146-54. Epub 2012 Jun 30.

Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1016/j.virol.2012.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579630PMC
October 2012

MEKK1-MKK4-JNK-AP1 pathway negatively regulates Rgs4 expression in colonic smooth muscle cells.

PLoS One 2012 24;7(4):e35646. Epub 2012 Apr 24.

Department of Neuroscience, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335800PMC
August 2012

Integrating role of T antigen, Rb2/p130, CTCF and BORIS in mediating non-canonical endoplasmic reticulum-dependent death pathways triggered by chronic ER stress in mouse medulloblastoma.

Cell Cycle 2012 May 1;11(9):1841-50. Epub 2012 May 1.

Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA.

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http://dx.doi.org/10.4161/cc.20242DOI Listing
May 2012

JC virus T-antigen regulates glucose metabolic pathways in brain tumor cells.

PLoS One 2012 9;7(4):e35054. Epub 2012 Apr 9.

Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322159PMC
August 2012

Oncogenic viruses and tumor glucose metabolism: like kids in a candy store.

Mol Cancer Ther 2012 Jan;11(1):14-23

Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-11
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http://dx.doi.org/10.1158/1535-7163.MCT-11-0517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257817PMC
January 2012

The pathogenesis of progressive multifocal leukoencephalopathy.

Discov Med 2011 Dec;12(67):495-503

Department of Neurology, University of Kentucky, 740 S. Limestone St., Lexington, Kentucky 40536, USA.

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December 2011

Nuclear factor kappa B signaling initiates early differentiation of neural stem cells.

Stem Cells 2012 Mar;30(3):510-24

Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, People's Republic of China.

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http://dx.doi.org/10.1002/stem.1006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707487PMC
March 2012

Growth inhibition of malignant glioblastoma by DING protein.

J Neurooncol 2012 Apr 4;107(2):247-56. Epub 2011 Nov 4.

Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Room 741 MERB, 3500 North Broad St., Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1007/s11060-011-0743-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631253PMC
April 2012