Kamel El Omari

Kamel El Omari

UNVERIFIED PROFILE

Are you Kamel El Omari?   Register this Author

Register author
Kamel El Omari

Kamel El Omari

Publications by authors named "Kamel El Omari"

Are you Kamel El Omari?   Register this Author

40Publications

533Reads

40Profile Views

Native de novo structural determinations of non-canonical nucleic acid motifs by X-ray crystallography at long wavelengths.

Nucleic Acids Res 2020 May 26. Epub 2020 May 26.

State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkaa439DOI Listing
May 2020

Identifying dynamic, partially occupied residues using anomalous scattering.

Acta Crystallogr D Struct Biol 2019 Dec 19;75(Pt 12):1084-1095. Epub 2019 Nov 19.

Department of Chemistry and Biochemistry and the Knoebel Institute for Healthy Aging, University of Denver, Denver, CO 80208, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2059798319014475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889914PMC
December 2019

Multiple liquid crystalline geometries of highly compacted nucleic acid in a dsRNA virus.

Nature 2019 06 29;570(7760):252-256. Epub 2019 May 29.

Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41586-019-1229-9DOI Listing
June 2019

Structure-Based Classification Defines the Discrete Conformational Classes Adopted by the Arenaviral GP1.

J Virol 2019 01 10;93(1). Epub 2018 Dec 10.

Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

View Article

Download full-text PDF

Source
http://jvi.asm.org/lookup/doi/10.1128/JVI.01048-18
Publisher Site
http://dx.doi.org/10.1128/JVI.01048-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288339PMC
January 2019

Anomalous X-ray diffraction studies of ion transport in K channels.

Nat Commun 2018 10 31;9(1):4540. Epub 2018 Oct 31.

Neutron Scattering Division, Oak Ridge National Laboratory, 1 Bethel Valley Rd, Oak Ridge, TN, 37831, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41467-018-06957-w
Publisher Site
http://dx.doi.org/10.1038/s41467-018-06957-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208422PMC
October 2018

Structural basis for the glycosyltransferase activity of the effector SseK3.

J Biol Chem 2018 04 15;293(14):5064-5078. Epub 2018 Feb 15.

From the Molecular Structure of Cell Signalling Laboratory, Francis Crick Institute, 1 Midland Road, London NW1 1AT, United Kingdom,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.RA118.001796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892559PMC
April 2018

Double-stranded RNA virus outer shell assembly by bona fide domain-swapping.

Nat Commun 2017 03 13;8:14814. Epub 2017 Mar 13.

Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms14814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355851PMC
March 2017

Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains.

Mol Cell 2016 Jan 17;61(1):125-37. Epub 2015 Dec 17.

European Molecular Biology Laboratory Grenoble Outstation and Unit of Virus Host-Cell Interactions, University Grenoble Alpes-CNRS-EMBL, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble Cedex 9, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2015.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712189PMC
January 2016

Unexpected features and mechanism of heterodimer formation of a herpesvirus nuclear egress complex.

EMBO J 2015 Dec 28;34(23):2937-52. Epub 2015 Oct 28.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/embj.201592651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687685PMC
December 2015

Crystal structure of the RNA-dependent RNA polymerase from influenza C virus.

Nature 2015 Nov 26;527(7576):114-7. Epub 2015 Oct 26.

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature15525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783868PMC
November 2015

Unexpected structure for the N-terminal domain of hepatitis C virus envelope glycoprotein E1.

Nat Commun 2014 Sep 16;5:4874. Epub 2014 Sep 16.

1] Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, UK [2] Diamond Light Source Limited, Harwell Science and Innovation Campus, Didcot OX11 0DE, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms5874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175578PMC
September 2014

Pushing the limits of sulfur SAD phasing: de novo structure solution of the N-terminal domain of the ectodomain of HCV E1.

Acta Crystallogr D Biol Crystallogr 2014 Aug 25;70(Pt 8):2197-203. Epub 2014 Jul 25.

Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, England.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S139900471401339XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118829PMC
August 2014

Tracking in atomic detail the functional specializations in viral RecA helicases that occur during evolution.

Nucleic Acids Res 2013 Nov 11;41(20):9396-410. Epub 2013 Aug 11.

Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, UK, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00290 Helsinki, Finland, Department of Environmental Research, Siauliai University, Vilniaus gatvė 88, 76285 Siauliai, Lithuania, Diamond Light Source Limited, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, UK, Department of Biosciences, University of Helsinki, Biocenter 2, PO Box 56, 00014 Helsinki, Finland, Institute of Biotechnology, University of Helsinki, Biocenter 2, PO Box 56, 00014 Helsinki, Finland and Astbury Centre for Structural Molecular Biology and School of Cellular and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkt713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814363PMC
November 2013

Plate tectonics of virus shell assembly and reorganization in phage φ8, a distant relative of mammalian reoviruses.

Structure 2013 Aug 25;21(8):1384-95. Epub 2013 Jul 25.

Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.str.2013.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737474PMC
August 2013

Structure of a pestivirus envelope glycoprotein E2 clarifies its role in cell entry.

Cell Rep 2013 Jan 27;3(1):30-5. Epub 2012 Dec 27.

Division of Structural Biology, The Wellcome Trust Center for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, UK.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22111247120042
Publisher Site
http://dx.doi.org/10.1016/j.celrep.2012.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607223PMC
January 2013

Expression, purification and crystallization of the ectodomain of the envelope glycoprotein E2 from Bovine viral diarrhoea virus.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2013 Jan 15;69(Pt 1):35-8. Epub 2012 Dec 15.

Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, England.

View Article

Download full-text PDF

Source
http://scripts.iucr.org/cgi-bin/paper?S1744309112049184
Publisher Site
http://dx.doi.org/10.1107/S1744309112049184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539699PMC
January 2013

Structure of the DNA-bound T-box domain of human TBX1, a transcription factor associated with the DiGeorge syndrome.

Proteins 2012 Feb 17;80(2):655-60. Epub 2011 Nov 17.

Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/prot.23208
Publisher Site
http://dx.doi.org/10.1002/prot.23208DOI Listing
February 2012

Crystallographic and microcalorimetric analyses reveal the structural basis for high arginine specificity in the Salmonella enterica serovar Typhimurium periplasmic binding protein STM4351.

Proteins 2011 Jul 10;79(7):2352-7. Epub 2011 May 10.

Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/prot.23060DOI Listing
July 2011

Purification, crystallization and preliminary X-ray analysis of a fusion of the LIM domains of LMO2 and the LID domain of Ldb1.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 Nov 28;66(Pt 11):1466-9. Epub 2010 Oct 28.

Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, England.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S1744309110032872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001649PMC
November 2010

Structural and functional characterization of Salmonella enterica serovar Typhimurium YcbL: an unusual Type II glyoxalase.

Protein Sci 2010 Oct;19(10):1897-905

Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pro.475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998724PMC
October 2010

The design and development of drugs acting against the smallpox virus.

Expert Opin Drug Discov 2007 Sep;2(9):1263-72

University of Oxford, Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, Oxford, OX3 7BN, UK +44 01865 287542 ; +44 01865 287547 ;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1517/17460441.2.9.1263DOI Listing
September 2007

Structure of Staphylococcus aureus guanylate monophosphate kinase.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 Oct 19;62(Pt 10):949-53. Epub 2006 Sep 19.

Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, England.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S174430910603613XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225188PMC
October 2006

Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design.

BMC Struct Biol 2006 Oct 24;6:22. Epub 2006 Oct 24.

Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1472-6807-6-22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636055PMC
October 2006

Mutations distal to the substrate site can affect varicella zoster virus thymidine kinase activity: implications for drug design.

Mol Pharmacol 2006 Jun 23;69(6):1891-6. Epub 2006 Mar 23.

Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/mol.106.023002DOI Listing
June 2006

Molecular architecture and ligand recognition determinants for T4 RNA ligase.

J Biol Chem 2006 Jan 1;281(3):1573-9. Epub 2005 Nov 1.

Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M509658200DOI Listing
January 2006

Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor.

J Biol Chem 2005 May 22;280(18):18229-36. Epub 2005 Feb 22.

Structural Biology Division and Oxford Protein Production Facility, The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M501113200DOI Listing
May 2005