Publications by authors named "Kalthur G"

82Publications

Stage specific response in early mouse embryos exposed to prednisolone in vitro.

J Endocrinol 2020 Dec 1. Epub 2020 Dec 1.

S Adiga, Department of Clinical Embryology, Manipal Academy of Higher Education, Manipal, 576104, India.

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December 2020

Current Insights and Latest Updates in Sperm Motility and Associated Applications in Assisted Reproduction.

Reprod Sci 2020 Dec 7. Epub 2020 Dec 7.

Department of Clinical Embryology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, 576104, India.

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December 2020

Nanoconstructs as a Versatile Tool for Detection and Diagnosis of Alzheimer Biomarkers.

Nanotechnology 2020 Nov 25. Epub 2020 Nov 25.

Pharmaceutics, Manipal Academy of Higher Education, Manipal, Karnataka, INDIA.

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November 2020

Quinoline Derivative Enhances Human Sperm Motility and Improves the Functional Competence.

Reprod Sci 2020 Nov 25. Epub 2020 Nov 25.

Department of Clinical Embryology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576 104, India.

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November 2020

Fertility preservation during the COVID-19 pandemic: mitigating the viral contamination risk to reproductive cells in cryostorage.

Reprod Biomed Online 2020 Dec 15;41(6):991-997. Epub 2020 Sep 15.

Department of Biology, University of Naples "Federico II", Complesso Universitario di Monte S. Angelo, Naples, Italy. Electronic address:

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December 2020

High-fat diet leads to elevated lipid accumulation and endoplasmic reticulum stress in oocytes, causing poor embryo development.

Reprod Fertil Dev 2020 Oct;32(14):1169-1179

Department of Clinical Embryology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal 576 104, Karnataka State, India; and Corresponding author. Email:

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October 2020

Epigallocatechin-3-gallate (EGCG) protects the oocytes from methyl parathion-induced cytoplasmic deformities by suppressing oxidative and endoplasmic reticulum stress.

Pestic Biochem Physiol 2020 Jul 20;167:104588. Epub 2020 Apr 20.

Department of Clinical Embryology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India. Electronic address:

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July 2020

Pullulan based stimuli responsive and sub cellular targeted nanoplatforms for biomedical application: Synthesis, nanoformulations and toxicological perspective.

Int J Biol Macromol 2020 Oct 3;161:1189-1205. Epub 2020 Jun 3.

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka State, India. Electronic address:

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October 2020

Naringin nano-ethosomal novel sunscreen creams: Development and performance evaluation.

Colloids Surf B Biointerfaces 2020 Sep 12;193:111122. Epub 2020 May 12.

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576 104, India. Electronic address:

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September 2020

Oncofertility: Knowledge, Attitudes, and Barriers Among Indian Oncologists and Gynecologists.

J Adolesc Young Adult Oncol 2020 May 22. Epub 2020 May 22.

Department of Clinical Embryology, Centre for Fertility Preservation, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India.

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May 2020

Ethanolic extract of Moringa oleifera leaves alleviate cyclophosphamide-induced testicular toxicity by improving endocrine function and modulating cell specific gene expression in mouse testis.

J Ethnopharmacol 2020 Sep 15;259:112922. Epub 2020 May 15.

Department of Clinical Embryology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India. Electronic address:

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September 2020

Reduced ovarian response to controlled ovarian stimulation is associated with increased oxidative stress in the follicular environment.

Reprod Biol 2020 Sep 5;20(3):402-407. Epub 2020 May 5.

Department of Clinical Embryology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal 576 104, India. Electronic address:

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September 2020

Antidiabetic drug metformin affects the developmental competence of cleavage-stage embryos.

J Assist Reprod Genet 2020 May 25;37(5):1227-1238. Epub 2020 Apr 25.

Department of Clinical Embryology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.

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May 2020

Germinal stage vitrification is superior to MII stage vitrification in prepubertal mouse oocytes.

Cryobiology 2020 04 27;93:49-55. Epub 2020 Feb 27.

Department of Clinical Embryology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, 576 104, India. Electronic address:

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April 2020

Cyclodextrins as Carriers in Targeted Delivery of Therapeutic Agents: Focused Review on Traditional and Inimitable Applications.

Curr Pharm Des 2019 ;25(4):444-454

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal 576104, Karnataka State, India.

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February 2020

Spent embryo culture medium metabolites are related to the in vitro attachment ability of blastocysts.

Sci Rep 2018 11 19;8(1):17025. Epub 2018 Nov 19.

Department of Clinical Embryology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.

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November 2018

Sperm-mediated DNA lesions alter metabolite levels in spent embryo culture medium.

Reprod Fertil Dev 2019 Mar;31(3):443-450

Department of Clinical Embryology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal-576104, India.

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March 2019

Sperm-derived factors enhance the in vitro developmental potential of haploid parthenotes.

Zygote 2017 Dec 28;25(6):697-710. Epub 2017 Nov 28.

Clinical Embryology,Kasturba Medical College,Manipal University,Manipal 576 104,Karnataka,India.

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December 2017

Epigenetic changes in preimplantation embryos subjected to laser manipulation.

Lasers Med Sci 2017 Dec 30;32(9):2081-2087. Epub 2017 Sep 30.

Division of Clinical Embryology, Level 2, Central Research Lab, Kasturba Medical College, Manipal University, Manipal, 576104, India.

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December 2017

Liposome-encapsulated diacyl glycerol and inositol triphosphate-induced delayed oocyte activation and poor development of parthenotes.

J Turk Ger Gynecol Assoc 2017 Sep;18(3):102-109

Department of Clinical Embryology, Central Research Lab, Kasturba Medical College, Manipal University, Manipal, India.

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September 2017

Indian propolis ameliorates the mitomycin C-induced testicular toxicity by reducing DNA damage and elevating the antioxidant activity.

Biomed Pharmacother 2017 Nov 12;95:252-263. Epub 2017 Sep 12.

Department of Clinical Embryology, Kasturba Medical College, Manipal, Manipal University, Manipal, 576 104, Karnataka, India.

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November 2017

Sunscreen creams containing naringenin nanoparticles: Formulation development and in vitro and in vivo evaluations.

Photodermatol Photoimmunol Photomed 2018 Jan 30;34(1):69-81. Epub 2017 Aug 30.

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka State, India.

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January 2018

Haploid parthenotes express differential response to in vitro exposure of ammonia compared to normally fertilized embryos.

Biochem Biophys Res Commun 2017 04 6;486(1):88-93. Epub 2017 Mar 6.

Clinical Embryology, Kasturba Medical College, Manipal University, Manipal 576104, India.

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April 2017

Influence of peptide dendrimers and sonophoresis on the transdermal delivery of ketoprofen.

Int J Pharm 2017 Apr 2;521(1-2):110-119. Epub 2017 Feb 2.

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka State, India. Electronic address:

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April 2017

Unraveling the association between genetic integrity and metabolic activity in pre-implantation stage embryos.

Sci Rep 2016 11 17;6:37291. Epub 2016 Nov 17.

Division of Clinical Embryology, Centre of Excellence in Clinical Embryology, Kasturba Medical College, Manipal University, Manipal, India.

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November 2016

Ethambutol induces testicular damage and decreases the sperm functional competence in Swiss albino mice.

Environ Toxicol Pharmacol 2016 Oct 12;47:28-37. Epub 2016 Aug 12.

Department of Clinical Embryology, Level 2, Central Research Lab., Manipal 576104, Karnataka, India.

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October 2016

Laser assisted zona hatching does not lead to immediate impairment in human embryo quality and metabolism.

Syst Biol Reprod Med 2016 Dec 6;62(6):396-403. Epub 2016 Sep 6.

a Division of Clinical Embryology , Kasturba Medical College, Manipal University , Manipal , India.

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December 2016

Influence of sperm DNA damage on human preimplantation embryo metabolism.

Reprod Biol 2016 Sep 1;16(3):234-241. Epub 2016 Aug 1.

Division of Clinical Embryology, Kasturba Medical College, Manipal University, Manipal, India. Electronic address:

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September 2016

Design and Microwave Assisted Synthesis of Coumarin Derivatives as PDE Inhibitors.

Int J Med Chem 2016 21;2016:9890630. Epub 2016 Feb 21.

Department of Studies in Chemistry, Mangalore University, Konaje, Karnataka 574199, India.

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March 2016

Ethanolic extract of Moringa oleifera Lam. leaves protect the pre-pubertal spermatogonial cells from cyclophosphamide-induced damage.

J Ethnopharmacol 2016 Apr 10;182:101-9. Epub 2016 Feb 10.

Center of Excellence in Clinical Embryology, Level 2, Central Research Lab, Kasturba Medical College, Manipal University, Manipal-576104, Karnataka, India.

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April 2016

Development and performance evaluation of novel nanoparticles of a grafted copolymer loaded with curcumin.

Int J Biol Macromol 2016 May 2;86:709-20. Epub 2016 Feb 2.

University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD 4102, Australia.

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May 2016

Mitigating effect of Indian propolis against mitomycin C induced bone marrow toxicity.

Cytotechnology 2016 Oct 21;68(5):1789-800. Epub 2015 Nov 21.

Division of Clinical Embryology, Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal University, Manipal, Karnataka, 576 104, India.

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October 2016

Plumbagin alters telomere dynamics, induces DNA damage and cell death in human brain tumour cells.

Mutat Res Genet Toxicol Environ Mutagen 2015 Nov 9;793:86-95. Epub 2015 Jun 9.

Genome Stability Laboratory, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore; Tembusu College, National University of Singapore, Singapore 138597, Singapore. Electronic address:

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November 2015

Sperm abnormalities induced by pre-pubertal exposure to cyclophosphamide are effectively mitigated by Moringa oleifera leaf extract.

Andrologia 2016 Mar 22;48(2):125-36. Epub 2015 Apr 22.

Division of Clinical Embryology, Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.

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March 2016

In vitro matured oocytes are more susceptible than in vivo matured oocytes to mock ICSI induced functional and genetic changes.

PLoS One 2015 18;10(3):e0119735. Epub 2015 Mar 18.

Division of Clinical Embryology, Department of Obstetrics & Gynecology, Kasturba Medical College, Manipal University, Manipal-576 104, India.

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February 2016

In situ viability detection assays induce heat-shock protein 70 expression in spermatozoa without affecting the chromatin integrity.

Andrologia 2015 Oct 13;47(8):958-65. Epub 2014 Oct 13.

Division of Clinical Embryology, Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal University, Manipal, India.

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October 2015

Methyl parathion inhibits the nuclear maturation, decreases the cytoplasmic quality in oocytes and alters the developmental potential of embryos of Swiss albino mice.

Toxicol Appl Pharmacol 2014 Sep 16;279(3):338-350. Epub 2014 Jul 16.

Division of Clinical Embryology, Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal University, Manipal 576 104, India.

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September 2014

Oocytes recovered after ovarian tissue slow freezing have impaired H2AX phosphorylation and functional competence.

Reprod Fertil Dev 2015 Nov;27(8):1242-8

Division of Clinical Embryology, Department of Obstetrics and Gynaecology, Kasturba Medical College, Manipal University, Manipal-576 104, India.

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November 2015

Laser-assisted hatching of cleavage-stage embryos impairs developmental potential and increases DNA damage in blastocysts.

Lasers Med Sci 2015 Jan 3;30(1):95-101. Epub 2014 Jul 3.

Division of Clinical Embryology, Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal University, Manipal, 576 104, India.

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January 2015

Ovarian tissue vitrification is more efficient than slow freezing in protecting oocyte and granulosa cell DNA integrity.

Syst Biol Reprod Med 2014 Dec 4;60(6):317-22. Epub 2014 Jun 4.

Division of Clinical Embryology, Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal University , Manipal , India.

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December 2014

Nuclear DNA fragmentation negatively affects zona binding competence of Y bearing mouse spermatozoa.

J Assist Reprod Genet 2013 Dec 19;30(12):1611-5. Epub 2013 Oct 19.

Division of Clinical Embryology, Department of Obstetrics & Gynecology, Kasturba Medical College, Manipal University, Manipal, 576 104, India.

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December 2013

Curcumin inhibits telomerase and induces telomere shortening and apoptosis in brain tumour cells.

J Cell Biochem 2013 Jun;114(6):1257-70

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

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June 2013

Addition of zinc to human ejaculate prior to cryopreservation prevents freeze-thaw-induced DNA damage and preserves sperm function.

J Assist Reprod Genet 2012 Dec 29;29(12):1447-53. Epub 2012 Nov 29.

Clinical Embryology, Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal University, Manipal, 576 104, India.

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December 2012

Germ cell abnormalities in streptozotocin induced diabetic mice do not correlate with blood glucose level.

J Assist Reprod Genet 2012 Dec 16;29(12):1405-13. Epub 2012 Oct 16.

Clinical Embryology, Obstetrics & Gynaecology, Kasturba Medical College, Manipal University, Manipal, 576 104, India.

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December 2012

The extent of paternal sperm DNA damage influences early post-natal survival of first generation mouse offspring.

Eur J Obstet Gynecol Reprod Biol 2013 Feb 12;166(2):164-7. Epub 2012 Oct 12.

Clinical Embryology, Department of Obstetrics & Gynecology, Kasturba Medical College, Manipal University, Manipal 576104, India.

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February 2013

Genistein induces growth arrest and suppresses telomerase activity in brain tumor cells.

Genes Chromosomes Cancer 2012 Oct 27;51(10):961-74. Epub 2012 Jun 27.

Department of Physiology, Genome Stability Laboratory, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Republic of Singapore.

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October 2012

Supplementation of biotin to sperm preparation medium increases the motility and longevity in cryopreserved human spermatozoa.

J Assist Reprod Genet 2012 Jul 21;29(7):631-5. Epub 2012 Apr 21.

Clinical Embryology, Division of Reproductive Medicine, Kasturba Medical College, Manipal University, Manipal, 576 104, India.

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July 2012

Controlled cooling versus rapid freezing of teratozoospermic semen samples: Impact on sperm chromatin integrity.

J Hum Reprod Sci 2011 Sep;4(3):121-4

Department of Physiology, Division of Reproductive Medicine, Clinical Embryology Laboratory, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.

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September 2011

Poor sperm quality and advancing age are associated with increased sperm DNA damage in infertile men.

Andrologia 2012 May 1;44 Suppl 1:642-9. Epub 2011 Nov 1.

Clinical Embryology, Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal University, Manipal, India.

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May 2012

Ejaculate fractions of asthenozoospermic and teratozoospermic patients have differences in the sperm DNA integrity.

Andrologia 2011 Dec 8;43(6):416-21. Epub 2011 Jun 8.

Clinical Embryology, Division of Reproductive Medicine, Kasturba Medical College, Manipal University, India.

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December 2011

Combination of swim-up and density gradient separation methods effectively eliminate DNA damaged sperm.

J Turk Ger Gynecol Assoc 2011 1;12(3):148-52. Epub 2011 Sep 1.

Clinical Embryology, Division of Reproductive Medicine, Kasturba Medical College, Manipal University, Manipal, India.

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March 2014

Vitamin E supplementation in semen-freezing medium improves the motility and protects sperm from freeze-thaw-induced DNA damage.

Fertil Steril 2011 Mar 10;95(3):1149-51. Epub 2010 Nov 10.

Division of Reproductive Medicine, Kasturba Medical College, Manipal University, Manipal, India.

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March 2011

Preimplantation diagnosis of genetic diseases.

J Postgrad Med 2010 Oct-Dec;56(4):317-20

Division of Reproductive Medicine, Kasturba Medical College, Manipal University, Manipal, India.

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November 2010

A randomized controlled study to evaluate the cost-effectiveness in sperm extraction using carbon dioxide and carbon dioxide free system in relation to intrauterine insemination pregnancy.

J Hum Reprod Sci 2010 Jan;3(1):8-10

Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal University, Manipal-576104 Karnataka, India.

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January 2010

Association between the extent of DNA damage in the spermatozoa, fertilization and developmental competence in preimplantation stage embryos.

J Turk Ger Gynecol Assoc 2010 1;11(4):182-6. Epub 2010 Dec 1.

Clinical Embryology, Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal University, Manipal, India.

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March 2014

Transgenerational changes in somatic and germ line genetic integrity of first-generation offspring derived from the DNA damaged sperm.

Fertil Steril 2010 May 9;93(8):2486-90. Epub 2009 Jul 9.

Division of Reproductive Medicine, Kasturba Medical College, Manipal University, Manipal, India.

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May 2010

Enhancement in motility of sperm co-incubated with cumulus oocyte complex (COC) in vitro.

Eur J Obstet Gynecol Reprod Biol 2009 Aug 30;145(2):167-71. Epub 2009 May 30.

Division of Reproductive Medicine, Kasturba Medical College, Manipal University, Manipal, India.

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August 2009

Effect of Withaferin A on the development and decay of thermotolerance in B16F1 melanoma: a preliminary study.

Integr Cancer Ther 2009 Mar 3;8(1):93-7. Epub 2009 Feb 3.

Division of Reproductive Medicine, Kasturba Medical College, Manipal, India.

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March 2009

Ability of deoxyribonucleic acid-damaged sperm to withstand freeze-thaw-induced damage during cryopreservation.

Fertil Steril 2009 Sep 30;92(3):959-963. Epub 2008 Sep 30.

Division of Reproductive Medicine, Kasturba Medical College, Manipal University, Manipal, India.

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September 2009

Susceptibility of peripheral lymphocytes of brain tumour patients to in vitro radiation-induced DNA damage, a preliminary study.

Clin Exp Med 2008 Sep 13;8(3):147-50. Epub 2008 Sep 13.

Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Kasturba Medical College and Hospital, Manipal, Karnataka, India.

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September 2008

Declining semen quality among south Indian infertile men: A retrospective study.

J Hum Reprod Sci 2008 Jan;1(1):15-8

Division of Reproductive Medicine, Kasturba Medical College, Manipal University, Manipal, India.

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January 2008

Effect of cryopreservation on sperm DNA integrity in patients with teratospermia.

Fertil Steril 2008 Jun 22;89(6):1723-7. Epub 2007 Oct 22.

Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal University, Manipal, India.

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June 2008