Kalipada Pahan

Kalipada Pahan

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Kalipada Pahan

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Cinnamic acid activates PPARα to stimulate Lysosomal biogenesis and lower Amyloid plaque pathology in an Alzheimer's disease mouse model.

Neurobiol Dis 2019 Apr 19;124:379-395. Epub 2018 Dec 19.

Department of Neurological Sciences, Rush University Medical Center, Chicago, USA; Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2018.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382282PMC
April 2019

Dietary lysophosphatidylcholine-EPA enriches both EPA and DHA in the brain: potential treatment for depression.

J Lipid Res 2019 Mar 10;60(3):566-578. Epub 2018 Dec 10.

Department of Medicine, University of Illinois at Chicago, Chicago, IL

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http://dx.doi.org/10.1194/jlr.M090464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399499PMC
March 2019

Cinnamic Acid Protects the Nigrostriatum in a Mouse Model of Parkinson's Disease via Peroxisome Proliferator-Activated Receptorα.

Neurochem Res 2019 Jan 5. Epub 2019 Jan 5.

Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, USA.

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http://dx.doi.org/10.1007/s11064-018-02705-0DOI Listing
January 2019

Chronic stress-induced gut dysfunction exacerbates Parkinson's disease phenotype and pathology in a rotenone-induced mouse model of Parkinson's disease.

Neurobiol Dis 2018 Dec 21. Epub 2018 Dec 21.

Department of Internal Medicine, Division of Digestive Diseases, Rush University Medical Center, Chicago, IL, USA; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2018.12.012DOI Listing
December 2018

Aspirin ameliorates experimental autoimmune encephalomyelitis through interleukin-11-mediated protection of regulatory T cells.

Sci Signal 2018 Nov 27;11(558). Epub 2018 Nov 27.

Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1126/scisignal.aar8278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325078PMC
November 2018

Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons: Implications for Parkinson's Disease.

J Neuroimmune Pharmacol 2018 Sep 5. Epub 2018 Sep 5.

Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1007/s11481-018-9808-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401361PMC
September 2018

Aspirin Induces Lysosomal Biogenesis and Attenuates Amyloid Plaque Pathology in a Mouse Model of Alzheimer's Disease via PPARα.

J Neurosci 2018 Jul 2;38(30):6682-6699. Epub 2018 Jul 2.

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612 and

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http://dx.doi.org/10.1523/JNEUROSCI.0054-18.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067079PMC
July 2018

Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory.

Proc Natl Acad Sci U S A 2018 07 16;115(31):E7408-E7417. Epub 2018 Jul 16.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612;

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http://dx.doi.org/10.1073/pnas.1802021115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077698PMC
July 2018

Increase in Mitochondrial Biogenesis in Neuronal Cells by RNS60, a Physically-Modified Saline, via Phosphatidylinositol 3-Kinase-Mediated Upregulation of PGC1α.

J Neuroimmune Pharmacol 2018 Jun 29;13(2):143-162. Epub 2017 Nov 29.

Department of Neurological Sciences, Rush University Medical Center, 1735 West Harrison St, Suite Cohn 310, Chicago, IL, 60612, USA.

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http://dx.doi.org/10.1007/s11481-017-9771-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928179PMC
June 2018

Correction to: Nebulization of RNS60, a Physically-Modified Saline, Attenuates the Adoptive Transfer of Experimental Allergic Encephalomyelitis in Mice: Implications for Multiple Sclerosis Therapy.

Neurochem Res 2018 05;43(5):1136-1139

Department of Neurological Sciences, Rush University Medical Center, 1735 West Harrison St, Suite 310, Chicago, IL, 60612, USA.

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http://dx.doi.org/10.1007/s11064-018-2506-yDOI Listing
May 2018

Upregulation of Myelin Gene Expression by a Physically-Modified Saline via Phosphatidylinositol 3-Kinase-Mediated Activation of CREB: Implications for Multiple Sclerosis.

Neurochem Res 2018 Feb 15;43(2):407-419. Epub 2017 Nov 15.

Department of Neurological Sciences, Rush University Medical Center, 1735 West Harrison St, Suite 310, Chicago, IL, 60612, USA.

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http://dx.doi.org/10.1007/s11064-017-2435-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799355PMC
February 2018

Upregulation of Suppressor of Cytokine Signaling 3 in Microglia by Cinnamic Acid.

Curr Alzheimer Res 2018 ;15(10):894-904

Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, IL-60612, United States.

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http://www.eurekaselect.com/161851/article
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http://dx.doi.org/10.2174/1567205015666180507104755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128770PMC
January 2018

Selective neutralization of IL-12 p40 monomer induces death in prostate cancer cells via IL-12-IFN-γ.

Proc Natl Acad Sci U S A 2017 10 9;114(43):11482-11487. Epub 2017 Oct 9.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612;

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http://dx.doi.org/10.1073/pnas.1705536114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664500PMC
October 2017

Induction of Adaptive Immunity Leads to Nigrostriatal Disease Progression in MPTP Mouse Model of Parkinson's Disease.

J Immunol 2017 06 26;198(11):4312-4326. Epub 2017 Apr 26.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612; and

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http://dx.doi.org/10.4049/jimmunol.1700149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467696PMC
June 2017

Gemfibrozil, food and drug administration-approved lipid-lowering drug, increases longevity in mouse model of late infantile neuronal ceroid lipofuscinosis.

J Neurochem 2017 05 3;141(3):423-435. Epub 2017 Apr 3.

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.

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http://dx.doi.org/10.1111/jnc.13987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395327PMC
May 2017

Nebulization of RNS60, a Physically-Modified Saline, Attenuates the Adoptive Transfer of Experimental Allergic Encephalomyelitis in Mice: Implications for Multiple Sclerosis Therapy.

Neurochem Res 2017 May 7;42(5):1555-1570. Epub 2017 Mar 7.

Department of Neurological Sciences, Rush University Medical Center, 1735 West Harrison St, Suite 310, Chicago, IL, 60612, USA.

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http://dx.doi.org/10.1007/s11064-017-2214-zDOI Listing
May 2017

Cinnamon Converts Poor Learning Mice to Good Learners: Implications for Memory Improvement.

J Neuroimmune Pharmacol 2016 12 24;11(4):693-707. Epub 2016 Jun 24.

Department of Neurological Sciences, Rush University Medical Center, 1735 West Harrison St, Suite, Chicago, IL, 310, USA.

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http://dx.doi.org/10.1007/s11481-016-9693-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097886PMC
December 2016

Identification and characterization of PPARα ligands in the hippocampus.

Nat Chem Biol 2016 Dec 17;12(12):1075-1083. Epub 2016 Oct 17.

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.

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http://dx.doi.org/10.1038/nchembio.2204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110367PMC
December 2016

Sodium Benzoate, a Food Additive and a Metabolite of Cinnamon, Enriches Regulatory T Cells via STAT6-Mediated Upregulation of TGF-β.

J Immunol 2016 10 7;197(8):3099-3110. Epub 2016 Sep 7.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612;

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http://dx.doi.org/10.4049/jimmunol.1501628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101135PMC
October 2016

Neutralization of RANTES and Eotaxin Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson Disease.

J Biol Chem 2016 07 12;291(29):15267-81. Epub 2016 May 12.

From the Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612

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http://dx.doi.org/10.1074/jbc.M116.714824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946939PMC
July 2016

Cinnamon and Its Metabolite Sodium Benzoate Attenuate the Activation of p21rac and Protect Memory and Learning in an Animal Model of Alzheimer's Disease.

PLoS One 2015 23;10(6):e0130398. Epub 2015 Jun 23.

Department of Neurological Sciences, Rush University Medical Center, Chicago, United States of America; Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, 820 South Damen Avenue, Chicago, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130398PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478015PMC
April 2016

BPOZ-2 Gene Delivery Ameliorates Alpha-Synucleinopathy in A53T Transgenic Mouse Model of Parkinson's Disease.

Sci Rep 2016 Feb 26;6:22067. Epub 2016 Feb 26.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1038/srep22067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768134PMC
February 2016

PPARα in lysosomal biogenesis: A perspective.

Pharmacol Res 2016 Jan 24;103:144-8. Epub 2015 Nov 24.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States; Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, 820 South Damen Avenue, Chicago, IL,United States. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2015.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861553PMC
January 2016

Cinnamon ameliorates experimental allergic encephalomyelitis in mice via regulatory T cells: implications for multiple sclerosis therapy.

PLoS One 2015 8;10(1):e0116566. Epub 2015 Jan 8.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116566PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287621PMC
December 2015

Sodium Benzoate, a Metabolite of Cinnamon and a Food Additive, Upregulates Ciliary Neurotrophic Factor in Astrocytes and Oligodendrocytes.

Neurochem Res 2015 Nov 23;40(11):2333-47. Epub 2015 Sep 23.

Department of Neurological Sciences, Rush University Medical Center, 1735 West Harrison St, Suite Cohn 320, Chicago, IL, 60612, USA.

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http://link.springer.com/10.1007/s11064-015-1723-x
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http://dx.doi.org/10.1007/s11064-015-1723-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644097PMC
November 2015

HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice.

Cell Metab 2015 Aug 25;22(2):253-65. Epub 2015 Jun 25.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA; Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, 820 South Darnen Avenue, Chicago, IL 60612, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.05.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526399PMC
August 2015

Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP.

Proc Natl Acad Sci U S A 2015 Jul 15;112(27):8445-50. Epub 2015 Jun 15.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612; Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612

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http://dx.doi.org/10.1073/pnas.1504890112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500265PMC
July 2015

Activation of peroxisome proliferator-activated receptor α induces lysosomal biogenesis in brain cells: implications for lysosomal storage disorders.

J Biol Chem 2015 Apr 6;290(16):10309-24. Epub 2015 Mar 6.

From the Departments of Neurological Sciences and the Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612

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http://www.jbc.org/lookup/doi/10.1074/jbc.M114.610659
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http://dx.doi.org/10.1074/jbc.M114.610659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400343PMC
April 2015

PPARα signaling in the hippocampus: crosstalk between fat and memory.

J Neuroimmune Pharmacol 2015 Mar 10;10(1):30-4. Epub 2015 Jan 10.

Department of Neurological Sciences, Rush University Medical Center, 1735 West Harrison St, Suite 320, Chicago, IL, 60612, USA.

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http://link.springer.com/content/pdf/10.1007/s11481-014-9582
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http://link.springer.com/10.1007/s11481-014-9582-9
Publisher Site
http://dx.doi.org/10.1007/s11481-014-9582-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360966PMC
March 2015

Can cinnamon bring aroma in Parkinson's disease treatment?

Neural Regen Res 2015 Jan;10(1):30-2

Department of Neurological Sciences, Division of Neuroscience, Rush University Medical Center, Chicago, IL 60612, USA.

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http://dx.doi.org/10.4103/1673-5374.150647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357107PMC
January 2015

Prospects of Cinnamon in Multiple Sclerosis.

Authors:
Kalipada Pahan

J Mult Scler (Foster City) 2015;2(3):1000149

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA ; Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, 820 South Damen Avenue, Chicago, IL 60612, USA.

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http://dx.doi.org/10.4172/2376-0389.1000149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568834PMC
January 2015

Cinnamon treatment upregulates neuroprotective proteins Parkin and DJ-1 and protects dopaminergic neurons in a mouse model of Parkinson's disease.

J Neuroimmune Pharmacol 2014 Sep 20;9(4):569-81. Epub 2014 Jun 20.

Department of Neurological Sciences, Rush University Medical Center, 1735 West Harrison St, Suite 320, Chicago, IL, 60612, USA.

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http://dx.doi.org/10.1007/s11481-014-9552-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167597PMC
September 2014

Ankyrin repeat and BTB/POZ domain containing protein-2 inhibits the aggregation of alpha-synuclein: implications for Parkinson's disease.

FEBS Lett 2013 Nov 25;587(21):3567-74. Epub 2013 Sep 25.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2013.09.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929398PMC
November 2013

Multiple Sclerosis and Experimental Allergic Encephalomyelitis.

Authors:
Kalipada Pahan

J Clin Cell Immunol 2013 Sep;4

Department of Neurological Sciences, Rush University Medical Center, Chicago, USA ; Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, 820 South Darnen Avenue, Chicago, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903289PMC
September 2013

Myelin Basic Protein-primed T Helper 2 Cells Suppress Microglial Activation via AlphaVBeta3 Integrin: Implications for Multiple Sclerosis.

J Clin Cell Immunol 2013 Aug;7:158

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA ; Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, 820 South Damen Avenue, Chicago, USA.

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http://dx.doi.org/10.4172/2155-9899.1000158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932617PMC
August 2013

Castration induces Parkinson disease pathologies in young male mice via inducible nitric-oxide synthase.

J Biol Chem 2013 Jul 6;288(29):20843-55. Epub 2013 Jun 6.

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA.

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http://dx.doi.org/10.1074/jbc.M112.443556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774356PMC
July 2013

Down-regulation of Myelin Gene Expression in Human Oligodendrocytes by Nitric Oxide: Implications for Demyelination in Multiple Sclerosis.

J Clin Cell Immunol 2013 Jul;4

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.4172/2155-9899.1000157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837467PMC
July 2013

Up-regulation of neurotrophic factors by cinnamon and its metabolite sodium benzoate: therapeutic implications for neurodegenerative disorders.

J Neuroimmune Pharmacol 2013 Jun 9;8(3):739-55. Epub 2013 Mar 9.

Department of Neurological Sciences, Rush University Medical Center, 1735 West Harrison St, Suite 320, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1007/s11481-013-9447-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663914PMC
June 2013

Up-regulation of ciliary neurotrophic factor in astrocytes by aspirin: implications for remyelination in multiple sclerosis.

J Biol Chem 2013 Jun 7;288(25):18533-45. Epub 2013 May 7.

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA.

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http://dx.doi.org/10.1074/jbc.M112.447268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689994PMC
June 2013

Sodium phenylbutyrate enhances astrocytic neurotrophin synthesis via protein kinase C (PKC)-mediated activation of cAMP-response element-binding protein (CREB): implications for Alzheimer disease therapy.

J Biol Chem 2013 Mar 12;288(12):8299-312. Epub 2013 Feb 12.

Graduate Program in Neuroscience, Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605648PMC
http://dx.doi.org/10.1074/jbc.M112.426536DOI Listing
March 2013

Crosstalk between Nitric Oxide and T helper cells.

J Clin Cell Immunol 2012 Nov;3(4)

Department of Neurological sciences, Rush University Medical Center, Chicago, IL 60612, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546537PMC
November 2012

Gemfibrozil, a lipid-lowering drug, increases myelin genes in human oligodendrocytes via peroxisome proliferator-activated receptor-β.

J Biol Chem 2012 Oct 9;287(41):34134-48. Epub 2012 Aug 9.

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.398552
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http://dx.doi.org/10.1074/jbc.M112.398552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464522PMC
October 2012

Testing NF-κB-based therapy in hemiparkinsonian monkeys.

J Neuroimmune Pharmacol 2012 Sep 3;7(3):544-56. Epub 2012 Jun 3.

Department of Neurological Sciences, Rush University Medical Center, 1735 West Harrison St, Suite 320, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1007/s11481-012-9377-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419771PMC
September 2012

Sympathetic innervation of the splanchnic region mediates the beneficial hemodynamic effects of 8-OH-DPAT in hemorrhagic shock.

Am J Physiol Regul Integr Comp Physiol 2012 Sep 20;303(5):R527-38. Epub 2012 Jun 20.

Department of Molecular Pharmacology and Therapeutics, Loyola University Chicago, Stritch School of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1152/ajpregu.00689.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468419PMC
September 2012

Gemfibrozil, a lipid lowering drug, inhibits the activation of primary human microglia via peroxisome proliferator-activated receptor β.

Neurochem Res 2012 Aug 17;37(8):1718-29. Epub 2012 Apr 17.

Department of Neurological Sciences, Rush University Medical Center, 1735 West Harrison St., Suite 320, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1007/s11064-012-0781-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389313PMC
August 2012

Gemfibrozil, a lipid-lowering drug, induces suppressor of cytokine signaling 3 in glial cells: implications for neurodegenerative disorders.

J Biol Chem 2012 Aug 8;287(32):27189-203. Epub 2012 Jun 8.

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA.

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http://dx.doi.org/10.1074/jbc.M112.346932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411061PMC
August 2012

Suppression of nuclear factor-κB activation and inflammation in microglia by physically modified saline.

J Biol Chem 2012 Aug 29;287(35):29529-42. Epub 2012 Jun 29.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1074/jbc.M111.338012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436140PMC
August 2012

Gemfibrozil, a lipid-lowering drug, upregulates IL-1 receptor antagonist in mouse cortical neurons: implications for neuronal self-defense.

J Immunol 2012 Jul 15;189(2):1002-13. Epub 2012 Jun 15.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.

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http://dx.doi.org/10.4049/jimmunol.1102624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523125PMC
July 2012

Regulation of encephalitogenicity of neuroantigen-primed T cells by nitric oxide: Implications for multiple sclerosis.

J Clin Cell Immunol 2012 Jul;3(3):124

Department of Neurological Sciences, Division of Neuroscience, Rush University Medical Center, Chicago, IL 60612.

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http://dx.doi.org/10.4172/2165-8048.1000124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530196PMC
July 2012

Sodium benzoate, a metabolite of cinnamon and a food additive, upregulates neuroprotective Parkinson disease protein DJ-1 in astrocytes and neurons.

J Neuroimmune Pharmacol 2012 Jun 24;7(2):424-35. Epub 2011 Jun 24.

Department of Neurological Sciences, Division of Neuroscience, Rush University Medical Center, 1735 West Harrison Street, Chicago, IL 60612, USA.

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http://link.springer.com/10.1007/s11481-011-9286-3
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http://dx.doi.org/10.1007/s11481-011-9286-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189510PMC
June 2012

Immunomodulation of experimental allergic encephalomyelitis by cinnamon metabolite sodium benzoate.

Authors:
Kalipada Pahan

Immunopharmacol Immunotoxicol 2011 Dec 22;33(4):586-93. Epub 2011 Mar 22.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.

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http://dx.doi.org/10.3109/08923973.2011.561861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206174PMC
December 2011

Prospects of statins in Parkinson disease.

Neuroscientist 2011 Jun 20;17(3):244-55. Epub 2011 Jan 20.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1177/1073858410385006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132406PMC
June 2011

Sphingolipids in multiple sclerosis.

Neuromolecular Med 2010 Dec 7;12(4):351-61. Epub 2010 Jul 7.

Department of Neurological Sciences, Rush University Medical Center, Cohn Research Building, Suite 320, 1735 West Harrison St., Chicago, IL 60612, USA.

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http://dx.doi.org/10.1007/s12017-010-8128-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987401PMC
December 2010

Fibrillar amyloid-beta-activated human astroglia kill primary human neurons via neutral sphingomyelinase: implications for Alzheimer's disease.

J Neurosci 2010 Sep;30(38):12676-89

Department of Neurological Science, Rush University Medical Center, Chicago, Illinois 60612, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1243-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020912PMC
September 2010

Neuroimmune pharmacological control of EAE.

Authors:
Kalipada Pahan

J Neuroimmune Pharmacol 2010 Jun 23;5(2):165-7. Epub 2010 Apr 23.

Department of Neurological sciences, Rush University Medical Center, Cohn Research Building, Suite 320, 1735 West Harrison St, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1007/s11481-010-9219-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881219PMC
June 2010

Gender-specific expression of beta1 integrin of VLA-4 in myelin basic protein-primed T cells: implications for gender bias in multiple sclerosis.

J Immunol 2010 Jun 5;184(11):6103-13. Epub 2010 May 5.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.

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http://dx.doi.org/10.4049/jimmunol.0804356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922040PMC
June 2010

Myelin basic protein priming reduces the expression of Foxp3 in T cells via nitric oxide.

J Immunol 2010 Feb 18;184(4):1799-809. Epub 2010 Jan 18.

Division of Neuroscience, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.

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http://dx.doi.org/10.4049/jimmunol.0804394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855656PMC
February 2010

Gemfibrozil, stretching arms beyond lipid lowering.

Immunopharmacol Immunotoxicol 2009 ;31(3):339-51

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA.

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http://dx.doi.org/10.1080/08923970902785253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772998PMC
January 2010

IL-12 p40 homodimer, the so-called biologically inactive molecule, induces nitric oxide synthase in microglia via IL-12R beta 1.

Glia 2009 Nov;57(14):1553-65

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA.

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http://dx.doi.org/10.1002/glia.20869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744843PMC
November 2009

Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglial inflammatory responses.

J Immunol 2009 Nov 7;183(9):5917-27. Epub 2009 Oct 7.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.

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http://dx.doi.org/10.4049/jimmunol.0803336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862570PMC
November 2009

Suppression of regulatory T cells by IL-12p40 homodimer via nitric oxide.

J Immunol 2009 Aug 8;183(3):2045-58. Epub 2009 Jul 8.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.

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http://dx.doi.org/10.4049/jimmunol.0800276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713791PMC
August 2009

TNF-alpha preconditioning protects neurons via neuron-specific up-regulation of CREB-binding protein.

J Immunol 2009 Aug 13;183(3):2068-78. Epub 2009 Jul 13.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.

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http://dx.doi.org/10.4049/jimmunol.0801892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724010PMC
August 2009

Induction of lymphotoxin-alpha by interleukin-12 p40 homodimer, the so-called biologically inactive molecule, but not IL-12 p70.

Immunology 2009 Jul 14;127(3):312-25. Epub 2008 Nov 14.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.

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http://doi.wiley.com/10.1111/j.1365-2567.2008.02985.x
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http://dx.doi.org/10.1111/j.1365-2567.2008.02985.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712100PMC
July 2009

Functional blocking monoclonal antibodies against IL-12p40 homodimer inhibit adoptive transfer of experimental allergic encephalomyelitis.

J Immunol 2009 Apr;182(8):5013-23

Department of Neurological Sciences, Division of Neuroscience, Rush University Medical Center, Chicago, IL 60612, USA.

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http://dx.doi.org/10.4049/jimmunol.0801734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721330PMC
April 2009

Ceramide and neurodegeneration: susceptibility of neurons and oligodendrocytes to cell damage and death.

J Neurol Sci 2009 Mar 14;278(1-2):5-15. Epub 2009 Jan 14.

Department of Neurological sciences, Rush University Medical Center, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1016/j.jns.2008.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660887PMC
March 2009

IL-12 p40 homodimer, but not IL-12 p70, induces the expression of IL-16 in microglia and macrophages.

Mol Immunol 2009 Feb 18;46(5):773-83. Epub 2008 Dec 18.

Department of Neurological Sciences, Rush University Medical Center, Cohn Research Building, Suite 320, 1735 West Harrison St., Chicago, IL 60612, United States.

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http://dx.doi.org/10.1016/j.molimm.2008.10.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660888PMC
February 2009

Fibrillar amyloid-beta peptides activate microglia via TLR2: implications for Alzheimer's disease.

J Immunol 2008 Nov;181(10):7254-62

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701549PMC
November 2008

Reactive oxygen species up-regulate CD11b in microglia via nitric oxide: Implications for neurodegenerative diseases.

Free Radic Biol Med 2008 Sep 6;45(5):686-99. Epub 2008 Jun 6.

Department of Neurological Science, Rush University Medical Center, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2008.05.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701551PMC
September 2008

Generation of functional blocking monoclonal antibodies against mouse interleukin-12 p40 homodimer and monomer.

Hybridoma (Larchmt) 2008 Jun;27(3):141-51

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA.

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http://dx.doi.org/10.1089/hyb.2007.0560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673812PMC
June 2008

A simplified method for isolating highly purified neurons, oligodendrocytes, astrocytes, and microglia from the same human fetal brain tissue.

Neurochem Res 2007 Dec 20;32(12):2015-22. Epub 2007 Apr 20.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.

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http://link.springer.com/10.1007/s11064-007-9340-y
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http://dx.doi.org/10.1007/s11064-007-9340-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2085356PMC
December 2007

Myelin basic protein-primed T cells induce neurotrophins in glial cells via alphavbeta3 [corrected] integrin.

J Biol Chem 2007 Nov 6;282(44):32222-32. Epub 2007 Sep 6.

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA.

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http://dx.doi.org/10.1074/jbc.M702899200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637617PMC
November 2007

MAPK p38 regulates transcriptional activity of NF-kappaB in primary human astrocytes via acetylation of p65.

J Immunol 2007 Nov;179(10):7101-9

Department of Neurological sciences, Rush University Medical Center, Chicago, IL 60612, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701546PMC
November 2007

Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease.

Proc Natl Acad Sci U S A 2007 Nov 13;104(47):18754-9. Epub 2007 Nov 13.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1073/pnas.0704908104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2141849PMC
November 2007

Gemfibrozil ameliorates relapsing-remitting experimental autoimmune encephalomyelitis independent of peroxisome proliferator-activated receptor-alpha.

Mol Pharmacol 2007 Oct 11;72(4):934-46. Epub 2007 Jul 11.

Department of Neurological Sciences, Rush University Medical Center, Cohn Research Building, Suite 320, 1735 West Harrison St, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1124/mol.106.033787DOI Listing
October 2007

Involvement of phosphatidylinositol 3-kinase-mediated up-regulation of I kappa B alpha in anti-inflammatory effect of gemfibrozil in microglia.

J Immunol 2007 Sep;179(6):4142-52

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604815PMC
September 2007

Sodium benzoate, a food additive and a metabolite of cinnamon, modifies T cells at multiple steps and inhibits adoptive transfer of experimental allergic encephalomyelitis.

J Immunol 2007 Jul;179(1):275-83

Department of Neurological Sciences, Rush University Medical Center, 1735 West Harrison Street, Chicago, IL 60612, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976122PMC
July 2007

Differential regulation of Mn-superoxide dismutase in neurons and astroglia by HIV-1 gp120: Implications for HIV-associated dementia.

Free Radic Biol Med 2007 Jun 31;42(12):1866-78. Epub 2007 Mar 31.

Section of Neuroscience, Department of Oral Biology, University of Nebraska Medical Center College of Dentistry, 40th and Holdrege Street, Lincoln, NE 68583, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2007.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1955471PMC
June 2007

Oxidative stress kills human primary oligodendrocytes via neutral sphingomyelinase: implications for multiple sclerosis.

J Neuroimmune Pharmacol 2007 Jun 8;2(2):184-93. Epub 2007 Mar 8.

Division of Neuroscience, Department of Neurological Sciences, Rush University Medical Center, Cohn Research Building, Suite 320, 1735 West Harrison St, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1007/s11481-007-9066-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131733PMC
June 2007

Regulation of inducible nitric oxide synthase gene in glial cells.

Antioxid Redox Signal 2006 May-Jun;8(5-6):929-47

Department of Oral Biology, Section of Neuroscience, University of Nebraska Medical Center, Lincoln, 68583, USA.

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http://dx.doi.org/10.1089/ars.2006.8.929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1963415PMC
March 2007

Up-regulation of BDNF in astrocytes by TNF-alpha: a case for the neuroprotective role of cytokine.

J Neuroimmune Pharmacol 2006 Sep 16;1(3):212-22. Epub 2006 May 16.

Section of Neuroscience, Department of Oral Biology, University of Nebraska Medical Center, 40th and Holdrege, Lincoln, NE 68583-0740, USA.

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http://link.springer.com/10.1007/s11481-006-9020-8
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http://dx.doi.org/10.1007/s11481-006-9020-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131740PMC
September 2006

Signals for the induction of nitric oxide synthase in astrocytes.

Neurochem Int 2006 Jul 5;49(2):154-63. Epub 2006 Jun 5.

Section of Neuroscience, Department of Oral Biology, University of Nebraska Medical Center College of Dentistry, 40th and Holdrege, Lincoln, NE 68583, United States.

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http://dx.doi.org/10.1016/j.neuint.2006.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1963413PMC
July 2006

Induction of glial fibrillary acidic protein expression in astrocytes by nitric oxide.

J Neurosci 2006 May;26(18):4930-9

Department of Oral Biology, University of Nebraska Medical Center, Lincoln, Nebraska 68583, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.5480-05.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1963412PMC
May 2006