Kakajan Komurov

Kakajan Komurov

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Kakajan Komurov

Kakajan Komurov

Publications by authors named "Kakajan Komurov"

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39Publications

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Graphical data mining of cancer mechanisms with SEMA.

Bioinformatics 2019 May 9. Epub 2019 May 9.

Divisions of Experimental Hematology and Cancer Biology, Human Genetics and Biomedical Informatics, Cincinnati Children's Hospital Medical Center.

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http://dx.doi.org/10.1093/bioinformatics/btz303DOI Listing
May 2019

Defective transcription elongation in a subset of cancers confers immunotherapy resistance.

Nat Commun 2018 10 23;9(1):4410. Epub 2018 Oct 23.

Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, 45229, OH, USA.

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http://www.nature.com/articles/s41467-018-06810-0
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http://dx.doi.org/10.1038/s41467-018-06810-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199328PMC
October 2018

Tumor Cell Autonomous RON Receptor Expression Promotes Prostate Cancer Growth Under Conditions of Androgen Deprivation.

Neoplasia 2018 09 15;20(9):917-929. Epub 2018 Aug 15.

Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Research Service, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45267, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098205PMC
September 2018

Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence.

PLoS Genet 2018 03 14;14(3):e1007227. Epub 2018 Mar 14.

Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1007227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884580PMC
March 2018

Selective DNA methylation in cancers controls collateral damage induced by large structural variations.

Oncotarget 2017 Sep 8;8(42):71385-71392. Epub 2016 Jul 8.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, OH, USA.

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http://dx.doi.org/10.18632/oncotarget.10487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641056PMC
September 2017

DEK associates with tumor stage and outcome in HPV16 positive oropharyngeal squamous cell carcinoma.

Oncotarget 2017 Apr;8(14):23414-23426

Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.

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http://dx.doi.org/10.18632/oncotarget.15582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410314PMC
April 2017

An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system.

Sci Rep 2017 03 3;7:43315. Epub 2017 Mar 3.

Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1038/srep43315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335359PMC
March 2017

A structure- and chemical genomics-based approach for repositioning of drugs against VCP/p97 ATPase.

Sci Rep 2017 03 21;7:44912. Epub 2017 Mar 21.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, OH, USA.

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http://dx.doi.org/10.1038/srep44912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359624PMC
March 2017

An integrated network platform for contextual prioritization of drugs and pathways.

Mol Biosyst 2015 Nov;11(11):2850-9

Cincinnati Children's Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, 3333 Burnet Ave, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1039/c5mb00444fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814269PMC
November 2015

HER2-mTOR signaling-driven breast cancer cells require ER-associated degradation to survive.

Sci Signal 2015 May 26;8(378):ra52. Epub 2015 May 26.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1126/scisignal.aaa6922DOI Listing
May 2015

Inhibition of mTORC1/2 overcomes resistance to MAPK pathway inhibitors mediated by PGC1α and oxidative phosphorylation in melanoma.

Cancer Res 2014 Dec 8;74(23):7037-47. Epub 2014 Oct 8.

Departments of Melanoma Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas. Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347853PMC
December 2014

Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-κB gene network.

Cell Rep 2014 Sep 4;8(5):1328-38. Epub 2014 Sep 4.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247140066
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http://dx.doi.org/10.1016/j.celrep.2014.07.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237069PMC
September 2014

Platelet-derived growth factor receptor alpha (PDGFRα) targeting and relevant biomarkers in ovarian carcinoma.

Gynecol Oncol 2014 Jan 29;132(1):166-75. Epub 2013 Oct 29.

Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Center for RNA Interference and Non-Coding RNA, University of Texas, Houston, TX, USA; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2013.10.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946949PMC
January 2014

Identification of novel driver tumor suppressors through functional interrogation of putative passenger mutations in colorectal cancer.

Int J Cancer 2013 Feb 21;132(3):732-7. Epub 2012 Jul 21.

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9039, USA.

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http://dx.doi.org/10.1002/ijc.27705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228351PMC
February 2013

NetWalker: a contextual network analysis tool for functional genomics.

BMC Genomics 2012 Jun 25;13:282. Epub 2012 Jun 25.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

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http://dx.doi.org/10.1186/1471-2164-13-282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439272PMC
June 2012

Modeling community-wide molecular networks of multicellular systems.

Authors:
Kakajan Komurov

Bioinformatics 2012 Mar 30;28(5):694-700. Epub 2011 Dec 30.

Divisions of Experimental Hematology and Cancer Biology, Human Genetics and Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

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http://dx.doi.org/10.1093/bioinformatics/btr718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338330PMC
March 2012

Patterns of human gene expression variance show strong associations with signaling network hierarchy.

BMC Syst Biol 2010 Nov 12;4:154. Epub 2010 Nov 12.

Department of Systems Biology, The University of Texas MD Anderson Cancer Center, 7435 Fannin St, Houston, TX 77054, USA.

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http://dx.doi.org/10.1186/1752-0509-4-154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992512PMC
November 2010

Use of data-biased random walks on graphs for the retrieval of context-specific networks from genomic data.

PLoS Comput Biol 2010 Aug 19;6(8). Epub 2010 Aug 19.

Department of Systems Biology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1000889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924243PMC
August 2010

Comprehensive mapping of the human kinome to epidermal growth factor receptor signaling.

J Biol Chem 2010 Jul 26;285(27):21134-42. Epub 2010 Apr 26.

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1074/jbc.M110.137828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898331PMC
July 2010

Fine-scale dissection of functional protein network organization by statistical network analysis.

PLoS One 2009 Jun 24;4(6):e6017. Epub 2009 Jun 24.

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006017PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699632PMC
June 2009

Revealing static and dynamic modular architecture of the eukaryotic protein interaction network.

Mol Syst Biol 2007 24;3:110. Epub 2007 Apr 24.

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9039, USA.

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http://dx.doi.org/10.1038/msb4100149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865589PMC
May 2007