Kaixin Zhou

Kaixin Zhou

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Kaixin Zhou

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Design, synthesis, and biological evaluation of a new class of histone acetyltransferase p300 inhibitors.

Eur J Med Chem 2019 Oct 9;180:171-190. Epub 2019 Jul 9.

Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.07.026DOI Listing
October 2019

A Multidrug Resistance Plasmid pIMP26, Carrying bla, fosA5, bla, and qnrB4 in Enterobacter cloacae.

Sci Rep 2019 Jul 15;9(1):10212. Epub 2019 Jul 15.

Department of Clinical Microbiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1038/s41598-019-46777-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629617PMC
July 2019

New genetic context of composed of two multi-resistance gene clusters in clinical ST-19 strains.

Antimicrob Resist Infect Control 2019 15;8:117. Epub 2019 Jul 15.

1Department of Clinical Microbiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025 China.

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http://dx.doi.org/10.1186/s13756-019-0563-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632187PMC
July 2019

Piperacillin-Tazobactam (TZP) Resistance in Due to Hyperproduction of TEM-1 β-Lactamase Mediated by the Promoter .

Front Microbiol 2019 16;10:833. Epub 2019 Apr 16.

Department of Clinical Microbiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.3389/fmicb.2019.00833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476967PMC
April 2019

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.

Authors:
A Mesut Erzurumluoglu Mengzhen Liu Victoria E Jackson Daniel R Barnes Gargi Datta Carl A Melbourne Robin Young Chiara Batini Praveen Surendran Tao Jiang Sheikh Daud Adnan Saima Afaq Arpana Agrawal Elisabeth Altmaier Antonis C Antoniou Folkert W Asselbergs Clemens Baumbach Laura Bierut Sarah Bertelsen Michael Boehnke Michiel L Bots David M Brazel John C Chambers Jenny Chang-Claude Chu Chen Janie Corley Yi-Ling Chou Sean P David Rudolf A de Boer Christiaan A de Leeuw Joe G Dennis Anna F Dominiczak Alison M Dunning Douglas F Easton Charles Eaton Paul Elliott Evangelos Evangelou Jessica D Faul Tatiana Foroud Alison Goate Jian Gong Hans J Grabe Jeff Haessler Christopher Haiman Göran Hallmans Anke R Hammerschlag Sarah E Harris Andrew Hattersley Andrew Heath Chris Hsu William G Iacono Stavroula Kanoni Manav Kapoor Jaakko Kaprio Sharon L Kardia Fredrik Karpe Jukka Kontto Jaspal S Kooner Charles Kooperberg Kari Kuulasmaa Markku Laakso Dongbing Lai Claudia Langenberg Nhung Le Guillaume Lettre Anu Loukola Jian'an Luan Pamela A F Madden Massimo Mangino Riccardo E Marioni Eirini Marouli Jonathan Marten Nicholas G Martin Matt McGue Kyriaki Michailidou Evelin Mihailov Alireza Moayyeri Marie Moitry Martina Müller-Nurasyid Aliya Naheed Matthias Nauck Matthew J Neville Sune Fallgaard Nielsen Kari North Markus Perola Paul D P Pharoah Giorgio Pistis Tinca J Polderman Danielle Posthuma Neil Poulter Beenish Qaiser Asif Rasheed Alex Reiner Frida Renström John Rice Rebecca Rohde Olov Rolandsson Nilesh J Samani Maria Samuel David Schlessinger Steven H Scholte Robert A Scott Peter Sever Yaming Shao Nick Shrine Jennifer A Smith John M Starr Kathleen Stirrups Danielle Stram Heather M Stringham Ioanna Tachmazidou Jean-Claude Tardif Deborah J Thompson Hilary A Tindle Vinicius Tragante Stella Trompet Valerie Turcot Jessica Tyrrell Ilonca Vaartjes Andries R van der Leij Peter van der Meer Tibor V Varga Niek Verweij Henry Völzke Nicholas J Wareham Helen R Warren David R Weir Stefan Weiss Leah Wetherill Hanieh Yaghootkar Ersin Yavas Yu Jiang Fang Chen Xiaowei Zhan Weihua Zhang Wei Zhao Wei Zhao Kaixin Zhou Philippe Amouyel Stefan Blankenberg Mark J Caulfield Rajiv Chowdhury Francesco Cucca Ian J Deary Panos Deloukas Emanuele Di Angelantonio Marco Ferrario Jean Ferrières Paul W Franks Tim M Frayling Philippe Frossard Ian P Hall Caroline Hayward Jan-Håkan Jansson J Wouter Jukema Frank Kee Satu Männistö Andres Metspalu Patricia B Munroe Børge Grønne Nordestgaard Colin N A Palmer Veikko Salomaa Naveed Sattar Timothy Spector David Peter Strachan Pim van der Harst Eleftheria Zeggini Danish Saleheen Adam S Butterworth Louise V Wain Goncalo R Abecasis John Danesh Martin D Tobin Scott Vrieze Dajiang J Liu Joanna M M Howson

Mol Psychiatry 2019 Jan 7. Epub 2019 Jan 7.

MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.

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http://www.nature.com/articles/s41380-018-0313-0
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http://dx.doi.org/10.1038/s41380-018-0313-0DOI Listing
January 2019

Piribedil disrupts the MLL1-WDR5 interaction and sensitizes MLL-rearranged acute myeloid leukemia (AML) to doxorubicin-induced apoptosis.

Cancer Lett 2018 09 30;431:150-160. Epub 2018 May 30.

Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, NO.19A Yuquan Road, Beijing, 100049, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835183036
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http://dx.doi.org/10.1016/j.canlet.2018.05.034DOI Listing
September 2018

Pathogenicity and Penetrance of Germline Variants in Pheochromocytoma and Paraganglioma (PPGL).

J Endocr Soc 2018 Jul 18;2(7):806-816. Epub 2018 Jun 18.

Division of Molecular & Clinical Medicine, Ninewells Hospital & Medical School, University of Dundee, Dundee, Scotland.

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http://dx.doi.org/10.1210/js.2018-00120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030830PMC
July 2018

Rates of glycaemic deterioration in a real-world population with type 2 diabetes.

Diabetologia 2018 03 19;61(3):607-615. Epub 2017 Dec 19.

Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK, Scotland.

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http://dx.doi.org/10.1007/s00125-017-4519-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448965PMC
March 2018

Interaction between variants in the CYP2C9 and POR genes and the risk of sulfonylurea-induced hypoglycaemia: A GoDARTS Study.

Diabetes Obes Metab 2018 01 25;20(1):211-214. Epub 2017 Aug 25.

Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, Scotland, UK.

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http://dx.doi.org/10.1111/dom.13046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724509PMC
January 2018

Utility of Population-Level DNA Sequence Data in the Diagnosis of Hereditary Endocrine Disease.

J Endocr Soc 2017 Dec 15;1(12):1507-1526. Epub 2017 Nov 15.

Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 7LJ United Kingdom.

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http://dx.doi.org/10.1210/js.2017-00330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740525PMC
December 2017

Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study.

Diabetes Obes Metab 2017 11 5;19(11):1579-1586. Epub 2017 Jul 5.

Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1111/dom.12978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655780PMC
November 2017

Evidence-based prioritisation and enrichment of genes interacting with metformin in type 2 diabetes.

Diabetologia 2017 Nov 25;60(11):2231-2239. Epub 2017 Aug 25.

Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.

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http://dx.doi.org/10.1007/s00125-017-4404-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448905PMC
November 2017

ICE, a Novel Integrative and Conjugative Element Carrying Antimicrobial Resistance Genes and Potential Virulence Factors in .

Front Microbiol 2017 5;8:1921. Epub 2017 Oct 5.

Department of Clinical Microbiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.3389/fmicb.2017.01921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633684PMC
October 2017

Coexistence of and Truncated on Different Plasmids in a Isolate in China.

Front Microbiol 2017 2;8:133. Epub 2017 Feb 2.

Department of Clinical Microbiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai, China.

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http://dx.doi.org/10.3389/fmicb.2017.00133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288367PMC
February 2017

CYP2C8 and SLCO1B1 Variants and Therapeutic Response to Thiazolidinediones in Patients With Type 2 Diabetes.

Diabetes Care 2016 Nov 6;39(11):1902-1908. Epub 2016 Jun 6.

Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, Scotland

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http://dx.doi.org/10.2337/dc15-2464DOI Listing
November 2016

Effect of Serotonin Transporter 5-HTTLPR Polymorphism on Gastrointestinal Intolerance to Metformin: A GoDARTS Study.

Diabetes Care 2016 Nov 4;39(11):1896-1901. Epub 2016 Aug 4.

Division of Molecular & Clinical Medicine, School of Medicine, University of Dundee, Dundee, Scotland, U.K.

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc16-070
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http://dx.doi.org/10.2337/dc16-0706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122449PMC
November 2016

Pharmacogenomics in diabetes mellitus: insights into drug action and drug discovery.

Nat Rev Endocrinol 2016 Jun 11;12(6):337-46. Epub 2016 Apr 11.

School of Medicine, University of Dundee, Dundee, DD1 9SY, UK.

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http://dx.doi.org/10.1038/nrendo.2016.51DOI Listing
June 2016

Pharmacogenetics in type 2 diabetes: influence on response to oral hypoglycemic agents.

Pharmgenomics Pers Med 2016 6;9:17-29. Epub 2016 Apr 6.

Division of Cardiovascular and Diabetes Medicine, Medical Research Institute, University of Dundee, Dundee, Scotland, UK.

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http://dx.doi.org/10.2147/PGPM.S84854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827904PMC
April 2016

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.

Authors:
Iris Postmus Stella Trompet Harshal A Deshmukh Michael R Barnes Xiaohui Li Helen R Warren Daniel I Chasman Kaixin Zhou Benoit J Arsenault Louise A Donnelly Kerri L Wiggins Christy L Avery Paula Griffin QiPing Feng Kent D Taylor Guo Li Daniel S Evans Albert V Smith Catherine E de Keyser Andrew D Johnson Anton J M de Craen David J Stott Brendan M Buckley Ian Ford Rudi G J Westendorp P Eline Slagboom Naveed Sattar Patricia B Munroe Peter Sever Neil Poulter Alice Stanton Denis C Shields Eoin O'Brien Sue Shaw-Hawkins Y-D Ida Chen Deborah A Nickerson Joshua D Smith Marie Pierre Dubé S Matthijs Boekholdt G Kees Hovingh John J P Kastelein Paul M McKeigue John Betteridge Andrew Neil Paul N Durrington Alex Doney Fiona Carr Andrew Morris Mark I McCarthy Leif Groop Emma Ahlqvist Joshua C Bis Kenneth Rice Nicholas L Smith Thomas Lumley Eric A Whitsel Til Stürmer Eric Boerwinkle Julius S Ngwa Christopher J O'Donnell Ramachandran S Vasan Wei-Qi Wei Russell A Wilke Ching-Ti Liu Fangui Sun Xiuqing Guo Susan R Heckbert Wendy Post Nona Sotoodehnia Alice M Arnold Jeanette M Stafford Jingzhong Ding David M Herrington Stephen B Kritchevsky Gudny Eiriksdottir Leonore J Launer Tamara B Harris Audrey Y Chu Franco Giulianini Jean G MacFadyen Bryan J Barratt Fredrik Nyberg Bruno H Stricker André G Uitterlinden Albert Hofman Fernando Rivadeneira Valur Emilsson Oscar H Franco Paul M Ridker Vilmundur Gudnason Yongmei Liu Joshua C Denny Christie M Ballantyne Jerome I Rotter L Adrienne Cupples Bruce M Psaty Colin N A Palmer Jean-Claude Tardif Helen M Colhoun Graham Hitman Ronald M Krauss J Wouter Jukema Mark J Caulfield

Nat Commun 2014 Oct 28;5:5068. Epub 2014 Oct 28.

1] NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London EC1M 6BQ, UK [2] Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London EC1M6BQ, UK.

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http://dx.doi.org/10.1038/ncomms6068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220464PMC
October 2014

Robust association of the LPA locus with low-density lipoprotein cholesterol lowering response to statin treatment in a meta-analysis of 30 467 individuals from both randomized control trials and observational studies and association with coronary artery disease outcome during statin treatment.

Pharmacogenet Genomics 2013 Oct;23(10):518-25

aMedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee bWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK cDivision of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University dDepartment of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1097/FPC.0b013e3283642fd6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110714PMC
October 2013

Insights from genome-wide association studies of drug response.

Annu Rev Pharmacol Toxicol 2013 16;53:299-310. Epub 2012 Oct 16.

Medical Research Institute, University of Dundee, Scotland, United Kingdom DD1 9SY.

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http://dx.doi.org/10.1146/annurev-pharmtox-011112-140237DOI Listing
July 2013

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

Authors:
Momoko Horikoshi Hanieh Yaghootkar Dennis O Mook-Kanamori Ulla Sovio H Rob Taal Branwen J Hennig Jonathan P Bradfield Beate St Pourcain David M Evans Pimphen Charoen Marika Kaakinen Diana L Cousminer Terho Lehtimäki Eskil Kreiner-Møller Nicole M Warrington Mariona Bustamante Bjarke Feenstra Diane J Berry Elisabeth Thiering Thiemo Pfab Sheila J Barton Beverley M Shields Marjan Kerkhof Elisabeth M van Leeuwen Anthony J Fulford Zoltán Kutalik Jing Hua Zhao Marcel den Hoed Anubha Mahajan Virpi Lindi Liang-Kee Goh Jouke-Jan Hottenga Ying Wu Olli T Raitakari Marie N Harder Aline Meirhaeghe Ioanna Ntalla Rany M Salem Karen A Jameson Kaixin Zhou Dorota M Monies Vasiliki Lagou Mirna Kirin Jani Heikkinen Linda S Adair Fowzan S Alkuraya Ali Al-Odaib Philippe Amouyel Ehm Astrid Andersson Amanda J Bennett Alexandra I F Blakemore Jessica L Buxton Jean Dallongeville Shikta Das Eco J C de Geus Xavier Estivill Claudia Flexeder Philippe Froguel Frank Geller Keith M Godfrey Frédéric Gottrand Christopher J Groves Torben Hansen Joel N Hirschhorn Albert Hofman Mads V Hollegaard David M Hougaard Elina Hyppönen Hazel M Inskip Aaron Isaacs Torben Jørgensen Christina Kanaka-Gantenbein John P Kemp Wieland Kiess Tuomas O Kilpeläinen Norman Klopp Bridget A Knight Christopher W Kuzawa George McMahon John P Newnham Harri Niinikoski Ben A Oostra Louise Pedersen Dirkje S Postma Susan M Ring Fernando Rivadeneira Neil R Robertson Sylvain Sebert Olli Simell Torsten Slowinski Carla M T Tiesler Anke Tönjes Allan Vaag Jorma S Viikari Jacqueline M Vink Nadja Hawwa Vissing Nicholas J Wareham Gonneke Willemsen Daniel R Witte Haitao Zhang Jianhua Zhao James F Wilson Michael Stumvoll Andrew M Prentice Brian F Meyer Ewan R Pearson Colin A G Boreham Cyrus Cooper Matthew W Gillman George V Dedoussis Luis A Moreno Oluf Pedersen Maiju Saarinen Karen L Mohlke Dorret I Boomsma Seang-Mei Saw Timo A Lakka Antje Körner Ruth J F Loos Ken K Ong Peter Vollenweider Cornelia M van Duijn Gerard H Koppelman Andrew T Hattersley John W Holloway Berthold Hocher Joachim Heinrich Chris Power Mads Melbye Mònica Guxens Craig E Pennell Klaus Bønnelykke Hans Bisgaard Johan G Eriksson Elisabeth Widén Hakon Hakonarson André G Uitterlinden Anneli Pouta Debbie A Lawlor George Davey Smith Timothy M Frayling Mark I McCarthy Struan F A Grant Vincent W V Jaddoe Marjo-Riitta Jarvelin Nicholas J Timpson Inga Prokopenko Rachel M Freathy

Nat Genet 2013 Jan 2;45(1):76-82. Epub 2012 Dec 2.

Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ng.2477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605762PMC
January 2013

A single nucleotide polymorphism on exon-4 of the gene encoding PPARdelta is associated with reduced height in adults and children.

J Clin Endocrinol Metab 2009 Jul 21;94(7):2587-93. Epub 2009 Apr 21.

Biomedical Research Institute, Ninewells Hospital, Dundee DD1-9SY, United Kingdom.

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http://dx.doi.org/10.1210/jc.2009-0392DOI Listing
July 2009

Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples.

Am J Med Genet B Neuropsychiatr Genet 2007 Jan;144B(1):83-6

MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.

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http://dx.doi.org/10.1002/ajmg.b.30406DOI Listing
January 2007

htSNPer1.0: software for haplotype block partition and htSNPs selection.

BMC Bioinformatics 2005 Mar 1;6:38. Epub 2005 Mar 1.

National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.

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http://dx.doi.org/10.1186/1471-2105-6-38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1274247PMC
March 2005

The effect of haplotype-block definitions on inference of haplotype-block structure and htSNPs selection.

Mol Biol Evol 2005 Jan 15;22(1):148-59. Epub 2004 Sep 15.

National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, People's Republic of China.

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http://dx.doi.org/10.1093/molbev/msh266DOI Listing
January 2005

Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma.

Cancer Res 2004 Jun;64(12):4378-84

Laboratory of Systems Biology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-0372DOI Listing
June 2004

Haplotype structure and evidence for positive selection at the human IL13 locus.

Mol Biol Evol 2004 Jan 29;21(1):29-35. Epub 2003 Aug 29.

Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Chinese National Human Genome Center at Beijing, China.

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http://dx.doi.org/10.1093/molbev/msg231DOI Listing
January 2004

LDA--a java-based linkage disequilibrium analyzer.

Bioinformatics 2003 Nov;19(16):2147-8

Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (and Peking Union Medical College, National Laboratory of Medical Molecular Biology, Beijing, 100005, People's Republic of China.

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http://dx.doi.org/10.1093/bioinformatics/btg276DOI Listing
November 2003