Publications by authors named "Kaipeng Wang"

34 Publications

Skin Tone, Discrimination, and Allostatic Load in Middle-Aged and Older Puerto Ricans.

Psychosom Med 2021 Sep;83(7):805-812

From the Department of Community Health (Cuevas, Chan, Carvalho, Flores) Tufts University, Medford; Boston College William F. Connell School of Nursing (Abuelezam), Chestnut Hill, Massachusetts; Graduate School of Social Work (Wang), University of Denver, Denver, Colorado; Department of Nutrition (Mattei), Harvard T.H. Chan School of Public Health, Boston; and Department of Biomedical and Nutritional Sciences (Tucker) and College of Fine Arts, Humanities and Social Sciences (Falcon), University of Massachusetts Lowell, Massachusetts.

Objective: A growing body of research suggests that skin tone may be a health risk indicator for Hispanics. Black and darker-skinned Hispanics have worse mental and physical outcomes than White and lighter-skinned Hispanics. Discrimination exposure has been implicated as a risk factor that may explain the association between skin tone and health. However, there is scant research examining the interrelationship between skin tone, discrimination, and health, particularly among Puerto Ricans. We examine the interrelationships between two measures of skin tone, two measures of discrimination, and allostatic load (AL) among Puerto Rican adults.

Methods: Using cross-sectional data from wave 3 of the Boston Puerto Rican Health Study (n = 882), we examined the indirect association (IA) of skin tone on physiological dysregulated systems, also known as AL, through major discrimination and everyday discrimination. We tested these associations using two distinct measures of skin tone: interviewer-ascribed skin tone and spectrophotometer-measured skin tone.

Results: Interviewer-ascribed skin tone was indirectly associated with AL through major discrimination (IA = 0.03, 95% confidence interval = 0.004 to 0.06). However, there was no evidence of an IA of interviewer-ascribed skin tone on AL through everyday discrimination (IA = -0.01, 95% confidence interval = -0.03 to 0.01). In addition, there was no evidence that spectrophotometer-measured skin tone was indirectly associated with AL through major discrimination or everyday discrimination.

Conclusions: The sociocultural significance of skin tone may affect how Puerto Ricans are perceived and treated by others, which can, in turn, have physiological health consequences. Future research is needed to replicate these findings and examine the interrelationship between skin tone, discrimination, and other health outcomes.
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http://dx.doi.org/10.1097/PSY.0000000000000969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419137PMC
September 2021

Dietary quality modifies the association between multimorbidity and change in mobility limitations among older Americans.

Prev Med 2021 Jul 19;153:106721. Epub 2021 Jul 19.

Department of Oncology, Dell Medical School, University of Texas at Austin, Austin, TX, USA.

To identify potentially modifiable risk-factors in the age-related disablement process, we examined the association between change in mobility limitations and multimorbidity and how dietary quality moderates this association. Information from 3320 adults aged 65 and older in 2012 was drawn from the Health and Retirement Study and the Health Care and Nutrition Study. Mobility limitations reported in 2012 and change in mobility limitations from 2012 to 2014 were regressed on multimorbidity measured as number of chronic conditions in 2012, dietary quality measured in 2013 using the Alternative Healthy Eating Index-2010 (AHEI-2010), and their interaction term using Poisson regression. Respondents reported an average of 2.9 (SD, 2.9) mobility limitations in 2012 and 3.1 (SD, 3.0) mobility limitations in 2014, an average of 2.64 (SD, 1.4) chronic conditions in 2012, and mean AHEI-2010 score in 2013 of 57.1 (SD, 10.9). Greater AHEI-2010 scores were associated with fewer mobility limitations at baseline (p < .001) and slower progression of mobility limitations over the two-year observational window (p < .001). For those with AHEI-2010 scores ≥48.4, dietary quality appeared to moderate the association between multimorbidity and change in mobility limitations. These results suggest that improving dietary quality may be an effective means of reducing the progression of mobility limitations among older adults and that dietary quality may modify the effect of multimorbidity on progressive disablement. Our work adds to research supporting dietary quality as a potentially intervenable factor in the reduction of disablement in aging populations.
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http://dx.doi.org/10.1016/j.ypmed.2021.106721DOI Listing
July 2021

The Effectiveness of Psychosocial Interventions for Elder Abuse in Community Settings: A Systematic Review and Meta-Analysis.

Front Psychol 2021 26;12:679541. Epub 2021 May 26.

Graduate School of Social Work, University of Denver, Denver, CO, United States.

As a global public health concern, elder abuse negatively affects health, psychosocial wellbeing, and mortality among elders. Research and practice efforts made to explore effective prevention and intervention strategies are growing. Despite the growing number of intervention studies on elder abuse, research synthesis on the empirical literature seems lacking. This study aims to identify the pooled effect size of prevention and interventions targeted ultimate and intermediate outcomes for elder abuse that occurred in community settings. Following the Cochrane guideline, our team searched across eight electronic databases and manually searched reference lists of eligible studies and existing systematic reviews for all potentially eligible studies. A random-effects model of 51 effect size estimates reported an overall positive and statistically significant treatment effect of psychosocial interventions for elder abuse, = 0.63, < 0.05. The overall treatment effect was approaching statistical significance at 0.1 level for ultimate outcomes, = 0.32, = 0.09, and intermediate outcomes, = 0.75, = 0.1. An overall significant effect size was found among family-based interventions, = 0.59, < 0.05, and interventions targeting older adults and their caregivers, = 0.45, < 0.05. Existing evidence supports an overall significant effect for psychosocial interventions for elder abuse. Interventions that used a family-based model, combined education and supportive services, and targeted both caregivers and elders, showed significant effect size, suggesting such features being considered in elder abuse intervention design. Future intervention research is needed to shed light on the link between intervention activities and ultimate change in elder abuse behaviors.
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http://dx.doi.org/10.3389/fpsyg.2021.679541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187616PMC
May 2021

Visual trajectories and risk of physical and cognitive impairment among older Chinese adults.

J Am Geriatr Soc 2021 Jun 10. Epub 2021 Jun 10.

Medical Informatics Center, Peking University, Beijing, China.

Background/objectives: To identify visual trajectories and examine their relationships with physical and cognitive function in older Chinese adults.

Design: Population-based longitudinal study.

Setting: The Chinese Longitudinal Healthy Longevity Survey.

Participants: A total of 16,151 participants aged ≥65 years.

Measurements: Visual, physical (including activities of daily living [ADL] and instrumental ADL [IADL]), and cognitive function were assessed at baseline and subsequently every 3 years. ADI disability and IADL disability were defined as needing any help in any item of the Katz scale and a modified Lawton's scale, respectively. Cognitive impairment was defined as a Chinese version of the Mini-Mental State Examination score below 24. A group-based trajectory model was used to determine visual trajectories adjusted for age, sex, and education. Associations of visual trajectories with ADL disability, IADL disability, and cognitive impairment were evaluated using generalized estimating equation models adjusted for potential confounders.

Results: This study identified three distinct visual trajectories, including no decline (32.4%), moderate decline (48.3%), and progressive decline (19.3%) during the follow-up period. Compared with the no decline trajectory, both the moderate decline (ADL disability: OR = 2.75, 95% CI: 2.30-3.28; IADL disability: OR = 3.01, 95% CI: 2.74-3.31; cognitive impairment: OR = 3.37, 95% CI: 3.02-3.76) and the progressive decline (ADL disability: OR = 8.50, 95% CI: 6.55-11.02; IADL disability: OR = 12.96, 95% CI: 9.95-16.87; cognitive impairment: OR = 10.84, 95% CI: 8.89-13.23) trajectories were significantly associated with an increased risk of functional impairment. Compared with the moderate decline trajectory, the progressive decline trajectory was significantly associated with an increased risk of ADL disability (OR = 3.09, 95% CI: 2.46-3.89), IADL disability (OR = 4.30, 95% CI: 3.29-5.61), and cognitive impairment (OR = 3.22, 95% CI:2.63-3.93).

Conclusion: Older Chinese adults exhibit three distinct visual trajectories and those with decline trajectories in vision have an increased risk of functional impairment than those with a trajectory of no decline in vision.
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http://dx.doi.org/10.1111/jgs.17311DOI Listing
June 2021

Chitosan/Montmorillonite Coatings for the Fabrication of Food-Safe Greaseproof Paper.

Polymers (Basel) 2021 May 16;13(10). Epub 2021 May 16.

State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510000, China.

Here, we report a non-toxic method for improving the oil-resistant performance of chitosan coated paper by coating the mixture of chitosan and montmorillonite (MMT) instead of coating chitosan solution only. Through combining MMT into the chitosan coatings, the coated paper exhibited a lower air permeability and enhanced oil resistance under a lower coating load. For coated papers C2.5 and C3 by coating 2.5% () and 3% () chitosan without adding MMT in the chitosan coating, the coating load was 3.76 g/m and 3.99 g/m, respectively, and the kit rating values were only 7-8/12. Regarding the sample C2M0.1 coated by the mixed solution containing 2% () chitosan and 0.1% () MMT, its coating load was only 3.65 g/m, the paper permeability after coating was reduced to 0.00507 μm/Pa·s, owing to the filling of MMT into the cellulosic fibers network, and the kit rating reached 9/12. Moreover, C2M0.1 showed improved mechanical properties, whereby its tearing resistance was 5.2% and 6.6% higher than that of the uncoated paper in the machine direction and the cross direction, respectively.
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http://dx.doi.org/10.3390/polym13101607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156055PMC
May 2021

Technology-Assisted Psychosocial Interventions for Childhood, Adolescent, and Young Adult Cancer Survivors: A Systematic Review and Meta-Analysis.

J Adolesc Young Adult Oncol 2021 May 6. Epub 2021 May 6.

University of Michigan School of Social Work, Ann Arbor, Michigan, USA.

Technology-assisted interventions are essential in supporting cancer survivors' psychosocial outcomes, especially for childhood, adolescent, and young adult (AYA) cancer survivors, a tech-savvy generation. This study aims to systematically evaluate review and meta-analyze technology-assisted interventions for childhood and AYA cancer survivors. Following the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines, the study team used a pre-set of key words and searched studies across 11 electronic databases and 4 professional websites, and conducted a manual search of reference lists from published reviews. Meta-analysis of small sample size corrected Hedges' was conducted using meta-regression with robust variance estimation. Final analysis included a total of 28 clinical trials, including 237 effect sizes reported an overall statistically significant treatment effect of technology-assisted psychosocial interventions for childhood and AYA cancer survivors,  = 0.382, 95% confidence interval (CI) 0.243 to 0.521,  < 0.0001. Subgroup analysis revealed that distraction-based interventions and interventions for psychosocial and emotional health were overall statistically significant, whereas interventions for childhood and AYA cancer survivors' cancer knowledge outcomes and physical and functional health outcomes were statistically nonsignificant. Moderator analysis found intervention target was a significant moderator. Technology-assisted interventions for childhood and AYA cancer survivors were overall effective across domains of survivorship outcomes. Favorable evidence was found primarily for childhood cancer survivors with limited support for AYA cancer survivors. Although existing technology-assisted interventions are overall promising, research support for cancer survivors from different age groups and with different psychosocial challenges varies and should be considered individually.
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http://dx.doi.org/10.1089/jayao.2021.0012DOI Listing
May 2021

Mental Health Service Use Among Middle-aged and Older Lesbians: Application of Andersen's Health Service Use Model.

J Homosex 2021 Apr 21:1-14. Epub 2021 Apr 21.

School of Social Work, North Carolina State University, Raleigh, North Carolina, USA.

Guided by Andersen's Health Service Use Model, this study examined the predisposing, enabling, and need factors of MH service use among middle-aged and older lesbians. Data were collected from 455 lesbians ages 50 and over through a national online survey. Ordered logistic regression was conducted to examine the predictors of mental health counseling use. Results show that those who were widowed and single were more likely to participate in MH counseling than those who were partnered. Being out to healthcare providers, the number of mental health conditions, and being unsatisfied with sex were positively associated with participation in MH counseling. The study highlights the need to tailor MH service among those who are widowed and single and the importance of enhancing MH referral and integrating MH service in primary care for this population. Further, sexual health should be treated as an integral part of psychological wellbeing in MH treatment.
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http://dx.doi.org/10.1080/00918369.2021.1912558DOI Listing
April 2021

A Brief Online Mindfulness-Based Group Intervention for Psychological Distress Among Chinese Residents During COVID-19: a Pilot Randomized Controlled Trial.

Mindfulness (N Y) 2021 Mar 18:1-11. Epub 2021 Mar 18.

Graduate School of Social Work, University of Denver, Denver, CO USA.

Objectives: The coronavirus (COVID-19) global pandemic has increased psychological distress among the general population. The objective of this study is to evaluate a mindfulness-based intervention for psychological distress among Chinese residents during COVID-19.

Methods: This study used a switching replications design to test the feasibility and efficacy of a brief online mindfulness-based intervention for Chinese residents' psychological distress. Fifty-one residents in the Hubei province were randomly allocated to two groups (experimental group and waitlist control group) with three waves of measurement at time 1, time 2, and time 3 for changes in mindfulness and psychological distress.

Results: In addition to significant within-group improvements over time for both groups, OLS linear regression with full information likelihood estimation revealed statistically significant between-group treatment effects across outcome domains, including mindfulness awareness, = 2.84, < 0.001, = 6.92, psychological distress, = -21.33, < 0.001, = 6.62, somatic symptoms, = -6.22, < 0.001, = 4.42, depressive symptoms, = -7.16, < 0.001, = 5.07, and anxiety symptoms, = -8.09, < 0.001, = 6.84.

Conclusions: Results suggest that a brief online mindfulness-based intervention can be a feasible and promising intervention for improving mindfulness and decreasing psychological distress among Chinese residents staying at home during the COVID-19 outbreak. The study used a small convenience sample which led to a concern of external generalizability and with limited evaluation of long-term change.
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http://dx.doi.org/10.1007/s12671-021-01618-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7972025PMC
March 2021

Psychosocial, behavioral, and supportive interventions for pediatric, adolescent, and young adult cancer survivors: A systematic review and meta-analysis.

Crit Rev Oncol Hematol 2021 Apr 3;160:103291. Epub 2021 Mar 3.

University of Michigan Medical School Department of Internal Medicine, United States.

Background: Pediatric, adolescent, and young adult (PAYA) cancer survivors suffer from multiple domains of adverse psychosocial and behavioral outcomes during and after their cancer treatment. This study conducted a systematic review and metaanalysis of psychosocial, behavioral, and supportive interventions for PAYA cancer survivors.

Methods: We searched 11 electronic databases, 4 professional websites, and manual search of reference lists in existing reviews. We selected randomized controlled trials and controlled trials without randomization focusing on PAYA cancer survivors across six outcome domains.

Results: We included 61 studies (4,402 participants) published between 1987 and 2020. Overall risk of bias across studies was low. We identified an overall moderate and statistically significant treatment effect size for PAYA cancer survivors across six outcome domains.

Conclusion: psychosocial, behavioral, and supportive interventions were overall effective for PAYA cancer survivors. However, interventions were not effective for certain outcome domains, and less effective among AYA versus pediatric cancer survivors.
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http://dx.doi.org/10.1016/j.critrevonc.2021.103291DOI Listing
April 2021

Attitude Toward Family Involvement in End-of-Life Care Among Older Chinese Americans: How Do Family Relationships Matter?

J Appl Gerontol 2021 Mar 4:733464821996865. Epub 2021 Mar 4.

University of Denver, CO, USA.

Family involvement is critical to end-of-life (EOL) care among older adults. This study aims to examine the association and pathways between family relationships and older Chinese Americans' attitude toward family involvement in EOL care discussions. Data were collected from 260 Chinese Americans aged 55 years and above. Structural equation modeling was used to examine the total and indirect effects of family relationships on attitude toward family involvement in discussing EOL care plans. Family relationships had a significant positive total effect on attitude toward family involvement in EOL care. Indirect effects of family relationships on attitude toward family involvement in EOL care through self-efficacy, perceived benefits, and perceived barriers of discussing EOL care with family members were all significant. Findings provide empirical evidence of how family relationships affect older Chinese Americans' attitude toward family involvement in EOL care and underline the need for family-centered EOL interventions for this population.
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http://dx.doi.org/10.1177/0733464821996865DOI Listing
March 2021

Impaired Financial Decision-Making as an Early Indicator of Cognitive Decline: A Commentary.

J Gerontol Soc Work 2021 Jun 26;64(4):340-347. Epub 2021 Feb 26.

Knoebel Institute for Healthy Aging, University of Denver, Denver, Colorado, USA.

Cognitive impairment and dementia are public health concerns with significant financial implications for both individual households and public insurance systems. Though research has refined diagnostic tools for cognitive impairment and dementia diseases, little attention has focused on how cognitive decline may impact financial security. Research indicates that financial decision-making may be one of the first cognitive abilities impacted by cognitive decline, putting individuals at risk of financial fraud and exploitation. However, financial decision-making is not directly assessed in cognitive screenings. Identification of prodromal decline in financial decision-making may help individuals to preserve their financial security and reduce the likelihood of relying on public benefits. This commentary outlines the need for social workers and researchers to better understand the relationship between cognitive health, financial decision-making, and financial security in later life to formulate culturally responsive strategies that can uphold and benefit financial statuses, especially for minoritized communities.
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http://dx.doi.org/10.1080/01634372.2021.1894522DOI Listing
June 2021

Vision impairment, vision correction, and cognitive decline among middle-aged and older Chinese: results from the China health and retirement longitudinal study.

Aging Ment Health 2020 Oct 16:1-8. Epub 2020 Oct 16.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.

Objectives: To investigate the associations between vision impairment (VI), vision correction (VC), and cognitive function.

Method: We included 20,677 participants aged ≥45 years from the China Health and Retirement Longitudinal Study (2011-2015). Participants were grouped into no VI, distance VI (DVI) only, near VI (NVI) only, or both distance and near VI (DNVI), and VI(+)/VC(-), VI(+)/VC(+), VI(-)/VC(-), or VI(-)/VC(+) further at baseline. Cognitive function at baseline and subsequently every two years was applied as a dependent variable in a generalized estimating equation model.

Results: DVI only, NVI only, and DNVI had significantly worse cognitive function over time than no VI (all  < .05). DNVI had significantly worse cognitive function over time than DVI only and NVI only (all  < .001). VI(+)/VC(+), VI(-)/VC(-), and VI(-)/VC(+) had significantly better cognitive function over time than VI(+)/VC(-) (all  < .05). VI(-)/VC(+) had significantly better cognitive function over time than VI(+)/VC(+) and VI(-)/VC(-) (all  < .05).

Conclusion: Cognitive function was worse in middle-aged and older Chinese with VI, especially in those with DNVI. VC was associated with better cognitive function over time regardless of the status of vision.
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http://dx.doi.org/10.1080/13607863.2020.1828271DOI Listing
October 2020

eHealth Literacy and Caregiver Burden Among Chinese Caregivers of Older Adults With Cognitive Impairment: Does Education Matter?

J Appl Gerontol 2020 Sep 10:733464820957151. Epub 2020 Sep 10.

Texas State University, San Marcos, USA.

eHealth literacy is a critical factor that influences caregivers' well-being. The purpose of this study is to examine the association between eHealth literacy, education, and caregiver burden among Chinese caregivers of older adults with cognitive impairment. Data came from structured interviews with 300 primary family caregiver-care recipient dyads in Wuhan, China. We used logistic regression to examine the association between eHealth literacy, education, and caregiver burden. An interaction effect between eHealth literacy and education on caregiver burden was identified. eHealth literacy was positively associated with caregiver burden among caregivers with less than a high school education, but not among those with a high school education or above. eHealth literacy is salient in the burden experienced by caregivers with low education. eHealth literacy needs to be enhanced with health information verification from health professionals and programs to support caregiving efficacy to realize its positive impact on caregivers' mental health.
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http://dx.doi.org/10.1177/0733464820957151DOI Listing
September 2020

eHealth Literacy and Caregiver Burden Among Chinese Caregivers of Older Adults With Cognitive Impairment: Does Education Matter?

J Appl Gerontol 2020 Sep 10:733464820957151. Epub 2020 Sep 10.

Texas State University, San Marcos, USA.

eHealth literacy is a critical factor that influences caregivers' well-being. The purpose of this study is to examine the association between eHealth literacy, education, and caregiver burden among Chinese caregivers of older adults with cognitive impairment. Data came from structured interviews with 300 primary family caregiver-care recipient dyads in Wuhan, China. We used logistic regression to examine the association between eHealth literacy, education, and caregiver burden. An interaction effect between eHealth literacy and education on caregiver burden was identified. eHealth literacy was positively associated with caregiver burden among caregivers with less than a high school education, but not among those with a high school education or above. eHealth literacy is salient in the burden experienced by caregivers with low education. eHealth literacy needs to be enhanced with health information verification from health professionals and programs to support caregiving efficacy to realize its positive impact on caregivers' mental health.
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http://dx.doi.org/10.1177/0733464820957151DOI Listing
September 2020

Advance Directive Completion and Its Associated Factors Among Older Chinese Americans.

J Am Med Dir Assoc 2021 02 4;22(2):344-348. Epub 2020 Aug 4.

Rory Meyers College of Nursing, New York University, New York, NY.

Objectives: To examine the factors of advance directive (AD) completion among older Chinese Americans.

Design: Cross-sectional survey.

Setting And Participants: Data came from 435 Chinese Americans aged 55 years and older living in 2 metropolitan areas through self-administered questionnaires and research assistant-administered interviews in 2018. Participants' average age was 75 years (standard deviation = 9.4).

Methods: Logistic regression was used to examine factors associated with AD completion.

Results: Approximately 14% of participants completed an AD. Older age [odds ratio (OR) 1.07, 95% confidence interval (CI) 1.02-1.12], higher level of acculturation (OR 2.15, 95% CI 1.39-3.33), higher expectation for intergenerational support (OR 1.52, 95% CI 1.02-2.27), and having US citizenship (OR 3.02, 95% CI 1.26-7.23) were positively associated with AD completion. Physical and mental health needs were not significantly associated with AD completion.

Conclusions And Implications: This study is among the first focusing on AD completion among Chinese Americans, one of the fastest-growing older minority populations in the United States. Findings highlight the influence of socioeconomic and cultural factors on AD completion and illustrate the importance of developing culturally sensitive interventions to promote end-of-life care decision making among older Chinese Americans.
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http://dx.doi.org/10.1016/j.jamda.2020.06.049DOI Listing
February 2021

Correction: Delivering siRNA to control osteogenic differentiation and real-time detection of cell differentiation in human mesenchymal stem cells using multifunctional gold nanoparticles.

J Mater Chem B 2020 Jul 17;8(25):5545-5546. Epub 2020 Jun 17.

MOE Key Laboratory of Laser Life Science & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.

Correction for 'Delivering siRNA to control osteogenic differentiation and real-time detection of cell differentiation in human mesenchymal stem cells using multifunctional gold nanoparticles' by Qian Wu et al., J. Mater. Chem. B, 2020, 8, 3016-3027, DOI: .
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http://dx.doi.org/10.1039/d0tb90095hDOI Listing
July 2020

Associations between Multimorbidity and Physical Performance in Older Chinese Adults.

Int J Environ Res Public Health 2020 06 24;17(12). Epub 2020 Jun 24.

Medical Informatics Center, Peking University, Beijing 100191, China.

: Evidence on the association between physical performance and multimorbidity is scarce in Asia. This study aimed to identify multimorbidity patterns and their association with physical performance among older Chinese adults. : Individuals aged ≥60 years from the China Health and Retirement Longitudinal Study 2011-2015 ( = 10,112) were included. Physical performance was measured by maximum grip strength (kg) and average gait speed (m/s) categorized as fast (>0.8 m/s), median (>0.6-0.8 m/s), and slow (≤0.6 m/s). Multimorbidity patterns were explored using exploratory factor analysis. Generalized estimating equation was conducted. : Four multimorbidity patterns were identified: cardio-metabolic, respiratory, mental-sensory, and visceral-arthritic. An increased number of chronic conditions was associated with decreased normalized grip strength (NGS). Additionally, the highest quartile of factor scores for cardio-metabolic (β = -0.06; 95% Confidence interval (CI) = -0.07, -0.05), respiratory (β = -0.03; 95% CI = -0.05, -0.02), mental-sensory (β = -0.04; 95% CI = -0.05, -0.03), and visceral-arthritic (β = -0.04; 95% CI = -0.05, -0.02) patterns were associated with lower NGS compared with the lowest quartile. Participants with ≥4 chronic conditions were 2.06 times more likely to have a slow gait speed. Furthermore, the odds ratios for the highest quartile of factor scores of four patterns with slow gait speed compared with the lowest quartile ranged from 1.26-2.01. : Multimorbidity was related to worse physical performance, and multimorbidity patterns were differentially associated with physical performance. A shift of focus from single conditions to the requirements of a complex multimorbid population was needed for research, clinical guidelines, and health-care services. Grip strength and gait speed could be targeted to routinely measure clinical performance among older adults with multimorbidity, especially mental-sensory disorders, in clinical settings.
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http://dx.doi.org/10.3390/ijerph17124546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344642PMC
June 2020

Correction: Near-infrared control and real-time detection of osteogenic differentiation in mesenchymal stem cells by multifunctional upconversion nanoparticles.

Nanoscale 2020 07;12(25):13840

Guangdong Provincial Key Laboratory of Laser Life Science, MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.

Correction for 'Near-infrared control and real-time detection of osteogenic differentiation in mesenchymal stem cells by multifunctional upconversion nanoparticles' by Kaipeng Wang et al., Nanoscale, 2020, 12, 10106-10116, DOI: 10.1039/D0NR00872A.
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http://dx.doi.org/10.1039/d0nr90136aDOI Listing
July 2020

The effectiveness of modified, group-based CBT for dementia worry among Chinese elders.

J Affect Disord 2020 09 22;274:76-84. Epub 2020 May 22.

University of Michigan, School of Social Work, Ann Arbor, MI, USA.

Objectives: Dementias are highly prevalent among Chinese elders. This study examined the effectiveness of a modified group cognitive behavioral therapy (CBT) on dementia worry among Chinese older adults.

Methods: Eighty-two older adults recruited from four elder group homes were randomly assigned to either intervention or control group. The intervention group (n= 44) received eight weekly 60-minute face-to-face CBT, while the control group (n=38) received treatment-as-usual.

Results: Outcomes indicated that the modified group CBT has significantly reduced dementia worry and culturally biased beliefs about dementia (p<.001). Study findings supported both statistically and clinically significant effect of modified group CBT on dementia worry [g=-1.52, 95% CI (-2.01, -1.03)] and biased beliefs about dementia [g=-.95, 95% CI (-1.40, -.49)].

Discussion: The culturally adapted CBT is promising in alleviating worries and anxiety over dementia among Chinese older adults. Future research needs to include larger samples and participants from different regions to replicate findings.
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http://dx.doi.org/10.1016/j.jad.2020.05.054DOI Listing
September 2020

Age moderates the association between psychological distress and engagement in mindfulness among cancer patients and survivors: A population-based study.

J Psychosoc Oncol 2020 Sep-Oct;38(5):513-526. Epub 2020 May 25.

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.

Purpose: We aim to evaluate the relationship between psychological distress and engagement in mindfulness among a national representative sample of cancer survivors.

Sample And Design: Using the 2017 National Health Interview Survey, our final analytical sample included 3068 participants who reported having been diagnosed with cancer.

Methods And Analysis: We used logistic regression analysis to assess the association and to test age as a moderator. We also conducted follow-up analysis using Fisher's -to- transformation. All analyses were adjusted for complex sample weights.

Findings: Cancer survivors who had subclinical and clinical psychological distress were more likely to engage in mindfulness, OR = 1.59, 95% CI [1.24, 2.02] and OR = 1.45, 95% CI [1.02, 2.05], respectively. Age significantly moderated such association with the relationship much stronger among those who are younger (younger than 65 years old) than those who are older (65 years or older),  = 0.97, 95% CI [0.95, 0.99].

Conclusions: The relationship between psychological distress and engagement in mindfulness differs significantly by a survivor's age. Psychosocial oncological providers need to account for a survivor's age when delivering mindfulness based care to address psychological distress.

Implications: Providers should be mindful of a survivor's age when recommending mindfulness oriented practices.
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http://dx.doi.org/10.1080/07347332.2020.1764158DOI Listing
June 2021

Near-infrared control and real-time detection of osteogenic differentiation in mesenchymal stem cells by multifunctional upconversion nanoparticles.

Nanoscale 2020 May;12(18):10106-10116

Guangdong Provincial Key Laboratory of Laser Life Science, MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.

Finding a method to control and detect the differentiation of stem cells in real time remains a challenge for regenerative medicine. Here we developed the multifunctional upconversion nanoparticle (UCNP) approach for both near-infrared (NIR) control and the real-time detection of osteogenic differentiation in mesenchymal stem cells (MSCs). We first synthesized Tm/Er doped core-shell UCNPs (NaYF4:Yb/Tm/[email protected]), and the core-shell UCNPs were coated with mesoporous silica for drug loading and installing photomechanical azobenzene (azo). Then the Arg-Gly-Asp (RGD) peptide and the matrix metalloproteinase 13 (MMP13) sensitive peptide-black hole quencher-3 group (CGPLGVRGK-BHQ-3) were conjugated on the surface of UCNPs for cell targeting and detection of cell differentiation. The final multifunctional UCNPs are called [email protected] The drug icariin (ICA), which can induce the osteogenic differentiation of MSCs, was loaded into [email protected] to form the UCNP nanocomplexes. ICA could be released from UCNP nanocomplexes in a NIR-controlled manner that is based on the transformation of the trans-isomer of azo into the cis isomer under the upconverted UV and visible light. Meanwhile, [email protected] could also be used as a nanoprobe to detect the activity of the MMP13 enzyme by enzyme digestion and UCNP fluorescence recovery. By detecting MMP13, which is produced by osteogenic differentiation, a real-time detection of cell differentiation in living differentiated MSCs could be achieved using UCNP nanoprobes. Thus, the multifunctional UCNPs combined the control of cell differentiation with the real-time detection of cell differentiation in MSCs, which makes them a powerful tool for regulating and detecting the differentiation of MSCs in regenerative medicine.
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http://dx.doi.org/10.1039/d0nr00872aDOI Listing
May 2020

Socioeconomic correlates of adherence to mineral intake recommendations among pregnant women in north China: Findings from a cross-sectional study.

Asia Pac J Clin Nutr 2020 ;29(1):127-135

Department of Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, China. Email:

Background And Objectives: The purpose of the present study is to examine the socioeconomic correlates of adherence to minimum mineral intake recommended by the Chinese Dietary Guidelines during each trimester of pregnancy among Chinese women.

Methods And Study Design: A total of 567 pregnant women with foetal age of 6 - 12 weeks were recruited from nine community health centres and three hospitals. Cross-sectional survey data were collected using structured interviews and questionnaires. Mineral intake was calculated from food consumption reported on 24-hour dietary reviews using the Chinese Food Composition Metrics. Logistic regression models were estimated to assess the relationship between sociodemographic factors and adherence to mineral intake recommendations for each trimester.

Results: Significant predictors of adherence to mineral intake recommendations include: (1) age (zinc: OR=1.09, p<0.05; copper: OR=1.11, p<0.05), having bachelor's degree (copper: OR=2.23, p<0.05; phosphorus: OR=2.23, p<0.01), and household income ≥5,000RMB (potassium: OR=2.51, p<0.001; phosphorus: OR=1.91, p<0.05) during the first trimester, (2) being employed (zinc: OR=0.54, p<0.001; selenium: OR=0.53, p<0.05) and household income ≥5,000 RMB (zinc: OR=1.86, p<0.05) during the second trimester, and (3) husband/partner with associate degree or vocational school education (selenium: OR=3.26, p<0.01) and household income of 3,000-4,999 RMB (potassium: OR=1.71, p<0.05; zinc: OR=1.48, p<0.05) during the third trimester.

Conclusions: To our knowledge, this is the first study that examines the relationship between socioeconomic factors and mineral intake among Chinese pregnant women at three trimesters. Findings highlight the importance of considering individuals' socioeconomic status to develop personalized interventions to prevent undernutrition among this population.
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http://dx.doi.org/10.6133/apjcn.202003_29(1).0017DOI Listing
January 2021

Delivering siRNA to control osteogenic differentiation and real-time detection of cell differentiation in human mesenchymal stem cells using multifunctional gold nanoparticles.

J Mater Chem B 2020 04 24;8(15):3016-3027. Epub 2020 Mar 24.

MOE Key Laboratory of Laser Life Science & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.

Controlling and detecting cell differentiation in human mesenchymal stem cells (hMSCs) for regenerative medicine remain challenging at present. Here, we developed multifunctional gold nanoparticles (AuNPs) to control and detect osteogenic differentiation in human mesenchymal stem cells (hMSCs) in real-time. The polyethyleneimine (PEI) capped AuNPs (Au-PEI) were synthesized first and were then conjugated with a matrix metalloproteinase 13 (MMP13)-sensitive peptide-FITC group (EGPLGVRGKG-FITC) to obtain multifunctional AuNPs (AuNP-PEI-peptide-FITC). AuNP-PEI-peptide-FITC could bind siRNA with PEI by electrostatic interactions to form the AuNP-PEI-peptide-FITC/siRNA nanocomplexes, allowing efficient siRNA delivery in hMSCs. The adipogenic-related gene peroxisome proliferator-activated receptor γ (PPARγ) was targeted for silencing by the AuNP-PEI-peptide-FITC/siRNA nanocomplexes to control osteogenic differentiation in hMSCs. After demonstrating that the AuNP nanocomplexes could control cell differentiation, the versatility of this tool was illustrated by showing that it can be used as a nanoprobe for real time detection of the osteogenic differentiation of hMSCs. This was done by measuring the activity of the MMP13 enzyme (produced during osteogenic differentiation) through the recovery of FITC fluorescence. This multifunctional AuNP showed a robust new methodology for controlling cell fate and simultaneously detecting cell differentiation in real-time for hMSCs, which is promising for multiple applications in regenerative medicine.
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http://dx.doi.org/10.1039/c9tb02899dDOI Listing
April 2020

Vulnerability to fraud among Chinese older adults: do personality traits and loneliness matter?

J Elder Abuse Negl 2020 Jan-Feb;32(1):46-59. Epub 2020 Feb 20.

Faculty of Psychology, Key Research Base of Humanities and Social Sciences of Ministry of Education, Tianjin Normal University, Tianjin, China.

This study examined correlates of the vulnerability to fraud among a group of urban Chinese older adults, focusing on the influence of personality traits and loneliness. A non-probability sample of 321 older participants recruited from six urban communities in Tianjin, China participated in a survey. Key measures included the Elder Risk for Fraud Scale, the short Big Five Inventory, and the Emotional-Social Loneliness Inventory. Regression analyses found that agreeableness personality was associated with lower risks for fraud while social loneliness was associated with higher risks for fraud. Older participants who needed medical assistance with their daily living were found at higher risks for fraud than their counterparts without medical needs. It is recommendded that policymakers and helping professionals in China should assess psychosocial risk factors for fraud. Great attention needs to be paid to older adults who demonstrate low levels of agreeableness and high levels of social loneliness.
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http://dx.doi.org/10.1080/08946566.2020.1731042DOI Listing
December 2020

Self-Rated Health Among Older Chinese Americans: The Roles of Acculturation and Family Cohesion.

J Appl Gerontol 2021 04 6;40(4):387-394. Epub 2020 Jan 6.

University of Michigan, Ann Arbor, USA.

Previous research has established the influence of acculturation and family cohesion on Chinese Americans' mental health and health behavior; however, the influence of acculturation and family cohesion on self-rated health among this population has not been examined. The purpose of this study is to examine the association between family cohesion, acculturation, and self-rated health among older Chinese Americans. Data came from structured interviews with 385 Chinese Americans aged 55 and older living in a large metropolitan area in Southwest. We used logistic regression to examine the association between acculturation, family cohesion, and self-rated health. Acculturation was positively associated with self-rated health only among those with medium (odds ratio [OR] = 2.27, < .05) and high (OR = 1.93, < .05) family cohesion, but not among those with low family cohesion. Findings highlight the significance of involving family members and strengthening family support in the acculturation and supportive services provided to older Chinese Americans.
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http://dx.doi.org/10.1177/0733464819898316DOI Listing
April 2021

The Association Between Perceived Discrimination and Allostatic Load in the Boston Puerto Rican Health Study.

Psychosom Med 2019 09;81(7):659-667

From the Department of Community Health (Cuevas), Tufts University, Medford, Massachusetts; School of Social Work (Wang), Texas State University, San Marcos; Department of Social and Behavioral Sciences (Williams), Harvard T.H. Chan School of Public Health, Boston; Department of African and African American Studies (Williams), Harvard University, Cambridge; Department of Nutrition (Mattei), Harvard T.H. Chan School of Public Health, Boston, Massachusetts; and Department of Biomedical and Nutritional Sciences (Tucker), and College of Fine Arts, Humanities and Social Sciences (Falcon), University of Massachusetts Lowell.

Objective: Perceived discrimination is a risk factor for poor health among ethnic and racial minority groups. However, few studies have examined the association between major lifetime and everyday perceived discrimination and allostatic load (AL), a preclinical indicator of disease. We examine the association between two measures of discrimination and AL among Puerto Rican adults.

Methods: Using primarily wave 3 data from the longitudinal Boston Puerto Rican Health Study, we examined the association between major lifetime and everyday perceived discrimination and AL (multisystem dysregulation of 11 physiological components) among Puerto Rican adults residing in the Boston metro area (N = 882). Five models were tested using multivariable regression. The final model adjusted for demographic factors, migration factors, socioeconomic status and work history, health behaviors/risk factors, and depressive symptom.

Results: Respondents had a M (SD) AL score of 5.11 (1.76; range = 0-11). They had an average score of 0.21 (0.42) for major lifetime perceived discrimination (0-3) and 0.29 (0.49) for everyday perceived discrimination (0-3). In a fully adjusted model, major lifetime perceived discrimination was associated with greater AL (b = 0.56; 95% CI = 0.19 to 0.92), whereas greater everyday perceived discrimination was marginally, but not significantly, associated with lower AL (b = -0.42; 95% CI = -0.87 to 0.04).

Conclusions: Perceived discrimination remains a common stressor and may be a determinant of AL for Puerto Ricans, although the type of perceived discrimination may have differing effects. Further research is needed to better understand the ways in which major lifetime and everyday perceived discrimination operate to effect physiological systems among Puerto Ricans.
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http://dx.doi.org/10.1097/PSY.0000000000000715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026860PMC
September 2019

Unfair treatment, coping strategies, and depression among Puerto Ricans in Boston.

Cultur Divers Ethnic Minor Psychol 2020 Apr 25;26(2):229-238. Epub 2019 Apr 25.

College of Fine Arts, Humanities and Social Sciences, University of Massachusetts Lowell.

Objectives: Unfair treatment is a chronic social stressor with negative consequences for the mental health status of socially disadvantaged individuals. How individuals cope with stressful situations may reduce or amplify the mental burden associated with unfair treatment. The present study focuses on identifying coping strategies that mitigate the association between unfair treatment and the risk of clinical depression among Puerto Ricans, 1 of the largest Latinx subgroups in the U.S.

Method: Data were from the third wave of the Boston Puerto Rican Health Study. Using logistic regression, we tested the moderating roles of 12 types of coping strategies in the associations between recent experiences of perceived unfair treatment and depression among 963 Puerto Rican adults, aged 49 to 81, living in the Boston, MA metropolitan area.

Results: Increased exposure to perceived unfair treatment was associated with higher odds of being at risk of clinical depression. Results suggest that coping strategies such as planning, acceptance, humor, and religion significantly mitigate the association between recent unfair treatment and depression.

Conclusions: Our findings offer guidance on developing a culturally sensitive therapy for Puerto Ricans that promotes specific types of coping strategies to reduce the mental burden of unfair treatment. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
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http://dx.doi.org/10.1037/cdp0000291DOI Listing
April 2020

Acculturation and Food Insecurity Among Puerto Ricans Living in Boston.

J Nutr Educ Behav 2018 09;50(8):829-835

College of Fine Arts, Humanities and Social Sciences, University of Massachusetts, Lowell, Lowell, MA.

Objective: To examine the associations among acculturation, food environment, and food insecurity among Puerto Ricans in Boston.

Methods: The researchers used data from the second wave of the Boston Puerto Rican Health Study. The sample included 719 Puerto Rican adults in Boston. The researchers used logistic regression to examine the associations between psychological and language acculturation and food insecurity.

Results: Individuals with medium psychological acculturation were more likely to be food insecure than were those with low or high psychological acculturation (P = .01). The association between language acculturation and food insecurity differed by distance of residence from primary shopping location (P = .02).

Conclusions And Implications: This study extends the understanding of acculturation and food insecurity by investigating the impact of psychological and language acculturation. The findings highlight biculturalism, indicated by medium psychological acculturation, as a risk factor for food insecurity. People with low language acculturation who live far from food shopping locations had the highest prevalence of food insecurity.
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http://dx.doi.org/10.1016/j.jneb.2018.05.020DOI Listing
September 2018

Food insecurity, comorbidity, and mobility limitations among older U.S. adults: Findings from the Health and Retirement Study and Health Care and Nutrition Study.

Prev Med 2018 09 9;114:180-187. Epub 2018 Jul 9.

School of Social Work, College of Applied Arts, Texas State University, 601 University Drive, San Marcos, TX 78666, USA.

Both food insecurity and comorbidity have been identified as precursors to functional limitation in older adults, yet whether food insecurity modifies the progression from chronic disease to disability has not been assessed. We examined 5986 respondents age 50 and older drawn from the 2012-2014 Health and Retirement Study (HRS) and 2013 Health Care and Nutrition Study (HCNS). Mobility limitations reported in 2014 and change in mobility limitations from 2012 to 2014 were regressed on measures of food insecurity, number of chronic conditions, and their interaction terms using Poisson regression. Around 17.3% of the sample was identified as food insecure. In 2012, respondents reported an average of 1.9 (SD = 1.5) chronic conditions and 2.4 mobility limitations (SD = 3.0). In 2014, individuals reported an average of 2.5 (SD = 3.1) mobility limitations. Food insecurity was associated with a greater number of mobility limitations (IRR = 1.20, 95% CI: 1.11-1.29, p < .001) and more rapid increase in mobility limitations over the two-year observational period (IRR = 1.06, 95% CI: 1.00-1.11, p = .047). Food security status also modified the association between comorbidity and both mobility limitation outcomes, with the food secure exhibiting a stronger positive association between chronic conditions and mobility limitations than the food insecure. The food insecure tended to have more mobility limitations than the food secure when few chronic conditions were reported. Our results suggest that food insecurity is associated with prevalence and change in mobility limitations among older adults.
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http://dx.doi.org/10.1016/j.ypmed.2018.07.001DOI Listing
September 2018

Racial and ethnic differences in associations between psychological distress and the presence of binge drinking: Results from the California health interview survey.

Addict Behav 2017 02 23;65:1-6. Epub 2016 Sep 23.

Boston College School of Social Work, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, United States.

Introduction: Racial and ethnic minorities often suffer from poorer health than Whites given their exposure to more stressors and fewer resources that buffer the effects of stress. Given that alcohol is often consumed to alleviate the negative moods, the present study hypothesized that psychological distress may impact the involvement in binge drinking differently across racial and ethnic groups.

Methods: We used data from the California Health Interview Survey (CHIS) from 2007 to 2012. The sample consisted of 130,556 adults including African Americans (N=6541), Asians (N=13,508), Latinos (N=18,128), and Whites (N=92,379). Binary logistic regression analysis was used with consideration for complex survey design.

Results: The results indicated that psychological distress was significantly associated with binge drinking across all racial and ethnic groups. However, this association differed by race and ethnicity adjusting for age, gender, marital status, education, poverty, and employment status. The results revealed that psychological distress had the largest effect on binge drinking for Asian Americans, particularly Filipinos and South Asians, compared to Whites.

Conclusions: This study highlights the importance of examining racial and ethnic differences in the impacts of psychological distress on alcohol consumption. Future research is needed to better understand the potential factors that mediate the effects of psychological distress on binge drinking specific to each racial and ethnic group in order to develop culturally sensitive interventions and hence decrease the alcohol-related racial health disparities.
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http://dx.doi.org/10.1016/j.addbeh.2016.09.004DOI Listing
February 2017
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