Publications by authors named "Kaihong Chen"

25 Publications

  • Page 1 of 1

Impact of the Malnutrition on Mortality in Elderly Patients Undergoing Percutaneous Coronary Intervention.

Clin Interv Aging 2021 14;16:1347-1356. Epub 2021 Jul 14.

Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, People's Republic of China.

Purpose: Malnutrition has been shown to be related to adverse clinical outcomes in patients with heart failure, hypertension, atrial fibrillation and other cardiovascular diseases. However, in the patients with coronary artery disease (CAD) undergoing percutaneous coronary interventions (PCI), especially in the elderly, the association of nutritional state and all-cause mortality remains unknown. We aimed to investigate the association of malnutrition with all-cause mortality in the elder patients undergoing PCI.

Patients And Methods: Based on the largest retrospective and observational cohort study from January 2007 to December 2017, the Controlling Nutritional Status (CONUT) score was applied to 21,479 consecutive patients with age ≥60 who undergoing PCI for nutritional assessment. Participants were classified as absent, mild, moderate and severe malnutrition by CONUT score. The Kaplan-Meier method was used to compare all-cause mortality among the above four groups. Multivariable Cox proportional hazard regression analyses were performed to examine the association of malnutrition with all-cause mortality.

Results: According to the CONUT score, 48.19%, 15.08% and 0.94% patients were mildly, moderately and severely malnourished, respectively. During a median follow-up of 5.16 years (interquartile range: 3.02 to 7.89 years), 3173 (14.77%) patients died. Kaplan-Meier analysis showed that the risk of all-cause mortality was significantly higher in patients with a worse nutritional status. Compared with normal nutritional state, malnutrition was associated with significantly increased risk for all-cause mortality (adjusted hazard ratio for mild, moderate and severe degrees of malnutrition, respectively: 1.20 [95% confidence interval (CI): 1.09 to 1.33], 1.32 [95% CI: 1.17 to 1.49] and 1.76 [95% CI: 1.33 to 2.33]).

Conclusion: Malnutrition is prevalent among elderly patients with CAD undergoing PCI, and is strongly related to the all-cause mortality increasing. For elderly patients with CAD undergoing PCI, it is necessary to assess the status of nutrition, and evaluate the efficacy of nutritional interventions.
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http://dx.doi.org/10.2147/CIA.S308569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286965PMC
July 2021

Predictive value of creatine kinase MB for contrast-induced acute kidney injury among myocardial infarction patients.

BMC Cardiovasc Disord 2021 Jul 13;21(1):337. Epub 2021 Jul 13.

Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.

Background: Predictive value of creatine kinase MB (CK-MB) for contrast-induced acute kidney injury (CI-AKI) among myocardial infarction (MI) patients has rarely been reported. We aim to evaluate the predictive value of CK-MB for CI-AKI among MI patients.

Methods: Totally, 1131 MI patients were included from the REduction of rIsk for Contrast-Induced Nephropathy (REICIN) study. The peak CK-MB before coronary angiography (CAG) was chosen. The study population was divided into two groups by log-transformed CK-MB cut-off point. The association between CK-MB and CI-AKI was tested by multivariable logistic regression. CK-MB was integrated with Age, creatinine and ejection fraction (ACEF) score and Mehran risk score (MRS) to evaluate the additive value of CK-MB. The integrated models were validated internally by the bootstrap method and externally by the PREdictive Value of COntrast voluMe to creatinine Clearance Ratio (PRECOMIN) study data set.

Results: Overall, 62(5.48%) patients developed CI-AKI, patients with CK-MB point > 4.7 displayed a higher incidence of CI-AKI than those without (11.9% vs. 4.0%, p < 0.001). CK-MB point > 4.7 was independently associated with CI-AKI (adjusted OR: 3.40, 95% CI: 1.93-5.98, p < 0.001). The additions of CK-MB to ACEF score, Mehran score A and Mehran score B resulted in increases in C-statistics, which ranged from 0.680 to 0.733 (p = 0.046), 0.694 to 0.727 (p = 0.091), 0.704 to 0.734 (p = 0.102), respectively. Internal validation also showed increases in C-statistics, and external validation performed well in discrimination and calibration.

Conclusions: Preprocedural peak CK-MB was a predictor of CI-AKI among MI patients.
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http://dx.doi.org/10.1186/s12872-021-02155-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276394PMC
July 2021

Designing and Accurately Developing a [6 + 2] Dipolar Cycloaddition for the Synthesis of Benzodiazocines.

Org Lett 2021 Jul 1;23(14):5430-5434. Epub 2021 Jul 1.

State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, People's Republic of China.

1,6-Dipolar cycloadditions represent a valuable strategy for the rapid construction of medium-sized rings. Herein, we describe the concept for the design of 1,6-dipoles that bypasses the regioselectivity. Through the introduction of an amino group into Morita-Baylis-Hillman (MBH) carbonates, unprecedented [6 + 2] dipolar cycloadditions were accurately developed with CsCO, efficiently delivering a series of benzodiazocines in mild conditions. Computational studies bring a deeper understanding of this reaction.
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http://dx.doi.org/10.1021/acs.orglett.1c01770DOI Listing
July 2021

Malnutrition and the risk for contrast-induced acute kidney injury in patients with coronary artery disease.

Int Urol Nephrol 2021 Jun 25. Epub 2021 Jun 25.

Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.

Purpose: Malnutrition is a common comorbidity of coronary artery disease (CAD) and is often associated with adverse events. The malnutrition often means lower cholesterol, albumin and high lymphocyte, as risk factors of Contrast-Induced Acute Kidney Injury (CI-AKI). We aim to evaluate the association between malnutrition and CI-AKI following coronary angiography (CAG) in CAD patients.

Methods: We analyzed 3170 CAD patients with variables of nutritional status (Controlling Nutritional Status score (CONUT)) from the prospective multicenter study, REICIN (NCT01402232) including 4,271 consecutive patients undergoing CAG from January 2013 to February 2016. Patients were divided into the normal group (CONUT score 0-1) and malnutrition group (CONUT score > 1). The association of malnutrition and the risk of CI-AKI was examined in all CAD patients using multivariable logistics regression analysis.

Results: Among the 3170 patients (mean age: 63.1 ± 10.7 years), 1865 (58.8%) suffered from malnutrition, 111 (3.5%) developed CI-AKI, including 23 (1.76%) in normal group and 88 (4.72%) in malnutrition group (p < 0.01). The malnourished patients were older, and likely had anemia and worse cardiorenal function. After adjustment for confounders, the risk of CI-AKI was 1.04 times higher in the malnutrition group than in the normal group (adjusted OR: 2.04, 95% CI 1.28-3.38, p < 0.01).

Conclusions: Among CAD patients undergoing CAG, malnutrition is extremely common and associated with a double risk of CI-AKI. Further studies are needed to investigate the potential renal protection of intervening malnutrition in CAD patients.
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http://dx.doi.org/10.1007/s11255-021-02915-6DOI Listing
June 2021

Risk factors and predictive model for abdominal wound dehiscence in neonates: a retrospective cohort study.

Ann Med 2021 12;53(1):900-907

Department of Pediatric Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China.

Background: Abdominal wound dehiscence (AWD) is a major complication of abdominal surgery, and neonates are a group with a high risk of AWD, which has serious consequences or can even result in death. The purpose of this study is to explore the risk factors for neonatal AWD and construct a predictive model.

Methods: The clinical data of 453 cases that underwent neonatal laparotomy from June 2009 to June 2020 were retrospectively analyzed, among which 27 cases of AWD were identified. Nine factors, including gender, age at admission, weight at admission, preterm delivery, level of preoperative anaemia, hypoalbuminemia, operation time, incision length, and incision type, were analyzed to explore their correlation with neonatal AWD.

Results: The incidence of neonatal AWD was 6.0% (27/453), among which partial wound dehiscence accounted for 4.9% (22/453) and complete wound dehiscence accounted for 1.1% (5/453). Hypoproteinemia and incision type were the independent risk factors for neonatal AWD, and weight at admission was a protective factor for AWD in the multivariate models. All these factors were incorporated to construct a nomogram, and a calibration curve was plotted. The result indicated that the actual risk was close to the predicted risk when the predicted risk rate was greater than about 35%.

Conclusions: Neonatal AWD is closely related to hypoproteinemia and incision contamination. Our predictive model showed the potential to provide an individualized risk estimate of AWD for neonatal patients undergoing abdominal surgery.Key messagesNeonatal abdominal wound dehiscence (AWD) has a serious consequence and the incidence of neonatal AWD was about 6.0% and the complete AWD morbidity is 1.1%.Hypoproteinemia and incision type were the independent risk factors for neonatal AWD.Our predictive model showed the potential to provide an individualized risk estimate of AWD for neonatal patients undergoing abdominal surgery.
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http://dx.doi.org/10.1080/07853890.2021.1938661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204998PMC
December 2021

Design and tuning of ionic liquid-based HNO donor through intramolecular hydrogen bond for efficient inhibition of tumor growth.

Sci Adv 2020 Nov 6;6(45). Epub 2020 Nov 6.

Department of Chemistry, ZJU-NHU United R&D Center, Zhejiang University, Hangzhou 310027, China.

Developing ionic liquid (IL) drugs broaden new horizons in pharmaceuticals. The tunable nature endows ILs with capacity to delivery active ingredients. However, the tunability is limited to screen ionic components, and none realizes the kinetic tuning of drug release, which is a key challenge in the design of IL drugs. Here, a series of ILs are developed using biocompatible ionic components, which realizes absorption of gaseous NO to yield IL-NONOates. These IL-NONOates serve as HNO donors to release active ingredient. The release kinetics can be tuned through configuring the geometric construction of ILs (release half-lives, 4.2 to 1061 min). Mechanism research indicates that the tunability depends on the strength of intramolecular hydrogen bond. Furthermore, the IL-based HNO donors exert pharmacological potential to inhibit tumor progression by regulating intratumoral redox state. Coupled with biosafety, these IL-based HNO donors with facile preparation and tunable functionalization can be promising candidates for pharmaceutical application.
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http://dx.doi.org/10.1126/sciadv.abb7788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673712PMC
November 2020

Characteristics and requirements of hypertensive patients willing to use digital health tools in the Chinese community: a multicentre cross-sectional survey.

BMC Public Health 2020 Sep 1;20(1):1333. Epub 2020 Sep 1.

Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510000, Guangdong, China.

Background: Digital health tools (WeChat or mobile health apps) provide opportunities for new methods of hypertension management for hypertensive patients. However, the willingness of these patients to use social media and mobile health apps for hypertension management remains unclear. This study explored the characteristics and requirements of patients willing to use digital health (WDH) tools to manage hypertension.

Methods: From February to March 2018, we administered questionnaires to 1089 patients with hypertension at eight Chinese primary medical units. We assessed independent risk factors of WDH and requirement among WDH patients.

Results: Overall, 43% (465/1089) of participants were WDH patients, who were younger (58 ± 12 vs 61 ± 13 years) and had a greater proportion of employed individuals (31% vs 14%) and higher education levels (65% vs 52%) than the non-WDH patients (all P < 0.0001). After adjusting for other risk factors, higher education (OR: 0.52; 95% CI: 0.34-0.79), good medicine adherence (OR: 1.5; 95% CI: 1.0-2.3) and blood pressure self-monitoring (OR: 1.6; 95% CI: 1.2-2.3) remained significantly associated with WDH (all P < 0.05). WDH patients responded that digital health tools should try to provide a platform for blood pressure monitoring (42%), medication reminders (41%), hypertension knowledge (39%) and doctor-patient communication (32%).

Conclusion: Our survey suggested that among hypertensive patients, willingness to use digital health tools was significantly associated with education, medicine adherence and blood pressure self-monitoring. Digital health tool developers and researchers should pay particular attention to recruiting older, less educated and unemployed patients with less willingness and who are less technologically savvy and research the requirements of WDH patients (blood pressure monitoring, medication reminders, and knowledge education) in the future.
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http://dx.doi.org/10.1186/s12889-020-09462-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465797PMC
September 2020

Population attributable risk estimates of risk factors for contrast-induced acute kidney injury following coronary angiography: a cohort study.

BMC Cardiovasc Disord 2020 06 12;20(1):289. Epub 2020 Jun 12.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.

Background: Contrast-induced acute kidney injury (CI-AKI) is a common complication with poor outcomes following coronary angiography (CAG) or percutaneous coronary intervention (PCI). However, no study has explored the population attributable risks (PARs) of the CI-AKI risk factors. Therefore, we aimed to identify the independent risk factors of CI-AKI and estimate their PARs.

Methods: We analyzed 3450 consecutive patients undergoing CAG/PCI from a prospective cohort in Guangdong Provincial People's Hospital. CI-AKI was defined as a serum creatinine elevation ≥50% or 0.3 mg/dL from baseline within the first 48 to 72 h after the procedure. Independent risk factors for CI-AKI were evaluated through stepwise approach and multivariable logistic regression analysis, and those that are potentially modifiable were of interest. PARs of independent risk factors were calculated with their odds ratios and prevalence among our cohort.

Results: The overall incidence of CI-AKI was 7.19% (n = 248), which was associated with increased long-term mortality. Independent risk factors for CI-AKI included heart failure (HF) symptoms, hypoalbuminemia, high contrast volume, hypotension, hypertension, chronic kidney disease stages, acute myocardial infarction and age > 75 years. Among the four risk factors of interest, the PAR of HF symptoms was the highest (38.06%), followed by hypoalbuminemia (17.69%), high contrast volume (12.91%) and hypotension (4.21%).

Conclusions: These modifiable risk factors (e.g., HF symptoms, hypoalbuminemia) could be important and cost-effective targets for prevention and treatment strategies to reduce the risk of CI-AKI. Intervention studies targeting these risk factors are needed.
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http://dx.doi.org/10.1186/s12872-020-01570-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291532PMC
June 2020

Nomogram for contrast-induced acute kidney injury in patients with chronic kidney disease undergoing coronary angiography in China: a cohort study.

BMJ Open 2020 05 26;10(5):e037256. Epub 2020 May 26.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China

Objectives: To establish a nomogram for contrast-induced acute kidney injury (CI-AKI) risk assessment among patients with chronic kidney disease (CKD) undergoing coronary angiography (CAG) or percutaneous coronary intervention (PCI).

Design: Prospective observational cohort study.

Setting: Southern China.

Interventions: None.

Participants: 643 consecutive patients with CKD (defined as estimated glomerular filtration rate calculated by Modification of Diet in Renal Disease formula <60 mL/min/1.73 mm) were enrolled.

Outcome Measures: The end point was CI-AKI defined as serum creatinine elevation ≥0.5 mg/dL or 25% from baseline within the first 48-72 hours following contrast exposure.Predictors of CI-AKI were selected by multivariable logistic regression and stepwise approach. A nomogram based on these predictors was constructed and compared with the classic Mehran Score. For validation, a bootstrap method (1000 times) was performed.

Results: The nomogram including age, weight, heart rate, hypotension, PCI and β-blocker demonstrated a better predictive value than the classic Mehran Score (area under the curve: 0.78 vs 0.71, p=0.024), as well as a well-fitted calibration curve (χ=12.146, p=0.145). Validation through the bootstrap method (1000 times) also indicated a good discriminative power (adjusted C-statistic: 0.76).

Conclusions: With fewer predictors and higher discriminative power, the present nomogram may be a simple and reliable tool to identify patients with CKD at risk of CI-AKI, whereas further external validations are needed.
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http://dx.doi.org/10.1136/bmjopen-2020-037256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259871PMC
May 2020

A comparison between different definitions of contrast-induced acute kidney injury for long-term mortality in patients with acute myocardial infarction.

Int J Cardiol Heart Vasc 2020 Jun 30;28:100522. Epub 2020 Apr 30.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.

Background: Few studies have demonstrated the association between contrast-induced acute kidney injury (CI-AKI) and long-term mortality and explored which definition of CI-AKI accounts for most long-term deaths among patients with acute myocardial infarction (AMI). Therefore, we aimed to evaluate this association and compared the population attributable risks (PARs) of three CI-AKI definitions.

Methods: We analyzed 1300 consecutive AMI patients undergoing angiography in Guangdong Provincial People's Hospital. The endpoint was all-cause mortality. CI-AKI was evaluated according to three definitions: (1) CI-AKI, with a serum creatinine elevation ≥ 50% or ≥ 0.3 mg/dL from baseline in the first 72 h after procedure; (2) CI-AKI, ≥ 0.5 mg/dL in 72 h; (3) CI-AKI: ≥ 25% in 72 h; multivariable Cox analysis was conducted to evaluate the association between CI-AKI and long-term mortality. PARs of CI-AKI under different definitions were calculated with their odds ratios and prevalence among our cohort.

Results: During the median follow-up period of 7.0 (5.5; 8.7) years, CI-AKI was significantly associated with poorer outcome regardless of the definition (adjusted hazard ratios: 1.417-2.711). Among the three definitions of CI-AKI, the prevalence was the highest for CI-AKI (18.77%), and PAR was the highest for CI-AKI (11.62%, 95% CI: 4.99-19.71), followed by CI-AKI (9.20%, 95% CI: 4.22-16.00) and CI-AKI (7.26%, 95% CI: 0.21-15.62).

Conclusions: Our results suggested that CI-AKI is associated with long-term mortality in patients with AMI irrespective of its definitions. Cardiologists and studies regarding long-term prognosis should pay more attention to the presence of CI-AKI, especially CI-AKI with the highest PAR.
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http://dx.doi.org/10.1016/j.ijcha.2020.100522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200302PMC
June 2020

Diagnosis and Treatment of Hypospadias With Megameatus Intact Prepuce.

Front Pediatr 2020 31;8:128. Epub 2020 Mar 31.

Department of Radiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.

To evaluate the diagnosis and treatment methods of hypospadias with megameatus intact prepuce (MIP). A retrospective analysis was performed in 27 MIP children, 13 of whom underwent tubularized incised plate urethroplasty (TIP procedure), 7 underwent the Duplay procedure, 5 underwent the Mathieu procedure, 1 underwent meatal advancement and glanuloplasty (MAGPI procedure), and 1 underwent the glans approximation procedure (GAP). The patients were followed for 6-36 months to evaluate the surgical outcomes by the Pediatric Penile Perception Score (PPPS). A total of 27 patients with a mean age of 8.12 ± 3.0 years were enrolled in this study, and 25 cases (25/27, 92.6%) were accidentally discovered during the first visit for phimosis. The patients had a formed urethra of 0.5 to 1.5 cm. Complications occurred in 4 of the 27 patients (14.81%): 2 patients with urethral fistula and 2 patients with meatal stenosis. One patient had a case of self-healed urethral fistula, and the remaining 3 patients underwent reoperation. The post-operative effect was satisfactory in all patients, and the urinary flow and stream during urination were normal. The overall average PPPS score of non-operative surgeons and parents was satisfactory. There were no significant differences in meatus appearance, glans appearance, skin appearance, and general appearance PPPS score among the Mathieu, TIP, and Duplay surgical procedures. MIP clinical manifestations are concealed and usually noted when circumcision is attempted. The suitable procedure for each patient should be tailored according to the anatomic features, and several techniques can be used with good functional and cosmetic results.
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http://dx.doi.org/10.3389/fped.2020.00128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136419PMC
March 2020

Fat Wasting Is Damaging: Role of Adipose Tissue in Cancer-Associated Cachexia.

Front Cell Dev Biol 2020 12;8:33. Epub 2020 Feb 12.

Department of Oral Implantology, School and Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.

Loss of body weight, especially loss of adipose tissue and skeletal muscle weight, characterizes cancer-associated cachexia (CAC). Clinically, therapeutic options for CAC are limited due to the complicated signaling between cancer and other organs. Recent research advances show that adipose tissues play a critical role during thermogenesis, glucose homeostasis, insulin sensitivity, and lipid metabolism. Understanding the adipocyte lipolysis, the formation of beige adipocytes, and the activation of brown adipocytes is vital for novel therapies for metabolic syndromes like CAC. The system-level crosstalk between adipose tissue and other organs involves adipocyte lipolysis, white adipose tissue browning, and secreted factors and metabolites. Novel CAC animal models and accumulating molecular signaling knowledge have provided mechanisms that may ultimately be translated into future therapeutic possibilities that benefit CAC patients. This mini review discusses the role of adipose tissue in CAC development, mechanism, and therapy.
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http://dx.doi.org/10.3389/fcell.2020.00033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028686PMC
February 2020

Megameatus intact prepuce treated with urethral plate-preserving surgery: a retrospective study of an unusual hypospadias variant.

Transl Androl Urol 2019 Dec;8(6):583-590

Department of Radiology, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China.

Background: Megameatus intact prepuce (MIP) is a unique variant of hypospadias and is a clinically rare condition. Due to the anatomical characteristics of the MIP hypospadias variant presenting a unique challenge to surgeons, no single urethroplasty method provides a universal solution for all patients. The purpose of this study was to evaluate the outcomes of hypospadias after MIP repair by urethral plate-preserving urethroplasty.

Methods: A retrospective study was performed on 25 coronal or distal MIP patients, with a median age of 8, with most deficiencies being discovered during their first hospital visit for phimosis. Correction with urethroplasty was performed for all patients; 5 underwent the Mathieu procedure, 13 underwent the tubularized incised plate (TIP) procedure, and 7 underwent the Duplay procedure. The 25 patients were followed up for 6 to 36 months to evaluate the surgical outcomes.

Results: There were no significant differences in intraoperative bleeding, hospital stays, postoperative analgesia rate, and cure rate among the three surgical procedures. The operative time for the Mathieu procedure was longer than that for the TIP and Duplay procedures, which did not differ. Complications occurred in 4 of the 25 patients (16.0%), and the overall complication-free survival rate at 1 year after surgery was 80.5%. The age at the time of surgery, urethral plate width, urethroplasty length, surgical procedures, or meatal location (coronal or distal penis) were not independently predictive of complications.

Conclusions: The clinical manifestations of MIP are often concealed and then accidentally discovered during hospital visits for phimosis; thus, the actual incidence of MIP might be higher. The urethral plate should be preserved during MIP-correcting treatment, especially for coronal or distal MIP. The same satisfactory outcomes can be obtained with Mathieu, TIP, or Duplay urethroplasty.
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http://dx.doi.org/10.21037/tau.2019.10.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987599PMC
December 2019

Berberine inhibits cardiac remodeling of heart failure after myocardial infarction by reducing myocardial cell apoptosis in rats.

Exp Ther Med 2018 Sep 11;16(3):2499-2505. Epub 2018 Jul 11.

Department of Cardiology, The Affiliated Longyan First Hospital of Fujian Medical University, Longyan, Fujian 364000, P.R. China.

The effects of berberine on cardiac function of heart failure after myocardial infarction and its possible mechanism were investigated. The anterior descending branches of 50 female Wistar rats were ligatured to establish the model of heart failure after myocardial infarction. At 4 weeks after successful modeling, the rats were randomly divided into two groups receiving 4-week gavage with saline (Sal group) and berberine (Ber group), while the sham-operation group (Sham group) was set up. After 4 weeks, the hemodynamics and serum BNP in rats were measured. The hearts of rats were taken to detect the degree of myocardial fibrosis. The myocardial cell apoptosis was detected. The expressions and changes in myocardial apoptosis-related proteins, including Bcl-2, Bax and caspase-3, were detected. The expression and changes in GRP78, CHOP and caspase-12 in myocardial tissue were detected. The results showed that Berberine improved the cardiac function of rats after myocardial infarction. After myocardial infarction, myocardial fibrosis and apoptosis were observed around the infarction area, berberine improved the myocardial fibrosis and reduced cell apoptosis. Furthermore, berberine alleviated endoplasmic reticulum stress (ERS) after myocardial infarction. In conclusion, Berberine can inhibit the myocardium cell apoptosis of heart failure after myocardial infarction, and its mechanism may be realized by affecting the ERS in myocardial tissue of heart failure after myocardial infarction and CHOP and caspase-12 apoptotic signaling pathway, upregulating Bcl-2/Bax expression and downregulating caspase-3 expression, thus inhibiting the cardiac remodeling and protecting the cardiac function.
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http://dx.doi.org/10.3892/etm.2018.6438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122433PMC
September 2018

Changes of serum trace elements in early stage trauma and its correlation with injury severity score.

Medicine (Baltimore) 2018 Jun;97(23):e10077

The Second Affiliated Hospital of Shantou University Medical College Department of Forensic Medicine, Shantou University Medical College, Shantou, Guangdong Province, People's Republic of China.

Background: Severe trauma can cause secondary multiple organ dysfunction syndrome and death. The absolute and relative concentrations of trace elements in both critical care and conventional treatment, which can lead to acute trace element deficiency, constitute an important mechanism of multiple organ dysfunction syndrome (MODS)/multiple organ failure (MOF).

Methods: We investigated the changes in serum Cu, Zn, and Fe in early stage trauma of patients with the high injury severity score (ISS) and correlated the change in trace elements with ISS. Blood samples were collected within an hour of admittance and the patients were scored according to ISS. We collected clinical data records and ISS score values, and determined serum Fe, Zn, and Cu by inductively coupled plasma mass spectrometry.

Results: Compared with the control group, the serum Zn and Fe values of trauma patients were decreased. There was no significant difference in serum Cu between the patients and the control group. In the trauma group, the serum Zn and Fe were lower than that of the minor injury group, and the difference of Cu concentration was not statistically significant.

Conclusions: Serum Zn and Fe levels in patients with multiple trauma fractures were significantly different than those in the normal group, suggesting that Zn and Fe need to be monitored in the early stage of trauma.
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http://dx.doi.org/10.1097/MD.0000000000010077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999505PMC
June 2018

Legumain suppresses OxLDL-induced macrophage apoptosis through enhancement of the autophagy pathway.

Gene 2018 Apr 4;652:16-24. Epub 2018 Feb 4.

Department of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, People's Republic of China. Electronic address:

Objective: Autophagy plays a prominent role in the pathogenesis of plaques formation and progression of atherosclerosis (AS). The cysteine protease legumain is known to participate in atherogenesis, but its function and underlying mechanism in AS macrophages remain unclear.

Methods: The expressions of legumain in plaques isolated from AS patients and in macrophages stimulated with oxLDL were examined. Moreover, we effectively altered legumain expression in macrophages to characterize the effect of legumain on oxLDL-induced macrophage apoptosis. The expression of apoptotic and autophagic factors was analysed.

Results: Legumain was present in plaques, and its expression was upregulated in macrophages treated with oxLDL. Suppressing legumain significantly increased oxLDL-induced macrophage apoptosis and the expression of caspase 3, caspase 9 and Bax. However, legumain overexpression decreased macrophage apoptosis upon oxLDL exposure and the levels of caspase 3, caspase 9 and Bax. In addition, recombinant legumain protein suppressed macrophage apoptosis. Biochemical experiments revealed that legumain deficiency decreased the levels of Beclin1 and LC3, whereas increased legumain expression increased the levels of Beclin1 and LC3 significantly.

Conclusion: Legumain regulates oxLDL-induced macrophage apoptosis by enhancing the autophagy pathway, which may also influence the vulnerability of atherosclerotic plaques.
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http://dx.doi.org/10.1016/j.gene.2018.02.012DOI Listing
April 2018

Anion-Functionalized Pillararenes for Efficient Sulfur Dioxide Capture: Significant Effect of the Anion and the Cavity.

Chemistry 2017 Oct 18;23(57):14143-14148. Epub 2017 Sep 18.

Department of Chemistry, ZJU-NHU United R&D Center, Zhejiang University, Hangzhou, 310027, P.R. China.

A series of anion-functionalized pillararenes were prepared and applied in the capture of SO through incorporating an anion with different basicity into pillararenes. A high SO absorption capacity up to 15.9 mmol g and excellent reversibility were achieved by tuning the basicity of the anion and the size of the cavity. Spectroscopic investigations and DFT calculations indicated that high SO capacity originated from multiple sites interaction between SO and the anion, where SO chemical absorption was significant strengthened by the cavity, because the anion was confined in the window of the cavity and the window was electron-deficient. Interestingly, a phase transition occurred during absorption and desorption process. The method proposed in this work provided an efficient strategy for improving gas absorption through a simple functionalization of the supermolecule, which was also very important for some other fields such as polymers and materials.
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http://dx.doi.org/10.1002/chem.201703007DOI Listing
October 2017

Highly Efficient Nitric Oxide Capture by Azole-Based Ionic Liquids through Multiple-Site Absorption.

Angew Chem Int Ed Engl 2016 11 14;55(46):14364-14368. Epub 2016 Oct 14.

Department of Chemistry, ZJU-NHU United R&D Center, Zhejiang University, Hangzhou, 310027, P.R. China.

A novel method for highly efficient nitric oxide absorption by azole-based ionic liquid was reported. The NO absorption capacity reached up to 4.52 mol per mol ionic liquid and is significant higher than the capacity other traditional absorbents. Moreover, the absorption of NO by this ionic liquid was reversible. Through a combination of experimental absorption, quantum chemical calculation, NMR and FT-IR spectroscopic investigation, the results indicated that such high capacity originated from multiple-site interactions between NO and the anion through the formation of NONOate with the chemical formula R R N-(NO )-N=O, where R and R are alkyl groups. We believe that this highly efficient and reversible NO absorption by an azole-based ionic liquid paves a new way for gas capture and utilization.
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http://dx.doi.org/10.1002/anie.201607528DOI Listing
November 2016

Computer-Assisted Design of Ionic Liquids for Efficient Synthesis of 3(2H)-Furanones: A Domino Reaction Triggered by CO.

J Am Chem Soc 2016 11 21;138(43):14198-14201. Epub 2016 Oct 21.

Department of Chemistry, ZJU-NHU United R&D Center, Zhejiang University , Hangzhou 310027, China.

A strategy for the highly efficient synthesis of 3(2H)-furanones by hydration of diyne alcohols catalyzed by base-functionalized ionic liquids under atmospheric-pressure CO that was developed through computer-assisted design is reported. The best range of basic ionic liquids as catalysts was predicted at first, and [HDBU][BenIm] exhibited the highest catalytic activity. Through a combination of NMR spectroscopic investigations and quantum-chemical calculations, the results indicated the importance of the basicity of the anion and the species of cation in the ionic liquid.
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http://dx.doi.org/10.1021/jacs.6b08895DOI Listing
November 2016

Reversible CO2 Capture by Conjugated Ionic Liquids through Dynamic Covalent Carbon-Oxygen Bonds.

ChemSusChem 2016 09 26;9(17):2351-7. Epub 2016 Jul 26.

Department of Chemistry, Zhejiang University, Hangzhou, 310027, P. R. China.

The strong chemisorption of CO2 is always accompanied by a high absorption enthalpy, and traditional methods to reduce the absorption enthalpy lead to decreased CO2 capacities. Through the introduction of a large π-conjugated structure into the anion, a dual-tuning approach for the improvement of CO2 capture by anion-functionalized ionic liquids (ILs) resulted in a high capacity of up to 0.96 molCO2  mol-1IL and excellent reversibility. The increased capacity and improved desorption were supported by quantum chemical calculations, spectroscopic investigations, and thermogravimetric analysis. The increased capacity may be a result of the strengthened dynamic covalent bonds in these π-electron-conjugated structures through anion aggregation upon the uptake of CO2 , and the improved desorption originates from the charge dispersion of interaction sites through the large π-electron delocalization. These results provide important insights into effective strategies for CO2 capture.
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http://dx.doi.org/10.1002/cssc.201600402DOI Listing
September 2016

Tuning the basicity of ionic liquids for efficient synthesis of alkylidene carbonates from CO2 at atmospheric pressure.

Chem Commun (Camb) 2016 Jun;52(50):7830-3

Department of Chemistry, ZJU-NHU United R&D Center, Zhejiang University, Hangzhou 310027, China. and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Zhejiang University, Hangzhou 310027, China.

A strategy to achieve the efficient synthesis of alkylidene carbonates from CO2 at atmospheric pressure by tuning the basicity of ionic liquids was developed. Excellent yields were obtained due to basic ionic liquids' dual roles both as absorbents and as activators. The reaction mechanism was investigated through a combination of NMR spectroscopy, controlled experiments and quantum calculations, indicating the importance of a moderate basicity.
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http://dx.doi.org/10.1039/c6cc02853eDOI Listing
June 2016

Elevated red blood cell distribution width in benign prostatic hyperplasia patients with metabolic syndrome.

Int J Clin Exp Med 2015 15;8(1):1213-9. Epub 2015 Jan 15.

Department of Ultrasonography, The Affiliated Longyan First Hospital of Fujian Medical University Longyan 364000, Fujian, China.

Red blood distribution width (RDW) is a novel prognostic marker that reflects oxidative stress and inflammation in patients. Chronic inflammation has been proposed as a candidate mechanism between benign prostatic hyperplasia (BPH) and metabolic syndrome (MetS). However, the relationship between RDW and MetS in BPH patients is unclear. Men aged 50 year-old or older with BPH were recruited into the study. The BPH patients were classified as MetS group and non-MetS group. 69 patients without BPH and MetS were as the control group. The clinical information and RDW were measured to identify their relationship. MetS was diagnosed in 34% of the patients. The RDW values were found to be higher in the BPH group than in the control group [(13.3 ± 0.8) vs. (12.6 ± 0.8), P < 0.001]. The total prostate volume (TPV) and post void residual (PVR) urine volume were significantly higher in subject with MetS than in non-MetS and related with the number of metabolic abnormalities. High serum triglyceride and low serum high- density lipoprotein cholesterol (HDL-C) levels were significantly associated with TPV even adjusting for age (adjusted r = 0.373, P < 0.001, and adjusted r = -0.425, P < 0.001, respectively).There was a significant correlation between RDW and TPV (r = 0.370, P < 0.001), Body mass index (BMI) (r = 0.367, P < 0.001) and MetS (r = 0.276, P < 0.001). The data indicated that RDW was independently correlated with the presence of MetS (odd ratio 1.226, 95% confidence intervals 0.89-1.87, P < 0.001). MetS is associated with BPH development in men. The RDW level is significantly higher in patients with BPH than that in control. RDW is an independent predictor of MetS in BPH patients.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358570PMC
March 2015

Highly efficient CO2 capture by carbonyl-containing ionic liquids through Lewis acid-base and cooperative C-H∙∙∙O hydrogen bonding interaction strengthened by the anion.

Chem Commun (Camb) 2014 Dec;50(95):15041-4

Department of Chemistry, ZJU-NHU United R&D Center, Zhejiang University, Hangzhou 310027, China.

A strategy to improve CO2 capture significantly through the non-covalent interaction strengthened by the anion was reported, which exhibits an extremely high capacity up to 1.24 mole CO2 per mole ionic liquid and excellent reversibility due to the presence of the enhanced Lewis acid-base and cooperative C-HO hydrogen bonding interactions.
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http://dx.doi.org/10.1039/c4cc06944gDOI Listing
December 2014

Renal function, acute kidney injury and hospital mortality in patients with acute myocardial infarction.

J Int Med Res 2014 Oct 22;42(5):1168-77. Epub 2014 Jul 22.

Department of Cardiology, The Affiliated Longyan First Hospital of Fujian Medical University, Longyan, Fujian Province, China.

Objectives: To examine retrospectively the relationship between acute kidney injury (AKI) and acute myocardial infarction (AMI), and the association between estimated glomerular filtration rate (eGFR) at admission and AKI outcome.

Methods: AKI was defined as an increase in serum creatinine (SCr) by ≥ 0.3 mg/dl within 48 h or an increase in SCr to ≥ 1.5 times baseline within the first 7 days of hospitalization. Patients with AMI were divided into subgroups according to their eGFR at admission and the development of AKI.

Results: This study enrolled 396 patients with AMI; 48 (12.1%) developed AKI. In-hospital mortality was 39.6% (19/48) for patients with AKI compared with 7.5% (26/348) in those without AKI (odds ratio [OR] 8.11; 95% confidence interval [CI] 4.02, 16.39). The mortality rate was 35.7% (five of 14) in the eGFR ≥ 60 ml/min/1.73 m(2) with AKI group (OR 6.21, 95% CI 1.50, 25.69) and 41.2% (14/34) in the eGFR <60 ml/min/1.73 m(2) with AKI group (OR 12.62, 95% CI 5.54, 28.74).

Conclusions: AKI development was common and associated with mortality in AMI patients with either preserved or impaired eGFR levels.
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http://dx.doi.org/10.1177/0300060514541254DOI Listing
October 2014

Therapeutic effects of blood purification in treatment of fulminant hepatic failure.

Braz J Infect Dis 2013 Jul-Aug;17(4):427-30. Epub 2013 Jun 27.

No. 5 People's Hospital of Wuxi, Wuxi, Jiangsu Province, China.

Objectives: To evaluate the clinical effects of blood purification for treating fulminant hepatic failure (FHF).

Methods: Thirty-three severe FHF patients with hepatic encephalopathy (HE) above grade III were subjected to a combined blood purification treatment in addition to the comprehensive liver protection therapy. Patients underwent continuous hemofiltration on a daily basis during the daytime followed by sequential treatment with plasma exchange or hemodialysis every 2-3 days. The therapeutic effects of this treatment were evaluated.

Results: After treatment with blood purification, restoration of consciousness (those who abandoned the treatment without restoration of consciousness were excluded) was achieved in 6 of 8 cases (75%) in acute liver failure (ALF) group, 3 of 3 cases (100%) in subacute liver failure (SALF) group, and 9 of 14 cases (64.29%) in acute/subacute on chronic liver failure (A/SCLF) group. Of all cases, 11 patients restored consciousness after 7 days in a coma. The rate of long-term survival (those who abandoned the treatment were excluded) was 3/7 (42.86%) for ALF group, 2/2 (100%) for SALF group, and 1/11 (9.09%) for A/SCLF group. The levels of hemoglobin and platelet in peripheral blood were significantly reduced after blood purification.

Conclusions: Treatment of FHF patients with daily continuous hemofiltration during the daytime is effective in treating HE and in improving health status in the early stages of the disease. Long-term prognosis also benefits from this treatment. The rate of consciousness recovery and long-term survival is highest in SALF group followed by ALF group. This treatment is less effective in A/SCLF patients. It should be noted that blood purification procedure may cause damage to blood cells.
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http://dx.doi.org/10.1016/j.bjid.2012.11.008DOI Listing
January 2014
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