Publications by authors named "Kaifeng Wang"

59 Publications

Ferromagnetic TiCNCl-decorated RGO aerogel: From 3D interconnecting conductive network construction to ultra-broadband microwave absorber with thermal insulation property.

J Colloid Interface Sci 2021 May 30;604:402-414. Epub 2021 May 30.

State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.

It remains urgent challenges to adopt suitable strategies to consume unwanted microwave pollution emitted by high-tech electronic devices satisfactorily. Confronted with narrow effective absorption bandwidth (EAB) and high filler loading bottlenecks of MXene-Based microwave absorber, herein, we employ Lewis molten salt etching approach to both exfoliate TiAlCN powders into TiCNCl suspension and intercalate ferromagnetic composition into interlamination simultaneously. By utilizing the crosslinking effect of dopamine, the TiCNCl are anchored on the surfaces of graphene oxide (GO) nanosheets, constructing interconnecting microstructure. Both the 3D conductive network and the modification of MXene manifest crucial impacts on enhancing microwave absorption performance of the resulting ultra-lightweight reduced GO (RGO)-based aerogel. The minimum intensity of reflection loss achieves -62.62 dB with the absorber mass loading of 0.7 wt%. Remarkably, more than 90% of the incident microwave is qualified to be absorbed over the whole Ku band. The EAB is broadened while tailoring the thickness to 3 mm, ranging from 10.2 to 18 GHz. Besides, the aerogel presents valuable thermal insulation properties. Our methodology of synthesizing MXene/RGO aerogel not only provides promising insights into microstructural construction but also endows the possibility for integrating thermal insulation property towards next-generation high-performance microwave absorption devices.
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http://dx.doi.org/10.1016/j.jcis.2021.05.166DOI Listing
May 2021

Cervical balance and clinical outcomes in cervical spondylotic myelopathy treated by three-level anterior cervical discectomy and fusion and hybrid cervical surgery: A CONSORT-compliant study with minimum follow-up period of 5 years.

Medicine (Baltimore) 2021 May;100(18):e25824

Department of Spinal Surgery, Peking University People's Hospital, Peking University, Beijing, P.R. China.

Abstract: As the technology of combining with fusion and nonfusion procedure, cervical hybrid surgery (HS) is an efficacious alternative for treatment with cervical spondylotic myelopathy. While studies on cervical alignment between 3-level HS and anterior cervical discectomy and fusion (ACDF) were seldom reported. The effects of cervical imbalance on its related clinical outcomes are yet undetermined as well.Patients with cervical spondylotic myelopathy, who underwent 3-level ACDF or HS, were included to compare cervical alignment parameters after surgery and then explore the relationship between cervical balance and clinical outcomes.Forty-one patients with HS (HS group) and 32 patients who with ACDF (ACDF group) were reviewed from February 2007 to September 2013 with the mean follow-up of 90.3 ± 25.5 (m) and 86.3 ± 28.9 (m), respectively. Cervical alignments parameters including the C2 to C7 cervical lordosis (CL), C2 to C7 sagittal vertical axis, T1 slope. and T1SCL (T1 slope minus CL), and the clinical outcomes like neck disability index (NDI) and Japanese Orthopedic Association (JOA) score were measured and recorded preoperatively (PreOP), intraoperatively, and on the first preoperative day and the last follow-up (FFU). The balance and imbalance groupings were sorted based on the T1SCL: T1SCL≤20°,balance; T1SCL > 20°, imbalance.We found significant improvements (P < .001) in NDI and JOA at intraoperatively and FFU after ACDF and HS, and no difference on cervical alignment and clinical outcomes between the 2 procedures on the basis of intergroup comparisons. By between-subgroups comparisons, however, we found significant differences in CL and T1SCL at PreOP (P < .05). Nonetheless, there was no significant difference on the clinical outcomes between balance and imbalance subgroups at FFU at PreOP (P > .05), indicating that the change of T1SCL was not correlated to NDI and JOA at FFU.Both HS and ACDF groups showed significant clinical improvements after surgery. There was no correlation between cervical balance and clinical symptoms.
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http://dx.doi.org/10.1097/MD.0000000000025824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104247PMC
May 2021

Bacteria in Surgical Smoke: A Self-Controlled Lab Study Using Porcine Spinal Tissues.

Spine (Phila Pa 1976) 2021 Apr 23. Epub 2021 Apr 23.

Peking University People's Hospital, Department of Spine Surgery, Beijing, China Stanford University Medical Center, Department of Orthopaedic Surgery, Redwood City, CA.

Study Design: A lab study performed in a self-controlled fashion.

Objective: To examine whether "surgical smoke" generated by using the electrocautery on porcine spinal tissues could contain viable bacteria.

Summary Of Background Data: The year 2020 has seen a surge in legislation regarding surgical smoke evacuation in the operating room across the United States. Surgical smoke contains numerous toxic and carcinogenic substances, which spine surgeons and operating room staff are regularly exposed to. While the smoke's chemical toxicity has been extensively studied, little is known about its biohazard level.

Methods: The electrocautery was used to "operate on" 20 segments of porcine spinal tissues on a clean bench. In each operation, the generated smoke was captured with a swab, which was positioned above the surgical site and within the smoke, to obtain bacteria cultures. Two other swabs -a tissue swab (swabbing the porcine tissue itself) and a blank swab (swabbing an empty sterile bowl)- were collected as controls. The culture results were compared among the three groups. An additional experiment was conducted to see whether using a mask can reduce the "infection rate" of the swab.

Results: While all blank swabs tested negative, 95% (19/20) of the smoke swabs tested positive, with a total of nine bacteria species identified. The most prevalent species observed in the smoke swabs included Serratia liquefaciens, Lactococcus garvieae, and Hafnia alvei, etc. Among the positive smoke swabs, 84% (16/19) had one or more bacteria species that were consistent with the cultures of their corresponding tissue swabs. Using a surgical or N95 mask reduced the "infection rate" of the swab.

Conclusions: "Surgical smoke" generated by electrocauterization of porcine spinal tissues contains viable bacteria. Further research in actual spine surgery is needed next.Level of Evidence: N/A.
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http://dx.doi.org/10.1097/BRS.0000000000004079DOI Listing
April 2021

Effect of a low-cost and highly efficient passivator synthesized by alkali-fused fly ash and swine manure on the leachability of heavy metals in a multi-metal contaminated soil.

Chemosphere 2021 Sep 12;279:130558. Epub 2021 Apr 12.

Guangdong Provincial Key Laboratory of Petrochemical Pollution Processes and Control, School of Environmental Science and Engineering, Guangdong University of Petrochemical Technology, Maoming, Guangdong, 525000, China. Electronic address:

Soil pollution, caused by heavy metals, is an environmental problem that requires an urgent solution in China. Chemical passivation is a technology that uses various passivators to reduce the availability of heavy metals in soil and realize the remediation of contaminated soil. In this study, we examined the effects of fly ash (FA), alkali-fused fly ash (AFFA), swine manure biochar (SB), and modifying biochar (MB) on the leachability of Cu, Zn, Pb, and Cd via soil culture experiments. The results showed that the addition of AFFA, SB, and MB significantly reduced the extractable contents of Cu, Pb, and Cd in the soil. AFFA and MB had the best passivation effect, followed by SB and FA. The passivation effect on Pb was the best, followed by that on Cu and Cd. AFFA modification significantly improved the passivation effect of MB on Cu, Pb, and Cd in composite contaminated soil. With the addition of 3% MB, the Pb, Cu, and Cd extracted by TCLP decreased by 95.7, 74.1, and 59.1%, respectively. Correlation analysis, Fourier transform infrared spectrometry, scanning electron microscopy, and energy-dispersive X-ray spectroscopy showed that the passivation mechanism is mainly due to an increase in the soil pH, silicate content, and cohesiveness. The soil culture experiments in this study proved that MB is a low-cost and highly efficient organic-inorganic composite passivator for multi-metal contaminated soils.
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http://dx.doi.org/10.1016/j.chemosphere.2021.130558DOI Listing
September 2021

Effects of aging on surface properties and endogenous copper and zinc leachability of swine manure biochar and its composite with alkali-fused fly ash.

Waste Manag 2021 May 6;126:400-410. Epub 2021 Apr 6.

Guangdong Provincial Key Laboratory of Petrochemical Pollution Processes and Control, School of Environmental Science and Engineering, Guangdong University of Petrochemical Technology, Maoming, Guangdong 525000, PR China. Electronic address:

Biochar aging is a key factor leading to the decline of biochar stability and the release of endogenous pollutants. This study investigated the effects of five artificial and simulated aging processes on the surface properties and endogenous copper (Cu) and zinc (Zn) leachability of swine manure biochar and its composite with alkali-fused fly ash. Aging obviously reduced carbon (C) content on the surface of swine manure biochar and increased oxygen (O) content. Among all the aging treatments, high-temperature aging had the greatest effect on C content. Following the aging treatments, the C-C bond contents on the surfaces of swine manure biochar decreased significantly, whereas the C-O bonds increased significantly; however, there were less changes in the amounts of C-C and C-O bonds on the surfaces of modified biochar than on swine manure biochar. Aging significantly enhanced the leaching toxicity of Cu and Zn, and Zn availability and bioaccessibility in swine manure biochar and modified biochar. However, it minimized Cu availability and bioaccessibility, especially under high-temperature aging. Greater amounts of Zn than Cu were extracted from swine manure biochar and modified biochar. However, under all the aging treatments, the leaching toxicity, availability, and bioaccessibility of Cu and Zn in modified biochar were significantly lower than in swine manure biochar. This implies that modified biochar application poses lower environmental risks than swine manure biochar.
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http://dx.doi.org/10.1016/j.wasman.2021.03.042DOI Listing
May 2021

Tailoring conductive network nanostructures of ZIF-derived cobalt-decorated N-doped graphene/carbon nanotubes for microwave absorption applications.

J Colloid Interface Sci 2021 Jun 18;591:463-473. Epub 2021 Feb 18.

State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.

Confronted with microwave pollution issues, there is an urgent need for microwave absorption materials that possess optimal combinations of dielectric loss and magnetic loss properties. While a variety of studies focus on the components, the construction of nanostructure is rarely studied, which is of equivalent significance to microwave absorber design. In this work, Co-ZIF-67 was adopted as self-template to grow N-doped graphene/carbon nanotube interlinked conductive networks in-situ under a one-step carbonization process with tailored microwave absorption properties. Diverse microwave absorption performance could be achieved by directly adjusting the proportions among ingredients and the calcination temperature, obtaining a maximum value of reflection loss of -65.45 dB at 17.5 GHz with a sample thickness of just 1.5 mm. The effective absorption bandwidth could be tailored from 3.75 to 18 GHz among different thickness as required. The nanostructures had an apparent impact on the corresponding microwave absorption performance, in which the N-doped carbon-based conductive networks, ferromagnetic cobalt atoms, and interfaces among heterostructure strengthened the dipolar polarization and conductivity loss, magnetic loss, and interfacial polarization, respectively. This synthesis strategy offers a promising pathway for integrating nanostructures and functions, catering to requirements for designing and optimizing prospective microwave absorbers.
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http://dx.doi.org/10.1016/j.jcis.2021.02.008DOI Listing
June 2021

Effect of Steel Slag Aggregate on Pavement and Flame-Retardant Performance of Warm-Mixed Flame-Retardant Asphalt Concrete.

Materials (Basel) 2021 Jan 29;14(3). Epub 2021 Jan 29.

School of Transportation, Wuhan University of Technology, Wuhan 430070, China.

With the rapid development of tunnel construction, tunnel safety and the shortage of high-quality aggregates have concerned researchers so that this issue has become a research hot spot in the past few years. In the present study, we intended to prepare warm-mixed flame-retardant asphalt concrete using steel slag aggregate and evaluate its pavement and flame retardant performance. In this regard, the chemical composition and microstructure of the steel slag were studied using X-ray fluorescence analysis (XRF) and scanning electron microscopy (SEM). Then diverse pavement performances, including the dynamic stability, immersion Marshall, freeze-thaw splitting strength and low-temperature bending, were investigated for the warm-mixed flame-retardant asphalt concrete with steel slag aggregate. Moreover, a creative method of the flame spray gun combustion test was proposed to characterize the combustion degree and evaluate the flame-retardant performance of the asphalt concrete with steel slag. The experimental results show that the high-temperature and moisture stability performance are improved due to the addition of steel slag, however, the low-temperature performance is reduced for the warm-mixed flame-retardant asphalt concrete while it is still higher than the requirement value of the Chinese specification (GB/T 30596-2014). Meanwhile, the ignition temperature is increased and the ignition time is delayed for warm-mixed flame-retardant asphalt concrete because of the addition of steel slag. It is concluded that asphalt concrete with steel slag has excellent flame-retardant performance so that it is an appropriate choice for tunnel pavement.
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http://dx.doi.org/10.3390/ma14030635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866494PMC
January 2021

Theoretical evaluation of the carbene-based site-selectivity in gold(III)-catalyzed annulations of alkynes with anthranils.

Chem Commun (Camb) 2021 Feb;57(12):1494-1497

School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, 273165, P. R. China.

The gold(iii)-catalyzed annulations of alkynes with anthranils were evaluated using DFT calculations. A unified rationale for the Br-migration on α-imino gold(iii)-carbene was proposed, from which an unprecedented "N-donation/abstraction substitution" mechanism was established using the substituted anthranils, while direct C-H nucleophilic attack was involved with the unsubstituted anthranils. The controlling factors guiding the site-selectivity were uncovered. These computational studies provide insight for developing new α-imino gold(iii)-carbene mediated reactions.
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http://dx.doi.org/10.1039/d0cc07440cDOI Listing
February 2021

A test-retest reliability study of assessing small cutaneous fibers by measuring current perception threshold with pin electrodes.

PLoS One 2020 17;15(11):e0242490. Epub 2020 Nov 17.

Department of Spinal Surgery, Peking University People's Hospital, Beijing, China.

Background: The quantitative measurement of current perception threshold (CPT) has been used as a method to assess the function of nerve fibers in neuropathy diseases. The aim of this study was to assess the test-retest reliability measuring CPT using the circular pin electrodes for assessing the function of cutaneous thin nerve fibers.

Methods: CPT measurement was repeated on two separate days with at least one-week interval in 55 volunteers. Superficial blood flow (SBF) and skin temperature (ST) were measured on the skin in an around area concentric to the circular pin electrodes after the process of finding CPTs. The coefficient of variation (CV) and intra-class correlation coefficient (ICC) were calculated. The correlation between each two of CPT, SBF increment and ST increment was analyzed.

Results: No significant differences were found for CPT, SBF and ST between two sessions. SBF was found to be significantly increased after the process of finding CPT. CPT values of males were found to be higher than females. SBF increment was found to be positively correlated with ST increment. The ICC values for CPT, SBF and ST were 0.595, 0.852 and 0.728, respectively. The CV values for CPT, SBF and ST were 25.53%, 12.59% and 1.94%, respectively.

Conclusions: The reliability of CPT measurement using circular pin electrodes is fair, and need consistence of measurements in longitudinal studies.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0242490PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671533PMC
January 2021

Influence of orifice geometry on atomization characteristics of pressure swirl atomizer.

Sci Prog 2020 Jul-Sep;103(3):36850420950182

College of Mechanical Engineering and Applied Electronics Technology, Beijing University of Technology, Beijing, China.

The spray characteristics of the pressure swirl nozzle are experimentally studied using particle dynamics analysis (PDA) and high-speed photography system in this paper, specifically focusing on the dependence of geometrical dimensions of orifice on the spray SMD, velocity magnitude and droplet distribution, and the spray cone angle. It is indicated that the increase of orifice diameter makes the initial swirling velocity lower and the spray liquid film thicker. When the spray cone is fully expanded, the flow rate of 900 μm orifice diameter nozzle increases by 30-40% and the SMD of 900 μm orifice diameter nozzle increases by 8.5% compared with that of 700 μm orifice diameter nozzle. According to the experimental conditions, the relationship between Re and spray angle was calculated as θ = 29.97*Re, ignoring the factors that had little influence on spray angle. The decrease of the orifice length makes the distance of gas-medium shearing action shorten so that thinner oil film near wall cannot be formed by the extrusion of air core, leading to the swirling intensity reducing and the suction effect weakened. The spray cone angle of the 450 μm orifice length atomizer is about 5° smaller than the nozzle of 500 μm orifice length, and more small SMD droplets are not sucked, resulting in the distribution range of spray SMD declining.
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http://dx.doi.org/10.1177/0036850420950182DOI Listing
September 2020

[Retracted] p53 suppresses stress‑induced cellular senescence via regulation of autophagy under the deprivation of serum.

Mol Med Rep 2020 11 1;22(5):4079. Epub 2020 Sep 1.

Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China.

Following the publication of this article, an interested reader drew to the Editor's attention that certain GAPDH control bands were strikingly similar, comparing between two different figures in the paper. Two GAPDH bands in Fig. 1D appeared to be duplicates of two GAPDH bands featured in Fig. 3B, although different conditions were represented by these figures. Furthermore, the protein bands featured in the two lanes in the left p62 panel in Fig. 1D, when flipped horizontally, looked remarkably similar to the Cyclin B lanes featured in the right-hand gel of Fig. 3B. Finally, the same protein bands were also strikingly similar to bands featured in Fig. 4B, albeit in a different experimental context. The Editor of Molecular Medicine Reports has investigated this matter, and we were able to confirm that the two sets of data bands featured in this trio of figures were indeed the same ones, beyond all reasonable doubt. Consequently, the Editor has decided that this article should be retracted from the publication on the basis of an overall lack of confidence in the presented data. The Editor apologizes to the readership of the Journal for any inconvenience caused. [the original article was published in Molecular Medicine Reports 11: 1214-1220, 2015; DOI: 10.3892/mmr.2014.2853].
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http://dx.doi.org/10.3892/mmr.2020.11474DOI Listing
November 2020

Hepatitis B virus-related hepatocellular carcinoma in the era of antiviral therapy: The emerging role of non-viral risk factors.

Liver Int 2020 10 3;40(10):2316-2325. Epub 2020 Aug 3.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Hepatocellular carcinoma (HCC), one of the major malignant lethal tumours, is most prevalent in Asian patients with chronic hepatitis B virus (HBV) infection. Both viral and non-viral factors contribute to the development of HCC. It is established that viral factors associated with HBV DNA level, HBV genotype, designated gene mutation, HBV DNA integration, HBx protein, hepatitis B surface antigen (HBsAg), hepatitis B core-related antigen (HBcrAg) and HBV RNA are correlated with hepatocarcinogenesis. Before the introduction of antiviral therapy, viral factors once attracted more attention during the development of HCC. With the widespread use of antiviral therapy, predominantly nucleos(t)ide analogues (NAs), most patients with chronic hepatitis B (CHB) have achieved sustained viral control. The role of non-viral factors, especially modifiable factors, is anticipated to be reinforced in the future. Herein, we reviewed the modifiable non-viral risk factors of HBV-related HCC, in the hope of providing substantial evidence for further development of novel precautionary measures for HCC. In addition, the therapeutic interventions for reducing the risk of HCC, like potential conventional pharmaceutical interventions and lifestyle modification are also discussed in this review. Future studies that would explore the specific mechanism of HBV-related HCC development in patients with satisfactory viral control and related precision treatment are warranted.
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http://dx.doi.org/10.1111/liv.14607DOI Listing
October 2020

Influence of Surface Compositions on the Reactivity of Pyrite toward Aqueous U(VI).

Environ Sci Technol 2020 07 10;54(13):8104-8114. Epub 2020 Jun 10.

Univ. Grenoble Alpes, Université Savoie Mont Blanc, CNRS, IRD, IFSTTAR, ISTerre, 38000 Grenoble, France.

Pyrite plays a significant role in governing the mobility of toxic uranium in an anaerobic environment via an oxidation-reduction process occurring at the mineral-water interface, but the factors influencing the reaction kinetics remain poorly understood. In this study, natural pyrites with different impurities (Pb, As, and Si) and different surface pretreatments were used to react with aqueous U(VI) from pH ∼3.0 to ∼9.5. Both aqueous and solid results indicated that freshly crushed pyrites, which do have more surface Fe/Fe and S sites that were generated from breakage of Fe(S)-S bonds during ball milling, exhibited a much stronger reactivity than those treated with acid washing. Besides, U(VI) reduction which involves the possible intermediate U(V) and the formation of hyperstoichiometric UO(s) was found to preferentially occur at Pb- and As-rich spots on the pyrite surface, suggesting that the incorporated impurities could act as reactive sites because of the generation of lattice defects and galena- and arsenopyrite-like local configurations. These reactive surface sites can be removed by acid washing, leaving a pyrite surface nearly inert toward aqueous U(VI). Thus, reactivity of pyrite toward U(VI) is largely governed by its surface compositions, which provides an insight into the chemical behavior of both pyrite and uranium in various environments.
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http://dx.doi.org/10.1021/acs.est.0c01854DOI Listing
July 2020

Synthesis of silica-composited biochars from alkali-fused fly ash and agricultural wastes for enhanced adsorption of methylene blue.

Sci Total Environ 2020 Aug 28;729:139055. Epub 2020 Apr 28.

Guangdong Provincial Key Laboratory of Petrochemical Pollution Processes and Control, School of Environmental Science and Engineering, Guangdong University of Petrochemical Technology, Maoming, Guangdong 525000, China.

Two types of silica-composited biochars were prepared by mixing swine manure or rice straw with alkali-fused fly ash (AFFA) followed by pyrolysis. A 10% (w/w) AFFA modification improved the specific surface area, pore volume, and average pore size of the biochars. Certain surface oxygen-containing functional groups (i.e., -OH and CO) in the biochars were protected, and silicon-oxygen bonds (i.e., O-Si-O and OSi) were strengthened considerably by AFFA modifications during high-temperature pyrolysis. The adsorption capacity of biochar for methylene blue (MB) was enhanced after AFFA modification, and a modified biochar with the highest adsorption capacity was prepared at a pyrolysis temperature of 700 °C, pyrolysis holding time of 2 h, and an AFFA proportion of 10%. The MB adsorption capacity of the modified biochars significantly increased when the pH of the solution increased (from 3 to 13). The adsorption data were well described by a pseudo-second-order model and Langmuir isotherms. The maximum MB adsorption capacities of the modified swine manure and rice straw biochars were 143.76 mg/g and 131.58 mg/g, respectively. The adsorption capacities of the AFFA-modified biochars were 10.7-112.3% higher than those of the unmodified biochars. The enhanced MB adsorption capacities of the former appear to be attributed to their increased specific surface areas, increased porosities, strong oxygen-containing functional groups, and high contents of exchangeable sodium ions. These results indicate that industrial and agricultural wastes can be reused to produce novel silica-composited biochars with high MB removal capacity. Accordingly, these biochars could be effectively used to treat wastewater and thus to mitigate solid waste disposal-related problems.
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http://dx.doi.org/10.1016/j.scitotenv.2020.139055DOI Listing
August 2020

Acidity and metallic elements release from AMD-affected river sediments: Effect of AMD standstill and dilution.

Environ Res 2020 07 9;186:109490. Epub 2020 Apr 9.

The Ministry of Education Key Laboratory of Pollution Control and Ecosystem Restoration in Industry Clusters, School of Environment and Energy, South China University of Technology, Guangzhou, 510006, China. Electronic address:

In acid mine drainage (AMD) polluted rivers, considerable fraction of potential toxic elements are temporarily sequestered by sediments. There are two main potential environmental hazards associated with the sediments, acidity liberation and re-mobilization of metallic elements, during environmental conditions change. The effects of AMD standstill and water dilution on metallic elements migration were assessed in an AMD standstill test and a dialysis experiment. Maintaining AMD standstill, often occurring in AMD damming process, could induce the occurrence of iron secondary minerals precipitation along with attenuation of dissolved elements and a decrease in water pH value. Both field sediments and lab precipitates were confirmed as being dominant with schwertmannite which was the most important source and sink for acidity and metallic elements. The mechanism of cation heavy metals scavenging implied by FTIR results mostly depended on the exchanging of H from surface hydroxyl groups (-OH) in schwertmannite-rich sediments. For arsenic oxyanion, its adsorption included surface complexation with iron hydroxyl groups at the mineral surface, as well as anion exchange of SO present in the structure. The quantities of acidity release differed significantly from 20 to 3714 mol H/t depending on the iron hydroxyl minerals type and their contents in the corresponding sediments in 35 d dialysis, with the release rate well fitted by the second order model. Slight degree of phase transformation in schwertmannite dominant sediment had resulted in a high risk of metallic element release during the 35 d dilution duration. The significant risk of metallic elements release was ranked in the order of Cd > Mn > Zn > Pb, and with more than 89% of Cd released from FS6 and 82% from LPS1. Relatively, Cu and As in sediments were much more stable. Overall, damming was an effective and low cost pretreatment strategy for AMD pollution control. Knowledge of the characteristics of iron secondary minerals in river sediments is essential premise for both comprehensive assessment of site contamination status and effective remediation strategy decision.
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http://dx.doi.org/10.1016/j.envres.2020.109490DOI Listing
July 2020

Exploration on sagittal alignment and clinical outcomes after consecutive three-level hybrid surgery and anterior cervical discectomy and fusion: a minimum of a 5-year follow-up.

J Orthop Surg Res 2020 Feb 26;15(1):79. Epub 2020 Feb 26.

Department of Spinal Surgery, Peking University People's Hospital, Peking University, No. 11 Xizhimen South Street, 100044, Xicheng District, Beijing, People's Republic of China.

Purpose: To compare sagittal alignment and clinical outcomes between three-level hybrid surgery (HS) and anterior cervical discectomy and fusion (ACDF) on cervical spondylotic myelopathy (CSM) over a 5-year follow-up.

Method: The study included 32 patients with ACDF, 36 patients with 1 prosthesis and 2 cages (HS1 group), and 25 cases with 2 prostheses and 1 cage (HS2 group). Alignment parameters included C2-C7 cervical lordosis (CL), C2-C7 sagittal vertical axis (SVA), T1 slope (T1S), and T1S minus CL (T1SCL). Radiographic parameters were range of motion (ROM), upper and lower adjacent ROM (UROM and LROM), and operated-segment lordosis (OPCL), as well as adjacent segment degeneration (ASD). Clinical outcomes included the neck disability index (NDI) and Japanese Orthopedic Association (JOA) score.

Results: Three groups were well-matched in demographics. All groups gained comparable improvement on NDI and JOA (P < 0.01). All groups gained CL improvement at the final visit (P < 0.05). There were no statistical differences on SVA and T1SCL among the groups and among preoperation, 1 week later, and final follow-up (P > 0.05) while T1S improved at 1 week later and final follow-up with HS2. The final change of all alignment parameters among the three groups was of no differences. ROM decreased and OPCL increased in all groups at the final follow-up (P < 0.05). UROM and LROM increased with ACDF but kept stable with HS1 and HS2. There was no inter-group difference on the incidence of ASD (P > 0.05).

Conclusion: Cervical alignment was comparably improved. HS and ACDF provided identified mid-term efficacy, and it was not necessary to have to use prosthesis on three-level CSM.
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http://dx.doi.org/10.1186/s13018-020-01589-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045368PMC
February 2020

TPGS-1000 exhibits potent anticancer activity for hepatocellular carcinoma and .

Aging (Albany NY) 2020 01 27;12(2):1624-1642. Epub 2020 Jan 27.

Cancer Research Institute, Hangzhou Cancer Hospital, Zhejiang, China.

D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS1000) is the most active water-soluble derivative of vitamin E and has been widely used as a carrier of solvents, plasticizers, emulsifiers, absorbent agents and refractory drug delivery systems. However, its anti-hepatocellular carcinoma (HCC) properties have not been explored. HCC cells were treated with different concentrations of TPGS1000. Cell survival was tested by CCK8 assay, and cell migration was tested by wound healing and Transwell assay. EdU staining verified cell proliferation, and signalling pathway was assayed by Western blot analysis. The BALB/c-nu mouse xenograft model was established to test HCC cell growth . TPGS1000 significantly inhibited the viability and mobility of HCC cells (HepG2, Hep3B and Huh7) in a dose-dependent manner. Cell cycle analysis indicated that TPGS1000 treatment arrested the HCC cell cycle in the G0/G1 phase, and induction of cell apoptosis was confirmed by TUNEL and Annexin V-7-AAD staining. Further pharmacological analysis indicated that collapse of the transmembrane potential of mitochondria, increased ROS generation, PARP-induced cell apoptosis and FoxM1-p21-mediated cell cycle arresting, were involved in the anti-HCC activity of TPGS1000. Moreover, treatment with TPGS1000 effectively impaired the growth of HCC xenografts in nude mice.
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http://dx.doi.org/10.18632/aging.102704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053644PMC
January 2020

Selenite Sorption on Hydrated CEM-V/A Cement in the Presence of Steel Corrosion Products: Redox vs Nonredox Sorption.

Environ Sci Technol 2020 02 4;54(4):2344-2352. Epub 2020 Feb 4.

Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, IRD, IFSTTAR, ISTerre , 38000 Grenoble , France.

Reinforced cementitious structures in nuclear waste repositories will act as barriers that limit the mobility of radionuclides (RNs) in case of eventual leakage. CEM-V/A cement, a ternary blended cement with blast furnace slag (BFS) and fly ash (FA), could be qualified and used in nuclear waste disposal. Chemical interactions between the cement and RNs are critical but not completely understood. Here, we combined wet chemistry methods, synchrotron-based X-ray techniques, and thermodynamic modeling to explore redox interactions and nonredox sorption processes in simulated steel-reinforced CEM-V/A hydration systems using selenite as a molecular probe. Among all of the steel corrosion products analyzed, only the addition of Fe can obviously enhance the reducing ability of cement toward selenite. In comparison, steel corrosion products showed stronger reducing power in the absence of cement hydrates. Selenium K-edge X-ray absorption spectroscopy (XAS) revealed that selenite immobilization mechanisms included nonredox inner-/outer-sphere complexations and reductive precipitations of FeSe and/or Se(0). Importantly, the hydrated pristine cement showed a good reducing ability, driven by ferrous phases and (bi)sulfides (as shown by sulfur K-edge XAS) originated from BFS and FA. The overall redox potential imposed by hydrated CEM-V/A was determined, hinting to a redox shift in underground cementitious structures.
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http://dx.doi.org/10.1021/acs.est.9b06876DOI Listing
February 2020

Decompression with fusion is not in superiority to decompression alone in lumbar stenosis based on randomized controlled trials: A PRISMA-compliant meta-analysis.

Medicine (Baltimore) 2019 Nov;98(46):e17849

Department of Spinal Surgery, Peking University People's Hospital, Peking University, Beijing.

Background: Although some studies had been published, it was more controversial on the superiority of decompression alone (D) and decompression with fusion (F) for the treatment of lumbar spinal stenosis (LSS) recently, especially newest articles with different opinions. A meta-analysis was performed to compare efficacy on D and F for LSS regardless of degenerative spondylolisthesis (DS) with randomized controlled trials (RCTs).

Methods: The databases include PUBMED/MEDLINE, EMBASE, Cochrane Library, and Web of Science from January 1970 to December 2018. The information of screened studies included demographics, clinical outcomes, and secondary measures, then data synthesis and meta-analysis were progressed. Subgroup analysis was stratified by DS and follow-up time (36 months). Continuous variables and dichotomous variables were respectively reported as weighted mean difference and odds ratios (ORs). The strength of evidence was evaluated by the grades of recommendation, assessment, development, and evaluation (GRADE) system.

Results: Nine RCTs met inclusion criteria with a total of 857 patients (367 were in D group and 490 were in F group). There were no statistical difference in visual analog scale changes on back and leg pain between D and F group (mean difference [MD] = -0.03, 95% confidence interval [CI] [-0.38, 0.76], z = 0.08, P = .94; MD = 0.11, 95% CI [-1.08, 1.30], z = 0.18, P = .86, respectively); patients' satisfaction was of no difference between the 2 groups, together with the change of the Oswestry disability index and European quality of life-5 dimensions (P > .05). There were no difference in the rate of complication (P = .50) and reoperation (P = .11) while a statistical significance of longer operation duration (P < .0001), more blood loss (P = .004) but amazing lower rate of adjacent segment degenerative/disease (ASD) (OR = 2.35, P = .02) in F group. The subgroup analysis on DS showed that basically all measures were in consistency with meta-analysis. There was a higher reoperation rate in middle-to-long term (>36 months) in D group and ASD was the most seasons of reoperation no matter the follow-up time. According to the GRADE system, the grade of this meta-analysis was of "High" quality.

Conclusion: F group has no better clinical results than D alone in LSS, regardless of DS and follow-up. The conclusion is of "High" quality and the grade strength of recommendation was "Strong."
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http://dx.doi.org/10.1097/MD.0000000000017849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867750PMC
November 2019

Association between back muscle degeneration and spinal-pelvic parameters in patients with degenerative spinal kyphosis.

BMC Musculoskelet Disord 2019 Oct 20;20(1):454. Epub 2019 Oct 20.

Department of Spinal Surgery, Peking University People's Hospital, Beijing, China.

Background: The paraspinal and psoas muscles have been considered to be essentially important for stabilizing the spinal column, and the muscle degeneration was found to exist in degenerative spinal kyphosis (DSK) patients. However, it is still not clear the relationship between muscle degeneration and spinal-pelvic alignment. The purpose of this study was to determine the correlations between the individual muscle degeneration at each lumbar spinal level and spinal-pelvic parameters in DSK patients.

Methods: The imaging data of 32 patients with DSK were retrospectively analyzed. The fat infiltration (FI) and relative cross-sectional area of muscle (RCSA) were quantitatively measured for multifidus (MF), erector spinae (ES) and psoas (PS) at each spinal level from L1/2 to L5/S1. The correlations were analyzed between RCSA and the sagittal vertical axis (SVA), thoracic kyphosis (TK), thoracolumbar kyphosis (TLK), lumbar lordosis (LL), sacral slope (SS), pelvic tilt (PT) and pelvic incidence (PI).

Results: The FI of MF and ES at L3/4, L4/5 and L5/S1 were higher than that at L1/2 and L2/3. The FI of PS at L4/5 and L5/S1 were lower than that of L1/2, L2/3 and L3/4. The RCSA of ES and PS from L1/2 to L5/S1 gradually increased, whereas the RCSA of ES from L1/2 to S5/S1 gradually decreased. The RCSA of MF at the L1/2 level was negatively correlated SVA (r = - 0.397,p = 0.024); the RCSA at L3/4, L4/5 and L5/S1 levels were negatively correlated with TK (r = - 0.364, p = 0.04; r = - 0.38, p = 0.032; r = - 0.432, p = 0.014); the RCSA at L4/5 level was positively correlated with LL (r = 0.528, p = 0.002). The RCSA of ES at L3/4 and L4/5 levels were positively correlated with PI (r = 0.377, p = 0.037) and SS (r = 0.420, p = 0.019).

Conclusions: FI of MF and ES at lower lumbar level is higher than that at upper level, but FI of PS at upper lumbar level is higher than that at lower level. MF and ES have different roles for maintaining the sagittal spinal-pelvic balance.
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http://dx.doi.org/10.1186/s12891-019-2837-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802345PMC
October 2019

Solid lipid nanoparticles as a drug delivery system to across the blood-brain barrier.

Biochem Biophys Res Commun 2019 11 10;519(2):385-390. Epub 2019 Sep 10.

Hangzhou PushKang Biotechnology Co., Ltd., Hangzhou, 310030, Zhejiang, PR China. Electronic address:

Solid lipid nanoparticles (SLNs) were prepared by biocompatible and biodegradable solid-phase lipids. β-elemene is a safe natural essential oil with broad-spectrum anti-tumor activity. However, its clinical application has been adversely affected by its poor water solubility and limited bioavailability. SLN incorporation is a potential strategy to bypass the blood-brain barrier, the most important factor limiting the bioactivity of neurotherapeutics. The SLNs-β has the same efficacy as commercially available elemene in vitro and an enhanced brain drug accumulation in vivo. The survival rate data was promising and acute toxicity experiment proved its safety. All these data suggested that SLN-β is a safe and effective drug delivery system, especially for brain tumor therapy, and warrants further development.
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http://dx.doi.org/10.1016/j.bbrc.2019.09.017DOI Listing
November 2019

Longitudinal Change of Body Mass Index Is Associated With Alanine Aminotransferase Elevation After Complete Viral Suppression in Chronic Hepatitis B Patients.

J Infect Dis 2019 09;220(9):1469-1476

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: Little is known about cause and intervention for alanine aminotransferase (ALT) elevation after complete viral suppression in patients with chronic hepatitis B (CHB).

Methods: In this prospective cohort study, patients with CHB who were treated with nucleos(t)ide analogs and maintained undetectable levels of hepatitis B virus (HBV) deoxyribonucleic acid (DNA) for at least 6 months were enrolled. Patients were followed up at 6-month intervals, and anthropometric, biochemical, and virological assessments were performed.

Results: Of 1965 patients with median follow-up of 18.36 months, one third of patients experienced ALT elevation. Baseline high body mass index ([BMI] defined as ≥25 kg/m2), younger age, and liver cirrhosis independently increased the risk of longitudinal ALT elevation. At the end of follow-up, 89 (4.8%) patients reverted to low BMI, and 92 (5.0%) developed to high BMI. Compared with persistent high BMI, reversion to low BMI reduced the risk of ALT elevation (adjusted odds ratio [aOR], 0.38; 95% confidence interval [CI], 0.19-0.77); compared with persistent low BMI, onset of high BMI increased the risk of ALT elevation (aOR, 1.78; 95% CI, 1.02-3.11).

Conclusions: High BMI is an independent predictor for ALT elevation after complete HBV DNA suppression. Improvement of BMI may have a beneficial effect on ALT normalization and even long-term outcomes.
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http://dx.doi.org/10.1093/infdis/jiz326DOI Listing
September 2019

Correction to: Radiological exploration on adjacent segments after total cervical disc replacement with Prodisc-C prosthesis.

J Orthop Surg Res 2019 Jul 8;14(1):207. Epub 2019 Jul 8.

Department of Spinal Surgery, Peking University People's Hospital, Peking University, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, People's Republic of China.

In the original publication of this article [1], the Table 1-5 were missing due to a mistake in the copy-editing stage.
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http://dx.doi.org/10.1186/s13018-019-1249-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613259PMC
July 2019

Anticancer activity of polymeric nanoparticles containing linoleic acid-SN38 (LA-SN38) conjugate in a murine model of colorectal cancer.

Colloids Surf B Biointerfaces 2019 Sep 15;181:822-829. Epub 2019 Jun 15.

Hangzhou PushKang Biotechnology Co., Ltd., Hangzhou 310030, Zhejiang, PR China. Electronic address:

Biodegradable polymeric nanoparticles (NPs) have been used frequently as nanocarriers for anticancer drugs. Linoleic acid conjugated SN38 (LA-SN38)-loaded NPs (EBNPs) were developed using biodegradable poly (ethylene oxide)-poly (butylene oxide) (PEO-PBO) diblock copolymer by titration hydration method without using a toxic organic solvent. The EBNPs had high drug loading efficiency and entrapment efficiency for LA-SN38, at 7.53% and 93.55%, respectively. The polydispersity index (PDI) and average diameter were 0.173 ± 0.019 and 226.1 ± 1.2 nm, respectively. The transmission electron microscope (TEM) image presented that the NPs were homogeneous in size and had spherical structures. In vitro study showed the release behavior of EBNPs was slow and sustained. Furthermore, cytotoxicity and apoptosis assay proved that EBNPs were more effective in growth inhibition of human colon cancer cells. Cell uptake experiments further demonstrated that EBNPs could avoid the phagocytosis by macrophages and promote the uptake by cancer cells. In vivo, EBNPs had prolonged blood circulation time and tumor selectivity in biodistribution. The tumor inhibitory rate of EBNPs was higher compared to SNPs group and CPT-11group (P < 0.01), and the drug did not show significant systemic toxicity at the tested dose. These results indicated that EBNPs are a promising candidate for delivery of LA-SN38 to treat colorectal cancer.
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http://dx.doi.org/10.1016/j.colsurfb.2019.06.020DOI Listing
September 2019

Efficacy and safety of sustained-release oxycodone compared with immediate-release morphine for pain titration in cancer patients: A multicenter, open-label, randomized controlled trial (SOCIAL).

Medicine (Baltimore) 2019 Jun;98(24):e15505

Department of Medical Oncology, Hangzhou Cancer Hospital, Hangzhou, China.

Background: The study aims to investigate the effect and safety of sustained-release oxycodone hydrochloride as background dose on pain titration in patients with moderate-to-severe cancer pain.

Material And Methods: Adult patients scheduled with a regular strong opioid for cancer-related pain were recruited and randomly assigned to sustained-release oxycodone group (tablets, 12 hourly) and immediate-release morphine group (5 mg initially, hourly). All patients were hourly reassessed for efficacy and dose titration.

Results: The primary end point was the number of titration cycles required to achieve adequate pain relief (numerical rating scale, NRS ≤ 3). Secondary end points included the proportion of patients achieving adequate pain relief during each cycle, potential predictive factors for titration performance, and side effects. Ninety (94.7%) patients in oxycodone group and 78 (86.7%) patients in morphine group achieved adequate pain control during 1 to 4 cycles of titration. Patients in oxycodone group reached adequate pain control within the first 2 cycles of titration, which was significantly shorter than morphine group wherein the number of titration cycles ranged from 1 to 4 (P = .034). Oxycodone prescription significantly increased the response rate of patients to morphine titration during the first cycle of titration (P = .010). The initial NRS score and oxycodone administration were significantly associated with titration performance. The mild or moderate adverse effects were similar in 2 groups, while severe adverse effects were only identified in morphine group (P = .001).

Conclusion: Use of background sustained-release oxycodone is more efficient and better tolerated on dose titration than immediate-release morphine.
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http://dx.doi.org/10.1097/MD.0000000000015505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587615PMC
June 2019

Radiological exploration on adjacent segments after total cervical disc replacement with Prodisc-C prosthesis.

J Orthop Surg Res 2019 May 28;14(1):160. Epub 2019 May 28.

Department of Spinal Surgery, Peking University People's Hospital, Peking University, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, People's Republic of China.

Purpose: The relationship between upper or lower adjacent segments (UAS/LAS) and the cervical spine parameters was not clear yet. So, the purpose was to analyze range of motion (ROM), lordosis (LOR), and intervertebral disc height (IDH) of UAS and LAS before and after total cervical disc replacement (TDR) and to explore the influencing factors of cervical spine radiological parameters on adjacent segments.

Methods: A single-center retrospective study was performed on patients completing 10-year follow-up undergone TDR. As the primary outcomes, radiological parameters included UAS-ROM/LAS-ROM, UAS-LOR/LAS-LOR, and UAS-IDH/LAS-IDH. The secondary outcomes were ROM and LOR of C2-C7 and surgical levels, IDH of surgical segments, prosthesis migration, subsidence, heterotopic ossification (HO), and adjacent segment degeneration (ASD), which were measured on X-ray.

Results: UAS-ROM and LAS-ROM remained stable in follow-up periods. There was no significance on UAS-LOR or LAS-LOR between pre- and post- operation, so was UAS-IDH or LAS-IDH. UAS-ROM was larger in the segments with ASD (P < 0.001), the same to LAS-ROM (P < 0.001), and UAS-LOR was larger in segments with ASD (P = 0.02). UAS-ROM was positively correlated with C2-C7 ROM and LOR (both P < 0.001). UAS-LOR was correlated with operated-segmental LOR while LAS-LOR were in correlation with surgical segment ROM. The influencing factors of UAS-ROM were the surgical segment ROM and C2-C7 LOR. The influencing factors of UAS-LOR and LAS-LOR were LAS-ROM and UAS-ROM, respectively. The influencing factors of UAS-IDH were LAS-IDH, surgical segment IDH, and HO while that of LAS-IDH were UAS-IDH and surgical segment IDH.

Conclusions: TDR has only a little effect on the adjacent segments. There is an interaction between UAS and LAS. The maintenance on surgical segments ROM and reconstruction of IDH will benefit to adjacent segments.
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http://dx.doi.org/10.1186/s13018-019-1194-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540473PMC
May 2019

[Effectiveness evaluation of Prodisc-C prosthesis for more than 10 years follow-up after total cervical disc replacement].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Apr;33(4):393-402

Department of Spinal Surgery, Peking University People's Hospital, Beijing, 100044,

Objective: To evaluate long-term radiographic and clinical effectiveness of total cervical disc replacement (TDR) with Prodisc-C prosthesis at a minimum of 10 years follow-up.

Methods: The clinical data of 118 patients with cervical disc degeneration disease (CDDD) treated with TDR by using Prodisc-C prosthesis between December 2005 and April 2008 were retrospectively analyzed. There were 66 males and 52 females, with the age of 25-62 years (mean, 46.8 years). There were 38 cases of cervical spondylotic radiculopathy, 28 cases of cervical spondylotic myelopathy, and 52 cases of mixed cervical spondylotic myelopathy. The operative segments were C , including 90 cases of single segment, 20 cases of continuous double segments, and 8 cases of continuous three segments. A total of 154 Prodisc-C prostheses were used during the operation. The clinical effectiveness was evaluated by pain visual analogue scale (VAS) score, neck disability index (NDI), Japanese Orthopaedic Association (JOA) score, and Odom grade before and after operation. Imaging evaluation indicators included range of motion (ROM), sagittal lordosis angle, intervertebral disc height (IDH), and prosthesis displacement, subsidence, loosening, locking, and heterotopic ossification (HO), adjacent segment degeneration (ASD), and other complications. Patients were grouped according to whether HO or ASD occurred or not, the ROM of surgical segment was compared.

Results: All patients were followed up 121-150 months (mean, 135.8 months). No revision operation was performed during the follow-up period. The VAS, NDI, JOA scores and Odom grades were significantly improved at 1 week after operation and last follow-up when compared with preoperative ones ( <0.05); VAS and NDI scores were further improved at last follow-up than those at 1 week after operation ( <0.05); there was no significant difference in JOA scores and improvement rates between at 1 week after operation and at last follow-up ( >0.05). The ROM of the whole cervical spine and the operative segment decreased at 1 week and 10 years after operation when compared with preoperative ones ( <0.05), but there was no significant difference in the other time points ( >0.05); there was no significant difference in the ROM between the upper adjacent segment (UAS) and the lower adjacent segment (LAS) at each time point after operation ( >0.05). There was no significant difference in sagittal lordosis angle of cervical spine before and after operation ( >0.05); the sagittal lordosis angle of operative segment increased significantly at 1 week, 6 months, 1 year, and 2 years after operation ( <0.05). The IDH of operative segment was significantly improved at each time point after operation ( <0.05), but there was no significant difference in IDH between UAS and LAS at each time point after operation ( >0.05). No prosthesis displacement, subsidence, or loosening occurred at each time point after operation. There was no significant difference of the prosthetic displacement and subsidence distance between all time points after 6 months after operation ( >0.05). At last follow-up, the incidence of prosthetic locking/fusion was 10.4%, showing no significant difference when compared with 6 months (1.9%) ( <0.05). The incidence of upper ASD and lower ASD was 1.3% and 2.6% respectively at 1 week after operation. The incidence of upper ASD and lower ASD increased gradually with time prolonging, and there were significant differences between different time points ( <0.05). The ROM of operative segment in ASD group was lower than that in non-ASD group at each time point after operation, but there was no significant difference ( >0.05). HO appeared in 58.4% of the segments at 6 months after operation, and the incidence of HO increased significantly with time, which was significantly different from that at 6 months after operation ( <0.05). The ROM of operative segments in HO group was significantly lower than that in non-HO group at 6 months, 2 years, 5 years, and 10 years after operation ( <0.05).

Conclusion: TDR has little effect on adjacent segments, although there are some imaging complications, it has no significant effect on the improvement of overall clinical effectiveness. Prodisc-C prosthesis can provide long-term, safe, and definite clinical effectiveness in the treatment of CDDD.
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http://dx.doi.org/10.7507/1002-1892.201810109DOI Listing
April 2019

Nanoscale zero valent iron supported on MgAl-LDH-decorated reduced graphene oxide: Enhanced performance in Cr(VI) removal, mechanism and regeneration.

J Hazard Mater 2019 07 20;373:176-186. Epub 2019 Mar 20.

Engineering Research Center for Waste Oil Recovery Technology and Equipment, Ministry of Education, Chongqing Technology and Business University, Chongqing 400067, China. Electronic address:

The scaled application of nanoscale zero-valent iron nanoparticles (nZVI or Fe° NPs) in environmental remediation is challenged by easy surface passivation and particle aggregation. To improve this situation and enhance their performance in Cr(VI) removal from water phase, we present one novel strategy to hybridize nZVI with layered double hydroxide (LDH) decorated reduced graphene oxide (rGO). The as-prepared ternary ([email protected]/rGO) composites possess better dispersibility, improved hydrophilicity and more positive surfaces that allows higher removal efficiency and capacity for Cr(VI) oxyanions. Composition proportion are optimized and influences of surroundings (solution pH, Cr(VI) concentration and temperature) are evaluated. Also, we demonstrate that [email protected]/rGO can be reused with suitable post-treatments, which combines alkaline solution desorption and NaBH revivification possess. Cr desorption and Fe leaching ratio during regeneration should be critical indicators that determine the recovery efficiency. Synergistic effect within this ternary system not only contributes to its superiorities in stability, but also continuous iron corrosion via the formation of micro Fe-C batteries, where rGO acts as cathode and alternative electron conductor. The present work suggests great potentials of [email protected]/rGO composites in groundwater remediation.
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http://dx.doi.org/10.1016/j.jhazmat.2019.03.091DOI Listing
July 2019

Position of the Aorta Relative to Vertebrae in Patients with Degenerative Thoracolumbar or Lumbar Scoliosis: A Case-Control Study.

World Neurosurg 2019 Jul 7;127:e1-e7. Epub 2019 Mar 7.

Department of Spinal Surgery, Peking University People's Hospital, Peking University, Beijing, P.R. China. Electronic address:

Objective: To investigate the position of the aorta relative to the spine in patients with de novo lumbar scoliosis (DLS).

Methods: This study enrolled 142 patients with DLS, including 80 cases of left thoracolumbar/lumbar scoliosis (left group) and 62 cases of right scoliosis (right group). In addition, 132 cases free of deformity were allocated to the control group. Parameters of the Cobb angle and apical vertebrae were measured by radiograph, whereas the left pedicle-vertebrae angle (α), rotation angle (γ), and left pedicle-vertebrae distance (d) of T12-L4 were obtained by magnetic resonance imaging. Independent sample t test was performed to compare α, γ, and d between the DLS and control groups, followed by a Pearson correlation analysis to study the correlation between Cobb angle and α, γ, and d.

Results: No difference was found between the right group and control group (P = 0.554). The value of mean d (4.62 ± 0.57 cm) gradually increased from T12 to L4 in the left group and showed significant difference with the corresponding value in the control group (4.44 ± 0.43 cm; P < 0.001). There was no significant difference between the right group and control group (P = 0.762). The value of mean d (4.54 ± 1.84 cm) showed no significant difference between the right group and control group (P = 0.530). The correlation analysis showed a significant correlation between rotation angle γ and Cobb angle (P < 0.001), but not in α and d with Cobb angle.

Conclusions: Although the position of the aorta relative to the spine showed no significant difference between patients with DLS and normal subjects, great attention should still be paid to prevent DLS-induced aorta injury.
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http://dx.doi.org/10.1016/j.wneu.2019.01.036DOI Listing
July 2019
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