Publications by authors named "Kai Yu"

786 Publications

Effects of different substrates on the adsorption behavior of supported-adsorbents: A case study of MoS for Ag adsorption.

Environ Res 2022 Aug 7:113969. Epub 2022 Aug 7.

National-Local Joint Engineering Research Center of Heavy Metals Pollutants Control and Resource Utilization, Nanchang Hangkong University, Nanchang, 330063, PR China; Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle, Nanchang Hangkong University, Nanchang, 330063, PR China. Electronic address:

Supported-adsorbents growing on the substrate in situ are equipped with the advantages of high adsorption capacity, excellent regeneration performance, and adaptability to complex wastewater. However, the effects of substrate on the adsorption properties of supported-adsorbent are rarely considered, which will hinder its development and scale-up applications. In this study, the influences of different substrates (Ti, Mo, W, CC) on the Ag adsorption behavior of supported-MoS adsorbents were investigated. The adsorption kinetics, adsorption mechanism, and the renewability of these supported-MoS were compared orderly. As a result, MoS grown on a tungsten substrate (MoS-W) exhibits a remarkable adsorption capacity for Ag (1.98 mg cm and 598.80 mg g), which is 6.38-33 times more than the other three supported-MoS. Moreover, the MoS-W also possesses an ultrahigh distribution coefficient (24.80 mL cm) for Ag, and the selection coefficient can reach 1984. XRD and electrochemical characterization analysis indicated that Ag adsorption performance of supported-MoS is positively correlated with the degree of its amorphous structure. Substrate W with the terrific electrical properties which may facilitate the disordered growth of MoS, resulting in more active sites exposed, and endow MoS-W with outstanding Ag capture performance. Finally, the supported-MoS retains a high removal efficiency of Ag  after 5 cycles of adsorption and desorption. This study provides a novel perspective for promoting the practical application of supported-sorbents to recycle heavy metals.
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http://dx.doi.org/10.1016/j.envres.2022.113969DOI Listing
August 2022

Transcranial ultrasound neuromodulation induces neuronal correlation change in the rat somatosensory cortex.

J Neural Eng 2022 Aug 10. Epub 2022 Aug 10.

Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, 4N115 Scott Hall, Pittsburgh, Pennsylvania, 15213-3815, UNITED STATES.

Transcranial focused ultrasound (tFUS) is a neuromodulation technique which has been the focus of increasing interest for noninvasive brain stimulation with high spatial specificity. Its ability to excite and inhibit neural circuits as well as to modulate perception and behavior has been demonstrated, however, we currently lack understanding of how tFUS modulates the ways neurons interact with each other. This understanding would help elucidate tFUS's mechanism of systemic neuromodulation and allow future development of therapies for neurological disorders. In this study, we investigate how tFUS modulates neural interaction and response to peripheral electrical limb stimulation through intracranial multi-electrode recordings in the rat somatosensory cortex. We deliver ultrasound in a pulsed pattern to induce frequency dependent plasticity in a manner similar to that found following electrical stimulation. We show that neural firing in response to peripheral electrical stimulation is increased after ultrasound stimulation at all frequencies, showing tFUS induced changes in excitability of individual neurons in vivo. We demonstrate tFUS sonication repetition frequency dependent pairwise correlation changes between neurons, with both increases and decreases observed at different frequencies. These results extend previous research showing tFUS to be capable of inducing synaptic depression and demonstrate its ability to modulate network dynamics as a whole.
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http://dx.doi.org/10.1088/1741-2552/ac889fDOI Listing
August 2022

Biodegradation [email protected] di-shell nanoheterostructure with enhanced nanozyme-mediated phototherapy.

Biomater Adv 2022 May 28;136:212778. Epub 2022 Mar 28.

Key Laboratory of Photochemical Biomaterials and Energy Storage Materials and College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, China; Laboratory for Photon and Electronic Bandgap Materials, Ministry of Education, Harbin Normal University, Harbin 150025, China. Electronic address:

The efficacy of phototherapy is dependent on intracellular O concentration and NIR harvest. Here, a simple nanoplatform with nanoenzyme mediated phototherapy enhances anticancer capacity. [email protected] (CMS/C) di-shell hollow nanospheres (50 nm) are synthesized successfully through two-step consecutive Kirkendall process. The nanoheterostructure reveals the higher near-infrared (NIR) light absorption and photothermal conversion rate of 66.3% than pure CoS (45.5%), owing to the decreased band gap and multi-reflection of incident light in the hollow structure. And CMS/C reveals the reactive oxygen species (ROS) production and nanoenzyme activities (mimic peroxidase and catalase) that are 6 and 2 times than those of pure CoS. Furthermore, the nanoenzyme exhibits NIR-enhanced abilities to produce more OH and O facilitating anticancer. In addition, it also depletes glutathione (mimicking glutathione oxidase), to disturb intracellular redox-homeostasis, boosting the increase of oxidative stress. With grafting bovine serum albumin (BSA) and drug loading, CMS/[email protected] integrated multi-therapy make the great anticancer effect in vitro and vivo. After that, the nanocomposite could be biodegraded and eliminated via urinary and feces within 14 days. Based on this work, the efficient charge-separation can be designed to reveal high performance nanoenzymes as well as photosensitizers for anticancer.
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http://dx.doi.org/10.1016/j.bioadv.2022.212778DOI Listing
May 2022

Presentation, Management, and Outcomes of Urinary Bladder Paraganglioma: Results from a Multi-center Study.

J Clin Endocrinol Metab 2022 Jul 26. Epub 2022 Jul 26.

Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA.

Context And Objectives: Urinary bladder paraganglioma (UBPGL) is rare. We aimed to characterize the presentation and outcomes of patients diagnosed with UBPGL.

Methods: We conducted a multi-center study of consecutive patients with pathologically-confirmed UBPGL evaluated between 1971 and 2021. Outcomes included repeat bladder surgery, metastases, and disease-specific mortality.

Results: 110 patients (56, 51% women) were diagnosed with UBPGL at a median age of 50 years (IQR, 36-61 years). Median tumor size was 2 cm (IQR, 1-4 cm). UBPGL was diagnosed prior to biopsy in only 37 (34%), and only 69 (63%) patients had evaluation for catecholamine excess. In addition to the initial bladder surgery, 26 (25%) required multiple therapies, including repeat surgery in 10 (9%). Synchronous metastases were present in 9 (8%) patients, and 24 (22%) other patients with UBPGL developed metachronous metastases at a median of 4 years (IQR, 2-10 years) after initial diagnosis. Development of metachronous metastases was associated with younger age (Hazard ratio, HR 0.97, 95%CI 0.94-0.99), UBPGL size (HR of 1.69, 95%CI of 1.31-2.17), and a higher degree of catecholamine excess (HR of 5.48, 95%CI of 1.40-21.39). Disease-specific mortality was higher in patients with synchronous metastases (HR of 20.80, 95%CI, 1.30-332.91). Choice of initial surgery, genetic association, sex, or presence of muscular involvement on pathology were not associated with development of metastases or mortality.

Conclusions: Only a minority of patients were diagnosed before biopsy/surgery, reflecting the need of better diagnostic strategies. All patients with UBPGL should be monitored life-long for development of recurrence and metastases.
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http://dx.doi.org/10.1210/clinem/dgac427DOI Listing
July 2022

Sugar easters and xanthones from the roots of Polygala tenuifolia Willd. and their cytoprotective activity.

Fitoterapia 2022 Jul 21;161:105256. Epub 2022 Jul 21.

Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation, Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Six new sugar esters (1-6), named tenuifolisides F-G (1-2) and tenuifolioses W-Z (3-6), together with 16 known compounds (7-22) were isolated from the roots of Polygala tenuifolia. The chemical structures of the new compounds were elucidated by 1D, 2D NMR and HRESIMS techniques together with chemical methods. All the compounds were evaluated for the cytoprotective activity against hydrogen peroxide (HO)-induced oxidative stress in human keratinocyte HaCaT cells. Compounds 4, 5, 13, 20 and 22 showed strong cytoprotective effect.
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http://dx.doi.org/10.1016/j.fitote.2022.105256DOI Listing
July 2022

Finite Element Analysis of Proximal Femur Bionic Nail (PFBN) Compared with Proximal Femoral Nail Antirotation and InterTan in Treatment of Intertrochanteric Fractures.

Orthop Surg 2022 Jul 18. Epub 2022 Jul 18.

Department of Orthopaedic Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, China.

Objective: To compare the biomechanical properties of proximal femur bionic nail (PFBN), proximal femoral nail antirotation (PFNA) and InterTan in the treatment of elderly intertrochanteric fractures AO/OTA 31-A1.3 by finite element analysis.

Methods: We used Mimics, Unigraphics and other software to establish normal femur and AO/OTA 31-A1.3 fracture models, and reconstructed PFBN, PFNA and InterTan intramedullary nail models, and assembled them on the fracture model. The ANSYS software was used to compare the femoral von Mises stress distribution, deformation distribution, and internal fixation stress distribution of each group under a load of 2100 N.

Results: It could be seen that the femoral maximum stress, femoral maximum displacement, and maximum stress of internal fixation of the PFBN group were lower than those in the PFNA group and the InterTan group. The maximum femoral stress of the PFBN was 190.25 MPa, while the maximum stress of the femur of the PFNA and InterTan groups were 238.41 Mpa and 226.97 Mpa. The maximum femoral displacement of each group were located at the top of the femoral head, and the maximum displacement of the PFBN group was 14.373 mm, and the maximum displacement values of the PFNA and InterTan groups were 19.49 and 15.225 mm. For the stress distribution of intramedullary nail, the maximum stress of the three kinds of internal fixation was located on the main nail. The maximum stress of PFBN was 1191.8 MPa, compared with 2142.8 MPa for PFNA and 1702.3 MPa for InterTan. And the maximum stress on the PFBN pressure nail was 345.35 MPa, compared with 868.6 MPa for the PFNA spiral blade and 545.5 MPa for InterTan interlocking twin nails.

Conclusion: Compared with PFNA and InterTan, PFBN has better mechanical properties. The biomechanical characteristics of PFBN are more advantageous than PFNA and InterTan internal fixation system in the treatment of femoral intertrochanteric fractures.
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http://dx.doi.org/10.1111/os.13247DOI Listing
July 2022

Advanced lung cancer patient with isolated heparin-induced thrombocytopenia: A case report.

Medicine (Baltimore) 2022 Jul 15;101(28):e29461. Epub 2022 Jul 15.

Department of General Practice, Changhai Hospital, Naval Medical University, Shanghai, China.

Rationale: Heparin-induced thrombocytopenia (HIT), a potentially devastating form of drug-induced thrombocytopenia, occurs in patients receiving heparin for thrombosis prevention or treatment. An isolated HIT is characterized by decreased platelet counts without thrombosis, which are atypical and difficult to clinically find.

Symptoms And Clinical Findings: A 33-year-old female patient's admission examination revealed elevated D-dimer levels. After prophylactic anticoagulation using low-molecular weight heparin, her blood platelet counts were rapidly decreased, whereas her D-dimer levels increased, followed by presentations of chest tightness, abdominal pain, and skin itching without thrombosis. After excluding all the other causes of thrombocytopenia, HIT was suspected. Her 4Ts score was 5 points, and enzyme-linked immunoassay for platelet factor 4 (PF4)/heparin antibodies was positive, indicating isolated HIT.

Diagnoses, Interventions, And Outcomes: The patient was diagnosed with advanced lung cancer presenting with isolated HIT. We immediately stopped low-molecular weight heparin and initiated rivaroxaban for anticoagulation. We administered thrombopoietin (TPO) and avatripopal maleate tablets to increase blood platelet counts, whereas intravenous immunoglobulin (IVIG) was administered to stimulate her immune system. The patient's thrombocytopenia was successfully treated without thrombosis and bleeding complications.

Lessons: Rivaroxaban is a potential option for tumor preventive anticoagulation and HIT treatment. Early HIT identification is necessary. After identification, the 4Ts score as well as PF4/heparin antibodies should be assessed and appropriate anticoagulants selected based on patients' conditions.
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http://dx.doi.org/10.1097/MD.0000000000029461DOI Listing
July 2022

Analysis on the Influence of Incident Light Angle on the Spatial Aberrations of Acousto-Optical Tunable Filter Imaging.

Authors:
Kai Yu Huijie Zhao

Materials (Basel) 2022 Jun 24;15(13). Epub 2022 Jun 24.

School of Instrumentation Science & Opto-Electronics Engineering, Beihang University, No. 37 Xueyuan Road, Haidian District, Beijing 100191, China.

Acousto-optical tunable filter (AOTF) does not conform to the pinhole model due to the acousto-optic interaction. A calculation method of AOTF aberrations under the condition of incident light with a large arbitrary angle is proposed to solve the problem of coordinate mapping between object space and image space of the AOTF system without refractive index approximation. This approach can provide accurate pointing information of the interested targets for the tracking and searching system based on AOTF. In addition, the effect of cut angle values of the paratellurite crystal on aberrations was analyzed to optimize the design of AOTF cutting according to different application requirements. Finally, distribution characteristics and quantitative calculation results of AOTF aberrations were verified by experiments with different targets, respectively. The experimental results are in good agreement with the simulations.
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http://dx.doi.org/10.3390/ma15134464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267257PMC
June 2022

Arginine methylation of MTHFD1 by PRMT5 enhances anoikis resistance and cancer metastasis.

Oncogene 2022 Aug 7;41(32):3912-3924. Epub 2022 Jul 7.

Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University, 510060, Guangzhou, PR China.

Metastasis accounts for the major cause of cancer-related mortality. How disseminated tumor cells survive under suspension conditions and avoid anoikis is largely unknown. Here, using a metabolic enzyme-centered CRISPR-Cas9 genetic screen, we identified methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 (MTHFD1) as a novel suppressor of anoikis. MTHFD1 depletion obviously restrained the capacity of cellular antioxidant defense and inhibited tumor distant metastasis. Mechanistically, MTHFD1 was found to bind the protein arginine methyltransferase 5 (PRMT5) and then undergo symmetric dimethylation on R173 by PRMT5. Under suspension conditions, the interaction between MTHFD1 and PRMT5 was strengthened, which increased the symmetric dimethylation of MTHFD1. The elevated methylation of MTHFD1 largely augmented its metabolic activity to generate NADPH, therefore leading to anoikis resistance and distant organ metastasis. Therapeutically, genetic depletion or pharmacological inhibition of PRMT5 declined tumor distant metastasis. And R173 symmetric dimethylation status was associated with metastasis and prognosis of ESCC patients. In conclusion, our study uncovered a novel regulatory role and therapeutic implications of PRMT5/MTHFD1 axis in facilitating anoikis resistance and cancer metastasis.
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http://dx.doi.org/10.1038/s41388-022-02387-7DOI Listing
August 2022

Proton Self-Enhanced Hydroxyl-Enriched Cerium Oxide for Effective Arsenic Extraction from Strongly Acidic Wastewater.

Environ Sci Technol 2022 07 6;56(14):10412-10422. Epub 2022 Jul 6.

National-Local Joint Engineering Research Center of Heavy Metals Pollutants Control and Resource Utilization, Nanchang Hangkong University, Nanchang 330063, P. R. China.

Acid recycling and arsenic recovery from strongly acidic wastewater are goals of the metallurgical industry to reduce carbon emissions. In this study, arsenic was recovered using a hydroxyl-enriched CeO adsorbent, and the adsorption mechanism in a strongly acidic solution was investigated. The adsorption capacities of 88.59 mg/g for As(III) and 126.211 mg/g for As(V) at pH 1.0 are the highest reported values to date. It is revealed that the hydroxyl groups on the CeO surface can buffer hydrogen ions, and the isoelectric point of the material can be reduced to pH 1.52. The binding energy of arsenic is -1.25 eV for the hydroxyl-enriched CeO and -2.24 eV for CeO without hydroxyl groups. Additionally, the protonated hydroxyl groups reduce the oxidation energy of As(III) and promote the adsorption of arsenic by forming new active sites in the strongly acidic solution. Nearly 98.11% of arsenic (initial concentration is 886.8 mg/L) is removed within 24 h without pH adjustment, indicating the feasibility of hydroxyl-enriched CeO for recovering arsenic and acid. This work investigated the adsorption and proton-enhanced oxidation mechanism of arsenic by hydroxyl-enriched CeO in strongly acidic wastewater.
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http://dx.doi.org/10.1021/acs.est.2c02675DOI Listing
July 2022

Anti-liver fibrosis effects of the total flavonoids of litchi semen on CCl-induced liver fibrosis in rats associated with the upregulation of retinol metabolism.

Pharm Biol 2022 Dec;60(1):1264-1277

College of Animal Science and Technology, Guangxi University, Nanning, China.

Context: The litchi semen are traditional medications for treating liver fibrosis (LF) in China. The mechanism remains unclear.

Objective: This study investigates the anti-liver fibrotic mechanism of the total flavonoids of litchi semen (TFL).

Materials And Methods: Sprague-Dawley rats with carbon tetrachloride-induced LF were treated with TFL (50 and 100 mg/kg) for 4 weeks. The anti-liver fibrotic effects of TFL were evaluated and the underlying mechanisms were investigated via histopathological analysis, proteomic analysis and molecular biology technology.

Results: Significant anti-LF effects were observed in the high-TFL-dose group (TFL-H,  < 0.05). Five hundred and eighty-five and 95 differentially expressed proteins (DEPs) were identified in the LF rat model (M group) and TFL-H group, respectively. The DEPs were significantly enriched in the retinol metabolism pathway ( < 0.0001). The content of 9--retinoic acid (0.93 ± 0.13 vs. 0.66 ± 0.10,  < 0.05, vs. the M group) increased significantly in the TFL-H group. The upregulation of RXRα (0.50 ± 0.05 vs. 0.27 ± 0.13 protein,  < 0.05), ALDH2 (1.24 ± 0.09 vs. 1.04 ± 0.08 protein,  < 0.05), MMP3 (0.89 ± 0.02 vs. 0.61 ± 0.12 protein,  < 0.05), Aldh1a7 (0.20 ± 0.03 vs. 0.03 ± 0.00 mRNA,  < 0.05) and Aox3 (0.72 ± 0.14 vs. 0.05 ± 0.01 mRNA,  < 0.05) after TFL treatment was verified.

Conclusions: TFL exhibited good anti-liver fibrotic effects, which may be related to the upregulation of the retinol metabolism pathway. TFL may be promising anti-LF agents with potential clinical application prospects.
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http://dx.doi.org/10.1080/13880209.2022.2086584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262366PMC
December 2022

Adsorption behaviors of triclosan by non-biodegradable and biodegradable microplastics: Kinetics and mechanism.

Sci Total Environ 2022 Jun 26;842:156832. Epub 2022 Jun 26.

School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, Heilongjiang 150090, PR China; State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, Heilongjiang 150090, PR China.

Microplastics (MPs) pollution has been becoming serious and widespread in the global environment. Although MPs have been identified as vectors for contaminants, adsorption and desorption behaviors of chemicals with non-biodegradable and biodegradable MPs during the aging process is limited. In this work, the adsorption behaviors of triclosan (TCS) by non-biodegradable polyethylene (PE) and polypropylene (PP), and biodegradable polylactic acid (PLA) were investigated. The differences in morphology, chemical structures, crystallization, and hydrophilicity were investigated after the ultraviolet aging process and compared with the virgin MPs. The results show that the water contact angles of the aged MPs were slightly reduced compared with the virgin MPs. The aged MPs exhibited a stronger adsorption capacity for TCS because of the physical and chemical changes in MPs. The virgin biodegradable PLA had a larger adsorption capacity than the non-biodegradable PE and PP. The adsorption capacity presented the opposite trend after aging. The main adsorption mechanism of MPs relied on hydrophobicity interaction, hydrogen bonding, and electrostatic interaction. The work provides new insights into TCS as hazardous environmental contaminants, which will enhance the vector potential of non-biodegradable and biodegradable MPs.
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http://dx.doi.org/10.1016/j.scitotenv.2022.156832DOI Listing
June 2022

Sea spray aerosols intervening phospholipids ozonolysis at the air-water interface.

J Hazard Mater 2022 05 10;430:128466. Epub 2022 Feb 10.

State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, Heilongjiang 150090, PR China; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, Heilongjiang 150090, PR China. Electronic address:

With more than half of the world's population lives along the coast and in its vicinity, the sea spray aerosols (SSAs) with respect to respiratory system impact has attracted increasing attention. In this paper, ozonolysis of model lung phospholipids intervened by salt cations in SSAs at air-water interface was investigated using acoustic levitation-nano-electrospray ionization-mass spectrometry (AL-nano-ESI-MS). The cation species facilitated the interfacial ozonolysis of phospholipids, and this increased ozonolysis showed a dependence on the concentration of salt cations. The charge number and ion radius of salt cations were also investigated, and the times of increased efficiency for phospholipids ozonolysis at the air-water interface were higher with more charge numbers or lower ion radius. The mechanism study revealed that the electrostatic interaction between the electronegative headgroup of phospholipids and the cations disturbed the packing of phospholipids, and resulted in oleyl chains more vulnerable with ozone. Finally, aerosolization of the salt-dominated artificial seawater and real seawater revealed a significant increase on ozonolysis of phospholipid intervened by salt cations. These results reveal SSAs intervening phospholipids interfacial reaction at the molecule level, which will be beneficial to gain the knowledge of the negative health effect concerning the components involved in SSAs.
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http://dx.doi.org/10.1016/j.jhazmat.2022.128466DOI Listing
May 2022

The arginine methyltransferase Carm1 is necessary for heart development.

G3 (Bethesda) 2022 Jul;12(8)

Center for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA 98101, USA.

To discover genes implicated in human congenital disorders, we performed ENU mutagenesis in the mouse and screened for mutations affecting embryonic development. In this work, we report defects of heart development in mice homozygous for a mutation of coactivator-associated arginine methyltransferase 1 (Carm1). While Carm1 has been extensively studied, it has never been previously associated with a role in heart development. Phenotype analysis combining histology and microcomputed tomography imaging shows a range of cardiac defects. Most notably, many affected midgestation embryos appear to have cardiac rupture and hemorrhaging in the thorax. Mice that survive to late gestation show a variety of cardiac defects, including ventricular septal defects, double outlet right ventricle, and persistent truncus arteriosus. Transcriptome analyses of the mutant embryos by mRNA-seq reveal the perturbation of several genes involved in cardiac morphogenesis and muscle development and function. In addition, we observe the mislocalization of cardiac neural crest cells at E12.5 in the outflow tract. The cardiac phenotype of Carm1 mutant embryos is similar to that of Pax3 null mutants, and PAX3 is a putative target of CARM1. However, our analysis does not support the hypothesis that developmental defects in Carm1 mutant embryos are primarily due to a functional defect of PAX3.
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http://dx.doi.org/10.1093/g3journal/jkac155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339313PMC
July 2022

Porous {PMoO}-type Poly(oxometalate) Metal-Organic Frameworks for Improved Pseudocapacitance and Electrochemical Sensing Performance.

ACS Appl Mater Interfaces 2022 Jul 21;14(26):30099-30111. Epub 2022 Jun 21.

Key Laboratory for Photonic and Electronic Bandgap Materials, Ministry of Education, School of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, P. R. China.

{PMo} poly(oxometalate) (POM) clusters have huge steric hindrance and limited active oxygen atoms, which make them difficult to combine with metal-organic units to form three-dimensional (3D) porous structures. Therefore, functionalization of such POMs has always been a bottleneck that is difficult to break through. In this study, {PMo} POM was successfully grafted on a lock-like metal-organic chain to generate a multiporous coordination polymer, [{Na(HO)(Hbtb)}{Cu(HO)(pz)Cl}{HSr⊂PMoMoO}]·3HO () (pz = pyrazine; btb = 1,4-bis(1,2,4-triazole) butane). Meanwhile, a zero-dimensional (0-D) control compound with only btb ligands as counterions, (Hbtb)[HSr⊂PMoMoO]·3HO (), was also obtained via a hydrothermal reaction. Compound represents the first basket-type 3D poly(oxometalate) metal-organic framework (POMOF) assembly, which possesses interpenetrating pores and complex topology. -GO-CPE displays improved supercapacitor (SC) performance (the specific capacitance of 929.4 F g at a current density of 3 A g with 94.1% of cycle efficiency after 5000 cycles) compared with -GO-CPE and most reported POMOF electrode materials, which may be due to the outstanding redox capability of basket-POM, introduction of metal-organic chains, intersecting pores, and excellent conductivity of graphene. An asymmetric SC device with -GO-CPE as the negative electrode exhibits an energy density of 29.7 Wh kg with a power density of 3148.2 W kg and long-lasting cycling life. In addition, -GO-GCE as an electrochemical sensor responds to dopamine (DA) at a voltage of 0.40 V and shows lower detection limits (0.19 μM (signal-to-noise ratio (SNR) = 3)), higher selectivity, and good reproducibility in the linear range of 0.56 μM to 0.24 mM. The ability to accurately detect the content of DA in biological samples further proves the feasibility of the sensor in practical applications.
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http://dx.doi.org/10.1021/acsami.2c06369DOI Listing
July 2022

Visible-light-induced defluorinative carbonylative coupling of alkyl iodides with α-trifluoromethyl substituted styrenes.

Org Biomol Chem 2022 07 6;20(26):5264-5269. Epub 2022 Jul 6.

Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023 Dalian, Liaoning, China.

A visible-light-mediated defluorinative carbonylative cross-coupling of alkyl iodides with α-trifluoromethyl styrenes has been developed. The reaction occurs at room temperature under blue light irradiation, and various -difluoroalkenes were obtained in moderate to good yields. Synthetic transformations of the obtained product were performed as well.
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http://dx.doi.org/10.1039/d2ob00916aDOI Listing
July 2022

NIR-II-driven intracellular photocatalytic oxygen-generation on Z-Scheme iron sulfide/cobalt sulfide nanosheets for hypoxic tumor therapy.

J Colloid Interface Sci 2022 Nov 7;625:145-157. Epub 2022 Jun 7.

Key Laboratory of Photochemical Biomaterials and Energy Storage Materials and College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, China; Laboratory for Photon and Electronic Bandgap Materials, Ministry of Education, Harbin Normal University, Harbin 150025, China. Electronic address:

Tumor hypoxia not only promotes the proliferation, invasion and metastasis of cancer cells but also seriously hinders photodynamic therapy (PDT). Here, second near-infrared (NIR-II) photocatalytic O generation is introduced to relieve hypoxia. FeS/[email protected] ([email protected]) nanosheets (∼80 nm) are prepared with Fe-Co layered double hydroxides (LDHs) as precursor. As-synthesized samples have great NIR-II harvest and photothermal conversion efficiency (50.5 %, 1064 nm). In addition, photothermal effect can elevate the thermal energy of nanocomposite to supply extra energy and to excite FeS (1.16 eV) and CoS (1.37 eV) simultaneously by low-energy NIR-II (1064 nm, 1.16 eV) irradiation. Band structure is further investigated to discover the Z-Scheme mechanism of [email protected], whose photogenerated charges remains high redox potential to oxidize water forming O and to capture O producing reactive oxygen species (ROS), respectively. In addition, [email protected] enhances peroxidase and catalase activities attributing to the lower resistance for charge transfer in heterostructure. Besides, the nanocomposite also can be used as glutathione oxidase (GSHOD) to deplete GSH and break intracellular redox balance, facilitating oxidative stress. Most importantly, [email protected] reveals excellent biodegradation and elimination via feces and urine within 14 D. [email protected] integrate magnetic resonance and photothermal imaging (MRI and PTI), O in situ supply, and synergistic photothermal therapy (PTT)/PDT/chemotherapy (CDT) to arouse immune response for anticancer.
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http://dx.doi.org/10.1016/j.jcis.2022.06.031DOI Listing
November 2022

Corrigendum to "Identifying traumatic brain injury (TBI) by ATR-FTIR spectroscopy in a mouse model" [Spectrochim. Acta Part A: Mol. Biomol. Spectrosc. 274 (2022) 121099].

Spectrochim Acta A Mol Biomol Spectrosc 2022 Jun 14:121489. Epub 2022 Jun 14.

Department of Forensic Pathology, College of Forensic Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, China. Electronic address:

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http://dx.doi.org/10.1016/j.saa.2022.121489DOI Listing
June 2022

Perioperative Protocol of Ankle Fracture and Distal Radius Fracture Based on Enhanced Recovery after Surgery Program: A Multicenter Prospective Clinical Controlled study.

Pain Res Manag 2022 7;2022:3458056. Epub 2022 Jun 7.

Department of Orthopaedic Trauma, Beijing Jishuitan Hospital, Beijing, China.

Background: The enhanced recovery after surgery (ERAS) program is aimed to shorten patients' recovery process and improve clinical outcomes. This study aimed to compare the outcomes between the ERAS program and the traditional pathway among patients with ankle fracture and distal radius fracture.

Methods: This is a multicenter prospective clinical controlled study consisting of 323 consecutive adults with ankle fracture from 12 centers and 323 consecutive adults with distal radial fracture from 13 centers scheduled for open reduction and internal fixation between January 2017 and December 2018. According to the perioperative protocol, patients were divided into two groups: the ERAS group and the traditional group. The primary outcome was the patients' satisfaction of the whole treatment on discharge and at 6 months postoperatively. The secondary outcomes include delapsed time between admission and surgery, length of hospital stay, postoperative complications, functional score, and the MOS item short form health survey-36.

Results: Data describing 772 patients with ankle fracture and 658 patients with distal radius fracture were collected, of which 323 patients with ankle fracture and 323 patients with distal radial fracture were included for analysis. The patients in the ERAS group showed higher satisfaction levels on discharge and at 6 months postoperatively than in the traditional group ( < 0.001). In the subgroup analysis, patients with distal radial fracture in the ERAS group were more satisfied with the treatment (=0.001). Furthermore, patients with ankle fracture had less time in bed ( < 0.001) and shorter hospital stay ( < 0.001) and patients with distal radial fracture received surgery quickly after being admitted into the ward in the ERAS group than in the traditional group (=0.001).

Conclusions: Perioperative protocol based on the ERAS program was associated with high satisfaction levels, less time in bed, and short hospital stay without increased complication rate and decreased functional outcomes.
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http://dx.doi.org/10.1155/2022/3458056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197648PMC
June 2022

Prevalence and outcomes of transurethral resection versus radical cystectomy for muscle-infiltrating bladder cancer in the United States: A population-based cohort study.

Int J Surg 2022 Jul 9;103:106693. Epub 2022 Jun 9.

Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address:

Introduction: Although radical cystectomy is considered as the first choice for muscle-invasive bladder cancer (MIBC), there are also concerns regarding the cost of long-term morbidity, loss of body image, and compromised quality of life. Transurethral resection of bladder tumor (TURBT) is a candidate for bladder sparing treatments, but its viability as a substitute for radical cystectomy is questionable. Therefore, we conducted this population-based study to investigate the prevalence of TURBT in the treatments of T2-stage MIBC in the United States, and to compare its therapeutic efficiency with that of radical cystectomy.

Methods: Information on patients with T2-stage bladder cancer (BC) between 2000 and 2017 was extracted from the Surveillance, Epidemiology, and End Results program. The overall survival (OS) and disease-specific survival (DSS) of patients with different interventions were fitted.

Results: A total of 22,074 patients with T2-stage MIBC were enrolled, of whom 14,021 reached the main endpoint. Only 28% of the patients with T2-stage MIBC chose radical cystectomy as the initial surgical treatment, while TURBT was applied as the primary surgical treatment in 66.6% of the patients. The TURBT rate increased significantly with age at cancer diagnosis (40-44 years, 45.5% to > 85 years, 90.9%). The survival rate of patients undergoing TURBT was significantly lower than for those undergoing radical cystectomy (median OS: 1.5 versus 9.7 years; median DSS: 2.7 years versus not reached). Upon multivariable Cox analyses, the OS (HR: 2.34; p < 0.001) and DSS (HR: 2.68; p < 0.001) of TURBT were found to be significantly worse than those of radical cystectomy.

Conclusion: Two-thirds of the patients with T2-stage MIBC were treated by TURBT in the United States. However, the long-term follow-up data indicate that the therapeutic efficiency of current TURBT techniques is far less effective than that of radical cystectomy. Further studies are urgently needed to devise the best management strategy for T2 stage bladder cancer.
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http://dx.doi.org/10.1016/j.ijsu.2022.106693DOI Listing
July 2022

High Expression of CKS2 Predicts Adverse Outcomes: A Potential Therapeutic Target for Glioma.

Front Immunol 2022 19;13:881453. Epub 2022 May 19.

Department of Orthopedic, JiangXi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China.

Cyclin-dependent kinase regulatory subunit 2 (CKS2) is a potential prognostic marker and is overexpressed in various cancers. This study analyzed sequencing and clinical data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus, with external validation using the Chinese Glioma Genome Atlas (CGGA) data. CKS2 expression in the normal brain and tumor tissue was compared. cBioPortal and MethSurv were utilized to scrutinize the prognostic value of CKS2 methylation. Gene set enrichment examination and single-sample gene set enrichment analysis were employed to explore the potential biological functions of CKS2. Cell viability, colony formation, and transwell assays were conducted to evaluate the influence of CKS2 on glioma cell proliferation and invasion. Compared with normal brain tissue, the expression of CKS2 was upregulated in glioma samples ( < 0.001). Multivariate data analysis from TCGA and CGGA indicated that increased expression of CKS2 was an independent risk factor for the prognosis of overall survival in glioma patients. CKS2 methylation was negatively associated with CKS2 expression. Patients with CKS2 hypomethylation had worse overall survival compared with patients with CKS2 methylation, as suggested by the analysis of both TCGA and CGGA datasets. The expression level of CKS2 is closely related to tumor immunity, including the correlation of tumor immune cell infiltration, immune score, and co-expression of multiple immune-related genes. In addition, CKS2 is associated with several immune checkpoints and responses to the chemotherapy drug cisplatin. CKS2 knockdown impeded the expansion and aggression of glioma cell lines. The changes in CKS2 expression may provide a novel prognostic biomarker that can be used to improve patient overall survival rates.
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http://dx.doi.org/10.3389/fimmu.2022.881453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160311PMC
May 2022

Durable Surfaces from Film-Forming Silver Assemblies for Long-Term Zero Bacterial Adhesion without Toxicity.

ACS Cent Sci 2022 May 27;8(5):546-561. Epub 2022 Apr 27.

Department of Chemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

The long-term prevention of biofilm formation on the surface of indwelling medical devices remains a challenge. Silver has been reutilized in recent years for combating biofilm formation due to its indisputable bactericidal potency; however, the toxicity, low stability, and short-term activity of the current silver coatings have limited their use. Here, we report the development of silver-based film-forming antibacterial engineered (SAFE) assemblies for the generation of durable lubricous antibiofilm surface long-term activity without silver toxicity that was applicable to diverse materials via a highly scalable dip/spray/solution-skinning process. The SAFE coating was obtained through a large-scale screening, resulting in effective incorporation of silver nanoparticles (∼10 nm) into a stable nonsticky coating with high surface hierarchy and coverage, which guaranteed sustained silver release. The lead coating showed zero bacterial adhesion over a 1 month experiment in the presence of a high load of diverse bacteria, including difficult-to-kill and stone-forming strains. The SAFE coating showed high biocompatibility and excellent antibiofilm activity .
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http://dx.doi.org/10.1021/acscentsci.1c01556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136974PMC
May 2022

Dual-hormone artificial pancreas for glucose control in type 1 diabetes: A meta-analysis.

Diabetes Obes Metab 2022 May 31. Epub 2022 May 31.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing, China.

Aim: To evaluate the efficacy and safety of a dual-hormone artificial pancreas (DH) in type 1 diabetes.

Material And Methods: PubMed, Embase, the Cochrane Library and ClinicalTrials.gov were searched for studies published up to February 16, 2022. We included randomized controlled trials that compared DH with single-hormone artificial pancreas (SH), continuous subcutaneous insulin infusion (CSII) or sensor-augmented pumps (SAP), and predictive low glucose suspend systems (PLGS) in type 1 diabetes. The primary outcome was percent time in target (3.9-10 mmol/L [70-180 mg/dL]). Data were summarized as mean differences (MDs) or risk differences (RDs).

Results: A total of 17 randomized crossover trials (438 participants) were included. There were nine trials of DH versus SH, 13 trials of DH versus SAP/CSII, and two trials of DH versus PLGS. For time in target, DH showed no significant difference in time in target compared with SH (MD 2.69%, 95% confidence interval [CI] -0.38 to 5.76) but resulted in 16.05% (95% CI 12.06 to 20.05) and 6.89% (95% CI 2.63 to 11.14) more time in target range compared with SAP/CSII and PLGS, respectively. DH slightly reduced time in hypoglycaemia (MD -1.20%, 95% CI -1.85 to -0.56) but increased the risk of gastrointestinal symptoms (RD 0.18, 95% CI 0.08 to 0.27) compared with SH.

Conclusions: The results of this study suggest that DH has a comparable effect on time in target compared with SH, but is associated with a longer time in target range compared with SAP/CSII and PLGS. The DH slightly reduced time in hypoglycaemia but may increase the risk of gastrointestinal symptoms compared with the SH. PROSPERO registration number: CRD42022314015.
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http://dx.doi.org/10.1111/dom.14781DOI Listing
May 2022

Application of nanoindentation technology in testing the mechanical properties of skull materials.

Sci Rep 2022 05 24;12(1):8717. Epub 2022 May 24.

School of Forensic Medicine, Guizhou Medical University, Guiyang, 550004, China.

Three-point bending test, compression test and tensile test can detect the mechanical properties of the whole layer of skull, but cannot detect the mechanical properties of the inner plate, the diploe and the outer plate of the skull. In this study, nanoindentation technology was applied to detect mechanical properties of micro-materials of the skull, and differences in micro-mechanical properties of the inner, diploe and outer plates of the skull and cranial suture of human carcasses at different ages were analyzed. The differences in hardness (HIT) and modulus of elasticity (E) were statistically significant among different age groups (P < 0.01). In terms of structure, the E of diploe was higher than that of other structures, while HIT had no significant statistical difference. In terms of location, both HIT and E showed that left frontal (LF) was significantly higher than coronal suture (CS). The above results were consistent with the multi-factor ANOVAs. In addition, the multi-factor ANOVAs further explained the interaction of HIT and E with age, location and structure. It was believed that the nanoindentation technique could be used to analyze laws of micromechanical properties of different structures of human cadaveric skull and cranial suture.
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http://dx.doi.org/10.1038/s41598-022-11216-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130296PMC
May 2022

Effectiveness of COVID-19 vaccines against SARS-CoV-2 variants of concern: a systematic review and meta-analysis.

BMC Med 2022 05 23;20(1):200. Epub 2022 May 23.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing, China.

Background: It was urgent and necessary to synthesize the evidence for vaccine effectiveness (VE) against SARS-CoV-2 variants of concern (VOC). We conducted a systematic review and meta-analysis to provide a comprehensive overview of the effectiveness profile of COVID-19 vaccines against VOC.

Methods: Published randomized controlled trials (RCTs), cohort studies, and case-control studies that evaluated the VE against VOC (Alpha, Beta, Gamma, Delta, or Omicron) were searched until 4 March 2022. Pooled estimates and 95% confidence intervals (CIs) were calculated using random-effects meta-analysis. VE was defined as (1-estimate).

Results: Eleven RCTs (161,388 participants), 20 cohort studies (52,782,321 participants), and 26 case-control studies (2,584,732 cases) were included. Eleven COVID-19 vaccines (mRNA-1273, BNT162b2, ChAdOx1, Ad26.COV2.S, NVX-CoV2373, BBV152, CoronaVac, BBIBP-CorV, SCB-2019, CVnCoV, and HB02) were included in this analysis. Full vaccination was effective against Alpha, Beta, Gamma, Delta, and Omicron variants, with VE of 88.0% (95% CI, 83.0-91.5), 73.0% (95% CI, 64.3-79.5), 63.0% (95% CI, 47.9-73.7), 77.8% (95% CI, 72.7-82.0), and 55.9% (95% CI, 40.9-67.0), respectively. Booster vaccination was more effective against Delta and Omicron variants, with VE of 95.5% (95% CI, 94.2-96.5) and 80.8% (95% CI, 58.6-91.1), respectively. mRNA vaccines (mRNA-1273/BNT162b2) seemed to have higher VE against VOC over others; significant interactions (p < 0.10) were observed between VE and vaccine type (mRNA vaccines vs. not mRNA vaccines).

Conclusions: Full vaccination of COVID-19 vaccines is highly effective against Alpha variant, and moderate effective against Beta, Gamma, and Delta variants. Booster vaccination is more effective against Delta and Omicron variants. mRNA vaccines seem to have higher VE against Alpha, Beta, Gamma, and Delta variants over others.
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http://dx.doi.org/10.1186/s12916-022-02397-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126103PMC
May 2022

Prediagnostic Serum Vitamin D, Vitamin D Binding Protein Isoforms, and Cancer Survival.

JNCI Cancer Spectr 2022 03;6(2)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Background: Higher circulating vitamin D has been associated with improved overall cancer survival, but data for organ-specific cancers are mixed.

Methods: We examined the association between prediagnostic serum 25-hydroxyvitamin D [25(OH)D], the recognized biomarker of vitamin D status, and cancer survival in 4038 men and women diagnosed with 1 of 11 malignancies during 22 years of follow-up (median = 15.6 years) within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Multivariable-adjusted proportional hazards regression estimated hazard ratios (HR) and 95% confidence intervals (CI) for associations between baseline 25(OH)D concentration and subsequent cancer survival; we also stratified on the common vitamin D binding protein isoforms (Gc1f, Gc1s, and Gc2) defined by two single-nucleotide polymorphisms (rs7041 and rs4588) in the vitamin D binding protein gene GC. All P values were 2-sided.

Results: Higher 25(OH)D concentrations were associated with greater overall cancer survival (HR for cancer mortality = 0.83, 95% CI = 0.70 to 0.98 for highest vs lowest quintile; Ptrend = .05) and lung cancer survival (HR = 0.63, 95% CI = 0.44 to 0.90; Ptrend = .03). These associations were limited to cases expressing the Gc2 isoform (HR = 0.38 for Gc2-2, 95% CI = 0.14 to 1.05 for highest vs lowest quintile; Ptrend = .02; and HR = 0.30 for Gc1-2/Gc2-2 combined, 95% CI = 0.16 to 0.56; Ptrend < .001 for overall and lung cancer, respectively).

Conclusions: Higher circulating 25(OH)D was associated with improved overall and lung cancer survival. As this was especially evident among cases with the genetically determined Gc2 isoform of vitamin D binding protein, such individuals may gain a cancer survival advantage by maintaining higher 25(OH)D blood concentrations.
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http://dx.doi.org/10.1093/jncics/pkac019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982405PMC
March 2022

Using echocardiography in newborn screening for congenital heart disease may reduce missed diagnoses.

World J Pediatr 2022 May 18. Epub 2022 May 18.

Heart Center, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, No. 3333 Binsheng Road, Binjiang District, Hangzhou, 310000, China.

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http://dx.doi.org/10.1007/s12519-022-00560-2DOI Listing
May 2022

Changing causes of death in persons with haematological cancers 1975-2016.

Leukemia 2022 07 16;36(7):1850-1860. Epub 2022 May 16.

State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong Province, China.

Causes of death in persons with haematological cancers include the index cancer, a new cancer or a seemingly unrelated cause such as cardio-vascular disease. These causes are complex and sometimes confounded. We analyzed trends in cause of death in 683,333 persons with an index haematological cancer diagnosed in 1975-2016 reported in the Surveillance, Epidemiology and End Results dataset. Non-cancer deaths were described using standardized mortality ratios. The index cancer was the predominant cause of death amongst persons with plasma cell myeloma, acute lymphoblastic leukaemia and acute myeloid leukaemia. Non-cancer death was the major cause of death in persons with chronic lymphocytic leukaemia, Hodgkin lymphoma and chronic myeloid leukaemia, mostly from cardio-vascular diseases. The greatest relative decrease in index-cancer deaths was amongst persons with Hodgkin lymphoma, chronic myeloid leukaemia and chronic lymphocytic leukaemia, where the proportion of non-cancer deaths increased substantially. Changing distribution of causes of death across haematological cancers reflects substantial progress in some cancers and suggests strategies to improve the survival of persons with haematological cancers in the future.
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http://dx.doi.org/10.1038/s41375-022-01596-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252904PMC
July 2022

Global methane and nitrous oxide emissions from inland waters and estuaries.

Glob Chang Biol 2022 Aug 27;28(15):4713-4725. Epub 2022 May 27.

Key Laboratory of Low-carbon and Green Agriculture in Southeastern China, Ministry of Agriculture and Rural Affairs, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing, China.

Inland waters (rivers, reservoirs, lakes, ponds, streams) and estuaries are significant emitters of methane (CH ) and nitrous oxide (N O) to the atmosphere, while global estimates of these emissions have been hampered due to the lack of a worldwide comprehensive data set of CH and N O flux components. Here, we synthesize 2997 in-situ flux or concentration measurements of CH and N O from 277 peer-reviewed publications to estimate global CH and N O emissions from inland waters and estuaries. Inland waters including rivers, reservoirs, lakes, and streams together release 95.18 Tg CH  year (ebullition plus diffusion) and 1.48 Tg N O year (diffusion) to the atmosphere, yielding an overall CO -equivalent emission total of 3.06 Pg CO  year . The estimate of CH and N O emissions represents roughly 60% of CO emissions (5.13 Pg CO  year ) from these four inland aquatic systems, among which lakes act as the largest emitter for both CH and N O. Ebullition showed as a dominant flux component of CH , contributing up to 62%-84% of total CH fluxes across all inland waters. Chamber-derived CH emission rates are significantly greater than those determined by diffusion model-based methods for commonly capturing of both diffusive and ebullitive fluxes. Water dissolved oxygen (DO) showed as a dominant factor among all variables to influence both CH (diffusive and ebullitive) and N O fluxes from inland waters. Our study reveals a major oversight in regional and global CH budgets from inland waters, caused by neglecting the dominant role of ebullition pathways in those emissions. The estimated indirect N O EF values suggest that a downward refinement is required in current IPCC default EF values for inland waters and estuaries. Our findings further indicate that a comprehensive understanding of the magnitude and patterns of CH and N O emissions from inland waters and estuaries is essential in defining the way of how these aquatic systems will shape our climate.
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http://dx.doi.org/10.1111/gcb.16233DOI Listing
August 2022
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