Publications by authors named "Kai Wucherpfennig"

100Publications

Inhibition of MAN2A1 Enhances the Immune Response to Anti-PD-L1 in Human Tumors.

Clin Cancer Res 2020 Nov 28;26(22):5990-6002. Epub 2020 Jul 28.

Department of Data Science, Dana-Farber Cancer Institute, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-20-0778DOI Listing
November 2020

Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy.

Cell 2020 Aug 29;182(3):655-671.e22. Epub 2020 Jun 29.

Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA; Department of Neurology, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415717PMC
August 2020

Metabolic labeling and targeted modulation of dendritic cells.

Nat Mater 2020 Nov 18;19(11):1244-1252. Epub 2020 May 18.

Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41563-020-0680-1DOI Listing
November 2020

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

Mol Cell 2020 06 15;78(6):1096-1113.e8. Epub 2020 May 15.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for Cancer Evolution, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Ludwig Center at Harvard, Boston, MA 02115, USA; The Eli and Edythe L. Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2020.04.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306005PMC
June 2020

Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells.

Cell Stem Cell 2020 03 20;26(3):377-390.e6. Epub 2020 Feb 20.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Departments of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02215, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147146PMC
March 2020

Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient.

Cell Stem Cell 2020 03 20;26(3):391-402.e5. Epub 2020 Feb 20.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2020.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412576PMC
March 2020

Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters.

Mol Cell 2020 04 5;78(1):141-151.e5. Epub 2020 Feb 5.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2020.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376365PMC
April 2020

Discovery of specialized NK cell populations infiltrating human melanoma metastases.

JCI Insight 2019 12 5;4(23). Epub 2019 Dec 5.

Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/jci.insight.133103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962021PMC
December 2019

T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes.

Cell 2019 08;178(4):1016-1028.e13

Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard University Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939866PMC
August 2019

Visualization and quantification of NK cell-mediated cytotoxicity over extended time periods by image cytometry.

J Immunol Methods 2019 06 2;469:47-51. Epub 2019 Apr 2.

Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, United States of America.

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http://dx.doi.org/10.1016/j.jim.2019.04.001DOI Listing
June 2019

Engineered MBP-specific human Tregs ameliorate MOG-induced EAE through IL-2-triggered inhibition of effector T cells.

J Autoimmun 2018 08 30;92:77-86. Epub 2018 May 30.

Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2018.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054915PMC
August 2018

Immunotherapy for glioblastoma: on the sidelines or in the game?

Discov Med 2017 11;24(133):201-208

Department of Neurosurgery, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA 02215, USA.

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November 2017

Immunomodulation for glioblastoma.

Curr Opin Neurol 2017 06;30(3):361-369

aCenter for Neuro-Oncology bDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts cDepartment of Neurosurgery, Duke University Medical Center, Durham, North Carolina, USA.

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http://dx.doi.org/10.1097/WCO.0000000000000451DOI Listing
June 2017

Studying Dynamic Plasma Membrane Binding of TCR-CD3 Chains During Immunological Synapse Formation Using Donor-Quenching FRET and FLIM-FRET.

Methods Mol Biol 2017 ;1584:259-289

Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/978-1-4939-6881-7_16DOI Listing
February 2018

Multicomponent Injectable Hydrogels for Antigen-Specific Tolerogenic Immune Modulation.

Adv Healthc Mater 2017 Mar 24;6(6). Epub 2017 Jan 24.

School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.

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http://dx.doi.org/10.1002/adhm.201600773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518671PMC
March 2017

Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling.

Sci Signal 2016 07 26;9(438):ra75. Epub 2016 Jul 26.

Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Program in Immunology, Harvard Medical School, Boston, MA 02115, USA. Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scisignal.aaf0626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929992PMC
July 2016

Genetic screens to study the immune system in cancer.

Curr Opin Immunol 2016 08 13;41:55-61. Epub 2016 Jun 13.

Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.coi.2016.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992665PMC
August 2016

Clinical and MRI phenotype of children with MOG antibodies.

Mult Scler 2016 Feb 3;22(2):174-84. Epub 2015 Jun 3.

Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA/Partners MS Center, Brigham and Women's Hospital, Boston, MA, USA/Partners Pediatric MS Center, Massachusetts General Hospital, Boston, MA, USA

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http://dx.doi.org/10.1177/1352458515587751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669239PMC
February 2016

Molecular mechanisms for contribution of MHC molecules to autoimmune diseases.

Curr Opin Immunol 2014 Dec 15;31:24-30. Epub 2014 Sep 15.

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Program in Immunology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2014.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254370PMC
December 2014

Immunotherapy advances for glioblastoma.

Neuro Oncol 2014 Nov 4;16(11):1441-58. Epub 2014 Sep 4.

Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (D.A.R., P.Y.W.); Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts (G.F., C.W., K.W.W.); Department of Medical Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (D.A.R., C.W.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.A.C.); Division of Neuro-Oncology, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts (P.Y.W.); Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina (J.H.S.); Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts (W.T.C.); Department of Medical Oncology and Cancer Vaccine Center, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (C.W., E.F.F., G.D.); Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts (G.D.).

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http://dx.doi.org/10.1093/neuonc/nou212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201077PMC
November 2014

B cell homeostasis and follicle confines are governed by fibroblastic reticular cells.

Nat Immunol 2014 Oct 24;15(10):973-81. Epub 2014 Aug 24.

1] Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts, USA. [2] Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA. [3].

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http://www.nature.com/doifinder/10.1038/ni.2965
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http://dx.doi.org/10.1038/ni.2965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205585PMC
October 2014

Discovering cancer immunotherapy targets in vivo.

Oncoimmunology 2014 17;3:e28500. Epub 2014 Apr 17.

Dana-Farber Cancer Institute; Boston, MA USA ; Program in Immunology; Harvard Medical School; Boston, MA USA.

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http://dx.doi.org/10.4161/onci.28500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063151PMC
April 2014

Deconstructing the peptide-MHC specificity of T cell recognition.

Cell 2014 May;157(5):1073-87

Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.03.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071348PMC
May 2014

The tumor microenvironment shapes lineage, transcriptional, and functional diversity of infiltrating myeloid cells.

Cancer Immunol Res 2014 Jul 31;2(7):655-67. Epub 2014 Mar 31.

Authors' Affiliations: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts; Departments of

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http://dx.doi.org/10.1158/2326-6066.CIR-13-0209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194071PMC
July 2014

Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse.

Nature 2014 Mar 2;507(7490):118-23. Epub 2014 Feb 2.

1] Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA [2] Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7FY, UK.

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http://www.nature.com/articles/nature12951
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http://dx.doi.org/10.1038/nature12951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949170PMC
March 2014

Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop.

Nat Commun 2013 ;4:2623

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/ncomms3623
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http://dx.doi.org/10.1038/ncomms3623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193804PMC
May 2014

Cracking the code of human T-cell immunity.

Nat Biotechnol 2013 Jul;31(7):609-10

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http://dx.doi.org/10.1038/nbt.2626DOI Listing
July 2013

Mechanisms of peptide repertoire selection by HLA-DM.

Trends Immunol 2013 Oct 5;34(10):495-501. Epub 2013 Jul 5.

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.it.2013.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796002PMC
October 2013

Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain.

J Exp Med 2012 Dec 19;209(13):2423-39. Epub 2012 Nov 19.

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1084/jem.20120790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526357PMC
December 2012

Functional single-cell analysis of T-cell activation by supported lipid bilayer-tethered ligands on arrays of nanowells.

Lab Chip 2013 Jan 15;13(1):90-9. Epub 2012 Oct 15.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1039/c2lc40869dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522575PMC
January 2013

Alternative RISC assembly: binding and repression of microRNA-mRNA duplexes by human Ago proteins.

RNA 2012 Nov 27;18(11):2041-55. Epub 2012 Sep 27.

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1261/rna.035675.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479394PMC
November 2012

Self-reactive human CD4 T cell clones form unusual immunological synapses.

J Exp Med 2012 Feb 6;209(2):335-52. Epub 2012 Feb 6.

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1084/jem.20111485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280872PMC
February 2012

The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathway.

Curr Opin Immunol 2012 Feb 2;24(1):105-11. Epub 2011 Dec 2.

Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.coi.2011.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288754PMC
February 2012

Cell surface display of functional human MHC class II proteins: yeast display versus insect cell display.

Protein Eng Des Sel 2011 Sep 13;24(9):701-9. Epub 2011 Jul 13.

Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1093/protein/gzr035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160208PMC
September 2011

Ex vivo characterization and isolation of rare memory B cells with antigen tetramers.

Blood 2011 Jul 6;118(2):348-57. Epub 2011 May 6.

Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Boston, MA 02215-5450, USA.

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http://dx.doi.org/10.1182/blood-2011-03-341917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138687PMC
July 2011

T cell receptor recognition of self and foreign antigens in the induction of autoimmunity.

Semin Immunol 2011 Apr;23(2):84-91

Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.smim.2011.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073734PMC
April 2011

HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide.

Nat Immunol 2011 Jan 5;12(1):54-61. Epub 2010 Dec 5.

Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ni.1967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018327PMC
January 2011

The first structures of T cell receptors bound to peptide-MHC.

J Immunol 2010 Dec;185(11):6391-3

Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.4049/jimmunol.1090110DOI Listing
December 2010

The structural basis for intramembrane assembly of an activating immunoreceptor complex.

Nat Immunol 2010 Nov 3;11(11):1023-9. Epub 2010 Oct 3.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.

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http://www.nature.com/articles/ni.1943
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http://dx.doi.org/10.1038/ni.1943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215083PMC
November 2010

Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling.

Cold Spring Harb Perspect Biol 2010 Apr 17;2(4):a005140. Epub 2010 Mar 17.

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/cshperspect.a005140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845206PMC
April 2010

Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence.

J Clin Invest 2010 Apr;120(4):1324-36

Immunology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://www.jci.org/articles/view/40220
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http://dx.doi.org/10.1172/JCI40220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846047PMC
April 2010

Positively selecting peptides: their job does not end in the thymus.

Nat Immunol 2009 Nov;10(11):1143-4

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http://dx.doi.org/10.1038/ni1109-1143DOI Listing
November 2009

Structural alterations in peptide-MHC recognition by self-reactive T cell receptors.

Curr Opin Immunol 2009 Dec 19;21(6):590-5. Epub 2009 Aug 19.

Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.coi.2009.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787854PMC
December 2009

B cells and autoantibodies in the pathogenesis of multiple sclerosis and related inflammatory demyelinating diseases.

Adv Immunol 2008 ;98:121-49

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S006527760800404
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http://dx.doi.org/10.1016/S0065-2776(08)00404-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520528PMC
December 2008

Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression.

Proc Natl Acad Sci U S A 2008 Mar 25;105(9):3479-84. Epub 2008 Feb 25.

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0800149105
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http://dx.doi.org/10.1073/pnas.0800149105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265184PMC
March 2008

Common themes in the assembly and architecture of activating immune receptors.

Nat Rev Immunol 2007 Nov;7(11):841-50

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nri2186DOI Listing
November 2007

Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway.

Immunity 2007 May;26(5):593-604

Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.immuni.2007.03.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428267PMC
May 2007

Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID).

J Clin Invest 2007 Jun 10;117(6):1550-7. Epub 2007 May 10.

Division of Immunology, Children's Hospital Boston, Boston, Massachusetts 02115, USA.

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http://www.jci.org/cgi/doi/10.1172/JCI31023
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http://dx.doi.org/10.1172/JCI31023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865037PMC
June 2007