Publications by authors named "Kai Savolainen"

77Publications

Redox Activity and Nano-Bio Interactions Determine the Skin Injury Potential of CoO-Based Metal Oxide Nanoparticles toward Zebrafish.

ACS Nano 2020 04 24;14(4):4166-4177. Epub 2020 Mar 24.

College of Environmental Science and Engineering, Biomedical Multidisciplinary Innovation Research Institute, Shanghai East Hospital, Tongji University, Shanghai 200092, China.

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http://dx.doi.org/10.1021/acsnano.9b08938DOI Listing
April 2020

Size, Surface Functionalization, and Genotoxicity of Gold Nanoparticles In Vitro.

Nanomaterials (Basel) 2020 Feb 6;10(2). Epub 2020 Feb 6.

Finnish Institute of Occupational Health, Työterveyslaitos, 00032 Helsinki, Finland.

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http://dx.doi.org/10.3390/nano10020271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075117PMC
February 2020

Nanomaterial exposure, toxicity, and impact on human health.

Wiley Interdiscip Rev Nanomed Nanobiotechnol 2018 Feb 23. Epub 2018 Feb 23.

Work Environment, Finnish Institute of Occupational Health, Helsinki, Finland.

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http://dx.doi.org/10.1002/wnan.1513DOI Listing
February 2018

Network Analysis Reveals Similar Transcriptomic Responses to Intrinsic Properties of Carbon Nanomaterials in Vitro and in Vivo.

ACS Nano 2017 04 11;11(4):3786-3796. Epub 2017 Apr 11.

Institute of Environmental Medicine (IMM), Karolinska Institutet , 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1021/acsnano.6b08650DOI Listing
April 2017

Environmental impacts of genetically modified plants: A review.

Environ Res 2017 07 27;156:818-833. Epub 2017 Mar 27.

Department of Biotechnology, Chonnam National University, Yeosu, Chonnam 59626, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.envres.2017.03.011DOI Listing
July 2017

Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA).

Authors:
Christopher J Portier Bruce K Armstrong Bruce C Baguley Xaver Baur Igor Belyaev Robert Bellé Fiorella Belpoggi Annibale Biggeri Maarten C Bosland Paolo Bruzzi Lygia Therese Budnik Merete D Bugge Kathleen Burns Gloria M Calaf David O Carpenter Hillary M Carpenter Lizbeth López-Carrillo Richard Clapp Pierluigi Cocco Dario Consonni Pietro Comba Elena Craft Mohamed Aqiel Dalvie Devra Davis Paul A Demers Anneclaire J De Roos Jamie DeWitt Francesco Forastiere Jonathan H Freedman Lin Fritschi Caroline Gaus Julia M Gohlke Marcel Goldberg Eberhard Greiser Johnni Hansen Lennart Hardell Michael Hauptmann Wei Huang James Huff Margaret O James C W Jameson Andreas Kortenkamp Annette Kopp-Schneider Hans Kromhout Marcelo L Larramendy Philip J Landrigan Lawrence H Lash Dariusz Leszczynski Charles F Lynch Corrado Magnani Daniele Mandrioli Francis L Martin Enzo Merler Paola Michelozzi Lucia Miligi Anthony B Miller Dario Mirabelli Franklin E Mirer Saloshni Naidoo Melissa J Perry Maria Grazia Petronio Roberta Pirastu Ralph J Portier Kenneth S Ramos Larry W Robertson Theresa Rodriguez Martin Röösli Matt K Ross Deodutta Roy Ivan Rusyn Paulo Saldiva Jennifer Sass Kai Savolainen Paul T J Scheepers Consolato Sergi Ellen K Silbergeld Martyn T Smith Bernard W Stewart Patrice Sutton Fabio Tateo Benedetto Terracini Heinz W Thielmann David B Thomas Harri Vainio John E Vena Paolo Vineis Elisabete Weiderpass Dennis D Weisenburger Tracey J Woodruff Takashi Yorifuji Il Je Yu Paola Zambon Hajo Zeeb Shu-Feng Zhou

J Epidemiol Community Health 2016 08 3;70(8):741-5. Epub 2016 Mar 3.

College of Pharmacy, University of South Florida, Tampa, Florida, USA.

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http://dx.doi.org/10.1136/jech-2015-207005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975799PMC
August 2016

Human exposure to carbon-based fibrous nanomaterials: A review.

Int J Hyg Environ Health 2016 Mar 23;219(2):166-75. Epub 2015 Dec 23.

Hoseo University, Toxicological Research Center, Asan, South Korea.

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https://linkinghub.elsevier.com/retrieve/pii/S14384639150016
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http://dx.doi.org/10.1016/j.ijheh.2015.12.005DOI Listing
March 2016

A secretomics analysis reveals major differences in the macrophage responses towards different types of carbon nanotubes.

Nanotoxicology 2015 17;9(6):719-28. Epub 2014 Oct 17.

Nanosafety Research Centre, Finnish Institute of Occupational Health , Helsinki , Finland.

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http://dx.doi.org/10.3109/17435390.2014.969346DOI Listing
April 2016

Genotoxic and immunotoxic effects of cellulose nanocrystals in vitro.

Environ Mol Mutagen 2015 Mar 24;56(2):171-82. Epub 2014 Sep 24.

Nanosafety Research Centre, Finnish Institute of Occupational Health, Helsinki, Finland; Systems Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland; Department of Anatomy, Embryology and Genetics, University of Zaragoza, Zaragoza, Spain.

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http://dx.doi.org/10.1002/em.21913DOI Listing
March 2015

Phagocytosis of nano-sized titanium dioxide triggers changes in protein acetylation.

J Proteomics 2014 Aug 25;108:469-83. Epub 2014 Jun 25.

Unit of Systems Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a b, FIN-00250 Helsinki, Finland; Nanosafety Research Centre, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a b, FIN-00250 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2014.06.011DOI Listing
August 2014

Range-finding risk assessment of inhalation exposure to nanodiamonds in a laboratory environment.

Int J Environ Res Public Health 2014 May 16;11(5):5382-402. Epub 2014 May 16.

Department of Physics, University of Helsinki, Gustaf Hällströmin Katu 2, P.O. Box 64, Helsinki FI-00014, Finland.

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http://dx.doi.org/10.3390/ijerph110505382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053885PMC
May 2014

Nanotoxicology.

Toxicology 2013 Nov 21;313(1):1-2. Epub 2013 Sep 21.

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.tox.2013.09.010DOI Listing
November 2013

Disseminating widely.

Nat Nanotechnol 2013 Feb;8(2):72

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http://dx.doi.org/10.1038/nnano.2013.3DOI Listing
February 2013

Broaden the discussion.

Nat Nanotechnol 2013 Feb;8(2):71

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http://dx.doi.org/10.1038/nnano.2013.2DOI Listing
February 2013

Genotoxicity of short single-wall and multi-wall carbon nanotubes in human bronchial epithelial and mesothelial cells in vitro.

Toxicology 2013 Nov 21;313(1):24-37. Epub 2012 Dec 21.

Nanosafety Research Center, Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland; Safe New Technologies, Work Environment Development, Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2012.12.008DOI Listing
November 2013

Genotoxicity of polyvinylpyrrolidone-coated silver nanoparticles in BEAS 2B cells.

Toxicology 2013 Nov 8;313(1):38-48. Epub 2012 Nov 8.

Nanosafety Research Center and Safe New Technologies, Work Environment Development, Finnish Institute of Occupational Health, Helsinki, Finland.

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https://linkinghub.elsevier.com/retrieve/pii/S0300483X120036
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http://dx.doi.org/10.1016/j.tox.2012.09.014DOI Listing
November 2013

Genotoxicity of inhaled nanosized TiO(2) in mice.

Mutat Res 2012 Jun 7;745(1-2):58-64. Epub 2011 Nov 7.

Nanosafety Research Center, Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.mrgentox.2011.10.011DOI Listing
June 2012

Induction of chromosomal aberrations by carbon nanotubes and titanium dioxide nanoparticles in human lymphocytes in vitro.

Nanotoxicology 2012 Dec 13;6:825-36. Epub 2011 Oct 13.

Finnish Institute of Occupational Health, Nanosafety Research Center, Helsinki, Finland.

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http://dx.doi.org/10.3109/17435390.2011.625130DOI Listing
December 2012

Long, needle-like carbon nanotubes and asbestos activate the NLRP3 inflammasome through a similar mechanism.

ACS Nano 2011 Sep 3;5(9):6861-70. Epub 2011 Aug 3.

Unit of Immunotoxicology, Finnish Institute of Occupational Health, 00250, Helsinki, Finland.

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http://dx.doi.org/10.1021/nn200595cDOI Listing
September 2011

[Health risks of engineered nanomaterials and nanotechnologies].

Duodecim 2011 ;127(11):1097-104

Työterveyslaitos, Nanoturvallisuuskeskus, Helsinki.

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September 2011

Proteomic characterization of engineered nanomaterial-protein interactions in relation to surface reactivity.

ACS Nano 2011 Jun 4;5(6):4300-9. Epub 2011 May 4.

Unit for Immunotoxicology, Health and Work Ability, Finnish Institute of Occupational Health, Helsinki, Finland.

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http://dx.doi.org/10.1021/nn101492kDOI Listing
June 2011

Nano-specific genotoxic effects.

J Biomed Nanotechnol 2011 Feb;7(1):19

Nanosafety Research Center, Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland.

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http://dx.doi.org/10.1166/jbn.2011.1179DOI Listing
February 2011

Potential hazard of nanoparticles: from properties to biological and environmental effects.

Toxicology 2010 Mar 20;269(2-3):89-91. Epub 2010 Feb 20.

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http://dx.doi.org/10.1016/j.tox.2010.02.012DOI Listing
March 2010

Risk assessment of engineered nanomaterials and nanotechnologies--a review.

Toxicology 2010 Mar 25;269(2-3):92-104. Epub 2010 Jan 25.

Finnish Institute of Occupational Health, New Technologies and Risks, Topeliuksenkatu 41 aA, 00250 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.tox.2010.01.013DOI Listing
March 2010

Wood dusts induce the production of reactive oxygen species and caspase-3 activity in human bronchial epithelial cells.

Toxicology 2009 Aug 30;262(3):265-70. Epub 2009 Jun 30.

Finnish Institute of Occupational Health, Topeliuksenkatu 41 a, 00280 Helsinki, Finland.

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http://linkinghub.elsevier.com/retrieve/pii/S0300483X0900341
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http://dx.doi.org/10.1016/j.tox.2009.06.019DOI Listing
August 2009

Sharpening the focus on occupational safety and health in nanotechnology.

Scand J Work Environ Health 2008 Dec;34(6):471-8

National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS C-14, Cincinnati, OH 45226, USA.

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http://dx.doi.org/10.5271/sjweh.1292DOI Listing
December 2008

Genotoxicity of nanomaterials: DNA damage and micronuclei induced by carbon nanotubes and graphite nanofibres in human bronchial epithelial cells in vitro.

Toxicol Lett 2009 May 7;186(3):166-73. Epub 2008 Dec 7.

New Technologies and Risks, Work Environment Development, Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.toxlet.2008.11.019DOI Listing
May 2009

Inflammatory response and genotoxicity of seven wood dusts in the human epithelial cell line A549.

Mutat Res 2007 Aug 21;632(1-2):78-88. Epub 2007 May 21.

National Research Centre for the Working Environment, Lersø Park Allé 105, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.mrgentox.2007.04.016DOI Listing
August 2007

Immunomodulatory effects of oak dust exposure in a murine model of allergic asthma.

Toxicol Sci 2007 Sep 19;99(1):260-6. Epub 2007 Jun 19.

Unit of Excellence in Immunotoxicology, Team for Biological Mechanisms and Prevention of Work-related Diseases, Finnish Institute of Occupational Health, Helsinki, Finland.

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http://dx.doi.org/10.1093/toxsci/kfm145DOI Listing
September 2007

Fumonisin B1-induced apoptosis in neuroblastoma, glioblastoma and hypothalamic cell lines.

Toxicology 2006 Aug 13;225(2-3):234-41. Epub 2006 Jun 13.

Unit of Excellence for Immunotoxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, 00250 Helsinki, Finland.

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http://linkinghub.elsevier.com/retrieve/pii/S0300483X0600402
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http://dx.doi.org/10.1016/j.tox.2006.06.006DOI Listing
August 2006

Mechanisms of particle-induced pulmonary inflammation in a mouse model: exposure to wood dust.

Toxicol Sci 2006 Sep 1;93(1):96-104. Epub 2006 Jun 1.

Department of Industrial Hygiene and Toxicology, Department of Occupational Medicine, and Lappeenranta Regional Institute of Occupational Health, Lappeenranta, Finland.

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http://dx.doi.org/10.1093/toxsci/kfl026DOI Listing
September 2006

Comparison of hardwood and softwood dust-induced expression of cytokines and chemokines in mouse macrophage RAW 264.7 cells.

Toxicology 2006 Jan 3;218(1):13-21. Epub 2005 Oct 3.

Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41a A, 00250 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.tox.2005.09.001DOI Listing
January 2006

Characterization of oak and birch dust-induced expression of cytokines and chemokines in mouse macrophage RAW 264.7 cells.

Toxicology 2005 Nov 24;215(1-2):25-36. Epub 2005 Aug 24.

Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, 00250 Helsinki, Finland.

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http://linkinghub.elsevier.com/retrieve/pii/S0300483X0500295
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http://dx.doi.org/10.1016/j.tox.2005.06.021DOI Listing
November 2005

Oxidative stress induced by fumonisin B1 in continuous human and rodent neural cell cultures.

Free Radic Res 2004 Sep;38(9):933-42

Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FIN-00250 Helsinki, Finland.

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http://dx.doi.org/10.1080/10715760412331273205DOI Listing
September 2004

Fumonisin B1-induced toxicity and oxidative damage in U-118MG glioblastoma cells.

Toxicology 2004 Oct;202(3):173-83

Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, 00250 Helsinki, Finland.

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http://linkinghub.elsevier.com/retrieve/pii/S0300483X0400290
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http://dx.doi.org/10.1016/j.tox.2004.05.002DOI Listing
October 2004

Exposure to Aspergillus fumigatus spores induces chemokine expression in mouse macrophages.

Toxicology 2004 Aug;200(2-3):255-63

Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki.

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http://dx.doi.org/10.1016/j.tox.2004.03.019DOI Listing
August 2004

Good Evaluation Practice: a proposal of guidelines.

Toxicol Lett 2004 Jun;151(1):19-23

Malmfors Consulting AB, Karlskronavägen 22, S-121 52 Johanneshov, Vastmannagatan 48, 11325 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.toxlet.2004.02.016DOI Listing
June 2004

The opportunities and obstacles to collaboration between the developing and developed countries in the field of occupational health.

Toxicology 2004 May;198(1-3):63-74

Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FIN 00250 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.tox.2004.01.038DOI Listing
May 2004

Glutamate increases toxicity of inorganic lead in GT1-7 neurons: partial protection induced by flunarizine.

Arch Toxicol 2003 Dec 4;77(12):663-71. Epub 2003 Sep 4.

Department of Pharmacology and Toxicology, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland.

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http://dx.doi.org/10.1007/s00204-003-0498-zDOI Listing
December 2003

Pb2+-induced toxicity is associated with p53-independent apoptosis and enhanced by glutamate in GT1-7 neurons.

Toxicol Lett 2003 Sep;144(2):235-46

Department of Pharmacology and Toxicology, University of Kuopio, P.O.Box 1627, FIN-70211 Kuopio, Finland.

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http://dx.doi.org/10.1016/s0378-4274(03)00220-0DOI Listing
September 2003