Publications by authors named "Kai Lehmberg"

60Publications

Cell Versus Cytokine - Directed Therapies for Hemophagocytic Lymphohistiocytosis (HLH) in Inborn Errors of Immunity.

Front Immunol 2020 8;11:808. Epub 2020 May 8.

Center for Chronic Immunodeficiency, Medical Center, Faculty of Medicine, Institute for Immunodeficiency, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.3389/fimmu.2020.00808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225316PMC
May 2020

Hemophagocytic lymphohistiocytosis in adults: collaborative analysis of 137 cases of a nationwide German registry.

J Cancer Res Clin Oncol 2020 Apr 20;146(4):1065-1077. Epub 2020 Feb 20.

Klinik für Innere Medizin II, Hämatologie, Onkologie, Immunologie, Infektiologie und Palliativmedizin, Schwarzwald-Baar Klinikum, Klinikstr. 11, 78052, Villingen-Schwenningen, Germany.

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http://dx.doi.org/10.1007/s00432-020-03139-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085479PMC
April 2020

Distinct molecular response patterns of activating STAT3 mutations associate with penetrance of lymphoproliferation and autoimmunity.

Clin Immunol 2020 01 23;210:108316. Epub 2019 Nov 23.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Pediatrics, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2019.108316DOI Listing
January 2020

Haematopoietic Stem Cell Transplantation for Primary Haemophagocytic Lymphohistiocytosis.

Front Pediatr 2019 25;7:435. Epub 2019 Oct 25.

Department of Paediatric Immunology, Great Ormond Street Hospital, London, United Kingdom.

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http://dx.doi.org/10.3389/fped.2019.00435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823612PMC
October 2019

Ulceration in Prolidase Deficiency: Successful Treatment with Anticoagulants.

Acta Derm Venereol 2020 Jan 7;100(1):adv00002. Epub 2020 Jan 7.

Department of Dermatology, University Hospital of Münster, 48149 Münster, Germany.

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http://dx.doi.org/10.2340/00015555-3324DOI Listing
January 2020

Functional flow cytometry of monocytes for routine diagnosis of innate primary immunodeficiencies.

J Allergy Clin Immunol 2020 01 14;145(1):434-437.e4. Epub 2019 Sep 14.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Pediatrics, Department of Pediatric Hematology and Oncology, University Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.09.002DOI Listing
January 2020

The German National Registry of Primary Immunodeficiencies (2012-2017).

Authors:
Sabine M El-Helou Anika-Kerstin Biegner Sebastian Bode Stephan R Ehl Maximilian Heeg Maria E Maccari Henrike Ritterbusch Carsten Speckmann Stephan Rusch Raphael Scheible Klaus Warnatz Faranaz Atschekzei Renata Beider Diana Ernst Stev Gerschmann Alexandra Jablonka Gudrun Mielke Reinhold E Schmidt Gesine Schürmann Georgios Sogkas Ulrich H Baumann Christian Klemann Dorothee Viemann Horst von Bernuth Renate Krüger Leif G Hanitsch Carmen M Scheibenbogen Kirsten Wittke Michael H Albert Anna Eichinger Fabian Hauck Christoph Klein Anita Rack-Hoch Franz M Sollinger Anne Avila Michael Borte Stephan Borte Maria Fasshauer Anja Hauenherm Nils Kellner Anna H Müller Anett Ülzen Peter Bader Shahrzad Bakhtiar Jae-Yun Lee Ursula Heß Ralf Schubert Sandra Wölke Stefan Zielen Sujal Ghosh Hans-Juergen Laws Jennifer Neubert Prasad T Oommen Manfred Hönig Ansgar Schulz Sandra Steinmann Klaus Schwarz Gregor Dückers Beate Lamers Vanessa Langemeyer Tim Niehues Sonu Shai Dagmar Graf Carmen Müglich Marc T Schmalzing Eva C Schwaneck Hans-Peter Tony Johannes Dirks Gabriele Haase Johannes G Liese Henner Morbach Dirk Foell Antje Hellige Helmut Wittkowski Katja Masjosthusmann Michael Mohr Linda Geberzahn Christian M Hedrich Christiane Müller Angela Rösen-Wolff Joachim Roesler Antje Zimmermann Uta Behrends Nikolaus Rieber Uwe Schauer Rupert Handgretinger Ursula Holzer Jörg Henes Lothar Kanz Christoph Boesecke Jürgen K Rockstroh Carolynne Schwarze-Zander Jan-Christian Wasmuth Dagmar Dilloo Brigitte Hülsmann Stefan Schönberger Stefan Schreiber Rainald Zeuner Tobias Ankermann Philipp von Bismarck Hans-Iko Huppertz Petra Kaiser-Labusch Johann Greil Donate Jakoby Andreas E Kulozik Markus Metzler Nora Naumann-Bartsch Bettina Sobik Norbert Graf Sabine Heine Robin Kobbe Kai Lehmberg Ingo Müller Friedrich Herrmann Gerd Horneff Ariane Klein Joachim Peitz Nadine Schmidt Stefan Bielack Ute Groß-Wieltsch Carl F Classen Jessica Klasen Peter Deutz Dirk Kamitz Lisa Lassay Klaus Tenbrock Norbert Wagner Benedikt Bernbeck Bastian Brummel Eusebia Lara-Villacanas Esther Münstermann Dominik T Schneider Nadine Tietsch Marco Westkemper Michael Weiß Christof Kramm Ingrid Kühnle Silke Kullmann Hermann Girschick Christof Specker Elisabeth Vinnemeier-Laubenthal Henriette Haenicke Claudia Schulz Lothar Schweigerer Thomas G Müller Martina Stiefel Bernd H Belohradsky Veronika Soetedjo Gerhard Kindle Bodo Grimbacher

Front Immunol 2019 19;10:1272. Epub 2019 Jul 19.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.3389/fimmu.2019.01272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659583PMC
July 2019

[Zinc deficiency as the cause of a "decubital ulcer" in a preterm neonate?]

Z Geburtshilfe Neonatol 2019 Dec 6;223(6):369-372. Epub 2019 Jun 6.

Klinik für Kinder- und Jugenmedizin, Sektion Neonatologie und Pädiatrische Intensivmedizin, Universitätsklinikum Hamburg-Eppendorf, Hamburg.

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http://dx.doi.org/10.1055/a-0915-9779DOI Listing
December 2019

Recommendations for the Use of Etoposide-Based Therapy and Bone Marrow Transplantation for the Treatment of HLH: Consensus Statements by the HLH Steering Committee of the Histiocyte Society.

J Allergy Clin Immunol Pract 2018 Sep - Oct;6(5):1508-1517. Epub 2018 Jul 4.

Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, and Theme of Children's and Women's Health, Karolinska University Hospital Solna, Stockholm, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132198183038
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http://dx.doi.org/10.1016/j.jaip.2018.05.031DOI Listing
November 2019

Is an infectious trigger always required for primary hemophagocytic lymphohistiocytosis? Lessons from in utero and neonatal disease.

Pediatr Blood Cancer 2018 11 1;65(11):e27344. Epub 2018 Aug 1.

Center for Chronic Immunodeficiency, Medical Center University of Freiburg, Faculty of Medicine, Freiburg, Germany.

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http://dx.doi.org/10.1002/pbc.27344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168068PMC
November 2018

Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)-LRR oligomerization interface.

J Allergy Clin Immunol 2018 12 17;142(6):1956-1967.e6. Epub 2018 May 17.

Inflammation Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia; Department of Medical Biology, University of Melbourne, Parkville, Australia; Immunology Laboratory, Guangzhou Institute of Paediatrics, Guangzhou, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183071
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http://dx.doi.org/10.1016/j.jaci.2018.04.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281029PMC
December 2018

T-cell gene therapy for perforin deficiency corrects cytotoxicity defects and prevents hemophagocytic lymphohistiocytosis manifestations.

J Allergy Clin Immunol 2018 09 31;142(3):904-913.e3. Epub 2018 Jan 31.

Infection, Immunity, Inflammation, Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.11.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127027PMC
September 2018

Effective Immunological Guidance of Genetic Analyses Including Exome Sequencing in Patients Evaluated for Hemophagocytic Lymphohistiocytosis.

J Clin Immunol 2017 Nov 21;37(8):770-780. Epub 2017 Sep 21.

Center for Chronic Immunodeficiency, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1007/s10875-017-0443-1DOI Listing
November 2017

Hemophagocytic lymphohistiocytosis as presenting manifestation of profound combined immunodeficiency due to an ORAI1 mutation.

J Allergy Clin Immunol 2017 12 19;140(6):1721-1724. Epub 2017 Jun 19.

Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Pediatrics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.05.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723226PMC
December 2017

Primary and secondary hemophagocytic lymphohistiocytosis have different patterns of T-cell activation, differentiation and repertoire.

Eur J Immunol 2017 02 3;47(2):364-373. Epub 2017 Jan 3.

Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

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http://doi.wiley.com/10.1002/eji.201646686
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http://dx.doi.org/10.1002/eji.201646686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163530PMC
February 2017

Inherited Thrombotic Thrombocytopenic Purpura (Upshaw Schulman Syndrome) as Differential Diagnosis to Neonatal Septicaemia with Disseminated Intravascular Coagulation - a Case Series.

Z Geburtshilfe Neonatol 2017 Feb 6;221(1):39-42. Epub 2016 Jul 6.

Pediatric Hematology and Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1055/s-0042-109404DOI Listing
February 2017

EZH2 mutation in an adolescent with Weaver syndrome developing acute myeloid leukemia and secondary hemophagocytic lymphohistiocytosis.

Am J Med Genet A 2016 May 14;170A(5):1274-7. Epub 2016 Jan 14.

Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1002/ajmg.a.37562DOI Listing
May 2016

Out of the haemophagocytic lymphohistiocytosis niche.

Authors:
Kai Lehmberg

Lancet Haematol 2015 Dec 3;2(12):e508-9. Epub 2015 Dec 3.

Department of Paediatric Haematology and Oncology, University Medical Centre Hamburg Eppendorf, Hamburg 20246, Germany. Electronic address:

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http://dx.doi.org/10.1016/S2352-3026(15)00250-1DOI Listing
December 2015

Hemophagocytic syndromes--an update.

Blood Rev 2014 Jul 22;28(4):135-42. Epub 2014 Mar 22.

Pediatric Hematology and Oncology, University Medical Center Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1016/j.blre.2014.03.002DOI Listing
July 2014

Determination of an appropriate cut-off value for ferritin in the diagnosis of hemophagocytic lymphohistiocytosis.

Pediatr Blood Cancer 2014 Nov 21;61(11):2101-3. Epub 2014 Apr 21.

Pediatric Hematology and Oncology, University Hospital Medical Center, Hamburg, Germany.

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http://dx.doi.org/10.1002/pbc.25058DOI Listing
November 2014

Hemophagocytic lymphohistiocytosis: pathogenesis and treatment.

Hematology Am Soc Hematol Educ Program 2013 ;2013:605-11

1University Medical Center Eppendorf, Hamburg, Germany.

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http://www.asheducationbook.org/cgi/doi/10.1182/asheducation
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http://dx.doi.org/10.1182/asheducation-2013.1.605DOI Listing
July 2014

Syntaxin binding mechanism and disease-causing mutations in Munc18-2.

Proc Natl Acad Sci U S A 2013 Nov 5;110(47):E4482-91. Epub 2013 Nov 5.

Cambridge Institute for Medical Research, University of Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0XY, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1313474110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839780PMC
November 2013

Differentiating macrophage activation syndrome in systemic juvenile idiopathic arthritis from other forms of hemophagocytic lymphohistiocytosis.

J Pediatr 2013 Jun 17;162(6):1245-51. Epub 2013 Jan 17.

Department of Pediatric Hematology and Oncology, University Medical Center Eppendorf, Germany.

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http://dx.doi.org/10.1016/j.jpeds.2012.11.081DOI Listing
June 2013

Diagnostic evaluation of patients with suspected haemophagocytic lymphohistiocytosis.

Br J Haematol 2013 Feb 4;160(3):275-87. Epub 2012 Dec 4.

Department of Paediatric Haematology and Oncology, University Medical Centre, Hamburg, Germany.

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http://doi.wiley.com/10.1111/bjh.12138
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http://dx.doi.org/10.1111/bjh.12138DOI Listing
February 2013

Administration of recombinant erythropoietin alone does not improve the phenotype in iron refractory iron deficiency anemia patients.

Ann Hematol 2013 Mar 20;92(3):387-94. Epub 2012 Nov 20.

Department of Pediatric Hematology and Oncology, University Medical Center Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.

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http://dx.doi.org/10.1007/s00277-012-1618-8DOI Listing
March 2013

Recent advances in the diagnosis and treatment of hemophagocytic lymphohistiocytosis.

Arthritis Res Ther 2012 Jun 8;14(3):213. Epub 2012 Jun 8.

Centre of Chronic Immunodeficiency, University Medical Center Freiburg, D-79106 Freiburg, Germany.

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http://arthritis-research.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/ar3843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446494PMC
June 2012

Fulminant Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis.

Laryngoscope 2013 Feb 30;123(2):362-5. Epub 2012 May 30.

Department of Otorhinolaryngology, Jena University Hospital, Jena, Germany.

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http://dx.doi.org/10.1002/lary.23433DOI Listing
February 2013

Risk factors for early death in children with haemophagocytic lymphohistiocytosis.

Acta Paediatr 2012 Mar 17;101(3):313-8. Epub 2011 Nov 17.

Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.

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http://doi.wiley.com/10.1111/j.1651-2227.2011.02501.x
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http://dx.doi.org/10.1111/j.1651-2227.2011.02501.xDOI Listing
March 2012

Pancytopenia in a 4-year-old boy. 22q11.2 microdeletion syndrome.

Acta Paediatr 2009 May;98(5):769-70, 912-4

Department of Haematology and Oncology, Children's Hospital, University of Hamburg, Germany.

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http://dx.doi.org/10.1111/j.1651-2227.2009.00920.xDOI Listing
May 2009