Kai Kisand

Kai Kisand

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Kai Kisand

Kai Kisand

Publications by authors named "Kai Kisand"

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60Publications

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Delineating the Healthy Human Skin UV Response and Early Induction of Interferon Pathway in Cutaneous Lupus Erythematosus.

J Invest Dermatol 2019 Sep 8;139(9):2058-2061.e4. Epub 2019 Apr 8.

Department of Dermatology and Allergology, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.jid.2019.02.035DOI Listing
September 2019

Interferon signature in patients with STAT1 gain-of-function mutation is epigenetically determined.

Eur J Immunol 2019 May 7;49(5):790-800. Epub 2019 Mar 7.

Department of Biomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.

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http://dx.doi.org/10.1002/eji.201847955DOI Listing
May 2019

Unstimulated Adult Human B Cells Include an IL-10+ Population with Suppressive Properties and an Activated Phenotype.

Cytometry A 2018 11 21;93(11):1150-1156. Epub 2018 Oct 21.

Department of Biomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.

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http://dx.doi.org/10.1002/cyto.a.23636DOI Listing
November 2018

Double Trouble? CMC with a Mutation in both AIRE and STAT1.

J Clin Immunol 2018 08 27;38(6):635-637. Epub 2018 Jul 27.

Department of Paediatric Immunology and Infectious Diseases, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland.

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http://dx.doi.org/10.1007/s10875-018-0536-5DOI Listing
August 2018

Aortic Calcification in a Patient with a Gain-of-Function STAT1 Mutation.

J Clin Immunol 2018 05 26;38(4):468-470. Epub 2018 May 26.

Department of Paediatric Immunology and Infectious Diseases, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland.

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http://dx.doi.org/10.1007/s10875-018-0513-zDOI Listing
May 2018

IL-22 neutralizing autoantibodies impair fungal clearance in murine oropharyngeal candidiasis model.

Eur J Immunol 2018 03 11;48(3):464-470. Epub 2017 Dec 11.

Department of Molecular Pathology, Institute of Biomedical and Translational Medicine, University of Tartu, Tartu, Estonia.

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http://dx.doi.org/10.1002/eji.201747209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844855PMC
March 2018

Irf4 Expression in Thymic Epithelium Is Critical for Thymic Regulatory T Cell Homeostasis.

J Immunol 2017 03 20;198(5):1952-1960. Epub 2017 Jan 20.

Institute of Biomedicine and Translational Medicine, University of Tartu, 50411 Tartu, Estonia; and.

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http://dx.doi.org/10.4049/jimmunol.1601698DOI Listing
March 2017

Pregnancy-induced thymic involution is associated with suppression of chemokines essential for T-lymphoid progenitor homing.

Eur J Immunol 2016 08 9;46(8):2008-17. Epub 2016 Jun 9.

Molecular Pathology, Institute of Biomedicine and Translational Medicine, Tartu University, Tartu, Estonia.

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http://dx.doi.org/10.1002/eji.201646309DOI Listing
August 2016

Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype.

Blood 2016 06 25;127(25):3154-64. Epub 2016 Apr 25.

Paris Descartes University, Sorbonne Paris Cité, Institut Imagine, Paris, France; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Necker Medical School, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY; Department of Infectious and Tropical Diseases, Necker-Enfants Malades Hospital, AP-HP, Paris, France.

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http://dx.doi.org/10.1182/blood-2015-11-679902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920021PMC
June 2016

IL-6-specific autoantibodies among APECED and thymoma patients.

Immun Inflamm Dis 2016 06 25;4(2):235-243. Epub 2016 May 25.

Molecular Pathology Research Group, Institute of Biomedicine and Translational Medicine University of Tartu Tartu Estonia.

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http://dx.doi.org/10.1002/iid3.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879469PMC
June 2016

SP140L, an Evolutionarily Recent Member of the SP100 Family, Is an Autoantigen in Primary Biliary Cirrhosis.

J Immunol Res 2015 11;2015:526518. Epub 2015 Aug 11.

Molecular Pathology Group, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411 Tartu, Estonia.

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http://dx.doi.org/10.1155/2015/526518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548144PMC
May 2016

Anticommensal Responses Are Associated with Regulatory T Cell Defect in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients.

J Immunol 2016 Apr 22;196(7):2955-64. Epub 2016 Feb 22.

Department of Bacteriology and Immunology, University of Helsinki, 00290 Helsinki, Finland; Research Programs Unit, Immunobiology Research Program, University of Helsinki, 00014 Helsinki, Finland;

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http://dx.doi.org/10.4049/jimmunol.1500301DOI Listing
April 2016

TNF superfamily members play distinct roles in shaping the thymic stromal microenvironment.

Mol Immunol 2016 Apr 21;72:92-102. Epub 2016 Mar 21.

Molecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu 50411, Estonia.

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http://dx.doi.org/10.1016/j.molimm.2016.02.015DOI Listing
April 2016

Epigenetic profiling in CD4+ and CD8+ T cells from Graves' disease patients reveals changes in genes associated with T cell receptor signaling.

J Autoimmun 2016 Feb 12;67:46-56. Epub 2015 Oct 12.

Molecular Pathology, Institute of Biomedical and Translational Medicine, Tartu, Estonia. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2015.09.006DOI Listing
February 2016

A highly conserved NF-κB-responsive enhancer is critical for thymic expression of Aire in mice.

Eur J Immunol 2015 Dec 26;45(12):3246-56. Epub 2015 Oct 26.

Molecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.

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http://doi.wiley.com/10.1002/eji.201545928
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http://dx.doi.org/10.1002/eji.201545928DOI Listing
December 2015

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy.

J Clin Immunol 2015 Jul 5;35(5):463-78. Epub 2015 Jul 5.

Institute of Biomedicine and Translational Medicine, University of Tartu, 19 Ravila Str., Tartu, EE50411, Estonia,

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http://dx.doi.org/10.1007/s10875-015-0176-yDOI Listing
July 2015

Clinical, Genetic and Immunological Characteristics of Paediatric Autoimmune Polyglandular Syndrome Type 1 Patients in Slovenia.

Zdr Varst 2015 Jun 13;54(2):112-8. Epub 2015 Mar 13.

University of Ljubljana, Faculty of Medicine, Vrazov trg 2, 1000 Ljubljana, Slovenia; University Medical Centre Ljubljana, University Children's Hospital, Unit for Special Laboratory Diagnostics, Vrazov trg 1, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1515/sjph-2015-0017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820163PMC
June 2015

Dysregulation of adaptive immune responses in complement C3-deficient patients.

Eur J Immunol 2015 Mar 19;45(3):915-21. Epub 2015 Jan 19.

Haartman Institute and Research Programs Unit, Immunobiology, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/eji.201444948DOI Listing
March 2015

In vivo analysis of helper T cell responses in patients with autoimmune polyendocrinopathy - candidiasis - ectodermal dystrophy provides evidence in support of an IL-22 defect.

Autoimmunity 2014 Dec 24;47(8):556-62. Epub 2014 Jun 24.

Department of Immunology, Haartman Institute, and Research Programs Unit, Immunobiology, University of Helsinki , Helsinki , Finland .

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http://dx.doi.org/10.3109/08916934.2014.929666DOI Listing
December 2014

Clinical and serologic parallels to APS-I in patients with thymomas and autoantigen transcripts in their tumors.

J Immunol 2014 Oct 17;193(8):3880-90. Epub 2014 Sep 17.

Department of Clinical Science, University of Bergen, 5021 Bergen, Norway; Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway;

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http://dx.doi.org/10.4049/jimmunol.1401068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190667PMC
October 2014

Lymphopenia-induced proliferation in aire-deficient mice helps to explain their autoimmunity and differences from human patients.

Front Immunol 2014 13;5:51. Epub 2014 Feb 13.

Molecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu , Tartu , Estonia.

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http://dx.doi.org/10.3389/fimmu.2014.00051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923166PMC
June 2014

CpG sites associated with NRP1, NRXN2 and miR-29b-2 are hypomethylated in monocytes during ageing.

Immun Ageing 2014 Jan 9;11(1). Epub 2014 Jan 9.

Molecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu, 19 Ravila St, Tartu 50411, Estonia.

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http://dx.doi.org/10.1186/1742-4933-11-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896835PMC
January 2014

Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study.

Lancet Neurol 2013 Dec 30;12(12):1159-69. Epub 2013 Oct 30.

Manchester Centre for Genomic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences Centre (MAHSC), Manchester, UK.

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http://dx.doi.org/10.1016/S1474-4422(13)70258-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349523PMC
December 2013

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy and other primary immunodeficiency diseases help to resolve the nature of protective immunity against chronic mucocutaneous candidiasis.

Curr Opin Pediatr 2013 Dec;25(6):715-21

Molecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.

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http://dx.doi.org/10.1097/MOP.0000000000000028DOI Listing
December 2013

Primary biliary cirrhosis: a multi-faced interactive disease involving genetics, environment and the immune response.

APMIS 2012 Nov 15;120(11):857-71. Epub 2012 May 15.

Institute of General and Molecular Pathology, Centre of Excellence for Translational Medicine, University of Tartu, Tartu, Estonia.

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http://dx.doi.org/10.1111/j.1600-0463.2012.02914.xDOI Listing
November 2012

AIRE-induced apoptosis is associated with nuclear translocation of stress sensor protein GAPDH.

Biochem Biophys Res Commun 2012 Jun 18;423(1):32-7. Epub 2012 May 18.

Molecular Pathology, Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia.

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X120093
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http://dx.doi.org/10.1016/j.bbrc.2012.05.057DOI Listing
June 2012

Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens.

Front Immunol 2012 Mar;3(March):19

Molecular Pathology, Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia.

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http://dx.doi.org/10.3389/fimmu.2012.00019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310317PMC
March 2012

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy: known and novel aspects of the syndrome.

Ann N Y Acad Sci 2011 Dec;1246:77-91

Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia.

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http://dx.doi.org/10.1111/j.1749-6632.2011.06308.xDOI Listing
December 2011

Mucocutaneous candidiasis and autoimmunity against cytokines in APECED and thymoma patients: clinical and pathogenetic implications.

Eur J Immunol 2011 Jun 13;41(6):1517-27. Epub 2011 May 13.

Molecular Pathology Group, Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia.

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http://doi.wiley.com/10.1002/eji.201041253
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http://dx.doi.org/10.1002/eji.201041253DOI Listing
June 2011

Human peripheral lymphoid tissues contain autoimmune regulator-expressing dendritic cells.

Am J Pathol 2010 Mar 21;176(3):1104-12. Epub 2010 Jan 21.

Department of Pathology, University of Brescia, P.le Spedali Civili 1, 25123, Brescia, Italy.

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http://dx.doi.org/10.2353/ajpath.2010.090956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832133PMC
March 2010

Ultrastructure of medullary thymic epithelial cells of autoimmune regulator (Aire)-deficient mice.

Immunol Cell Biol 2010 Jan 1;88(1):50-6. Epub 2009 Sep 1.

Faculty of Medicine, Institute of Histology and Embryology, University of Beograd, Beograd, Serbia.

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http://dx.doi.org/10.1038/icb.2009.55DOI Listing
January 2010

AIRE activated tissue specific genes have histone modifications associated with inactive chromatin.

Hum Mol Genet 2009 Dec 10;18(24):4699-710. Epub 2009 Sep 10.

Department of Molecular Pathology, Institute of General and Molecular Pathology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.

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http://dx.doi.org/10.1093/hmg/ddp433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778368PMC
December 2009

Metallophilic macrophages are fully developed in the thymus of autoimmune regulator (Aire)-deficient mice.

Histochem Cell Biol 2009 May 16;131(5):643-9. Epub 2009 Jan 16.

Institute of Histology and Embryology, University of Belgrade Medical School, Belgrade, Serbia.

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http://dx.doi.org/10.1007/s00418-008-0553-1DOI Listing
May 2009

Incontinentia pigmenti in a female conceived by in vitro fertilization.

Am J Med Genet A 2008 Dec;146A(23):3092-4

Department of Immunology, Institute of General and Molecular Pathology, University of Tartu, and Department of Genetics, United Laboratory, Tartu University Hospital, Tartu, Estonia.

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http://dx.doi.org/10.1002/ajmg.a.32565DOI Listing
December 2008

Modulation of Aire regulates the expression of tissue-restricted antigens.

Mol Immunol 2008 Jan 28;45(1):25-33. Epub 2007 Jun 28.

Molecular Pathology, Biomedicum, Tartu University, Ravila 19, 50411 Tartu, Estonia.

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http://dx.doi.org/10.1016/j.molimm.2007.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994210PMC
January 2008

Propensity to excessive proinflammatory response in chronic Lyme borreliosis.

APMIS 2007 Feb;115(2):134-41

Department of Immunology, Institute of General and Molecular Pathology, Centre of Molecular and Clinical Medicine, Tartu, Estonia.

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http://dx.doi.org/10.1111/j.1600-0463.2007.apm_538.xDOI Listing
February 2007

Serological description of Estonian patients with Lyme disease, a comparison with control sera from endemic and non-endemic areas.

Int J Med Microbiol 2004 Apr;293 Suppl 37:174-8

University of Tartu, Department of Immunology, Tartu, Estonia.

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http://dx.doi.org/10.1016/s1433-1128(04)80035-4DOI Listing
April 2004