Kai Kappert

Kai Kappert

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Kai Kappert

Publications by authors named "Kai Kappert"

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Underfilling of vacuum blood collection tubes leads to increased lactate dehydrogenase activity in serum and heparin plasma samples.

Clin Chem Lab Med 2020 Jan;58(2):213-221

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Berlin, Germany.

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http://dx.doi.org/10.1515/cclm-2019-0616DOI Listing
January 2020

Sex-specific metabolic and functional differences in human umbilical vein endothelial cells from twin pairs.

Atherosclerosis 2019 12 10;291:99-106. Epub 2019 Oct 10.

Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Medizinische Klinik für Kardiologie und Angiologie, Campus Mitte, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.10.007DOI Listing
December 2019

Platelet-derived growth factor receptor β activation and regulation in murine myelofibrosis.

Haematologica 2019 Oct 31. Epub 2019 Oct 31.

Charité-Universitätsmedizin Berlin, Germany;

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http://dx.doi.org/10.3324/haematol.2019.226332DOI Listing
October 2019

Pulmonary arterial remodelling by deficiency of peroxisome proliferator-activated receptor-γ in murine vascular smooth muscle cells occurs independently of obesity-related pulmonary hypertension.

Respir Res 2019 Feb 27;20(1):42. Epub 2019 Feb 27.

Berlin Institute of Health, Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Center for Cardiovascular Research (CCR), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

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http://dx.doi.org/10.1186/s12931-019-1003-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391752PMC
February 2019

The effect of blood sampling and preanalytical processing on human N-glycome.

PLoS One 2018 11;13(7):e0200507. Epub 2018 Jul 11.

Charité -Universitätsmedizin Berlin, Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Berlin, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200507PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040761PMC
January 2019

The cytoskeleton in 'couch potato-ism': Insights from a murine model of impaired actin dynamics.

Exp Neurol 2018 08 21;306:34-44. Epub 2018 Apr 21.

Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Klinik für Psychiatrie und Psychotherapie, 10117 Berlin, Germany; Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsmedizin Rostock, 18147 Rostock, Germany.

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http://dx.doi.org/10.1016/j.expneurol.2018.04.004DOI Listing
August 2018

AT1-receptor blockade attenuates outward aortic remodeling associated with diet-induced obesity in mice.

Clin Sci (Lond) 2017 Aug 13;131(15):1989-2005. Epub 2017 Jul 13.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; and Berlin Institute of Health, Institute of Pharmacology, Center for Cardiovascular Research (CCR), Germany

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http://dx.doi.org/10.1042/CS20170131DOI Listing
August 2017

High incidence of cardiac dysfunction and response to antiviral treatment in patients with chronic hepatitis C virus infection.

Clin Res Cardiol 2017 Jul 24;106(7):551-556. Epub 2017 Feb 24.

Department of Cardiology, Campus Benjamin Franklin, CC11, Charité-Universitätsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany.

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http://dx.doi.org/10.1007/s00392-017-1086-1DOI Listing
July 2017

PCSK9 regulates the chemokine receptor CCR2 on monocytes.

Biochem Biophys Res Commun 2017 04 20;485(2):312-318. Epub 2017 Feb 20.

Department of Medicine/Cardiology, Deutsches Herzzentrum Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.02.085DOI Listing
April 2017

Activation of Peroxisome Proliferator-Activated Receptor-δ as Novel Therapeutic Strategy to Prevent In-Stent Restenosis and Stent Thrombosis.

Arterioscler Thromb Vasc Biol 2016 08 9;36(8):1534-48. Epub 2016 Jun 9.

From the Department of Molecular Medicine, A.I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland (J.H., S.Y.-H.); Centre for R&D, Uppsala University/County Council of Gaevleborg, Gaevle, Sweden (O.L.); Institute for Pathology, University Clinic of Schleswig-Holstein, Campus Kiel, Kiel, Germany (J.H.B.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (W.-H.S., D.M., A.H., J.-D.D., L.T., F.B.); Department of Cardiology (B.P., F.B.) and Center for Cardiovascular Research/CCR, Institute of Laboratory Medicine Clinical Chemistry and Pathobiochemistry (K.K.), Charité-Universitaetsmedizin Berlin, Berlin, Germany; Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies (BCRT), Helmholtz-Zentrum Geesthacht, Teltow, Germany (F.J., C.M.); Institute for Diabetes and Obesity, Helmholtz Zentrum Muenchen, Munich, German Research Center for Environmental Health, Germany (M.J.); and Cologne Interventional Immunology, University Hospital of Cologne, Cologne, Germany (M.v.B.-B.).

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.115.306962
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http://dx.doi.org/10.1161/ATVBAHA.115.306962DOI Listing
August 2016

The pharmacological rationale behind polypharmacy in heart failure.

Heart Fail Monit 2008 ;6(1):20-7

Center for Cardiovascular Research/Institute of Pharmacology, Charité University Medicine Berlin, Berlin, Germany.

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April 2016

Inhibition of Src homology 2 domain-containing phosphatase 1 increases insulin sensitivity in high-fat diet-induced insulin-resistant mice.

FEBS Open Bio 2016 Mar 4;6(3):179-89. Epub 2016 Jan 4.

Center for Cardiovascular Research/CCR Institute of Laboratory Medicine Clinical Chemistry and Pathobiochemistry Charité - Universitätsmedizin Germany.

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http://dx.doi.org/10.1002/2211-5463.12000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794785PMC
March 2016

Fibroblast VEGF-receptor 1 expression as molecular target in periodontitis.

J Clin Periodontol 2016 Feb 23;43(2):128-37. Epub 2016 Feb 23.

Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Center for Cardiovascular Research (CCR), Charité-University Medicine Berlin, Berlin, Germany.

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http://dx.doi.org/10.1111/jcpe.12495DOI Listing
February 2016

CT-proET1 predicts pulmonary hemodynamics in Scleroderma-associated pulmonary hypertension.

Clin Res Cardiol 2015 Jun 24;104(6):525-9. Epub 2015 Feb 24.

Klinik III für Innere Medizin, Herzzentrum der Universität zu Köln, Kerpener Str. 62, 50937, Cologne, Germany.

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http://dx.doi.org/10.1007/s00392-015-0825-4DOI Listing
June 2015

Enhanced insulin signaling in density-enhanced phosphatase-1 (DEP-1) knockout mice.

Mol Metab 2015 Apr 12;4(4):325-36. Epub 2015 Feb 12.

Center for Cardiovascular Research/CCR, Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Hessische Str. 3-4, 10115 Berlin, Charité - Universitätsmedizin Berlin, Germany.

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http://dx.doi.org/10.1016/j.molmet.2015.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354926PMC
April 2015

Inhibition of protein tyrosine phosphatases enhances cerebral collateral growth in rats.

J Mol Med (Berl) 2014 Sep 27;92(9):983-94. Epub 2014 May 27.

Center for Cardiovascular Research (CCR), Department of Internal Medicine/Cardiology, Richard-Thoma-Laboratories for Arteriogenesis, Charité-University Medicine Berlin, Hessische Str. 3-4, 10115, Berlin, Germany.

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http://dx.doi.org/10.1007/s00109-014-1164-zDOI Listing
September 2014

Knockout of Density-Enhanced Phosphatase-1 impairs cerebrovascular reserve capacity in an arteriogenesis model in mice.

Biomed Res Int 2013 20;2013:802149. Epub 2013 Aug 20.

Center for Cardiovascular Research (CCR), Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charité-University Medicine Berlin, Hessische Straße 3-4, 10115 Berlin, Germany.

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http://dx.doi.org/10.1155/2013/802149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763586PMC
April 2014

Cannabinoid receptor 1 inhibition improves cardiac function and remodelling after myocardial infarction and in experimental metabolic syndrome.

J Mol Med (Berl) 2013 Jul 1;91(7):811-23. Epub 2013 May 1.

Center for Cardiovascular Research (CCR) and Institute of Pharmacology, Charité-Universitätsmedizin, Hessische Strasse 3-4, 10115 Berlin, Germany.

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http://dx.doi.org/10.1007/s00109-013-1034-0DOI Listing
July 2013

Proprotein convertase furin enhances survival and migration of vascular smooth muscle cells via processing of pro-nerve growth factor.

J Biochem 2013 Feb 21;153(2):197-207. Epub 2012 Nov 21.

Department of Medicine/Cardiology, Deutsches Herzzentrum Berlin, Germany.

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http://dx.doi.org/10.1093/jb/mvs137DOI Listing
February 2013

The molecular biology of furin-like proprotein convertases in vascular remodelling.

Methods Mol Biol 2011 ;768:191-206

Department of Medicine/Cardiology, Deutsches Herzzentrum Berlin, D-13353, Berlin, Germany.

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http://link.springer.com/10.1007/978-1-61779-204-5_9
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http://dx.doi.org/10.1007/978-1-61779-204-5_9DOI Listing
March 2012

Histone deacetylase 6 (HDAC6) is an essential modifier of glucocorticoid-induced hepatic gluconeogenesis.

Diabetes 2012 Feb 30;61(2):513-23. Epub 2011 Dec 30.

Institute of Pharmacology, Department of Endocrinology, Diabetes and Nutrition, Charité Medical University, the Center for Cardiovascular Research, Berlin, Germany.

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http://dx.doi.org/10.2337/db11-0313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266407PMC
February 2012

High-dose treatment with telmisartan induces monocytic peroxisome proliferator-activated receptor-γ target genes in patients with the metabolic syndrome.

Hypertension 2011 Oct 29;58(4):725-32. Epub 2011 Aug 29.

Center for Cardiovascular Research, Institute of Pharmacology, Outpatient Clinic, Charité Campus Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.173542DOI Listing
October 2011

Adipose tissue-derived soluble fms-like tyrosine kinase 1 is an obesity-relevant endogenous paracrine adipokine.

Hypertension 2011 Jul 9;58(1):37-42. Epub 2011 May 9.

Experimental and Clinical Research Center, Max-Delbrueck Center for Molecular Medicine, Charitè Campus Buch, Lindenbergerweg 80, 13125 Berlin, Germany.

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.111.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.171322DOI Listing
July 2011

Hypoxia followed by re-oxygenation induces oxidation of tyrosine phosphatases.

Cell Signal 2011 May 15;23(5):820-6. Epub 2011 Jan 15.

Cancer Centrum Karolinska, Department of Oncology-Pathology, Karolinska Institutet, 17176 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.cellsig.2011.01.004DOI Listing
May 2011

Hypoxia enhances platelet-derived growth factor signaling in the pulmonary vasculature by down-regulation of protein tyrosine phosphatases.

Am J Respir Crit Care Med 2011 Apr 22;183(8):1092-102. Epub 2010 Dec 22.

Klinik III für Innere Medizin, Herzzentrum der Universität zu Köln, Kerpener Strasse 62, Köln, Germany.

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http://dx.doi.org/10.1164/rccm.200911-1663OCDOI Listing
April 2011

U373-MG cells express PepT2 and accumulate the fluorescently tagged dipeptide-derivative β-Ala-Lys-N(ε)-AMCA.

Neurosci Lett 2010 Dec 22;486(3):174-8. Epub 2010 Sep 22.

Zentralinstitut für Laboratoriumsmedizin und Pathobiochemie, Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany.

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http://dx.doi.org/10.1016/j.neulet.2010.09.046DOI Listing
December 2010

Effect of high-dose valsartan on inflammatory and lipid parameters in patients with Type 2 diabetes and hypertension.

Diabetes Res Clin Pract 2010 Sep;89(3):209-15

Center for Cardiovascular Research, Institute of Pharmacology, Charité-Universitätsmedizin Berlin, Hessische Str 3-4, 10115 Berlin, Germany.

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http://dx.doi.org/10.1016/j.diabres.2010.04.018DOI Listing
September 2010

IGF-1 increases macrophage motility via PKC/p38-dependent alphavbeta3-integrin inside-out signaling.

Biochem Biophys Res Commun 2010 Apr 15;394(3):786-91. Epub 2010 Mar 15.

Department of Medicine/Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2010.03.072DOI Listing
April 2010

Integrin cleavage regulates bidirectional signalling in vascular smooth muscle cells.

Thromb Haemost 2010 Mar 13;103(3):556-63. Epub 2010 Jan 13.

Department of Medicine/ Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany.

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http://dx.doi.org/10.1160/TH09-07-0478DOI Listing
March 2010

Cardiac c-kit+AT2+ cell population is increased in response to ischemic injury and supports cardiomyocyte performance.

Stem Cells 2009 Oct;27(10):2488-97

Center for Cardiovascular Research and Institute of Pharmacology, Charité - Universitätsmedizin Berlin, Germany.

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http://dx.doi.org/10.1002/stem.171DOI Listing
October 2009

Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARgamma activation.

Hypertension 2009 Oct 17;54(4):738-43. Epub 2009 Aug 17.

Center for Cardiovascular Research, Institute of Pharmacology, Charité-Universitätsmedizin Berlin, Hessische Strasse 3-4, Berlin, Germany.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.109.132886DOI Listing
October 2009

Integrin cleavage facilitates cell surface-associated proteolysis required for vascular smooth muscle cell invasion.

Int J Biochem Cell Biol 2009 Jul 8;41(7):1511-7. Epub 2009 Jan 8.

Department of Medicine/Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, Berlin, Germany.

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http://dx.doi.org/10.1016/j.biocel.2009.01.004DOI Listing
July 2009

Estrogen receptor alpha supports cardiomyocytes indirectly through post-infarct cardiac c-kit+ cells.

J Mol Cell Cardiol 2009 Jul 31;47(1):66-75. Epub 2009 Mar 31.

Center for Cardiovascular Research (CCR) and Institute of Pharmacology, Charité - Universitätsmedizin Berlin, Hessische Str. 3-4, 10115 Berlin, Germany.

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http://dx.doi.org/10.1016/j.yjmcc.2009.03.014DOI Listing
July 2009

Regulation of tyrosine phosphatases in the adventitia during vascular remodelling.

Biochem Biophys Res Commun 2009 May 18;382(4):678-84. Epub 2009 Mar 18.

Cancer Centrum Karolinska, Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bbrc.2009.03.078DOI Listing
May 2009

bFGF rescues imatinib/STI571-induced apoptosis of sis-NIH3T3 fibroblasts.

Biochem Biophys Res Commun 2009 Apr 10;381(2):165-70. Epub 2009 Feb 10.

Department of Biochemistry, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8310, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2009.02.012DOI Listing
April 2009

Insulin facilitates monocyte migration: a possible link to tissue inflammation in insulin-resistance.

Biochem Biophys Res Commun 2008 Jan 20;365(3):503-8. Epub 2007 Nov 20.

Center for Cardiovascular Research, Institute of Pharmacology, Charité Campus Mitte, Charité-Universitätsmedizin Berlin, Hessische Str. 3-4, D-10115 Berlin, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2007.11.006DOI Listing
January 2008

Oxidation sensitivity of the catalytic cysteine of the protein-tyrosine phosphatases SHP-1 and SHP-2.

Free Radic Biol Med 2007 Jul 31;43(1):100-10. Epub 2007 Mar 31.

Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, SE-75185 Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.freeradbiomed.2007.03.021DOI Listing
July 2007

In situ identification of genes regulated specifically in fibroblasts of human basal cell carcinoma.

J Invest Dermatol 2007 Jun 1;127(6):1516-23. Epub 2007 Feb 1.

Department of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/sj.jid.5700714DOI Listing
June 2007

Dynamic changes in the expression of DEP-1 and other PDGF receptor-antagonizing PTPs during onset and termination of neointima formation.

FASEB J 2007 Feb 8;21(2):523-34. Epub 2006 Dec 8.

Cancer Centrum Karolinska, Department of Oncology-Pathology, Karolinska Institutet, 17176 Stockholm, Sweden.

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http://dx.doi.org/10.1096/fj.06-6219comDOI Listing
February 2007

Antioxidants relieve phosphatase inhibition and reduce PDGF signaling in cultured VSMCs and in restenosis.

Arterioscler Thromb Vasc Biol 2006 Dec 21;26(12):2644-51. Epub 2006 Sep 21.

Department of Oncology-Pathology, Karolinska Institutet, 17176 Stockholm, Sweden.

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https://www.ahajournals.org/doi/10.1161/01.ATV.0000246777.30
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http://dx.doi.org/10.1161/01.ATV.0000246777.30819.85DOI Listing
December 2006

17Beta-estradiol attenuates PDGF signaling in vascular smooth muscle cells at the postreceptor level.

Am J Physiol Heart Circ Physiol 2006 Feb 14;290(2):H538-46. Epub 2005 Oct 14.

Klinik III für Innere Medizin der Universität zu Köln, Kerpener Str. 62, 50924 Köln, Germany.

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http://dx.doi.org/10.1152/ajpheart.00240.2005DOI Listing
February 2006

Tyrosine phosphatases in vessel wall signaling.

Cardiovasc Res 2005 Feb;65(3):587-98

Cancer Center Karolinska, Department of Oncology and Pathology, Karolinska Institutet, 17176 Stockholm, Sweden.

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https://academic.oup.com/cardiovascres/article-lookup/doi/10
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http://dx.doi.org/10.1016/j.cardiores.2004.08.016DOI Listing
February 2005

An antibody-based method for monitoring in vivo oxidation of protein tyrosine phosphatases.

Methods 2005 Jan;35(1):37-43

Ludwig Institute for Cancer Research, Box 595, SE-751 24 Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.ymeth.2004.07.006DOI Listing
January 2005

Ritonavir exhibits anti-atherogenic properties on vascular smooth muscle cells.

AIDS 2004 Feb;18(3):403-11

Klinik III für Innere Medizin, the Abteilung für Herzchirurgie der Universität zu Köln, Joseph-Stelzmann-Str. 9, 50924 Köln, Klinik I für Innere Medizin, Germany.

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http://dx.doi.org/10.1097/00002030-200402200-00005DOI Listing
February 2004

Angiotensin II-augmented migration of VSMCs towards PDGF-BB involves Pyk2 and ERK 1/2 activation.

Basic Res Cardiol 2002 Jul;97(4):334-42

Deutsches Herzzentrum Berlin, Department of Medicine/Cardiology, Augustenburger Platz 1, 13353 Berlin, Germany.

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http://dx.doi.org/10.1007/s00395-002-0357-8DOI Listing
July 2002