Publications by authors named "Kah-Leong Lim"

100Publications

Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development.

Authors:
Saravanan Gunaseelan Ziyin Wang Venetia Kok Jing Tong Sylvester Wong Shu Ming Rafhanah Banu Bte Abdul Razar Sumitra Srimasorn Wei-Yi Ong Kah-Leong Lim John Jia En Chua

Hum Mol Genet 2021 Jan 4. Epub 2021 Jan 4.

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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January 2021

Nanotheranostic agents for neurodegenerative diseases.

Authors:
Parasuraman Padmanabhan Mathangi Palanivel Ajay Kumar Domokos Máthé George K Radda Kah-Leong Lim Balázs Gulyás

Emerg Top Life Sci 2020 Dec 15. Epub 2020 Dec 15.

Lee Kong Chian School of Medicine, Nanyang Technological University (NTU), Singapore 636921.

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December 2020

Complete Genome Sequence of Serratia marcescens FY, Isolated from Drosophila melanogaster.

Authors:
Wei Liu Ruxue Kang Kah Leong Lim Eng King Tan

Microbiol Resour Announc 2020 Nov 5;9(45). Epub 2020 Nov 5.

Department of Neurology, National Neuroscience Institute, Singapore, Singapore

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November 2020

Mitochondria-targeted polydopamine nanoprobes for visualizing endogenous sulfur dioxide derivatives in a rat epilepsy model.

Authors:
Qiaoqiao Ci Xiaofei Qin Jinhua Liu Rui Wang Zheng Li Wenjing Qin Kah-Leong Lim Cheng-Wu Zhang Lin Li

Chem Commun (Camb) 2020 Oct 3;56(79):11823-11826. Epub 2020 Sep 3.

Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, P. R. China.

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October 2020

A microfiber scaffold-based 3D in vitro human neuronal culture model of Alzheimer's disease.

Authors:
Vivek Damodar Ranjan Lifeng Qiu Jolene Wei-Ling Lee Xuelong Chen Se Eun Jang Chou Chai Kah-Leong Lim Eng-King Tan Yilei Zhang Wei Min Huang Li Zeng

Biomater Sci 2020 Sep 13;8(17):4861-4874. Epub 2020 Aug 13.

NTU Institute for Health Technologies, Interdisciplinary Graduate School, Nanyang Technological University, Singapore 639798, Singapore.

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September 2020

A Flexi-PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy.

Authors:
Daniel Boon Loong Teh Akshaya Bansal Chou Chai Tan Boon Toh Robert Alan Jappy Tucker Gil Gerald Lasam Gammad Yanzhuang Yeo Zhendong Lei Xiang Zheng Fengyuan Yang John S Ho Nagarjun Bolem Bing Cheng Wu Muthu Kumar Gnanasammandhan Lissa Hooi Gavin Stewart Dawe Camilo Libedinsky Wei-Yi Ong Barry Halliwell Edward Kai-Hua Chow Kah-Leong Lim Yong Zhang Brian K Kennedy

Adv Mater 2020 Jul 2;32(29):e2001459. Epub 2020 Jun 2.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117456, Singapore.

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July 2020

PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function.

Authors:
Sreekanth Rajan Yongwoo Jang Chun-Hyung Kim Woori Kim Hui Ting Toh Jeha Jeon Bin Song Aida Serra Julien Lescar Jun Yeob Yoo Serap Beldar Hong Ye Congbao Kang Xue-Wei Liu Melissa Feitosa Yeahan Kim Dabin Hwang Geraldine Goh Kah-Leong Lim Hye Min Park Choong Hwan Lee Sungwhan F Oh Gregory A Petsko Ho Sup Yoon Kwang-Soo Kim

Nat Chem Biol 2020 08 25;16(8):876-886. Epub 2020 May 25.

Molecular Neurobiology Laboratory, Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.

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August 2020

Mitochondrial Dysfunction and Parkinson's Disease-Near-Infrared Photobiomodulation as a Potential Therapeutic Strategy.

Authors:
Aaron Song Chuan Foo Tuck Wah Soong Tseng Tsai Yeo Kah-Leong Lim

Front Aging Neurosci 2020 3;12:89. Epub 2020 Apr 3.

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

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April 2020

Potassium channel dysfunction in human neuronal models of Angelman syndrome.

Authors:
Alfred Xuyang Sun Qiang Yuan Masahiro Fukuda Weonjin Yu Haidun Yan Grace Gui Yin Lim Mui Hoon Nai Giuseppe Alessandro D'Agostino Hoang-Dai Tran Yoko Itahana Danlei Wang Hidayat Lokman Koji Itahana Stephanie Wai Lin Lim Jiong Tang Ya Yin Chang Menglan Zhang Stuart A Cook Owen J L Rackham Chwee Teck Lim Eng King Tan Huck Hui Ng Kah Leong Lim Yong-Hui Jiang Hyunsoo Shawn Je

Science 2019 12;366(6472):1486-1492

Signature Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.

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December 2019

Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity.

Authors:
Joan Poh Ling Sim Wang Ziyin Adeline Henry Basil Shuping Lin Zhongcan Chen Chengwu Zhang Li Zeng Yu Cai Kah-Leong Lim

Neuromolecular Med 2020 06 29;22(2):218-226. Epub 2019 Oct 29.

Neurodegeneration Research Laboratory, National Neuroscience Institute, 11, Jalan Tan Tock Seng, Singapore, 308433, Singapore.

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June 2020

Physiological and pathological roles of LRRK2 in the nuclear envelope integrity.

Authors:
Vered Shani Hazem Safory Raymonde Szargel Ninghan Wang Tsipora Cohen Fatimah Abd Elghani Haya Hamza Mor Savyon Inna Radzishevsky Lihi Shaulov Ruth Rott Kah-Leong Lim Christopher A Ross Rina Bandopadhyay Hui Zhang Simone Engelender

Hum Mol Genet 2019 12;28(23):3982-3996

Dept. of Biochemistry, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

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December 2019

Visualization of Intra-neuronal Motor Protein Transport through Upconversion Microscopy.

Authors:
Xiao Zeng Shuo Chen Adam Weitemier Sanyang Han Agata Blasiak Ankshita Prasad Kezhi Zheng Zhigao Yi Baiwen Luo In-Hong Yang Nitish Thakor Chou Chai Kah-Leong Lim Thomas J McHugh Angelo H All Xiaogang Liu

Angew Chem Int Ed Engl 2019 07 28;58(27):9262-9268. Epub 2019 May 28.

Department of Chemistry, National University of Singapore, Singapore, 117543, Singapore.

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July 2019

Mitochondria-Targeted Two-Photon Fluorescent Photosensitizers for Cancer Cell Apoptosis via Spatial Selectability.

Authors:
Yun Ni Hang Zhang Chou Chai Bo Peng Ang Zhao Jie Zhang Lin Li Chengwu Zhang Bo Ma Hua Bai Kah-Leong Lim Wei Huang

Adv Healthc Mater 2019 07 13;8(14):e1900212. Epub 2019 May 13.

Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 210009, P. R. China.

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July 2019

Cerebral transcriptome analysis reveals age-dependent progression of neuroinflammation in P301S mutant tau transgenic male mice.

Authors:
Joonki Kim Sharmelee Selvaraji Sung Wook Kang Wei Thye Lee Christopher Li-Hsian Chen Hyungwon Choi Edward H Koo Dong-Gyu Jo Kah Leong Lim Yun-An Lim Thiruma V Arumugam

Brain Behav Immun 2019 08 11;80:344-357. Epub 2019 Apr 11.

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do, Republic of Korea; Neurobiology Programme, Life Sciences Institute, National University of Singapore, Singapore. Electronic address:

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August 2019

Structure-Based Specific Detection and Inhibition of Monoamine Oxidases and Their Applications in Central Nervous System Diseases.

Authors:
Riri Shi Qiong Wu Chenqi Xin Houzhi Yu Kah-Leong Lim Xin Li Zhenxiong Shi Cheng-Wu Zhang Linghui Qian Lin Li Wei Huang

Chembiochem 2019 06 8;20(12):1487-1497. Epub 2019 Apr 8.

Key Laboratory of Flexible Electronics (KLOFE) and, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, 30 South Puzhu Road, Nanjing, 211816, P.R. China.

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June 2019

AMP Kinase Activation is Selectively Disrupted in the Ventral Midbrain of Mice Deficient in Parkin or PINK1 Expression.

Authors:
Liting Hang John Thundyil Geraldine W Y Goh Kah-Leong Lim

Neuromolecular Med 2019 03 8;21(1):25-32. Epub 2018 Nov 8.

National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.

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March 2019

Vascular Bed Molecular Profiling by Differential Systemic Decellularization In Vivo.

Authors:
Aida Serra Xavier Gallart-Palau Jung Eun Park Grace Gui Yin Lim Kah Leong Lim Hee Hwa Ho James P Tam Siu Kwan Sze

Arterioscler Thromb Vasc Biol 2018 10;38(10):2396-2409

From the School of Biological Sciences, Nanyang Technological University, Singapore (A.S., X.G.-P., J.E.P., J.P.T., S.K.S.).

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October 2018

Polydopamine Dots-Based Fluorescent Nanoswitch Assay for Reversible Recognition of Glutamic Acid and Al in Human Serum and Living Cell.

Authors:
Qiaoqiao Ci Jinhua Liu Xiaofei Qin Linqi Han Hai Li Haidong Yu Kah-Leong Lim Cheng-Wu Zhang Lin Li Wei Huang

ACS Appl Mater Interfaces 2018 Oct 11;10(42):35760-35769. Epub 2018 Oct 11.

Key Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) , Nanjing Tech University (NanjingTech) , 30 South Puzhu Road , Nanjing 211816 , China.

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October 2018

The Sources of Reactive Oxygen Species and Its Possible Role in the Pathogenesis of Parkinson's Disease.

Authors:
Minrui Weng Xiaoji Xie Chao Liu Kah-Leong Lim Cheng-Wu Zhang Lin Li

Parkinsons Dis 2018 2;2018:9163040. Epub 2018 Sep 2.

Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (Nanjing Tech), 30 South Puzhu Road, Nanjing 211816, China.

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September 2018

Natural Molecules From Chinese Herbs Protecting Against Parkinson's Disease via Anti-oxidative Stress.

Authors:
Yaqi Ding Chenqi Xin Cheng-Wu Zhang Kah-Leong Lim Hang Zhang ZhenQian Fu Lin Li Wei Huang

Front Aging Neurosci 2018 28;10:246. Epub 2018 Aug 28.

Key Laboratory of Flexible Electronics - Institute of Advanced Materials, Jiangsu National Synergistic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing, China.

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August 2018