Publications by authors named "Kaarel Krjutškov"

54Publications

Distinct whole-blood transcriptome profile of children with metabolic healthy overweight/obesity compared to metabolic unhealthy overweight/obesity.

Pediatr Res 2020 Nov 23. Epub 2020 Nov 23.

PROFITH "PROmoting FITness and Health Through Physical Activity" Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, 18011, Granada, Spain.

View Article and Find Full Text PDF
November 2020

Identification of fetal unmodified and 5-hydroxymethylated CG sites in maternal cell-free DNA for non-invasive prenatal testing.

Clin Epigenetics 2020 Oct 20;12(1):153. Epub 2020 Oct 20.

Department of Biological DNA Modification, Institute of Biotechnology, Vilnius University, Saulėtekio av. 7, 10257, Vilnius, Lithuania.

View Article and Find Full Text PDF
October 2020

Seroprevalence of SARS-CoV-2 antibodies among pregnant women in Estonia: A call for epidemiological studies.

Acta Obstet Gynecol Scand 2020 12 8;99(12):1736-1737. Epub 2020 Oct 8.

Department of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.

View Article and Find Full Text PDF
December 2020

Fetal HLA-G mediated immune tolerance and interferon response in preeclampsia.

EBioMedicine 2020 Sep 14;59:102872. Epub 2020 Jul 14.

Stem Cells and Metabolism Research Program, University of Helsinki, and Folkhälsan Research Center, 00290 Helsinki, Finland; Department of Biosciences and Nutrition, Karolinska Institutet, 14183 Huddinge, Sweden. Electronic address:

View Article and Find Full Text PDF
September 2020

Method for the Identification of Plant DNA in Food Using Alignment-Free Analysis of Sequencing Reads: A Case Study on Lupin.

Front Plant Sci 2020 21;11:646. Epub 2020 May 21.

Department of Bioinformatics, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.

View Article and Find Full Text PDF
May 2020

Dyslexia Candidate Gene and Ciliary Gene Expression Dynamics During Human Neuronal Differentiation.

Mol Neurobiol 2020 Jul 22;57(7):2944-2958. Epub 2020 May 22.

Department of Medicine, Solna, Karolinska Institutet, Solna, Sweden.

View Article and Find Full Text PDF
July 2020

MUC20 expression marks the receptive phase of the human endometrium.

Reprod Biomed Online 2019 Nov 11;39(5):725-736. Epub 2019 May 11.

Competence Centre on Health Technologies, Tiigi 61b, Tartu 50410, Estonia; Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu, L. Puusepa 8, Tartu 50406, Estonia; Department of Biomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 19, Tartu 50411, Estonia; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 2, Helsinki 00014, Finland. Electronic address:

View Article and Find Full Text PDF
November 2019

Guide for library design and bias correction for large-scale transcriptome studies using highly multiplexed RNAseq methods.

BMC Bioinformatics 2019 Aug 13;20(1):418. Epub 2019 Aug 13.

Department of Biosciences and Nutrition, Karolinska Institutet, 14183, Huddinge, Sweden.

View Article and Find Full Text PDF
August 2019

Computational framework for targeted high-coverage sequencing based NIPT.

PLoS One 2019 8;14(7):e0209139. Epub 2019 Jul 8.

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.

View Article and Find Full Text PDF
February 2020

Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy.

J Allergy Clin Immunol 2019 11 13;144(5):1364-1376. Epub 2019 Jun 13.

Adult Immunodeficiency Unit, Infectious Diseases, Inflammation Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Rare Diseases Center and Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Electronic address:

View Article and Find Full Text PDF
November 2019

Delineating the Healthy Human Skin UV Response and Early Induction of Interferon Pathway in Cutaneous Lupus Erythematosus.

J Invest Dermatol 2019 09 8;139(9):2058-2061.e4. Epub 2019 Apr 8.

Department of Dermatology and Allergology, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland.

View Article and Find Full Text PDF
September 2019

Comprehensive RNA-Sequencing Analysis in Serum and Muscle Reveals Novel Small RNA Signatures with Biomarker Potential for DMD.

Mol Ther Nucleic Acids 2018 Dec 17;13:1-15. Epub 2018 Aug 17.

Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK; Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address:

View Article and Find Full Text PDF
December 2018

MANF protects human pancreatic beta cells against stress-induced cell death.

Diabetologia 2018 10 21;61(10):2202-2214. Epub 2018 Jul 21.

Research Programs Unit, Molecular Neurology, Biomedicum Helsinki, University of Helsinki, PO Box 63, (Haartmaninkatu 8), 00014, Helsinki, Finland.

View Article and Find Full Text PDF
October 2018

Human pluripotent reprogramming with CRISPR activators.

Nat Commun 2018 07 6;9(1):2643. Epub 2018 Jul 6.

Research Programs Unit, Molecular Neurology and Biomedicum Stem Cell Centre, Faculty of Medicine, University of Helsinki, Helsinki, 00014, Finland.

View Article and Find Full Text PDF
July 2018

Optimizing bone morphogenic protein 4-mediated human embryonic stem cell differentiation into trophoblast-like cells using fibroblast growth factor 2 and transforming growth factor-β/activin/nodal signalling inhibition.

Reprod Biomed Online 2017 Sep 12;35(3):253-263. Epub 2017 Jun 12.

Competence Centre on Health Technologies, Tartu, Estonia; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Obstetrics and Gynaecology, University of Tartu, Tartu, Estonia; Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.

View Article and Find Full Text PDF
September 2017

Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes.

J Allergy Clin Immunol 2017 Sep 21;140(3):782-796. Epub 2017 Jan 21.

Adult Immunodeficiency Unit, Infectious Diseases, Inflammation Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Rare Diseases Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

View Article and Find Full Text PDF
September 2017

Combined immunodeficiency and hypoglycemia associated with mutations in hypoxia upregulated 1.

J Allergy Clin Immunol 2017 04 29;139(4):1391-1393.e11. Epub 2016 Nov 29.

Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland; Research Programs Unit, Molecular Neurology, University of Helsinki, Helsinki, Finland; Center for Innovative Medicine, Karolinska Institutet, Huddinge, Sweden.

View Article and Find Full Text PDF
April 2017

The human PRD-like homeobox gene LEUTX has a central role in embryo genome activation.

Development 2016 10 30;143(19):3459-3469. Epub 2016 Aug 30.

Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Huddinge 141 83, Sweden Science for Life Laboratory, Tomtebodavägen 23 A, Solna 171 21, Sweden Molecular Neurology Research Program, University of Helsinki and Folkhälsan Institute of Genetics, Biomedicum 1, Haartmaninkatu 8, Helsinki 00290, Finland

View Article and Find Full Text PDF
October 2016

Complementary seminovaginal microbiome in couples.

Res Microbiol 2015 Jun 11;166(5):440-447. Epub 2015 Apr 11.

Competence Centre on Health Technologies, Tartu, Estonia; Faculty of Science and Technology, University of Tartu, Tartu, Estonia.

View Article and Find Full Text PDF
June 2015

Tissue-specific mitochondrial heteroplasmy at position 16,093 within the same individual.

Curr Genet 2014 Feb 11;60(1):11-6. Epub 2013 Jul 11.

Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia,

View Article and Find Full Text PDF
February 2014

A novel amplification strategy for genotyping with liquid chromatography-electrospray ionization mass spectrometry.

Analyst 2012 Nov;137(22):5325-33

Institute of Legal Medicine, Innsbruck Medical University, Muellerstrasse 44, 6020 Innsbruck, Austria.

View Article and Find Full Text PDF
November 2012

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.

Authors:
Andrew P Morris Benjamin F Voight Tanya M Teslovich Teresa Ferreira Ayellet V Segrè Valgerdur Steinthorsdottir Rona J Strawbridge Hassan Khan Harald Grallert Anubha Mahajan Inga Prokopenko Hyun Min Kang Christian Dina Tonu Esko Ross M Fraser Stavroula Kanoni Ashish Kumar Vasiliki Lagou Claudia Langenberg Jian'an Luan Cecilia M Lindgren Martina Müller-Nurasyid Sonali Pechlivanis N William Rayner Laura J Scott Steven Wiltshire Loic Yengo Leena Kinnunen Elizabeth J Rossin Soumya Raychaudhuri Andrew D Johnson Antigone S Dimas Ruth J F Loos Sailaja Vedantam Han Chen Jose C Florez Caroline Fox Ching-Ti Liu Denis Rybin David J Couper Wen Hong L Kao Man Li Marilyn C Cornelis Peter Kraft Qi Sun Rob M van Dam Heather M Stringham Peter S Chines Krista Fischer Pierre Fontanillas Oddgeir L Holmen Sarah E Hunt Anne U Jackson Augustine Kong Robert Lawrence Julia Meyer John R B Perry Carl G P Platou Simon Potter Emil Rehnberg Neil Robertson Suthesh Sivapalaratnam Alena Stančáková Kathleen Stirrups Gudmar Thorleifsson Emmi Tikkanen Andrew R Wood Peter Almgren Mustafa Atalay Rafn Benediktsson Lori L Bonnycastle Noël Burtt Jason Carey Guillaume Charpentier Andrew T Crenshaw Alex S F Doney Mozhgan Dorkhan Sarah Edkins Valur Emilsson Elodie Eury Tom Forsen Karl Gertow Bruna Gigante George B Grant Christopher J Groves Candace Guiducci Christian Herder Astradur B Hreidarsson Jennie Hui Alan James Anna Jonsson Wolfgang Rathmann Norman Klopp Jasmina Kravic Kaarel Krjutškov Cordelia Langford Karin Leander Eero Lindholm Stéphane Lobbens Satu Männistö Ghazala Mirza Thomas W Mühleisen Bill Musk Melissa Parkin Loukianos Rallidis Jouko Saramies Bengt Sennblad Sonia Shah Gunnar Sigurðsson Angela Silveira Gerald Steinbach Barbara Thorand Joseph Trakalo Fabrizio Veglia Roman Wennauer Wendy Winckler Delilah Zabaneh Harry Campbell Cornelia van Duijn Andre G Uitterlinden Albert Hofman Eric Sijbrands Goncalo R Abecasis Katharine R Owen Eleftheria Zeggini Mieke D Trip Nita G Forouhi Ann-Christine Syvänen Johan G Eriksson Leena Peltonen Markus M Nöthen Beverley Balkau Colin N A Palmer Valeriya Lyssenko Tiinamaija Tuomi Bo Isomaa David J Hunter Lu Qi Alan R Shuldiner Michael Roden Ines Barroso Tom Wilsgaard John Beilby Kees Hovingh Jackie F Price James F Wilson Rainer Rauramaa Timo A Lakka Lars Lind George Dedoussis Inger Njølstad Nancy L Pedersen Kay-Tee Khaw Nicholas J Wareham Sirkka M Keinanen-Kiukaanniemi Timo E Saaristo Eeva Korpi-Hyövälti Juha Saltevo Markku Laakso Johanna Kuusisto Andres Metspalu Francis S Collins Karen L Mohlke Richard N Bergman Jaakko Tuomilehto Bernhard O Boehm Christian Gieger Kristian Hveem Stephane Cauchi Philippe Froguel Damiano Baldassarre Elena Tremoli Steve E Humphries Danish Saleheen John Danesh Erik Ingelsson Samuli Ripatti Veikko Salomaa Raimund Erbel Karl-Heinz Jöckel Susanne Moebus Annette Peters Thomas Illig Ulf de Faire Anders Hamsten Andrew D Morris Peter J Donnelly Timothy M Frayling Andrew T Hattersley Eric Boerwinkle Olle Melander Sekar Kathiresan Peter M Nilsson Panos Deloukas Unnur Thorsteinsdottir Leif C Groop Kari Stefansson Frank Hu James S Pankow Josée Dupuis James B Meigs David Altshuler Michael Boehnke Mark I McCarthy

Nat Genet 2012 Sep 12;44(9):981-90. Epub 2012 Aug 12.

Wellcome Trust Centre for Human Genetics, University of Oxford, UK.

View Article and Find Full Text PDF
September 2012

MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate.

Eur J Oral Sci 2010 Jun;118(3):213-20

Department of Stomatology, Faculty of Medicine, University of Tartu, Tartu, Estonia.

View Article and Find Full Text PDF
June 2010

Evaluation of the 124-plex SNP typing microarray for forensic testing.

Forensic Sci Int Genet 2009 Dec 15;4(1):43-8. Epub 2009 May 15.

Department of Biotechnology, IMCB, University of Tartu, 23 Riia St, 51010 Tartu, Estonia.

View Article and Find Full Text PDF
December 2009

Comparison of DNA extraction methods for multiplex polymerase chain reaction.

Anal Biochem 2010 Mar 20;398(2):260-2. Epub 2009 Nov 20.

Department of Biotechnology, IMCB, University of Tartu, Tartu, Estonia.

View Article and Find Full Text PDF
March 2010