Kurt Stenmark

Kurt Stenmark

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Kurt Stenmark

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Pre-clinical assessment of a water-in-fluorocarbon emulsion for the treatment of pulmonary vascular diseases.

Drug Deliv 2019 Dec;26(1):147-157

a Cardiovascular and Pulmonary Research Laboratory, Department of Medicine , University of Colorado Denver, Anschutz Medical Campus , Aurora , CO , USA.

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http://dx.doi.org/10.1080/10717544.2019.1568621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407583PMC
December 2019

Differences in pulmonary arterial flow hemodynamics between children and adults with pulmonary arterial hypertension as assessed by 4D-flow CMR studies.

Am J Physiol Heart Circ Physiol 2019 May 1;316(5):H1091-H1104. Epub 2019 Mar 1.

Division of Pediatric Cardiology, Heart Institute, Children's Hospital Colorado, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado.

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http://dx.doi.org/10.1152/ajpheart.00802.2018DOI Listing
May 2019

Layer-specific arterial micromechanics and microstructure: Influences of age, anatomical location, and processing technique.

J Biomech 2019 May 2;88:113-121. Epub 2019 Apr 2.

Department of Mechanical Engineering, University of Colorado Boulder, Boulder, CO 80309, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jbiomech.2019.03.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499687PMC
May 2019

Proximal pulmonary vascular stiffness as a prognostic factor in children with pulmonary arterial hypertension.

Eur Heart J Cardiovasc Imaging 2019 02;20(2):209-217

Division of Cardiology, Heart Institute, Children's Hospital Colorado, University of Colorado Denver, Anschutz Medical Campus, 13123 E 16th Avenue, Aurora, CO, USA.

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http://dx.doi.org/10.1093/ehjci/jey069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343079PMC
February 2019

Mechanisms contributing to persistently activated cell phenotypes in pulmonary hypertension.

J Physiol 2019 Feb 7;597(4):1103-1119. Epub 2018 Aug 7.

Cardiovascular Pulmonary Research Laboratories, Departments of Pediatrics and Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

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http://dx.doi.org/10.1113/JP275857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375873PMC
February 2019

Effects of living at moderate altitude on pulmonary vascular function and exercise capacity in mice with sickle cell anaemia.

J Physiol 2019 Feb 25;597(4):1073-1085. Epub 2018 Aug 25.

Cardiovascular and Pulmonary Research Laboratory, Department of Medicine, Anschutz Medical Campus, University of Colorado-Denver School of Medicine, Aurora, CO, USA.

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http://dx.doi.org/10.1113/JP275810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376072PMC
February 2019

Tissue-informed engineering strategies for modeling human pulmonary diseases.

Am J Physiol Lung Cell Mol Physiol 2019 Feb 21;316(2):L303-L320. Epub 2018 Nov 21.

Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado.

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http://dx.doi.org/10.1152/ajplung.00353.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397349PMC
February 2019

Hypoxia-induced pulmonary hypertension and chronic lung disease: caveolin-1 dysfunction an important underlying feature.

Pulm Circ 2019 Jan-Mar;9(1):2045894019837876

1 Department of Pediatrics, Maria Fareri Children's Hospital at Westchester Medical Center, New York Medical College, Valhalla, NY, USA.

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http://dx.doi.org/10.1177/2045894019837876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434444PMC
February 2019

Inhaled combination of sildenafil and rosiglitazone improves pulmonary hemodynamics, cardiac function, and arterial remodeling.

Am J Physiol Lung Cell Mol Physiol 2019 Jan 11;316(1):L119-L130. Epub 2018 Oct 11.

Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center , Amarillo, Texas.

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https://www.physiology.org/doi/10.1152/ajplung.00381.2018
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http://dx.doi.org/10.1152/ajplung.00381.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383494PMC
January 2019

How Many FOXs Are There on The Road to Pulmonary Hypertension?

Am J Respir Crit Care Med 2018 Sep;198(6):704-707

5 Department of Lung Development and Remodeling Max Planck Institute for Heart and Lung Research, member of the German Center for Lung Research Bad Nauheim, Germany.

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https://www.atsjournals.org/doi/10.1164/rccm.201804-0702ED
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http://dx.doi.org/10.1164/rccm.201804-0702EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222465PMC
September 2018

Cardiopulmonary remodeling in fattened beef cattle: a naturally occurring large animal model of obesity-associated pulmonary hypertension with left heart disease.

Pulm Circ 2019 Jan-Mar;9(1):2045894018796804. Epub 2018 Aug 20.

1 Department of Pediatrics, Critical Care Medicine and Cardiovascular Pulmonary Research Labs, University of Colorado Denver Anschutz School of Medicine, Aurora, CO, USA.

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http://dx.doi.org/10.1177/2045894018796804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333945PMC
August 2018

Biomimetic soft fibrous hydrogels for contractile and pharmacologically responsive smooth muscle.

Acta Biomater 2018 07 16;74:121-130. Epub 2018 May 16.

Department of Mechanical Engineering, University of Colorado at Boulder, Boulder, CO 80309, USA. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2018.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004336PMC
July 2018

Urocortin 2: will a drug targeting both the vasculature and the right ventricle be the future of pulmonary hypertension therapy?

Cardiovasc Res 2018 Jul;114(8):1057-1059

Cardiovascular Pulmonary Research Laboratories, Departments of Pediatrics and Medicine; and.

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http://dx.doi.org/10.1093/cvr/cvy117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279057PMC
July 2018

Impact of cell-free hemoglobin on contracting skeletal muscle microvascular oxygen pressure dynamics.

Nitric Oxide 2018 06 8;76:29-36. Epub 2018 Mar 8.

Cardiovascular and Pulmonary Research Group, School of Medicine, University of Colorado, Denver, Aurora, CO, USA.

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http://dx.doi.org/10.1016/j.niox.2018.03.005DOI Listing
June 2018

Repurposing rosiglitazone, a PPAR-γ agonist and oral antidiabetic, as an inhaled formulation, for the treatment of PAH.

J Control Release 2018 06 30;280:113-123. Epub 2018 Apr 30.

Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center School of Pharmacy, Amarillo, TX 79106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2018.04.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993641PMC
June 2018

Peroxisome Proliferator-activated Receptor γ and Mitochondria: Drivers or Passengers on the Road to Pulmonary Hypertension?

Am J Respir Cell Mol Biol 2018 May;58(5):555-557

2 Department of Medicine University of Colorado Anschutz Medical Campus Aurora, Colorado.

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http://dx.doi.org/10.1165/rcmb.2017-0318EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946332PMC
May 2018

JNK2 regulates vascular remodeling in pulmonary hypertension.

Pulm Circ 2018 Jul-Sep;8(3):2045894018778156. Epub 2018 May 2.

4 Cardiovascular Pulmonary Research Laboratories, Departments of Pediatrics and Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

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http://dx.doi.org/10.1177/2045894018778156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055330PMC
May 2018

Metabolic Reprogramming and Redox Signaling in Pulmonary Hypertension.

Adv Exp Med Biol 2017 ;967:241-260

Developmental Lung Biology and Cardiovascular Pulmonary Research Laboratories, University of Colorado, Denver, CO, USA.

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http://dx.doi.org/10.1007/978-3-319-63245-2_14DOI Listing
April 2018

Dynamic and diverse changes in the functional properties of vascular smooth muscle cells in pulmonary hypertension.

Cardiovasc Res 2018 Mar;114(4):551-564

Pulmonary and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, 12700 E. 19th Avenue, RC2, B131, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1093/cvr/cvy004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852549PMC
March 2018

A Twist on Pulmonary Vascular Remodeling: Endothelial to Mesenchymal Transition?

Am J Respir Cell Mol Biol 2018 02;58(2):140-141

2 Cardiovascular Pulmonary Research Laboratories University of Colorado Anschutz Medical Campus Aurora, Colorado.

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http://dx.doi.org/10.1165/rcmb.2017-0314EDDOI Listing
February 2018

Development of an electrospun biomimetic polyurea scaffold suitable for vascular grafting.

J Biomed Mater Res B Appl Biomater 2018 Jan 27;106(1):278-290. Epub 2017 Jan 27.

Department of Bioengineering, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, 80045.

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http://dx.doi.org/10.1002/jbm.b.33853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080858PMC
January 2018

Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming.

Antioxid Redox Signal 2018 Jan 14;28(3):230-250. Epub 2017 Aug 14.

2 Developmental Lung Biology and Cardiovascular Pulmonary Research Laboratories, University of Colorado - Denver , Colorado.

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http://dx.doi.org/10.1089/ars.2017.7217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737722PMC
January 2018

Identification of Infants at Risk for Chronic Lung Disease at Birth. Potential for a Personalized Approach to Disease Prevention.

Am J Respir Crit Care Med 2017 10;196(8):951-952

2 Developmental Lung Biology and Cardiovascular Pulmonary Research Laboratories University of Colorado Anschutz Medical Campus Aurora, Colorado.

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http://www.atsjournals.org/doi/10.1164/rccm.201706-1065ED
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http://dx.doi.org/10.1164/rccm.201706-1065EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649991PMC
October 2017

A photoclickable peptide microarray platform for facile and rapid screening of 3-D tissue microenvironments.

Biomaterials 2017 Oct 20;143:17-28. Epub 2017 Jul 20.

Department of Chemical and Biological Engineering, University of Colorado-Boulder, Boulder, CO, 80309, USA; Material Science and Engineering Program, University of Colorado-Boulder, Boulder, CO, 80309, USA; BioFrontiers Institute, University of Colorado-Boulder, Boulder, CO, 80309, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2017.07.025DOI Listing
October 2017

Varicella zoster virus-infected cerebrovascular cells produce a proinflammatory environment.

Neurol Neuroimmunol Neuroinflamm 2017 Sep 13;4(5):e382. Epub 2017 Jul 13.

Department of Neurology (D.J., M.A.N.), Department of Medicine (C.P.N., B.E.P.), and Department of Pediatrics (K.S.), University of Colorado School of Medicine, Aurora.

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http://dx.doi.org/10.1212/NXI.0000000000000382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682918PMC
September 2017

A Time- and Compartment-Specific Activation of Lung Macrophages in Hypoxic Pulmonary Hypertension.

J Immunol 2017 06 12;198(12):4802-4812. Epub 2017 May 12.

Cardiovascular Pulmonary Research Laboratories, Departments of Pediatrics and Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045;

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http://dx.doi.org/10.4049/jimmunol.1601692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501258PMC
June 2017

Superoxide Dismutase 3 R213G Single-Nucleotide Polymorphism Blocks Murine Bleomycin-Induced Fibrosis and Promotes Resolution of Inflammation.

Am J Respir Cell Mol Biol 2017 03;56(3):362-371

1 Developmental Lung Biology and Cardiovascular Pulmonary Research Laboratories, Departments of Pediatrics and Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado; and.

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http://dx.doi.org/10.1165/rcmb.2016-0153OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359538PMC
March 2017

Cocktail of Superoxide Dismutase and Fasudil Encapsulated in Targeted Liposomes Slows PAH Progression at a Reduced Dosing Frequency.

Mol Pharm 2017 03 17;14(3):830-841. Epub 2017 Feb 17.

Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center , 1300 Coulter Drive, Amarillo, Texas 79106, United States.

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http://pubs.acs.org/doi/10.1021/acs.molpharmaceut.6b01061
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http://dx.doi.org/10.1021/acs.molpharmaceut.6b01061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814122PMC
March 2017

Inhaled sildenafil as an alternative to oral sildenafil in the treatment of pulmonary arterial hypertension (PAH).

J Control Release 2017 03 7;250:96-106. Epub 2017 Feb 7.

Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter St, Amarillo, TX 79106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2017.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380153PMC
March 2017

Unique aspects of the developing lung circulation: structural development and regulation of vasomotor tone.

Pulm Circ 2016 Dec;6(4):407-425

Department of Pediatrics, University of Illinois College of Medicine at Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.1086/688890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130074PMC
December 2016

Transcription factors, transcriptional coregulators, and epigenetic modulation in the control of pulmonary vascular cell phenotype: therapeutic implications for pulmonary hypertension (2015 Grover Conference series).

Pulm Circ 2016 Dec;6(4):448-464

Cardiovascular Pulmonary Research Laboratories, Department of Medicine and Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

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http://dx.doi.org/10.1086/688908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210074PMC
December 2016

Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1.

Circulation 2016 Oct 25;134(15):1105-1121. Epub 2016 Aug 25.

From Cardiovascular Pulmonary Research Laboratories, Department of Pediatrics and Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO (M.L., S.R., H.Z., A.F., B.A.M., M.F., S.K., M.A.F., K.R.S.); Department of Biochemistry and Molecular Genetics and Biological Mass Spectrometry Shared Resource (A.D., K.C.H.), Department of Anesthesiology (N.J.S.), Advanced Light Microscopy Core Facility (R.M.), Department of Dermatology (H.L., H.L., Q.Z.), and Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition (K.C.E.K.), University of Colorado, Denver; Department of Mitochondrial Physiology, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic (L.P.-H., P.J.); Department of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany (D.I., S.P.); Center for Genetic Improvement of Livestock, Department of Animal Bioscience, University of Guelph, Guelph, ON, Canada (A.C.); Department of Animal Science, University of California-Davis, Davis (J.F.M.); and Department of Animal Science, Colorado State University, Fort Collins (M.G.T.).

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http://circ.ahajournals.org/content/134/15/1105.full.pdf?dow
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069179PMC
http://dx.doi.org/10.1161/CIRCULATIONAHA.116.023171DOI Listing
October 2016

Constitutive Reprogramming of Fibroblast Mitochondrial Metabolism in Pulmonary Hypertension.

Am J Respir Cell Mol Biol 2016 07;55(1):47-57

2 Developmental Lung Biology and Cardiovascular Pulmonary Research Laboratory, University of Colorado, Denver, Colorado.

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http://dx.doi.org/10.1165/rcmb.2015-0142OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942204PMC
July 2016

Right Ventricular Longitudinal Strain Is Depressed in a Bovine Model of Pulmonary Hypertension.

Anesth Analg 2016 May;122(5):1280-6

From the *Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado; †Cardiovascular Pulmonary Research and Developmental Lung Biology Laboratories, University of Colorado School of Medicine, Aurora, Colorado; ‡Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado; §Division of Cardiology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado; ∥Department of Animal and Food Sciences, Texas Tech University, Lubbock, Texas; and ¶Department of Cardiology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado.

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http://dx.doi.org/10.1213/ANE.0000000000001215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840046PMC
May 2016

Endothelial-to-Mesenchymal Transition: An Evolving Paradigm and a Promising Therapeutic Target in PAH.

Circulation 2016 May 4;133(18):1734-7. Epub 2016 Apr 4.

From University of Colorado Anschutz Medical Campus, Developmental Lung Biology and Cardiovascular Pulmonary Research Laboratories, Aurora (K.R.S., M.F.); and Université Paris-Saclay - LabEx LERMIT - DHU Thorax Innovation (TORINO), Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (F.B.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.022479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866805PMC
May 2016

Pulmonary Arterial Stiffness: Toward a New Paradigm in Pulmonary Arterial Hypertension Pathophysiology and Assessment.

Curr Hypertens Rep 2016 Jan;18(1)

University of Colorado Anschutz Medical Campus, 12700 E. 19th Avenue, Box B131, Aurora, CO, 80045, USA.

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http://dx.doi.org/10.1007/s11906-015-0609-2DOI Listing
January 2016

Differential regulation of matrix metalloproteinases in varicella zoster virus-infected human brain vascular adventitial fibroblasts.

J Neurol Sci 2015 Nov 16;358(1-2):444-6. Epub 2015 Sep 16.

Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0022510X150243
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http://dx.doi.org/10.1016/j.jns.2015.09.349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628845PMC
November 2015

Coming to terms with tissue engineering and regenerative medicine in the lung.

Am J Physiol Lung Cell Mol Physiol 2015 Oct 7;309(7):L625-38. Epub 2015 Aug 7.

Department of Pediatrics, University of Colorado, Aurora, Colorado.

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http://dx.doi.org/10.1152/ajplung.00204.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593835PMC
October 2015

Contribution of metabolic reprogramming to macrophage plasticity and function.

Semin Immunol 2015 Aug 9;27(4):267-75. Epub 2015 Oct 9.

University of Colorado Denver, School of Medicine, Section of Pediatric Critical Care and Cardiovascular Pulmonary Research, Department of Medicine, Aurora, CO, USA.

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http://dx.doi.org/10.1016/j.smim.2015.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677817PMC
August 2015

Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration.

Free Radic Biol Med 2015 May 2;82:50-62. Epub 2015 Feb 2.

Laboratory of Biochemistry and Vascular Biology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland.

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http://dx.doi.org/10.1016/j.freeradbiomed.2015.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387123PMC
May 2015

Increased prevalence of EPAS1 variant in cattle with high-altitude pulmonary hypertension.

Nat Commun 2015 Apr 15;6:6863. Epub 2015 Apr 15.

Department of Pediatrics, Division of Medical Genetics and Genomic Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1038/ncomms7863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399003PMC
April 2015

Stiffening-induced high pulsatility flow activates endothelial inflammation via a TLR2/NF-κB pathway.

PLoS One 2014 16;9(7):e102195. Epub 2014 Jul 16.

Department of Mechanical Engineering, University of Colorado at Boulder, Boulder, Colorado, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102195PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100881PMC
March 2015

Emerging roles for histone deacetylases in pulmonary hypertension and right ventricular remodeling (2013 Grover Conference series).

Pulm Circ 2015 Mar;5(1):63-72

Department of Medicine, Division of Cardiology, University of Colorado Denver, Aurora, Colorado, USA.

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http://journals.sagepub.com/doi/10.1086/679700
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http://dx.doi.org/10.1086/679700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405717PMC
March 2015

The role of inflammation in hypoxic pulmonary hypertension: from cellular mechanisms to clinical phenotypes.

Am J Physiol Lung Cell Mol Physiol 2015 Feb 21;308(3):L229-52. Epub 2014 Nov 21.

Developmental Lung Biology, Cardiovascular Pulmonary Research Laboratories, Division of Pulmonary Sciences and Critical Care Medicine, Division of Pediatrics-Critical Care, Departments of Medicine and Pediatrics, University of Colorado, Anschutz Medical Campus, Aurora, Colorado;

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http://www.physiology.org/doi/10.1152/ajplung.00238.2014
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http://dx.doi.org/10.1152/ajplung.00238.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338929PMC
February 2015

Chemotherapy-induced pulmonary hypertension: role of alkylating agents.

Am J Pathol 2015 Feb 11;185(2):356-71. Epub 2014 Dec 11.

Faculty of Medicine, Université Paris-Sud, Faculté de Médecine, Hôpital de Bicêtre, Le Kremlin-Bicêtre, Paris, France; INSERM U999, Pulmonary Arterial Hypertension: Pathophysiology and Therapeutic Innovation, Centre Chirurgical Marie Lannelongue, Le Plessis-Robinson, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2014.10.021DOI Listing
February 2015

Mitochondrial integrity in a neonatal bovine model of right ventricular dysfunction.

Am J Physiol Lung Cell Mol Physiol 2015 Jan 21;308(2):L158-67. Epub 2014 Nov 21.

Department of Medicine, Cardiology, University of Colorado-Denver, Aurora, Colorado; and

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http://dx.doi.org/10.1152/ajplung.00270.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338944PMC
January 2015

Selective depletion of vascular EC-SOD augments chronic hypoxic pulmonary hypertension.

Am J Physiol Lung Cell Mol Physiol 2014 Dec 17;307(11):L868-76. Epub 2014 Oct 17.

Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois; and.

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http://dx.doi.org/10.1152/ajplung.00096.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254965PMC
December 2014

Vascular stiffening in pulmonary hypertension: cause or consequence? (2013 Grover Conference series).

Pulm Circ 2014 Dec;4(4):560-80

Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA ; Cardiovascular Pulmonary Research Laboratories, University of Colorado Denver, Aurora, Colorado, USA.

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http://journals.sagepub.com/doi/10.1086/677370
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http://dx.doi.org/10.1086/677370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278618PMC
December 2014

Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension.

J Immunol 2014 Jul 13;193(2):597-609. Epub 2014 Jun 13.

Division of Critical Care Medicine/Cardiovascular Pulmonary Research Laboratories, Department of Pediatrics and Medicine, School of Medicine, University of Colorado Denver, Aurora, CO 80045;

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http://dx.doi.org/10.4049/jimmunol.1303048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100597PMC
July 2014

Biomarkers for pediatric pulmonary arterial hypertension - a call to collaborate.

Front Pediatr 2014 3;2. Epub 2014 Feb 3.

Department of Bioengineering, University of Colorado Denver , Aurora, CO , USA ; Department of Pediatrics-Critical Care, University of Colorado Denver , Aurora, CO , USA ; Cardiovascular Pulmonary Research, University of Colorado Denver , Aurora, CO , USA ; Linda Crnic Institute for Down Syndrome, University of Colorado Denver , Aurora, CO , USA.

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http://dx.doi.org/10.3389/fped.2014.00007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910125PMC
June 2014

Is uric acid an underdiagnosed mediator of adverse outcome in metabolically healthy overweight/obese individuals?

Am J Med 2014 Jun;127(6):e21

Department of Medicine, University of Colorado Denver, School of Medicine, Aurora; Division of Renal Diseases and Hypertension, University of Colorado Denver, School of Medicine, Aurora.

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http://dx.doi.org/10.1016/j.amjmed.2014.02.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505511PMC
June 2014

Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension.

Circulation 2014 Apr 6;129(17):1770-80. Epub 2014 Feb 6.

Centre for Pharmacology and Therapeutics, Department of Medicine, Imperial College London, London, UK (B.W.-S., V.B.A.-S., K.H.L., H.T., R.J.E., C.J.R., J.W., L.Z., M.R.W.); Cardiovascular Pulmonary Research Group, University of Colorado Denver Health Sciences Center, Aurora (D.C.I., C.L., Z.L., K.R.S.); Division of Nephrology, Department of Internal Medicine, St. Louis University, St. Louis MO (J.C.E.); Laboratory of Cancer Biology & Genetics, Centre for Cancer Research, Bethesda, MD (S.H.Y.); and National Pulmonary Hypertension Service and National Heart & Lung Institute, Imperial College Healthcare NHS Trust, London, UK (L.S.H., J.S.R.G.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.006797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033409PMC
April 2014

High proliferative potential endothelial colony-forming cells contribute to hypoxia-induced pulmonary artery vasa vasorum neovascularization.

Am J Physiol Lung Cell Mol Physiol 2014 Apr 7;306(7):L661-71. Epub 2014 Feb 7.

Univ. of Colorado Denver, Pediatric Critical Care Medicine, Box B131, Research 2, Rm. 6119, 12700 E. 19th Ave., Aurora, CO 80045.

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http://dx.doi.org/10.1152/ajplung.00244.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962625PMC
April 2014

MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts.

Circ Res 2014 Jan 11;114(1):67-78. Epub 2013 Oct 11.

From the Department of Pediatrics (D.W., H.Z., M.L., M.G.F., A.R.F., B.A.K., M.E.Y., M.A.F.), Department of Medicine (T.A.M., C.C.S.), Department of Medicine and Pediatrics (K.R.S.), Department of Medicine (N.W.M.), Department of Lung Development and Remodeling (S.S.P., S.V., W.S.), Department of Medicine (H.Z.), University of Colorado Anschutz Medical Campus, Aurora, CO; University of Cambridge, Cambridge, United Kingdom (N.W.M.); Addenbrooke's & Papworth Hospitals, Cambridge, United Kingdom (N.W.M.); Max-Planck-Institute for Heart and Lung Research; University of Giessen and Marburg Lung Center, Bad Nauheim, Germany (S.S.P., S.V., W.S.); and Shengjing Hospital of China Medical University, Shenyang, China (H.Z.).

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http://circres.ahajournals.org/content/early/2013/10/11/CIRC
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http://circres.ahajournals.org/lookup/doi/10.1161/CIRCRESAHA
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http://dx.doi.org/10.1161/CIRCRESAHA.114.301633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117588PMC
January 2014

Relevant issues in the pathology and pathobiology of pulmonary hypertension.

J Am Coll Cardiol 2013 Dec;62(25 Suppl):D4-12

Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2013.10.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970402PMC
December 2013

Cellular, pharmacological, and biophysical evaluation of explanted lungs from a patient with sickle cell disease and severe pulmonary arterial hypertension.

Pulm Circ 2013 Dec;3(4):936-51

Vascular Medicine Institute of the University of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA ; Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1086/674754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070844PMC
December 2013

The adventitia: essential regulator of vascular wall structure and function.

Annu Rev Physiol 2013 3;75:23-47. Epub 2012 Dec 3.

Division of Pediatric Critical Care, University of Colorado Denver, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1146/annurev-physiol-030212-183802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762248PMC
August 2013

High Pulsatility Flow Induces Acute Endothelial Inflammation through Overpolarizing Cells to Activate NF-κB.

Cardiovasc Eng Technol 2013 Mar;4(1):26-38

Department of Pediatrics, University of Colorado at Denver, Aurora, CO 80045.

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http://link.springer.com/10.1007/s13239-012-0115-5
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http://dx.doi.org/10.1007/s13239-012-0115-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646301PMC
March 2013

High pulsatility flow stimulates smooth muscle cell hypertrophy and contractile protein expression.

Am J Physiol Lung Cell Mol Physiol 2013 Jan 19;304(1):L70-81. Epub 2012 Oct 19.

Department of Mechanical Engineering, University of Colorado at Boulder, USA.

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http://dx.doi.org/10.1152/ajplung.00342.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543641PMC
January 2013

Varicella-zoster virus vasculopathy: immune characteristics of virus-infected arteries.

Neurology 2013 Jan 12;80(1):62-8. Epub 2012 Dec 12.

Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA.

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http://dx.doi.org/10.1212/WNL.0b013e31827b1ab9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589199PMC
January 2013

Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism.

Am J Physiol Lung Cell Mol Physiol 2012 Aug 22;303(4):L312-26. Epub 2012 Jun 22.

Laboratory of Biochemistry and Vascular Biology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD, USA.

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http://dx.doi.org/10.1152/ajplung.00074.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423829PMC
August 2012

Hypoxia induces unique proliferative response in adventitial fibroblasts by activating PDGFβ receptor-JNK1 signalling.

Cardiovasc Res 2012 Aug 26;95(3):356-65. Epub 2012 Jun 26.

Department of Pharmaceutical Sciences, University of Wyoming, Laramie, WY, USA.

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http://dx.doi.org/10.1093/cvr/cvs194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400360PMC
August 2012

Activation of the unfolded protein response is associated with pulmonary hypertension.

Pulm Circ 2012 Apr-Jun;2(2):229-40

Department of Pediatrics, Division of Pulmonary and Critical Care Medicine, University of Colorado Denver, Aurora, Colorado, USA.

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http://dx.doi.org/10.4103/2045-8932.97613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401877PMC
August 2012