Publications by authors named "K Soni"

270 Publications

COVID-19 Illness in a Patient With Anti-Glomerular Basement Membrane Disease: A Clinical Dilemma.

Cureus 2021 May 8;13(5):e14912. Epub 2021 May 8.

Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, IND.

Anti-glomerular basement membrane (anti-GBM) disease is a rare autoimmune disease affecting the kidneys and lungs. COVID-19 infection in a patient with pre-existing anti-GBM disease presents a unique set of clinical challenges. The formulation of a judicious treatment plan balancing both disease processes is tricky, especially with regard to anticoagulation. We present the case of a young patient with anti-GBM disease who acquired COVID-19 infection and eventually succumbed to his illness.
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http://dx.doi.org/10.7759/cureus.14912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191424PMC
May 2021

The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain.

Nat Commun 2021 06 8;12(1):3456. Epub 2021 Jun 8.

Heidelberg University Biochemistry Center (BZH), Heidelberg, Germany.

Cryptic unstable transcripts (CUTs) are rapidly degraded by the nuclear exosome in a process requiring the RNA helicase Mtr4 and specific adaptor complexes for RNA substrate recognition. The PAXT and MTREC complexes have recently been identified as homologous exosome adaptors in human and fission yeast, respectively. The eleven-subunit MTREC comprises the zinc-finger protein Red1 and the Mtr4 homologue Mtl1. Here, we use yeast two-hybrid and pull-down assays to derive a detailed interaction map. We show that Red1 bridges MTREC submodules and serves as the central scaffold. In the crystal structure of a minimal Mtl1/Red1 complex an unstructured region adjacent to the Red1 zinc-finger domain binds to both the Mtl1 KOW domain and stalk helices. This interaction extends the canonical interface seen in Mtr4-adaptor complexes. In vivo mutational analysis shows that this interface is essential for cell survival. Our results add to Mtr4 versatility and provide mechanistic insights into the MTREC complex.
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http://dx.doi.org/10.1038/s41467-021-23565-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187409PMC
June 2021

Distal biceps rupture: Evaluation and management.

J Clin Orthop Trauma 2021 Aug 20;19:132-138. Epub 2021 May 20.

Medical Student, Parul Institute of Medical Sciences and Research, Parul University, Vadodara, India.

Injury to the distal biceps occurs in certain high risk groups. Anatomical continuity of the lacertus fibrosus has bearing on the extent of retraction of the torn tendon stump. The objective of clinical and imaging evaluation is to discriminate between tendinosis, partial tear, acute complete tear and chronic complete tear. A complete tear of the distal biceps tendon can be diagnosed clinically with the Hook test. The traditional Hook test and the resisted Hook test are useful clinical tests. Though x-rays are routinely done, MRI remains the investigation of choice. Non-operative treatment has a role in selected patients with partial tear or patients with complete tear who have low functional demands. Operative treatment is the recommended treatment for complete tear of the distal biceps and is associated with good functional outcome and patient satisfaction.
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http://dx.doi.org/10.1016/j.jcot.2021.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167284PMC
August 2021

Changes in the behaviour of monocyte subsets in acute post-traumatic sepsis patients.

Mol Immunol 2021 Jun 1;136:65-72. Epub 2021 Jun 1.

Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Trauma remains a major public health problem worldwide, marked as the fourth leading cause of death among all diseases. Trauma patients who survived at initial stages in the Emergency Department (ED), have significantly higher chances of mortality due to sepsis associated complications in the ICU at the later stage. There is paucity of literature regarding the role of circulating monocytes subsets and development of sepsis complications following trauma haemorrhagic shock (THS). The study was conducted to investigate the circulating level of monocyte subsets (Classical, Inflammatory, and Patrolling) and its functions in patients with acute post-traumatic sepsis. A total 72, THS patients and 30 age matched healthy controls were recruited. Blood samples were collected at different time points on days 1, 7, and 14 to measure the serum levels of cytokines by Cytometric bead assay (CBA), for the immunophenotyping of monocytes subsets, and also for the cell sorting of monocytes subsets for the functional studies. The circulating levels of monocytes subsets were found to be significantly differs among THS patients, who developed sepsis when compared with others who did not. The levels of patrolling monocytes were elevated in THS patients who developed sepsis and showed negative correlation with Sequential organ failure assessment (SOFA) score on days 7 and 14. Classical monocytes responded strongly to bacterial TLR-agonist (LPS) and produced anti-inflammatory cytokines, whereas patrolling monocytes responded with viral TLR agonist TLR-7/8 (R848) and produced inflammatory cytokines in post-traumatic sepsis patients. In conclusion, this study shows disparity in the behaviour of monocytes subsets in patients with acute post-traumatic sepsis.
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http://dx.doi.org/10.1016/j.molimm.2021.04.005DOI Listing
June 2021

Engineering the AEG1 promoter from cotton to develop male sterile lines.

Plant Cell Rep 2021 May 21. Epub 2021 May 21.

Department of Genetics, University of Delhi South Campus, Benito Juarez Road, New Delhi, 110021, India.

Keymessage: A promoter expressing in anther and roots is made anther specific. The modified promoter is used to drive barnase gene and develop male sterile lines.
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http://dx.doi.org/10.1007/s00299-021-02704-6DOI Listing
May 2021