Publications by authors named "Karin J Metzner"

72Publications

Emergence of Resistance to Integrase Strand Transfer Inhibitors during Dolutegravir Containing Triple-Therapy in a Treatment-Experienced Patient with Pre-Existing M184V/I Mutation.

Viruses 2020 11 19;12(11). Epub 2020 Nov 19.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.

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http://dx.doi.org/10.3390/v12111330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699495PMC
November 2020

Preclinical Evaluation of a Novel TALEN Targeting CCR5 Confirms Efficacy and Safety in Conferring Resistance to HIV-1 Infection.

Biotechnol J 2020 Oct 25:e2000023. Epub 2020 Oct 25.

Institute for Transfusion Medicine and Gene Therapy, Center for Chronic Immunodeficiency, Medical Center-University of Freiburg, Freiburg, 79106, Germany.

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http://dx.doi.org/10.1002/biot.202000023DOI Listing
October 2020

Prevalence of integrase strand transfer inhibitor resistance mutations in antiretroviral-naive HIV-1-infected individuals in Cameroon.

J Antimicrob Chemother 2020 Sep 20. Epub 2020 Sep 20.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.

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http://dx.doi.org/10.1093/jac/dkaa383DOI Listing
September 2020

Impact of pretreatment low-abundance HIV-1 drug-resistant variants on virological failure among HIV-1/TB-co-infected individuals.

J Antimicrob Chemother 2020 Nov;75(11):3319-3326

KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), College of Health Sciences, University of KwaZulu-Natal, Doris Duke Medical Research Institute, Durban, South Africa.

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http://dx.doi.org/10.1093/jac/dkaa343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566390PMC
November 2020

Reversal of T Cell Exhaustion in Chronic HCV Infection.

Viruses 2020 07 25;12(8). Epub 2020 Jul 25.

Department of Immunopathology of Infectious and Parasitic Diseases, Medical University of Warsaw, 02-091 Warsaw, Poland.

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http://dx.doi.org/10.3390/v12080799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472290PMC
July 2020

Parallel evolution of HIV-1 in a long-term experiment.

Mol Biol Evol 2019 Jun 28. Epub 2019 Jun 28.

Department of Environmental Systems Sciences, ETH Zurich, Zurich.

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http://dx.doi.org/10.1093/molbev/msz155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805227PMC
June 2019

Unravelling HIV-1 Latency, One Cell at a Time.

Trends Microbiol 2017 11 28;25(11):932-941. Epub 2017 Jun 28.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland; Institute of Medical Virology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.tim.2017.06.002DOI Listing
November 2017

MinVar: A rapid and versatile tool for HIV-1 drug resistance genotyping by deep sequencing.

J Virol Methods 2017 02 17;240:7-13. Epub 2016 Nov 17.

Institute of Medical Virology, University of Zurich, Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jviromet.2016.11.008DOI Listing
February 2017

HIV Whole-Genome Sequencing Now: Answering Still-Open Questions.

Authors:
Karin J Metzner

J Clin Microbiol 2016 Apr 20;54(4):834-5. Epub 2016 Jan 20.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland; Institute of Medical Virology, University of Zurich, Zurich, Switzerland

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http://dx.doi.org/10.1128/JCM.03265-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809914PMC
April 2016

A Comprehensive Analysis of Primer IDs to Study Heterogeneous HIV-1 Populations.

J Mol Biol 2016 Jan 19;428(1):238-250. Epub 2015 Dec 19.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland; Institute of Medical Virology, University of Zurich, 8091 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2015.12.012DOI Listing
January 2016

HIV-1 RNAs are Not Part of the Argonaute 2 Associated RNA Interference Pathway in Macrophages.

PLoS One 2015 30;10(7):e0132127. Epub 2015 Jul 30.

University Hospital Zurich, Division of Infectious Diseases and Hospital Epidemiology, University of Zurich, Zurich, Switzerland; Institute of Medical Virology, University of Zurich, Zurich, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132127PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520458PMC
May 2016

[Pathogenesis of HIV-1].

Authors:
Karin J Metzner

Ther Umsch 2014 Aug;71(8):443-50

Klinik für Infektionskrankheiten und Spitalhygiene, Universitätsspital Zürich.

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https://econtent.hogrefe.com/doi/10.1024/0040-5930/a000536
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http://dx.doi.org/10.1024/0040-5930/a000536DOI Listing
August 2014

Limited clinical benefit of minority K103N and Y181C-variant detection in addition to routine genotypic resistance testing in antiretroviral therapy-naive patients.

AIDS 2014 Sep;28(15):2231-9

aDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich bInstitute of Medical Virology, Swiss National Center for Retroviruses, University of Zurich, Zurich cLaboratory of Virology and AIDS Center, University Hospital Geneva, Geneva dDepartment of Biomedicine, Haus Petersplatz, University of Basel, Basel eDivision of Immunology, University Hospital Lausanne, Lausanne fDepartment of Infectious Diseases, Bern University Hospital and University of Bern, Bern gDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel, Basel hDivision of Infectious Diseases, Cantonal Hospital St. Gallen, St. Gallen iInfectious Diseases Service, University Hospital Lausanne, Lausanne jDivision of Infectious Diseases, Geneva University Hospitals, Geneva kDivision of Infectious Diseases, Regional Hospital Lugano, Lugano, Switzerland. *Karin J. Metzner, Alexandra U. Scherrer and Viktor Von Wyl contributed equally to this work.

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http://dx.doi.org/10.1097/QAD.0000000000000397DOI Listing
September 2014

Breast milk and gut microbiota in African mothers and infants from an area of high HIV prevalence.

PLoS One 2013 26;8(11):e80299. Epub 2013 Nov 26.

Barcelona Centre for International Heath Research (CRESIB, Hospital Clínic -Universitat de Barcelona), Barcelona, Spain ; Manhiça Health Research Centre (CISM), Maputo, Mozambique.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080299PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841168PMC
October 2014

Tailored enrichment strategy detects low abundant small noncoding RNAs in HIV-1 infected cells.

Retrovirology 2012 Mar 29;9:27. Epub 2012 Mar 29.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland.

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http://retrovirology.biomedcentral.com/articles/10.1186/1742
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http://dx.doi.org/10.1186/1742-4690-9-27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341194PMC
March 2012

In-depth analysis of G-to-A hypermutation rate in HIV-1 env DNA induced by endogenous APOBEC3 proteins using massively parallel sequencing.

J Virol Methods 2011 Feb 24;171(2):329-38. Epub 2010 Nov 24.

Institute of Clinical and Molecular Virology, University of Erlangen-Nuremberg, Germany.

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http://dx.doi.org/10.1016/j.jviromet.2010.11.016DOI Listing
February 2011

The antiretroviral potency of emtricitabine is approximately 3-fold higher compared to lamivudine in dual human immunodeficiency virus type 1 infection/competition experiments in vitro.

Antiviral Res 2010 Jun 17;86(3):312-5. Epub 2010 Mar 17.

University of Erlangen-Nuremberg, Institute of Clinical and Molecular Virology, Erlangen, Germany.

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http://dx.doi.org/10.1016/j.antiviral.2010.03.006DOI Listing
June 2010

Detection and significance of minority quasispecies of drug-resistant HIV-1.

Authors:
Karin J Metzner

J HIV Ther 2006 Dec;11(4):74-81

Institute of Clinical and Molecular Virology, University of Erlangen-Nuremberg, Schlossgarten, Erlangen, Germany.

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December 2006

Rapid selection of drug-resistant HIV-1 during the first months of suppressive ART in treatment-naive patients.

AIDS 2007 Mar;21(6):703-11

University of Erlangen-Nuremberg, Institute of Clinical and Molecular Virology, Erlangen, Germany.

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https://insights.ovid.com/crossref?an=00002030-200703300-000
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http://dx.doi.org/10.1097/QAD.0b013e3280121ac6DOI Listing
March 2007

Molecular characterisation of Lac s 1, the major allergen from lettuce (Lactuca sativa).

Mol Immunol 2007 Apr 8;44(11):2820-30. Epub 2007 Mar 8.

Division of Allergology, Paul-Ehrlich-Institut, Paul-Ehrlich-Strasse 51-59, 63225 Langen, Germany.

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http://dx.doi.org/10.1016/j.molimm.2007.01.030DOI Listing
April 2007

Persistence of lamivudine-sensitive HIV-1 quasispecies in the presence of lamivudine in vitro and in vivo.

J Acquir Immune Defic Syndr 2007 Apr;44(4):377-85

Institute of Clinical and Moleculr Virology, University of Erlangen-Nuremburg, Erlangen, Germany.

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http://dx.doi.org/10.1097/QAI.0b013e31803104c0DOI Listing
April 2007

Tenofovir treatment augments anti-viral immunity against drug-resistant SIV challenge in chronically infected rhesus macaques.

Retrovirology 2006 Dec 21;3:97. Epub 2006 Dec 21.

Aaron Diamond AIDS Research Center and The Rockefeller University, New York, NY 10016, USA.

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http://dx.doi.org/10.1186/1742-4690-3-97DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769512PMC
December 2006

Inhibition of drug-resistant HIV-1 by RNA interference.

Antiviral Res 2006 Jan 2;69(1):1-8. Epub 2005 Nov 2.

University of Erlangen-Nuremberg, Institute of Clinical and Molecular Virology, Schlossgarten 4, D-91054 Erlangen, Germany.

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http://dx.doi.org/10.1016/j.antiviral.2005.10.001DOI Listing
January 2006

Detection of minor populations of drug-resistant HIV-1 in acute seroconverters.

AIDS 2005 Nov;19(16):1819-25

University of Erlangen-Nuremberg, Institute of Clinical and Molecular Virology, Germany.

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http://dx.doi.org/10.1097/01.aids.0000189878.97480.edDOI Listing
November 2005