Publications by authors named "K M Myers"

1,127 Publications

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Cochlear Implant Behavioral Outcomes for Children With Auditory Neuropathy Spectrum Disorder: A Mini-Systematic Review.

Am J Audiol 2021 Jul 23:1-13. Epub 2021 Jul 23.

Department of Audiology, Nova Southeastern University, Fort Lauderdale, FL.

Objective The aim of this mini-systematic review was to evaluate the evidence reporting speech, language, and auditory behavioral outcome measures for children with a diagnosis of auditory neuropathy spectrum disorder (ANSD) who received cochlear implants (CIs) prior to 3 years of age. Method A mini-systematic review of the literature supporting evidence-based practices was performed. Two databases were searched utilizing a search strategy derived from the PICO (patient, intervention, comparison, outcome) framework. Peer-reviewed articles published between 2009 and 2019 evaluating children with a diagnosis of ANSD who were implanted prior to 3 years of age with a range of speech, language, and auditory behavioral outcomes were included. Four articles meeting inclusion criteria were critically appraised for reputable research design and risks of bias. Each of the four studies was assigned a level of evidence for effectiveness and quality assessment rating. Results Evidence supports cochlear implantation as an appropriate intervention for children with ANSD. Improvements in outcome performance were observed in all the included studies. Children with ANSD fit with CIs can achieve outcomes similar to children with sensorineural hearing loss and CIs, despite the heterogeneity of ANSD. Conclusion These findings have implications for clinical practice and for future research with current CI technology for facilitating parent education, counseling, and realistic expectations for children with ANSD and CIs.
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http://dx.doi.org/10.1044/2021_AJA-20-00175DOI Listing
July 2021

Improving mobilization of foreign DNA into ZM4 by removal of multiple restriction systems.

Appl Environ Microbiol 2021 Jul 21:AEM0080821. Epub 2021 Jul 21.

DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, USA.

has emerged as a promising candidate for production of high value bioproducts from plant biomass. However, a major limitation in equipping with novel pathways to achieve this goal is restriction of heterologous DNA. Here, we characterized the contribution of several defense systems of strain ZM4 to impeding heterologous gene transfer from an donor. Bioinformatic analysis revealed that ZM4 encodes a previously described -like Type IV Restriction Modification (RM) system, a Type I-F CRISPR system, a chromosomal Type I RM () and a previously uncharacterized Type I RM system, located on an endogenous plasmid (). The DNA recognition motif of HsdRMS was identified by comparing the methylated DNA sequence pattern of mutants lacking one or both of the and systems to the parent strain. The conjugation efficiency of synthetic plasmids containing single or combinations of the HsdMS and HsdRMS recognition sites indicated that both systems are active and decrease uptake of foreign DNA. In contrast, deletions of and led to no detectable improvement in conjugation efficiency for the exogenous DNA tested. Thus, the suite of markerless restriction strains that we constructed, and the knowledge of this new restriction system and its DNA recognition motif provide the necessary platform to flexibly engineer the next generation of strains for synthesis of valuable products. is equipped with a number of traits that make it a desirable platform organism for metabolic engineering to produce valuable bioproducts. Engineering strains equipped with synthetic pathways for biosynthesis of new molecules requires integration of foreign genes. In this study we have developed an all-purpose strain, devoid of known host restriction systems and free of any antibiotic resistance markers, which dramatically improves the uptake efficiency of heterologous DNA into ZM4. We also confirmed the role of a previously known restriction system as well as identified a previously unknown Type I RM system on an endogenous plasmid. Elimination of the barriers to DNA uptake as shown here will allow facile genetic engineering of .
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http://dx.doi.org/10.1128/AEM.00808-21DOI Listing
July 2021

A National Pediatric Telepsychiatry Curriculum for Graduate Medical Education and Continuing Medical Education.

J Child Adolesc Psychopharmacol 2021 Jul 20. Epub 2021 Jul 20.

Department of Psychiatry, Cambridge Health Alliance/Harvard Medical School, Cambridge, Massachusetts, USA.

Our goal was to develop an open access nationally disseminated online curriculum for use in graduate and continuing medical education on the topic of pediatric telepsychiatry to enhance the uptake of telepsychiatry among child psychiatry training programs and improve access to mental health care for youth and families. Following Kern's 6-stage model of curriculum development, we identified a core problem, conducted a needs assessment, developed broad goals and measurable objectives in a competency-based model, and developed educational content and methods. The curriculum was reviewed by experts and feedback incorporated. Given the urgent need for such a curriculum due to the COVID-19 pandemic, the curriculum was immediately posted on the American Academy of Child and Adolescent Psychiatry and American Association of Directors of Psychiatric Residency Training websites. Further evaluation will be conducted over the next year. The curriculum covers the six areas of core competence adapted for pediatric telepsychiatry and includes teaching content and resources, evaluation tools, and information about other resources. This online curriculum is available online and provides an important resource and set of standards for pediatric telepsychiatry training. Its online format allows for ongoing revision as the telepsychiatry landscape changes.
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http://dx.doi.org/10.1089/cap.2021.0024DOI Listing
July 2021
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