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1 Department of Radiology, University of Pennsylvania, Philadelphia, PA. 2 Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA. 3 Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA. 4 Department of Radiology, University of Iowa, Iowa City, IA. 5 Department of Biomedical Engineering, Boston University, Boston, MA. 6 Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA. 7 Department of Physiology, University of Pennsylvania, Philadelphia, PA.