Publications by authors named "Karen Horsburgh"

47Publications

Deficiency of Nrf2 exacerbates white matter damage and microglia/macrophage levels in a mouse model of vascular cognitive impairment.

Authors:
Emma Sigfridsson Martina Marangoni Giles E Hardingham Karen Horsburgh Jill H Fowler

J Neuroinflammation 2020 Dec 1;17(1):367. Epub 2020 Dec 1.

Centre for Discovery Brain Sciences, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.

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December 2020

Long-term effects of experimental carotid stenosis on hippocampal infarct pathology, neurons and glia and amelioration by environmental enrichment.

Authors:
William Stevenson Yoshiki Hase Elle Wilson Annabel Hollins Mai Hase Abdel Ennaceur Lucy Craggs Masafumi Ihara Karen Horsburgh Raj N Kalaria

Brain Res Bull 2020 10 21;163:72-83. Epub 2020 Jul 21.

Neurovascular Research Group, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK. Electronic address:

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October 2020

UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: Questionnaire and workshop proceedings.

Authors:
Aisling McFall Tuuli M Hietamies Ashton Bernard Margaux Aimable Stuart M Allan Philip M Bath Gaia Brezzo Roxana O Carare Hilary V Carswell Andrew N Clarkson Gillian Currie Tracy D Farr Jill H Fowler Mark Good Atticus H Hainsworth Catherine Hall Karen Horsburgh Rajesh Kalaria Patrick Kehoe Catherine Lawrence Malcolm Macleod Barry W McColl Alison McNeilly Alyson A Miller Scott Miners Vincent Mok Michael O'Sullivan Bettina Platt Emily S Sena Matthew Sharp Patrick Strangward Stefan Szymkowiak Rhian M Touyz Rebecca C Trueman Claire White Chris McCabe Lorraine M Work Terence J Quinn

J Cereb Blood Flow Metab 2020 Jul 9;40(7):1402-1414. Epub 2020 Mar 9.

Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.

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July 2020

Small vessel disease pathological changes in neurodegenerative and vascular dementias concomitant with autonomic dysfunction.

Authors:
Yoshiki Hase Tuomo M Polvikoski Michael J Firbank Lucinda J L Craggs Emily Hawthorne Charlotte Platten William Stevenson Vincent Deramecourt Clive Ballard Rose Anne Kenny Robert H Perry Paul Ince Roxana O Carare Louise M Allan Karen Horsburgh Raj N Kalaria

Brain Pathol 2020 01 16;30(1):191-202. Epub 2019 Aug 16.

Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom.

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January 2020

4-Sodium phenyl butyric acid has both efficacy and counter-indicative effects in the treatment of Col4a1 disease.

Authors:
Frances E Jones Lydia S Murray Sarah McNeilly Afshan Dean Alisha Aman Yinhui Lu Nija Nikolova Ruben Malomgré Karen Horsburgh William M Holmes Karl E Kadler Tom Van Agtmael

Hum Mol Genet 2019 02;28(4):628-638

Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

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February 2019

Astrocyte-specific overexpression of Nrf2 protects against optic tract damage and behavioural alterations in a mouse model of cerebral hypoperfusion.

Authors:
Emma Sigfridsson Martina Marangoni Jeffrey A Johnson Giles E Hardingham Jill H Fowler Karen Horsburgh

Sci Rep 2018 08 22;8(1):12552. Epub 2018 Aug 22.

Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.

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August 2018

Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.

Authors:
Karen Horsburgh Joanna M Wardlaw Tom van Agtmael Stuart M Allan Mike L J Ashford Philip M Bath Rosalind Brown Jason Berwick M Zameel Cader Roxana O Carare John B Davis Jessica Duncombe Tracy D Farr Jill H Fowler Jozien Goense Alessandra Granata Catherine N Hall Atticus H Hainsworth Adam Harvey Cheryl A Hawkes Anne Joutel Rajesh N Kalaria Patrick G Kehoe Catherine B Lawrence Andy Lockhart Seth Love Malcolm R Macleod I Mhairi Macrae Hugh S Markus Chris McCabe Barry W McColl Paul J Meakin Alyson Miller Maiken Nedergaard Michael O'Sullivan Terry J Quinn Rikesh Rajani Lisa M Saksida Colin Smith Kenneth J Smith Rhian M Touyz Rebecca C Trueman Tao Wang Anna Williams Steven C R Williams Lorraine M Work

Clin Sci (Lond) 2018 04 30;132(8):851-868. Epub 2018 Apr 30.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K.

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April 2018

White matter degeneration in vascular and other ageing-related dementias.

Authors:
Yoshiki Hase Karen Horsburgh Masafumi Ihara Raj N Kalaria

J Neurochem 2018 03 9;144(5):617-633. Epub 2018 Jan 9.

Neurovascular Research Group, Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, UK.

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March 2018

Chronic cerebral hypoperfusion: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and human vascular cognitive impairment and dementia.

Authors:
Jessica Duncombe Akihiro Kitamura Yoshiki Hase Masafumi Ihara Raj N Kalaria Karen Horsburgh

Clin Sci (Lond) 2017 Oct 28;131(19):2451-2468. Epub 2017 Sep 28.

National Cerebral and Cardiovascular Center, Osaka, Japan

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October 2017

Minocycline reduces microgliosis and improves subcortical white matter function in a model of cerebral vascular disease.

Authors:
Yasmina Manso Philip R Holland Akihiro Kitamura Stefan Szymkowiak Jessica Duncombe Edel Hennessy James L Searcy Martina Marangoni Andrew D Randall Jon T Brown Barry W McColl Karen Horsburgh

Glia 2018 01 19;66(1):34-46. Epub 2017 Jul 19.

Centre for Neuroregeneration, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, United Kingdom.

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January 2018

Chronic cerebral hypoperfusion alters amyloid-β peptide pools leading to cerebral amyloid angiopathy, microinfarcts and haemorrhages in Tg-SwDI mice.

Authors:
Natalia Salvadores James L Searcy Philip R Holland Karen Horsburgh

Clin Sci (Lond) 2017 Aug 24;131(16):2109-2123. Epub 2017 Jul 24.

Centre for Neuroregeneration, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh EH164SB, U.K.

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August 2017

Long-term cilostazol treatment reduces gliovascular damage and memory impairment in a mouse model of chronic cerebral hypoperfusion.

Authors:
Akihiro Kitamura Yasmina Manso Jessica Duncombe James Searcy Juraj Koudelka Margaret Binnie Scott Webster Ross Lennen Maurits Jansen Ian Marshall Masafumi Ihara Raj N Kalaria Karen Horsburgh

Sci Rep 2017 06 27;7(1):4299. Epub 2017 Jun 27.

University of Edinburgh, Edinburgh, UK.

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June 2017

Dimethyl fumarate improves white matter function following severe hypoperfusion: Involvement of microglia/macrophages and inflammatory mediators.

Authors:
Jill H Fowler Jamie McQueen Philip R Holland Yasmina Manso Martina Marangoni Fiona Scott Emma Chisholm Robert H Scannevin Giles E Hardingham Karen Horsburgh

J Cereb Blood Flow Metab 2018 08 13;38(8):1354-1370. Epub 2017 Jun 13.

1 Centre for Neuroregeneration, University of Edinburgh, Edinburgh, UK.

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August 2018

Effects of environmental enrichment on white matter glial responses in a mouse model of chronic cerebral hypoperfusion.

Authors:
Yoshiki Hase Lucinda Craggs Mai Hase William Stevenson Janet Slade Dianne Lopez Rubin Mehta Aiqing Chen Di Liang Arthur Oakley Masafumi Ihara Karen Horsburgh Raj N Kalaria

J Neuroinflammation 2017 04 11;14(1):81. Epub 2017 Apr 11.

Neurovascular Research Group, Institute of Neuroscience, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK.

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April 2017

The effects of environmental enrichment on white matter pathology in a mouse model of chronic cerebral hypoperfusion.

Authors:
Yoshiki Hase Lucinda Craggs Mai Hase William Stevenson Janet Slade Aiqing Chen Di Liang Abdel Ennaceur Arthur Oakley Masafumi Ihara Karen Horsburgh Raj N Kalaria

J Cereb Blood Flow Metab 2018 01 3;38(1):151-165. Epub 2017 Mar 3.

1 Neurovascular Research Group, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.

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January 2018

Recent progress in translational research on neurovascular and neurodegenerative disorders.

Authors:
Hans-Ulrich Demuth Rick M Dijkhuizen Tracy D Farr Mathias Gelderblom Karen Horsburgh Costantino Iadecola Damian D Mcleod Dominik Michalski Tim H Murphy Josune Orbe Willem M Otte Gabor C Petzold Nikolaus Plesnila Georg Reiser Klaus G Reymann Maria A Rueger Dorothee Saur Sean I Savitz Stephan Schilling Neil J Spratt Renée J Turner Raghu Vemuganti Denis Vivien Manuel Yepes Marietta Zille Johannes Boltze

Restor Neurol Neurosci 2017 ;35(1):87-103

Department of Medical Cell Technology, Fraunhofer Research Institution for Marine Biotechnology; Institute for Medical and Marine Biotechnology, University of Lübeck, Lübeck, Germany.

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January 2018

Small vessels, dementia and chronic diseases-molecular mechanisms and pathophysiology.

Authors:
Joanna M Wardlaw Karen Horsburgh

Clin Sci (Lond) 2016 11;130(21):1875-9

Centre for Neuroregeneration, Chancellor's Building, University of Edinburgh, Edinburgh EH16 4SB, U.K.

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November 2016

Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia.

Authors:
Aiqing Chen Rufus O Akinyemi Yoshiki Hase Michael J Firbank Michael N Ndung'u Vincent Foster Lucy J L Craggs Kazuo Washida Yoko Okamoto Alan J Thomas Tuomo M Polvikoski Louise M Allan Arthur E Oakley John T O'Brien Karen Horsburgh Masafumi Ihara Raj N Kalaria

Brain 2016 Jan 14;139(Pt 1):242-58. Epub 2015 Dec 14.

1 Neurovascular Research Group, Institute of Neuroscience, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne, UK

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January 2016

Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory.

Authors:
Akihiro Kitamura Satoshi Saito Takakuni Maki Naoya Oishi Takashi Ayaki Yorito Hattori Yumi Yamamoto Makoto Urushitani Raj N Kalaria Hidenao Fukuyama Karen Horsburgh Ryosuke Takahashi Masafumi Ihara

J Cereb Blood Flow Metab 2016 09 13;36(9):1592-602. Epub 2015 Oct 13.

Department of Stroke and Cerebrovascular Diseases, National Cerebral and Cardiovascular Center, Suita, Japan.

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September 2016

Gliovascular disruption and cognitive deficits in a mouse model with features of small vessel disease.

Authors:
Philip R Holland James L Searcy Natalia Salvadores Gillian Scullion Guiquan Chen Greig Lawson Fiona Scott Mark E Bastin Masafumi Ihara Rajesh Kalaria Emma R Wood Colin Smith Joanna M Wardlaw Karen Horsburgh

J Cereb Blood Flow Metab 2015 Jun 11;35(6):1005-14. Epub 2015 Feb 11.

Centre for Neuroregeneration, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.

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June 2015