Justine L Lam

Justine L Lam

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Justine L Lam

Justine L Lam

Publications by authors named "Justine L Lam"

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13Publications

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Metabolism, excretion and pharmacokinetics of [C]glasdegib (PF-04449913) in healthy volunteers following oral administration.

Xenobiotica 2017 Dec 3;47(12):1064-1076. Epub 2017 Jan 3.

c Department of Clinical Pharmacology, Pfizer Inc , San Diego , CA , USA , and.

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http://dx.doi.org/10.1080/00498254.2016.1261307DOI Listing
December 2017

Mechanistic understanding of translational pharmacokinetic-pharmacodynamic relationships in nonclinical tumor models: a case study of orally available novel inhibitors of anaplastic lymphoma kinase.

Drug Metab Dispos 2015 Jan 27;43(1):54-62. Epub 2014 Oct 27.

Pharmacokinetics, Dynamics and Metabolism (S.Y., J.L.L., P.V.) and Oncology Research Unit (H.Y.Z., H.W., T.S.), Pfizer Worldwide Research & Development, San Diego, California.

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http://dx.doi.org/10.1124/dmd.114.061143DOI Listing
January 2015

Translational pharmacokinetic-pharmacodynamic modeling for an orally available novel inhibitor of anaplastic lymphoma kinase and c-Ros oncogene 1.

J Pharmacol Exp Ther 2014 Oct 29;351(1):67-76. Epub 2014 Jul 29.

Pharmacokinetics, Dynamics and Metabolism (S.Y., J.L.L., P.V.) and Oncology Research Unit (H.Y.Z., H.W., T.S.), Pfizer Worldwide Research & Development, San Diego, California.

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http://dx.doi.org/10.1124/jpet.114.217141DOI Listing
October 2014

Quantitative prediction of repaglinide-rifampicin complex drug interactions using dynamic and static mechanistic models: delineating differential CYP3A4 induction and OATP1B1 inhibition potential of rifampicin.

Drug Metab Dispos 2013 May 7;41(5):966-74. Epub 2013 Feb 7.

Department of Pharmacokinetics, Dynamics, and Metabolism, MS 8220-2451, Pfizer World Wide Research and Development, Pfizer Inc., Groton, CT 06340, USA.

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http://dx.doi.org/10.1124/dmd.112.050583DOI Listing
May 2013

Expression and functional analysis of hepatic cytochromes P450, nuclear receptors, and membrane transporters in 10- and 25-week-old db/db mice.

Drug Metab Dispos 2010 Dec 24;38(12):2252-8. Epub 2010 Aug 24.

Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Pfizer Inc, La Jolla Laboratories, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1124/dmd.110.034223DOI Listing
December 2010

Elucidating the effect of final-day dosing of rifampin in induction studies on hepatic drug disposition and metabolism.

J Pharmacol Exp Ther 2006 Nov 11;319(2):864-70. Epub 2006 Aug 11.

Department of Biopharmaceutical Sciences, University of California San Francisco, 533 Parnassus, Room U-68, San Francisco, CA 94143-0446, USA.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.106.10828
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http://dx.doi.org/10.1124/jpet.106.108282DOI Listing
November 2006

In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: characterizing the importance of transporter-enzyme interplay.

Drug Metab Dispos 2006 Aug 12;34(8):1336-44. Epub 2006 May 12.

Professor, Department of Biopharmaceutical Sciences, University of California San Francisco, 533 Parnassus, Room U-68, San Francisco, CA 94143-0446, USA.

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http://dx.doi.org/10.1124/dmd.106.009258DOI Listing
August 2006

Hepatic microsome studies are insufficient to characterize in vivo hepatic metabolic clearance and metabolic drug-drug interactions: studies of digoxin metabolism in primary rat hepatocytes versus microsomes.

Drug Metab Dispos 2004 Nov;32(11):1311-6

Department of Biopharmaceutical Sciences, University of California San Francisco, 533 Parnassus, Room U-68, San Francisco, CA 94143-0446, USA.

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http://dx.doi.org/10.1124/dmd.32.11.DOI Listing
November 2004