Publications by authors named "Justin Hanes"

99Publications

Avoiding a Sticky Situation: Bypassing the Mucus Barrier for Improved Local Drug Delivery.

Trends Mol Med 2021 Jan 4. Epub 2021 Jan 4.

Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21287, USA; Departments Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address:

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January 2021

Sunitinib malate-loaded biodegradable microspheres for the prevention of corneal neovascularization in rats.

J Control Release 2020 Nov 18;327:456-466. Epub 2020 Aug 18.

Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; The Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Departments of Pharmaceutics, Virginia Commonwealth University, Richmond, VA 23298, USA; Department of Ophthalmology, Massey Cancer Center, Center for Pharmaceutical Engineering, Institute for Structural Biology, Drug Discovery & Development, Virginia Commonwealth University, Richmond, VA 23298, USA. Electronic address:

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November 2020

Nanoparticle-based thymulin gene therapy therapeutically reverses key pathology of experimental allergic asthma.

Sci Adv 2020 Jun 10;6(24):eaay7973. Epub 2020 Jun 10.

Laboratory of Cellular and Molecular Physiology, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

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June 2020

Non-adhesive and highly stable biodegradable nanoparticles that provide widespread and safe transgene expression in orthotopic brain tumors.

Drug Deliv Transl Res 2020 06;10(3):572-581

Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.

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June 2020

Sustained delivery of acriflavine from the suprachoroidal space provides long term suppression of choroidal neovascularization.

Biomaterials 2020 06 4;243:119935. Epub 2020 Mar 4.

The Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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June 2020

Validation of hyaluronic acid-agar-based hydrogels as vitreous humor mimetics for in vitro drug and particle migration evaluations.

Eur J Pharm Biopharm 2020 Mar 22;148:118-125. Epub 2020 Jan 22.

Buchanan Ocular Therapeutics Unit, Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

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March 2020

The cervicovaginal mucus barrier to HIV-1 is diminished in bacterial vaginosis.

PLoS Pathog 2020 01 23;16(1):e1008236. Epub 2020 Jan 23.

The Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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January 2020

Characterization of an Adapted Murine Model of Intrauterine Inflammation-Induced Preterm Birth.

Am J Pathol 2020 02 16;190(2):295-305. Epub 2019 Dec 16.

The Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland; Department of Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland; Division of Maternal Fetal Medicine, Department of Gynecology and Obstetrics, Integrated Research Center for Fetal Medicine, Johns Hopkins University, Baltimore, Maryland. Electronic address:

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February 2020

Widespread gene transfer to malignant gliomas with In vitro-to-In vivo correlation.

J Control Release 2019 06 9;303:1-11. Epub 2019 Apr 9.

Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, United States of America; Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, United States of America; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, United States of America. Electronic address:

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June 2019

Parkinson's disease gene therapy: Will focused ultrasound and nanovectors be the next frontier?

Mov Disord 2019 09 25;34(9):1279-1282. Epub 2019 Mar 25.

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.

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September 2019

Controlled release of dexamethasone sodium phosphate with biodegradable nanoparticles for preventing experimental corneal neovascularization.

Nanomedicine 2019 04 21;17:119-123. Epub 2019 Jan 21.

Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; Center for Nanomedicine, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA, USA; Department of Ophthalmology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA. Electronic address:

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April 2019

Controlled release of corticosteroid with biodegradable nanoparticles for treating experimental autoimmune uveitis.

J Control Release 2019 02 17;296:68-80. Epub 2019 Jan 17.

Department of Ophthalmology, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA; Center for Nanomedicine, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA; Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA; Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21231, USA; Departments of Oncology, Neurosurgery, and Pharmacology & Molecular Sciences, The Johns Hopkins University, Baltimore, MD 21231, USA. Electronic address:

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February 2019

Development of a mucoinert progesterone nanosuspension for safer and more effective prevention of preterm birth.

J Control Release 2019 02 28;295:74-86. Epub 2018 Dec 28.

The Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA; Department of Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland, Baltimore, MD 21287, USA; Department of Gynecology and Obstetrics, Johns Hopkins University, Baltimore, Maryland, Baltimore, MD 21287, USA. Electronic address:

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February 2019

Hypoxia-tropic Protein Nanocages for Modulation of Tumor- and Chemotherapy-Associated Hypoxia.

ACS Nano 2019 01 26;13(1):236-247. Epub 2018 Dec 26.

Center for Nanomedicine, Wilmer Eye Institute , Johns Hopkins University School of Medicine , Baltimore , Maryland 21231 , United States.

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January 2019

Mucus-penetrating budesonide nanosuspension enema for local treatment of inflammatory bowel disease.

Biomaterials 2018 12 7;185:97-105. Epub 2018 Sep 7.

The Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N Broadway, Baltimore, MD 21231, USA; Department of Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N. Broadway, Baltimore, MD 21231, USA; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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December 2018

An Adeno-Associated Viral Vector Capable of Penetrating the Mucus Barrier to Inhaled Gene Therapy.

Mol Ther Methods Clin Dev 2018 Jun 22;9:296-304. Epub 2018 Mar 22.

Center for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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June 2018

PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy.

J Control Release 2018 09 3;285:35-45. Epub 2018 Jul 3.

Wolfson Centre for Stem Cells, Tissue Engineering, and Modelling (STEM), Centre of Biomolecular Sciences, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK. Electronic address:

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September 2018

Sustained Dorzolamide Release Prevents Axonal and Retinal Ganglion Cell Loss in a Rat Model of IOP-Glaucoma.

Transl Vis Sci Technol 2018 Apr 28;7(2):13. Epub 2018 Mar 28.

Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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April 2018

Pseudomonas aeruginosa pyocyanin production reduced by quorum-sensing inhibiting nanocarriers.

Int J Pharm 2018 Jun 30;544(1):75-82. Epub 2018 Mar 30.

Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, United States. Electronic address:

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June 2018

Effects of enzymatic degradation on dynamic mechanical properties of the vitreous and intravitreal nanoparticle mobility.

Eur J Pharm Sci 2018 Jun 21;118:124-133. Epub 2018 Mar 21.

Buchanan Ocular Therapeutics Unit, Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. Electronic address:

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June 2018

Fate of PEGylated antibody fragments following delivery to the lungs: Influence of delivery site, PEG size and lung inflammation.

J Control Release 2018 02 13;272:62-71. Epub 2017 Dec 13.

Advanced Drug Delivery & Biomaterials, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium. Electronic address:

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February 2018

Protein nanocages that penetrate airway mucus and tumor tissue.

Proc Natl Acad Sci U S A 2017 08 24;114(32):E6595-E6602. Epub 2017 Jul 24.

Center for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231;

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August 2017

Strategies to enhance the distribution of nanotherapeutics in the brain.

J Control Release 2017 Dec 21;267:232-239. Epub 2017 Jul 21.

Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, United States; Department of Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, United States. Electronic address:

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December 2017

NanoDDS 2016: The 14th International Nanomedicine and Drug Delivery Symposium.

J Control Release 2017 10 20;263:1-3. Epub 2017 Jul 20.

Department of Chemical and Biomolecular Engineering and Institute for NanoBioTechnology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, United States; Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, United States. Electronic address:

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October 2017

Biodegradable brain-penetrating DNA nanocomplexes and their use to treat malignant brain tumors.

J Control Release 2017 Sep 8;262:37-46. Epub 2017 Jul 8.

Center for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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September 2017

Photoactivatable fluorescent probes reveal heterogeneous nanoparticle permeation through biological gels at multiple scales.

J Control Release 2017 08 31;260:124-133. Epub 2017 May 31.

Department of Physics & Astronomy, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address:

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August 2017

Immunomodulation-accelerated neuronal regeneration following selective rod photoreceptor cell ablation in the zebrafish retina.

Proc Natl Acad Sci U S A 2017 05 17;114(18):E3719-E3728. Epub 2017 Apr 17.

Wilmer Eye Institute; Johns Hopkins School of Medicine, Baltimore, MD 21231;

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May 2017

MR image-guided delivery of cisplatin-loaded brain-penetrating nanoparticles to invasive glioma with focused ultrasound.

J Control Release 2017 Oct 11;263:120-131. Epub 2017 Mar 11.

Department of Biomedical Engineering, University of Virginia, 415 Lane Road Building MR5, Charlottesville, VA 22908, United States. Electronic address:

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October 2017

Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats.

J Control Release 2017 Oct 7;263:112-119. Epub 2017 Mar 7.

Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, United States; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States; Department of Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, United States; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, United States; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, United States; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, United States. Electronic address:

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October 2017

Development of Absorbable, Antibiotic-Eluting Sutures for Ophthalmic Surgery.

Transl Vis Sci Technol 2017 Jan 3;6(1). Epub 2017 Jan 3.

Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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January 2017

Hyaluronic acid-conjugated lipoplexes for targeted delivery of siRNA in a murine metastatic lung cancer model.

Int J Pharm 2016 Nov;514(1):103-111

Université Paris-Sud, Faculté de Pharmacie, Institut Galien Paris-Sud, 5 rue JB Clément, 92296 Châtenay-Malabry Cedex, France; CNRS, UMR 8612, 5 rue JB Clément, 92296 Châtenay-Malabry Cedex, France. Electronic address:

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November 2016

The Mucus Barrier to Inhaled Gene Therapy.

Mol Ther 2016 Dec 20;24(12):2043-2053. Epub 2016 Sep 20.

Center for Nanomedicine, Johns Hopkins University, Baltimore, Maryland, USA.

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December 2016

Mucus-Penetrating Nanosuspensions for Enhanced Delivery of Poorly Soluble Drugs to Mucosal Surfaces.

Adv Healthc Mater 2016 11 26;5(21):2745-2750. Epub 2016 Sep 26.

Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N Broadway, Baltimore, MD, 21231, USA.

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November 2016

Enhancing Intracranial Delivery of Clinically Relevant Non-viral Gene Vectors.

RSC Adv 2016;48(6):41665-41674. Epub 2016 Apr 19.

The Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.

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April 2016

Particle-Tracking Microrheology Using Micro-Optical Coherence Tomography.

Biophys J 2016 Sep;111(5):1053-63

Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts; Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

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September 2016

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer.

Proc Natl Acad Sci U S A 2016 09 24;113(36):E5328-36. Epub 2016 Aug 24.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205;

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September 2016

Subconjunctival Delivery of Dorzolamide-Loaded Poly(ether-anhydride) Microparticles Produces Sustained Lowering of Intraocular Pressure in Rabbits.

Mol Pharm 2016 09 7;13(9):2987-95. Epub 2016 Jul 7.

Department of Ophthalmology, ‡Center for Nanomedicine, and ∥Glaucoma Center of Excellence, The Johns Hopkins University School of Medicine , Baltimore, Maryland 21287, United States.

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September 2016

Nanoparticles for oral delivery: Design, evaluation and state-of-the-art.

J Control Release 2016 10 9;240:504-526. Epub 2016 Jun 9.

The Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N Broadway, Baltimore, MD 21231, USA; Department of Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N. Broadway, Baltimore, MD 21231, USA; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA. Electronic address:

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October 2016

Barriers to inhaled gene therapy of obstructive lung diseases: A review.

J Control Release 2016 10 16;240:465-488. Epub 2016 May 16.

The Center for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. Electronic address:

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October 2016

Nanoparticles coated with high molecular weight PEG penetrate mucus and provide uniform vaginal and colorectal distribution in vivo.

Nanomedicine (Lond) 2016 06 12;11(11):1337-43. Epub 2016 May 12.

Center for Nanomedicine, Johns Hopkins University School of Medicine, 400 N. Broadway, Baltimore, MD 21231, USA.

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June 2016

Combination therapy with cystic fibrosis transmembrane conductance regulator modulators augment the airway functional microanatomy.

Am J Physiol Lung Cell Mol Physiol 2016 05 11;310(10):L928-39. Epub 2016 Mar 11.

Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama; Department of Cellular, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama;

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May 2016

Targeted gene transfer to the brain via the delivery of brain-penetrating DNA nanoparticles with focused ultrasound.

J Control Release 2016 Feb 28;223:109-117. Epub 2015 Dec 28.

Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA. Electronic address:

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February 2016

Biodegradable DNA Nanoparticles that Provide Widespread Gene Delivery in the Brain.

Small 2016 Feb 17;12(5):678-85. Epub 2015 Dec 17.

Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins School of Medicine, 400 N. Broadway, Baltimore, MD 21231, USA.

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February 2016

Editorial.

J Control Release 2015 Dec;219

The Center for Nanomedicine at the Wilmer Eye Institute http://cnm-hopkins.org/ Johns Hopkins University School of Medicine, USA. Electronic address:

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December 2015

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery.

Adv Drug Deliv Rev 2016 Apr 9;99(Pt A):28-51. Epub 2015 Oct 9.

The Center for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, United States; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, United States; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, United States. Electronic address:

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April 2016

Journal of Drug Targeting Life Time Achievement Award for Prof. Robert Langer.

J Drug Target 2015 ;23(7-8):579

b Johns Hopkins University , Baltimore , MD , USA.

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July 2016

Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo.

ACS Nano 2015 Sep 31;9(9):9217-27. Epub 2015 Aug 31.

Department of Ophthalmology, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine , Baltimore, Maryland 21231, United States.

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September 2015

Highly compacted biodegradable DNA nanoparticles capable of overcoming the mucus barrier for inhaled lung gene therapy.

Proc Natl Acad Sci U S A 2015 Jul 29;112(28):8720-5. Epub 2015 Jun 29.

Center for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21297;

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July 2015

Enema ion compositions for enhancing colorectal drug delivery.

J Control Release 2015 Jul 30;209:280-7. Epub 2015 Apr 30.

Center for Nanomedicine, Johns Hopkins University School of Medicine, 400N. Broadway, Baltimore, MD 21231 USA; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205 USA; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218 USA; Department of Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N. Broadway, Baltimore, MD 21231, USA; Center for Cancer Nanotechnology Excellence, the Institute for NanoBioTechnology, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA; Departments of Neurosurgery, Oncology, and Pharmacology & Molecular Sciences, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA. Electronic address:

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July 2015

Particle tracking in drug and gene delivery research: State-of-the-art applications and methods.

Adv Drug Deliv Rev 2015 Aug 7;91:70-91. Epub 2015 Apr 7.

Center for Nanomedicine, Johns Hopkins University School of Medicine , Baltimore, MD 21231, USA.

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August 2015

Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers.

Biomaterials 2015 Jun 18;52:507-16. Epub 2015 Mar 18.

Center for Nanomedicine at the Wilmer Eye Institute, Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, United States; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, United States; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, United States. Electronic address:

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June 2015

Highly PEGylated DNA Nanoparticles Provide Uniform and Widespread Gene Transfer in the Brain.

Adv Healthc Mater 2015 May 11;4(7):1023-33. Epub 2015 Mar 11.

Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N. Broadway, Baltimore, MD, 21231, USA.

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May 2015

Corticosteroid-loaded biodegradable nanoparticles for prevention of corneal allograft rejection in rats.

J Control Release 2015 Mar 8;201:32-40. Epub 2015 Jan 8.

Department of Ophthalmology, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA; Center for Nanomedicine, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA; Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA. Electronic address:

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March 2015

Minimizing the non-specific binding of nanoparticles to the brain enables active targeting of Fn14-positive glioblastoma cells.

Biomaterials 2015 Feb 13;42:42-51. Epub 2014 Dec 13.

Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA. Electronic address:

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February 2015

Highly compacted pH-responsive DNA nanoparticles mediate transgene silencing in experimental glioma.

J Mater Chem B 2014 Dec;2(46):8165-8173

Center for Nanomedicine, Johns Hopkins University School of Medicine, 400 North Broadway Street, Baltimore, MD 21231 (USA) ; Department of Ophthalmology, Biomedical Engineering, Chemical & Biomolecular Engineering, Neurosurgery, and Oncology, Johns Hopkins University School of Medicine, 400 North Broadway Street, Baltimore, MD 21231 (USA) ; Center for Cancer Nanotechnology Excellence, Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland, 21231 (USA).

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December 2014

Non-covalent photo-patterning of gelatin matrices using caged collagen mimetic peptides.

Macromol Biosci 2015 Jan 4;15(1):52-62. Epub 2014 Dec 4.

Department of Bioengineering, University of Utah, 36 S. Wasatch Drive, 3100 SMBB, Salt Lake City, Utah, 84112, USA.

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January 2015

Liposome-based mucus-penetrating particles (MPP) for mucosal theranostics: demonstration of diamagnetic chemical exchange saturation transfer (diaCEST) magnetic resonance imaging (MRI).

Nanomedicine 2015 Feb 15;11(2):401-5. Epub 2014 Nov 15.

Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Center for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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February 2015

Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse.

J Control Release 2015 Jan 4;197:48-57. Epub 2014 Nov 4.

Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N. Broadway, Baltimore, MD 21231, United States; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, United States; Department of Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N. Broadway, Baltimore, MD 21231, United States; Center for Cancer Nanotechnology Excellence, Institute for NanoBioTechnology, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, United States. Electronic address:

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January 2015

Single particle tracking reveals spatial and dynamic organization of the biofilm matrix.

New J Phys 2014 Aug;16(8):085014

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.

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August 2014

Pretreatment of human cervicovaginal mucus with pluronic F127 enhances nanoparticle penetration without compromising mucus barrier properties to herpes simplex virus.

Biomacromolecules 2014 Dec 11;15(12):4403-9. Epub 2014 Nov 11.

Center for Nanomedicine, ‡Department of Ophthalmology, The Wilmer Eye Institute, ⊥Department of Biomedical Engineering, and ○Departments of Neurosurgery and Oncology, Johns Hopkins University, School of Medicine , Baltimore, Maryland, United States.

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December 2014

Brain-penetrating nanoparticles improve paclitaxel efficacy in malignant glioma following local administration.

ACS Nano 2014 Oct 8;8(10):10655-64. Epub 2014 Oct 8.

Center for Nanomedicine at the Wilmer Eye Institute, ‡Department of Biomedical Engineering, ∥Department of Ophthalmology, #Deparments of Oncology, Pharmacology and Molecular Sciences, and Neurosurgery, Johns Hopkins University School of Medicine , Baltimore, Maryland 21231, United States.

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October 2014

Hydroxyl PAMAM dendrimer-based gene vectors for transgene delivery to human retinal pigment epithelial cells.

Nanoscale 2015 Mar;7(9):3845-56

Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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March 2015

Cellular trafficking and anticancer activity of Garcinia mangostana extract-encapsulated polymeric nanoparticles.

Int J Nanomedicine 2014 6;9:3677-86. Epub 2014 Aug 6.

Center for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA ; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA ; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA.

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May 2015

Emerging insights into barriers to effective brain tumor therapeutics.

Front Oncol 2014 21;4:126. Epub 2014 Jul 21.

Department of Neurosurgery, Johns Hopkins University School of Medicine , Baltimore, MD , USA.

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August 2014

Nanoparticle penetration of human cervicovaginal mucus: the effect of polyvinyl alcohol.

J Control Release 2014 Oct 29;192:202-8. Epub 2014 Jul 29.

Center for Nanomedicine, Johns Hopkins University School of Medicine, 400 N Broadway, Baltimore, MD 21287, USA; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA; Center for Cancer Nanotechnology Excellence, Institute for NanoBioTechnology, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA; Department of Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N Broadway, Baltimore, MD 21287, USA. Electronic address:

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October 2014

Overcoming the cystic fibrosis sputum barrier to leading adeno-associated virus gene therapy vectors.

Mol Ther 2014 Aug 29;22(8):1484-1493. Epub 2014 May 29.

Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Center for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland, USA. Electronic address:

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August 2014

Nanoparticle-based drug delivery to the vagina: a review.

J Control Release 2014 Sep 14;190:500-14. Epub 2014 May 14.

Center for Nanomedicine, Johns Hopkins University School of Medicine, 400 N. Broadway, Baltimore 21231, USA; Department of Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N. Broadway, Baltimore 21231, USA; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore 21205, USA; Center for Cancer Nanotechnology Excellence, Institute for NanoBioTechnology, Johns Hopkins University, 3400 N. Charles Street, Baltimore 21218, USA; Department of Neurosurgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore 21287, USA; Department of Oncology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore 21287, USA.

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September 2014

Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model.

Drug Deliv Transl Res 2014 Apr;4(2):203-9

Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205 (USA) ; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218 (USA) ; Department of Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N Broadway, Baltimore, MD 21287 (USA) ; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287 (USA) ; Center for Cancer Nanotechnology Excellence, Institute for NanoBioTechnology, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218 (USA) ; Center for Nanomedicine, Johns Hopkins University School of Medicine, 400 N Broadway, Baltimore, MD 21287 (USA).

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April 2014

Scleral permeability varies by mouse strain and is decreased by chronic experimental glaucoma.

Invest Ophthalmol Vis Sci 2014 Apr 21;55(4):2564-73. Epub 2014 Apr 21.

Glaucoma Center of Excellence and Center for Nanomedicine, Wilmer Ophthalmological Institute, Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.

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April 2014

DNA nanoparticle-mediated thymulin gene therapy prevents airway remodeling in experimental allergic asthma.

J Control Release 2014 Apr 17;180:125-33. Epub 2014 Feb 17.

Laboratory of Cellular and Molecular Physiology, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:

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April 2014

A diaCEST MRI approach for monitoring liposomal accumulation in tumors.

J Control Release 2014 Apr 15;180:51-9. Epub 2014 Feb 15.

Russell H. Morgan Department of Radiology and Radiological Sciences, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore 21287, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore 21205, USA; Center for Nanomedicine, The Johns Hopkins University School of Medicine, Baltimore 21287, USA. Electronic address:

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April 2014

Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier.

J Control Release 2014 Mar 14;178:8-17. Epub 2014 Jan 14.

The Center for Nanomedicine, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore 21231, USA; Department of Ophthalmology, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore 21231, USA; Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore 21205, USA; Department of Chemical & Biomolecular Engineering, The Johns Hopkins University, 3400 North Charles Street, Baltimore 21218, USA. Electronic address:

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March 2014