Jussi Taipale

Jussi Taipale

UNVERIFIED PROFILE

Are you Jussi Taipale?   Register this Author

Register author
Jussi Taipale

Jussi Taipale

Publications by authors named "Jussi Taipale"

Are you Jussi Taipale?   Register this Author

89Publications

2153Reads

18Profile Views

Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy.

J Allergy Clin Immunol 2019 Jun 13. Epub 2019 Jun 13.

Adult Immunodeficiency Unit, Infectious Diseases, Inflammation Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Rare Diseases Center and Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2019.06.003DOI Listing
June 2019

The chromatin of cancer.

Authors:
Jussi Taipale

Science 2018 10;362(6413):401-402

Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aav3494DOI Listing
October 2018

A protein activity assay to measure global transcription factor activity reveals determinants of chromatin accessibility.

Nat Biotechnol 2018 07 21;36(6):521-529. Epub 2018 May 21.

Division of Functional Genomics and Systems Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nbt.4138DOI Listing
July 2018

CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response.

Nat Med 2018 07 11;24(7):927-930. Epub 2018 Jun 11.

Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41591-018-0049-zDOI Listing
July 2018

Modular discovery of monomeric and dimeric transcription factor binding motifs for large data sets.

Nucleic Acids Res 2018 05;46(8):e44

Department of Computer Science, P.O. Box 68, FI-00014 University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gky027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934673PMC
May 2018

Informational limits of biological organisms.

Authors:
Jussi Taipale

EMBO J 2018 05 18;37(10). Epub 2018 Apr 18.

Department of Biochemistry, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/embj.201696114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978287PMC
May 2018

The Human Transcription Factors.

Cell 2018 02;172(4):650-665

Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA; Divisions of Biomedical Informatics and Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2018.01.029DOI Listing
February 2018

Structural perspective of cooperative transcription factor binding.

Curr Opin Struct Biol 2017 12 24;47:1-8. Epub 2017 Mar 24.

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden; Genome-Scale Biology Research Program, P.O. Box 63, FI-00014 University of Helsinki, Finland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sbi.2017.03.006DOI Listing
December 2017

CRISPR/Cas9 screening using unique molecular identifiers.

Mol Syst Biol 2017 10 9;13(10):945. Epub 2017 Oct 9.

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658704PMC
http://dx.doi.org/10.15252/msb.20177834DOI Listing
October 2017

Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes.

J Allergy Clin Immunol 2017 Sep 21;140(3):782-796. Epub 2017 Jan 21.

Adult Immunodeficiency Unit, Infectious Diseases, Inflammation Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Rare Diseases Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2016.10.054DOI Listing
September 2017

Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates.

Nature 2017 04 5;544(7649):245-249. Epub 2017 Apr 5.

Department of Pathology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94305, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature21722DOI Listing
April 2017

Fast motif matching revisited: high-order PWMs, SNPs and indels.

Bioinformatics 2017 02;33(4):514-521

Helsinki Institute for Information Technology HIIT, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btw683DOI Listing
February 2017

Transcription factor family-specific DNA shape readout revealed by quantitative specificity models.

Mol Syst Biol 2017 02 6;13(2):910. Epub 2017 Feb 6.

Molecular and Computational Biology Program, Departments of Biological Sciences, Chemistry, Physics & Astronomy, and Computer Science, University of Southern California, Los Angeles, CA, USA

View Article

Download full-text PDF

Source
http://msb.embopress.org/lookup/doi/10.15252/msb.20167238
Publisher Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327724PMC
http://dx.doi.org/10.15252/msb.20167238DOI Listing
February 2017

PeakXus: comprehensive transcription factor binding site discovery from ChIP-Nexus and ChIP-Exo experiments.

Bioinformatics 2016 09;32(17):i629-i638

Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btw448DOI Listing
September 2016

The role of enhancers in cancer.

Nat Rev Cancer 2016 08 1;16(8):483-93. Epub 2016 Jul 1.

Division of Functional Genomics and Systems Biology, Department of Medical Biochemistry and Biophysics, and Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm SE-171 77, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrc.2016.62DOI Listing
August 2016

Methods for Analysis of Transcription Factor DNA-Binding Specificity In Vitro.

Subcell Biochem 2011 ;52:155-73

Department of Biosciences and Nutrition, SE-171 77, Stockholm, Sweden,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-90-481-9069-0_7DOI Listing
April 2016

Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent Mutations in TP53, ATRX, and MED12.

PLoS Genet 2016 Feb 18;12(2):e1005850. Epub 2016 Feb 18.

Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1005850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758603PMC
February 2016

Structural insights into the DNA-binding specificity of E2F family transcription factors.

Nat Commun 2015 Dec 3;6:10050. Epub 2015 Dec 3.

Department of Biosciences and Nutrition, Karolinska Institutet, SE 141 83 Stockholm, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms10050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686757PMC
December 2015

DNA-dependent formation of transcription factor pairs alters their binding specificity.

Nature 2015 Nov 9;527(7578):384-8. Epub 2015 Nov 9.

Department of Biosciences and Nutrition, Karolinska Institutet, SE 141 83, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature15518DOI Listing
November 2015

CTCF/cohesin-binding sites are frequently mutated in cancer.

Nat Genet 2015 Jul 8;47(7):818-21. Epub 2015 Jun 8.

1] Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland. [2] Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3335DOI Listing
July 2015

Cancer. Cancer by super-enhancer.

Science 2014 Dec;346(6215):1291-2

Genome-Scale Biology Program, University of Helsinki, Finland. Science for Life Laboratory, Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aaa3247DOI Listing
December 2014

Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity.

Cell Rep 2014 May 18;7(3):654-60. Epub 2014 Apr 18.

Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 8257, STRF, San Antonio, TX 78229-3900, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2014.03.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041330PMC
May 2014

A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding.

Nat Genet 2014 Feb 5;46(2):126-35. Epub 2014 Jan 5.

1] Biocenter Oulu, University of Oulu, Oulu, Finland. [2] Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine, University of Oulu, Oulu, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.2862DOI Listing
February 2014

Frequent L1 retrotranspositions originating from TTC28 in colorectal cancer.

Oncotarget 2014 Feb;5(3):853-9

Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996660PMC
http://dx.doi.org/10.18632/oncotarget.1781DOI Listing
February 2014

Human kinome analysis reveals novel kinases contributing to virus infection and retinoic-acid inducible gene I-induced type I and type III IFN gene expression.

Innate Immun 2013 Oct 12;19(5):516-30. Epub 2013 Feb 12.

1Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare (THL), Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1753425912473345DOI Listing
October 2013

Transcription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites.

Cell 2013 Aug;154(4):801-13

Science for Life Laboratory, Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm 14183, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2013.07.034DOI Listing
August 2013

Lessons from functional analysis of genome-wide association studies.

Cancer Res 2013 Jul 5;73(14):4180-4. Epub 2013 Jul 5.

Department of Biosciences and Nutrition, SciLife Center, Karolinska Institutet, Clinical Research Center, Karolinska University Hospital, Stockholm, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-13-0789DOI Listing
July 2013

A versatile platform for creating a comprehensive UAS-ORFeome library in Drosophila.

Development 2013 Jun 1;140(11):2434-42. Epub 2013 May 1.

Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dev.088757DOI Listing
June 2013

Systematic screening of a Drosophila ORF library in vivo uncovers Wnt/Wg pathway components.

Dev Cell 2013 Apr 11;25(2):207-19. Epub 2013 Apr 11.

Institute of Molecular Life Sciences, University of Zurich, Zurich 8057, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.devcel.2013.02.019DOI Listing
April 2013

Transcriptional networks controlling the cell cycle.

G3 (Bethesda) 2013 Jan 1;3(1):75-90. Epub 2013 Jan 1.

Genome-Scale Biology Research Program, Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1534/g3.112.004283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538345PMC
January 2013

Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors.

Science 2012 Dec 1;338(6112):1360-3. Epub 2012 Nov 1.

Science for Life Center, Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1228606DOI Listing
December 2012

Counting absolute numbers of molecules using unique molecular identifiers.

Nat Methods 2011 Nov 20;9(1):72-4. Epub 2011 Nov 20.

Genome-Scale Biology Program, Institute of Biomedicine, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nmeth.1778DOI Listing
November 2011

Beyond the balance of activator and repressor.

Sci Signal 2011 Jun 7;4(176):pe29. Epub 2011 Jun 7.

Department of Biosciences and Nutrition, Karolinska Institutet, SE-141 83 Stockholm, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scisignal.2002183DOI Listing
June 2011

Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation.

Cancer Res 2010 Oct 28;70(20):7851-61. Epub 2010 Sep 28.

Molecular Cancer Biology Research Program, Departments of Pathology and Virology, Haartman Institute, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-10-1223DOI Listing
October 2010

FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex.

Proc Natl Acad Sci U S A 2010 Sep 23;107(36):15786-91. Epub 2010 Aug 23.

Department of Pathology, Haartman Institute, University of Helsinki, Helsinki University Central Hospital, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0914459107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936587PMC
September 2010

Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo.

EMBO J 2010 Jul 1;29(13):2147-60. Epub 2010 Jun 1.

Public Health Genomics Unit, National Institute for Health and Welfare (THL) and Genome-Scale Biology Program, Institute of Biomedicine and High Throughput Center, University of Helsinki, Biomedicum, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/emboj.2010.106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905244PMC
July 2010

Multiplexed massively parallel SELEX for characterization of human transcription factor binding specificities.

Genome Res 2010 Jun 8;20(6):861-73. Epub 2010 Apr 8.

Department of Molecular Medicine, National Public Health Institute (KTL) and Genome-Scale Biology Program, Institute of Biomedicine and High Throughput Center, University of Helsinki, Biomedicum, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gr.100552.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877582PMC
June 2010

KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA.

PLoS Pathog 2009 Mar 6;5(3):e1000324. Epub 2009 Mar 6.

Genome-Scale Biology Program, Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1000324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648312PMC
March 2009

Hedgehog: functions and mechanisms.

Genes Dev 2008 Sep;22(18):2454-72

Department of Molecular Medicine, National Public Health Institute (KTL), and Genome-Scale Biology Program, Biomedicum Helsinki, Institute of Biomedicine and High Throughput Center, Faculty of Medicine, University of Helsinki, Helsinki FI-00014, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gad.1693608DOI Listing
September 2008

Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos.

Mol Cell Biol 2008 Aug 2;28(15):4843-50. Epub 2008 Jun 2.

Molecular/Cancer Biology Laboratory, Haartman Institute, Biomedicum Helsinki and Helsinki University Central Hospital, P. O. B. 63 (Haartmaninkatu 8), University of Helsinki, 00014 Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.02214-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493372PMC
August 2008

High-throughput assay for determining specificity and affinity of protein-DNA binding interactions.

Nat Protoc 2006 ;1(1):215-22

Molecular/Cancer Biology Program, Institute of Biomedicine, University of Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nprot.2006.33DOI Listing
June 2007

Locating potential enhancer elements by comparative genomics using the EEL software.

Nat Protoc 2006 ;1(1):368-74

Department of Computer Science, P.O. Box 68 (Gustaf Hällströmin katu 2b) FIN-00014, University of Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nprot.2006.56DOI Listing
June 2007

Hedgehog signaling.

J Cell Sci 2007 Jan;120(Pt 1):3-6

Institute of Biomedicine and High Throughput Center, and Department of Molecular Medicine, National Public Health Institute (KTL), Biomedicum, P.O. Box 63 (Haartmaninkatu 8), FIN-00014 University of Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/jcs.03309DOI Listing
January 2007

Divergence of hedgehog signal transduction mechanism between Drosophila and mammals.

Dev Cell 2006 Feb;10(2):177-86

Molecular and Cancer Biology Program, Biomedicum, University of Helsinki and Department of Molecular Medicine, National Public Health Institute, P.O. Box 63, Helsinki FIN-00014, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.devcel.2005.12.014DOI Listing
February 2006

Identification of pathways regulating cell size and cell-cycle progression by RNAi.

Nature 2006 Feb;439(7079):1009-13

Molecular and Cancer Biology Program, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014 University of Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature04469DOI Listing
February 2006

Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity.

Cell 2006 Jan;124(1):47-59

Molecular and Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2005.10.042DOI Listing
January 2006

[Epithelial stem cell and cancer].

Authors:
Jussi Taipale

Duodecim 2004 ;120(4):373-5

View Article

Download full-text PDF

Source
September 2004

Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins.

Nat Immunol 2004 Jan 23;5(1):74-80. Epub 2003 Nov 23.

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, PO Box 63, 00014 Helsinki, Finland.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/ni1013
Publisher Site
http://dx.doi.org/10.1038/ni1013DOI Listing
January 2004

Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2.

Mol Cell 2003 Nov;12(5):1261-74

Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1097-2765(03)00426-xDOI Listing
November 2003

A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis.

Nat Genet 2003 Apr 24;33(4):508-13. Epub 2003 Mar 24.

Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng1134DOI Listing
April 2003

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.

Genes Dev 2002 Nov;16(21):2743-8

Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gad.1025302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC187469PMC
November 2002

Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched.

Cell 2002 Oct;111(1):63-75

Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0092-8674(02)00977-7DOI Listing
October 2002

Small molecule modulation of Smoothened activity.

Proc Natl Acad Sci U S A 2002 Oct 21;99(22):14071-6. Epub 2002 Oct 21.

Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.182542899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC137838PMC
October 2002

Medulloblastoma growth inhibition by hedgehog pathway blockade.

Science 2002 Aug;297(5586):1559-61

Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1073733DOI Listing
August 2002