Publications by authors named "Juro Sakai"

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Overexpression of p54/NONO induces differential splicing and contributes to castration-resistant prostate cancer growth.
Oncotarget 2018 Feb 8;9(12):10510-10524. Epub 2018 Jan 8.
Laboratory for Systems Biology and Medicine (LSBM), Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Tokyo 153-8904, Japan.

Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP.
Cell Chem Biol 2017 Feb 26;24(2):207-217. Epub 2017 Jan 26.
Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Uji, Kyoto 611-0011, Japan; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan; CREST, AMED. Electronic address:

The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages.
Sci Rep 2016 Jun 28;6:28845. Epub 2016 Jun 28.
Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.


H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation.
Mol Cell 2015 Nov;60(4):584-96
Division of Metabolic Medicine, The University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan; The Translational Systems Biology and Medicine Initiative (TSBMI), Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan. Electronic address:

Analysis of the subcellular localization of the human histone methyltransferase SETDB1.
Biochem Biophys Res Commun 2015 Oct 18;465(4):725-31. Epub 2015 Aug 18.
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address:

Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver.
J Atheroscler Thromb 2015 Aug 4;22(8):754-72. Epub 2015 Jun 4.
Laboratory for Systems Biology and Medicine (LSBM), Research Center for Advanced Science and Technology (RCAST), University of Tokyo.

JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
Nat Commun 2015 May 7;6:7052. Epub 2015 May 7.
1] Division of Metabolic Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Tokyo 153-8904, Japan [2] The Translational Systems Biology and Medicine Initiative, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan.

The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis.
J Biol Chem 2015 Feb 22;290(7):4163-77. Epub 2014 Dec 22.
From the Division of Metabolic Medicine, the Translational Systems Biology and Medicine Initiative Center for Disease Biology and Integrative Medicine, University of Tokyo, Tokyo 153-8904, Japan,




Novel repressor regulates insulin sensitivity through interaction with Foxo1.
EMBO J 2012 May 17;31(10):2275-95. Epub 2012 Apr 17.
Frontier Medicine on Metabolic Syndrome, Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.



Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells.
J Biol Chem 2009 Aug 24;284(33):22195-205. Epub 2009 Jun 24.
Graduate School of Pharmaceutical Sciences, Osaka University, Department of Molecular Pharmaceutical Science, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.

Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice.
Genes Cells 2009 Aug 15;14(8):991-1001. Epub 2009 Jul 15.
Metabolism and Endocrinology Division, Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153-8904, Japan.


COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis.
Proc Natl Acad Sci U S A 2009 Apr 23;106(14):5819-24. Epub 2009 Mar 23.
Laboratory of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan.

Expression of liver X receptor alpha and lipid metabolism in granulocyte-macrophage colony-stimulating factor-induced human monocyte-derived macrophage.
Pathol Int 2009 Mar;59(3):152-60
Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.




Expression of liver X receptor alpha in rat fetal tissues at different developmental stages.
J Histochem Cytochem 2007 Jun 6;55(6):641-9. Epub 2007 Mar 6.
Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori 1-757, 951-8510, Niigata, Japan.


SOX6 suppresses cyclin D1 promoter activity by interacting with beta-catenin and histone deacetylase 1, and its down-regulation induces pancreatic beta-cell proliferation.
J Biol Chem 2007 Jun 4;282(26):19052-61. Epub 2007 Apr 4.
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153-8904, Japan.

Identification of human low-density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha.
FEBS Lett 2006 Sep 14;580(20):4929-33. Epub 2006 Aug 14.
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.





Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues.
Biochem Biophys Res Commun 2005 Aug;333(3):778-86
Yanagisawa Orphan Receptor Project, Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Tokyo 135-0064, Japan.

Angiopoietin-related growth factor antagonizes obesity and insulin resistance.
Nat Med 2005 Apr 20;11(4):400-8. Epub 2005 Mar 20.
Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2.
J Biol Chem 2004 Apr 10;279(17):16954-62. Epub 2004 Feb 10.
Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, the Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.







QRFP-Deficient Mice Are Hypophagic, Lean, Hypoactive and Exhibit Increased Anxiety-Like Behavior.
PLoS One 2016 11;11(11):e0164716. Epub 2016 Nov 11.
Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan.

KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability.
J Cell Biol 2017 04 28;216(4):999-1013. Epub 2017 Feb 28.
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU Scotland, UK

Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression.
Cell Rep 2017 02;18(9):2228-2242
The Translational Systems Biology and Medicine Initiative (TSBMI), Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan; Laboratory for Systems Biology and Medicine, RCAST, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan. Electronic address:

Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase.
Biochem Biophys Res Commun 2017 06 5;488(1):159-164. Epub 2017 May 5.
Laboratory of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address:

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