Publications by authors named "Jurgen Wess"

211Publications

Key Metabolic Functions of β-Arrestins: Studies with Novel Mouse Models.

Trends Endocrinol Metab 2021 Feb 23;32(2):118-129. Epub 2020 Dec 23.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA. Electronic address:

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February 2021

Lack of adipocyte purinergic P2Y receptor greatly improves whole body glucose homeostasis.

Proc Natl Acad Sci U S A 2020 12 16;117(48):30763-30774. Epub 2020 Nov 16.

Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892;

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December 2020

Use of DREADD Technology to Identify Novel Targets for Antidiabetic Drugs.

Annu Rev Pharmacol Toxicol 2021 01 3;61:421-440. Epub 2020 Aug 3.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA; email:

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January 2021

β-arrestin-1 suppresses myogenic reprogramming of brown fat to maintain euglycemia.

Sci Adv 2020 Jun 5;6(23):eaba1733. Epub 2020 Jun 5.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.

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June 2020

Beneficial metabolic role of β-arrestin-1 expressed by AgRP neurons.

Sci Adv 2020 Jun 3;6(23):eaaz1341. Epub 2020 Jun 3.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.

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June 2020

Adipocyte G signaling is essential for maintaining whole-body glucose homeostasis and insulin sensitivity.

Nat Commun 2020 06 12;11(1):2995. Epub 2020 Jun 12.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA.

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June 2020

Beta-cell M muscarinic acetylcholine receptors as potential targets for novel antidiabetic drugs.

Int Immunopharmacol 2020 Apr 7;81:106267. Epub 2020 Feb 7.

Molecular Signaling Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address:

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April 2020

Metabolic effects of skeletal muscle-specific deletion of beta-arrestin-1 and -2 in mice.

PLoS Genet 2019 10 17;15(10):e1008424. Epub 2019 Oct 17.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, United States of America.

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October 2019

Allosteric modulation of β-cell M muscarinic acetylcholine receptors greatly improves glucose homeostasis in lean and obese mice.

Proc Natl Acad Sci U S A 2019 09 26;116(37):18684-18690. Epub 2019 Aug 26.

Molecular Signaling Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;

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September 2019

Selective activation of G signaling in adipocytes causes striking metabolic improvements in mice.

Mol Metab 2019 09 20;27:83-91. Epub 2019 Jun 20.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA. Electronic address:

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September 2019

Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis.

Nat Commun 2019 07 3;10(1):2936. Epub 2019 Jul 3.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, NIH-20892, USA.

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July 2019

β-Cell-intrinsic β-arrestin 1 signaling enhances sulfonylurea-induced insulin secretion.

J Clin Invest 2019 06 11;129(9):3732-3737. Epub 2019 Jun 11.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.

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June 2019

Intra-islet glucagon signaling is critical for maintaining glucose homeostasis.

JCI Insight 2019 04 23;5. Epub 2019 Apr 23.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.

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April 2019

Skeletal Muscle-Specific Activation of G Signaling Maintains Glucose Homeostasis.

Diabetes 2019 06 1;68(6):1341-1352. Epub 2019 Apr 1.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD

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June 2019

Impaired object-location learning and recognition memory but enhanced sustained attention in M2 muscarinic receptor-deficient mice.

Psychopharmacology (Berl) 2018 Dec 16;235(12):3495-3508. Epub 2018 Oct 16.

Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.

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December 2018