Publications by authors named "Juraj Velcicky"

20Publications

The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells.

iScience 2020 Feb 17;23(2):100848. Epub 2020 Jan 17.

Department of Anatomy and Cell Biology, East Carolina University, Greenville, NC 27834, USA; Department of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA. Electronic address:

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February 2020

Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors.

ACS Med Chem Lett 2019 Jun 23;10(6):887-892. Epub 2019 May 23.

Global Discovery Chemistry, and Autoimmunity Transplantation Inflammation, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

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June 2019

Pharmacological inhibition of GPR4 remediates intestinal inflammation in a mouse colitis model.

Eur J Pharmacol 2019 Jun 28;852:218-230. Epub 2019 Mar 28.

Department of Internal Medicine, Brody School of Medicine, East Carolina University, USA; Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, USA. Electronic address:

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June 2019

Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis.

J Med Chem 2017 05 26;60(9):3672-3683. Epub 2017 Apr 26.

Global Discovery Chemistry, ‡Autoimmunity Transplantation Inflammation, §Musculoskeletal, ∥Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research , CH-4002 Basel, Switzerland.

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May 2017

Palladium-catalyzed cyanomethylation of aryl halides through domino Suzuki coupling-isoxazole fragmentation.

J Am Chem Soc 2011 May 19;133(18):6948-51. Epub 2011 Apr 19.

Novartis Institutes for Biomedical Research, Forum 1, Novartis Campus, CH-4056 Basel, Switzerland.

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May 2011

Pyrrolo-pyrimidones: a novel class of MK2 inhibitors with potent cellular activity.

Bioorg Med Chem Lett 2008 Dec 11;18(23):6142-6. Epub 2008 Oct 11.

Novartis Institutes for BioMedical Research, global Discovery Chemistry, WSJ-88.508, CH-4002 Basel, Switzerland.

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December 2008

Total synthesis of (-)- and ent-(+)-vindoline and related alkaloids.

J Am Chem Soc 2006 Aug;128(32):10596-612

Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

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August 2006

Total synthesis of (-)- and ent-(+)-vindorosine: tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition of 1,3,4-oxadiazoles.

Angew Chem Int Ed Engl 2006 Jan;45(4):620-2

Department of Chemistry, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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January 2006

Total synthesis of (-)- and ent-(+)-vindoline.

Org Lett 2005 Sep;7(20):4539-42

Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

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September 2005

Transition-metal-mediated synthesis of novel carbocyclic nucleoside analogues with antitumoral activity.

Chemistry 2004 Oct;10(20):5087-110

Institut für Organische Chemie, Universität zu Köln, Greinstrasse 4, 50939 Köln, Germany.

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October 2004

Iron-containing nucleoside analogues with pronounced apoptosis-inducing activity.

Angew Chem Int Ed Engl 2004 Mar;43(13):1731-4

Institut für Organische Chemie, Universität zu Köln, Greinstrasse 4, 50939 Köln, Germany.

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March 2004

An efficient organometallic approach to new carbocyclic nucleoside analogues.

Org Lett 2002 Feb;4(4):565-8

Institut für Organische Chemie, Universität zu Köln, Greinstrasse 4 D-50939 Köln, Germany.

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February 2002