Publications by authors named "Junyu Xiao"

45Publications

POMK regulates dystroglycan function via LARGE1-mediated elongation of matriglycan.

Elife 2020 09 25;9. Epub 2020 Sep 25.

Howard Hughes Medical Institute, Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, Department of Molecular Physiology and Biophysics and Department of Neurology, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, United States.

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http://dx.doi.org/10.7554/eLife.61388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556876PMC
September 2020

Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy.

Cell 2020 11 14;183(4):1013-1023.e13. Epub 2020 Sep 14.

Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.09.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489885PMC
November 2020

Cellular Synthesis and X-ray Crystal Structure of a Designed Protein Heterocatenane.

Angew Chem Int Ed Engl 2020 09 9;59(37):16122-16127. Epub 2020 Jul 9.

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry &, Physics of Ministry of Education, Center for Soft Matter Science and Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, P. R. China.

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http://dx.doi.org/10.1002/anie.202005490DOI Listing
September 2020

Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells.

Cell 2020 07 18;182(1):73-84.e16. Epub 2020 May 18.

Beijing Advanced Innovation Center for Genomics (ICG) & Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences (CLS), Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China; School of Life Sciences, Peking University, Beijing 100871, China. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.05.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231725PMC
July 2020

Structural insights into secretory immunoglobulin A and its interaction with a pneumococcal adhesin.

Cell Res 2020 Jul 12;30(7):602-609. Epub 2020 May 12.

State Key Laboratory of Protein and Plant Gene Research, Peking University, Beijing, 100871, China.

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http://dx.doi.org/10.1038/s41422-020-0336-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343866PMC
July 2020

Structural insights into immunoglobulin M.

Science 2020 02 6;367(6481):1014-1017. Epub 2020 Feb 6.

State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China.

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http://dx.doi.org/10.1126/science.aaz5425DOI Listing
February 2020

LLG2/3 Are Co-receptors in BUPS/ANX-RALF Signaling to Regulate Arabidopsis Pollen Tube Integrity.

Curr Biol 2019 10 26;29(19):3256-3265.e5. Epub 2019 Sep 26.

State Key Laboratory for Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences at College of Life Sciences, Peking University, Beijing 100871, China; The National Plant Gene Research Center (Beijing), Beijing 100101, China. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2019.08.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179479PMC
October 2019

Structural mechanism for guanylate-binding proteins (GBPs) targeting by the Shigella E3 ligase IpaH9.8.

PLoS Pathog 2019 06 19;15(6):e1007876. Epub 2019 Jun 19.

The State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.

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http://dx.doi.org/10.1371/journal.ppat.1007876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602295PMC
June 2019

Cysteine-rich peptides promote interspecific genetic isolation in .

Science 2019 05;364(6443)

State Key Laboratory for Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences at the College of Life Sciences, Peking University, Beijing 100871, People's Republic of China.

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http://dx.doi.org/10.1126/science.aau9564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184628PMC
May 2019

Legionella effector SetA as a general O-glucosyltransferase for eukaryotic proteins.

Nat Chem Biol 2019 03 7;15(3):213-216. Epub 2019 Jan 7.

College of Chemistry and Molecular Engineering, Peking University, Beijing, China.

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http://www.nature.com/articles/s41589-018-0189-y
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http://dx.doi.org/10.1038/s41589-018-0189-yDOI Listing
March 2019

Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2.

Proc Natl Acad Sci U S A 2018 08 9;115(32):8155-8160. Epub 2018 Jul 9.

The Life Sciences Institute, Zhejiang University, 310058 Hangzhou, China

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http://dx.doi.org/10.1073/pnas.1806797115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094102PMC
August 2018

Cryo-EM structure of human mitochondrial trifunctional protein.

Proc Natl Acad Sci U S A 2018 07 18;115(27):7039-7044. Epub 2018 Jun 18.

State Key Laboratory of Protein and Plant Gene Research, Peking University, 100871 Beijing, China;

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http://dx.doi.org/10.1073/pnas.1801252115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142257PMC
July 2018

Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1α.

EMBO J 2018 07 1;37(14). Epub 2018 Jun 1.

National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

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http://dx.doi.org/10.15252/embj.201798699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043849PMC
July 2018

Structure and evolution of the Fam20 kinases.

Nat Commun 2018 03 23;9(1):1218. Epub 2018 Mar 23.

The State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, 100871, Beijing, China.

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http://www.nature.com/articles/s41467-018-03615-z
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http://dx.doi.org/10.1038/s41467-018-03615-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865150PMC
March 2018

Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1 through DCC.

Neuron 2018 03 1;97(6):1261-1267.e4. Epub 2018 Mar 1.

European Molecular Biology Laboratory (EMBL), Hamburg Outstation, Notkestrasse 85, D-22607 Hamburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871715PMC
March 2018

Crystal structures of the extracellular domains of the CrRLK1L receptor-like kinases ANXUR1 and ANXUR2.

Protein Sci 2018 04 12;27(4):886-892. Epub 2018 Mar 12.

The State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, 100871, China.

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http://dx.doi.org/10.1002/pro.3381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866931PMC
April 2018

pollen tube integrity and sperm release are regulated by RALF-mediated signaling.

Science 2017 12 14;358(6370):1596-1600. Epub 2017 Dec 14.

State Key Laboratory for Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences at College of Life Sciences, Peking University, Beijing 100871, People's Republic of China.

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http://www.sciencemag.org/lookup/doi/10.1126/science.aao3642
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http://dx.doi.org/10.1126/science.aao3642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964610PMC
December 2017

Structure of unliganded membrane-proximal domains FN4-FN5-FN6 of DCC.

Protein Cell 2017 09;8(9):701-705

State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing, 100871, China.

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http://dx.doi.org/10.1007/s13238-017-0439-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563286PMC
September 2017

Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding.

Elife 2017 04 22;6. Epub 2017 Apr 22.

The State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.

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http://dx.doi.org/10.7554/eLife.23990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413348PMC
April 2017

Structure of protein O-mannose kinase reveals a unique active site architecture.

Elife 2016 11 23;5. Epub 2016 Nov 23.

The State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China.

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http://dx.doi.org/10.7554/eLife.22238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142810PMC
November 2016

Methods to Purify and Assay Secretory Pathway Kinases.

Methods Mol Biol 2016 ;1496:197-215

State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China.

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http://dx.doi.org/10.1007/978-1-4939-6463-5_16DOI Listing
January 2018

Transcriptome analyses of insect cells to facilitate baculovirus-insect expression.

Protein Cell 2016 05 26;7(5):373-82. Epub 2016 Mar 26.

Biodynamic Optical Imaging Center, School of Life Science, Peking University, Beijing, 100871, China.

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http://dx.doi.org/10.1007/s13238-016-0260-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853316PMC
May 2016

The Histone Chaperone FACT Contributes to DNA Replication-Coupled Nucleosome Assembly.

Cell Rep 2016 Feb 21;14(5):1128-1141. Epub 2016 Jan 21.

State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247150155
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http://dx.doi.org/10.1016/j.celrep.2015.12.096DOI Listing
February 2016

A Single Kinase Generates the Majority of the Secreted Phosphoproteome.

Cell 2015 Jun;161(7):1619-32

Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.05.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963185PMC
June 2015

Protein Crystallography from the Perspective of Technology Developments.

Crystallogr Rev 2015;21(1-2):122-153

Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, People's Republic of China.

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http://dx.doi.org/10.1080/0889311X.2014.973868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430849PMC
January 2015

Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis.

Proc Natl Acad Sci U S A 2014 Apr 26;111(15):5520-5. Epub 2014 Mar 26.

Departments of Pharmacology, Pediatrics, Cellular and Molecular Medicine, and Chemistry and Biochemistry and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093.

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http://dx.doi.org/10.1073/pnas.1402218111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992636PMC
April 2014

Phosphorylation of substrates destined for secretion by the Fam20 kinases.

Biochem Soc Trans 2013 Aug;41(4):1061-5

Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1042/BST20130059DOI Listing
August 2013

Crystal structure of the Golgi casein kinase.

Proc Natl Acad Sci U S A 2013 Jun 10;110(26):10574-9. Epub 2013 Jun 10.

Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.1309211110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696822PMC
June 2013

Secreted kinase phosphorylates extracellular proteins that regulate biomineralization.

Science 2012 Jun 10;336(6085):1150-3. Epub 2012 May 10.

Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093-0721, USA.

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http://dx.doi.org/10.1126/science.1217817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754843PMC
June 2012

UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity.

Proc Natl Acad Sci U S A 2011 Nov 26;108(46):18649-54. Epub 2011 Sep 26.

Department of Pharmacology, University of California-San Diego, La Jolla, CA 92093-0721, USA.

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http://dx.doi.org/10.1073/pnas.1113170108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219150PMC
November 2011

Comparative analysis of Histophilus somni immunoglobulin-binding protein A (IbpA) with other fic domain-containing enzymes reveals differences in substrate and nucleotide specificities.

J Biol Chem 2011 Sep 27;286(37):32834-42. Epub 2011 Jul 27.

Department of Pharmacology, Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California 92093-0721, USA.

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http://dx.doi.org/10.1074/jbc.M111.227603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173180PMC
September 2011

Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis.

Proc Natl Acad Sci U S A 2011 Jul 5;108(29):11860-5. Epub 2011 Jul 5.

Department of Pharmacology, University of California, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.1109290108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142007PMC
July 2011

Exocyst function is regulated by effector phosphorylation.

Nat Cell Biol 2011 May 24;13(5):580-8. Epub 2011 Apr 24.

Life Sciences Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1038/ncb2226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904505PMC
May 2011

Structural basis of Fic-mediated adenylylation.

Nat Struct Mol Biol 2010 Aug 11;17(8):1004-10. Epub 2010 Jul 11.

Department of Pharmacology, Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1038/nsmb.1867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920259PMC
August 2010

Structural basis of Ist1 function and Ist1-Did2 interaction in the multivesicular body pathway and cytokinesis.

Mol Biol Cell 2009 Aug 28;20(15):3514-24. Epub 2009 May 28.

Life Sciences Institute and Department of Biological Chemistry, Department of Molecular and Integrative Physiology, Medical School, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1091/mbc.e09-05-0403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719569PMC
August 2009

ESCRT-III family members stimulate Vps4 ATPase activity directly or via Vta1.

Dev Cell 2008 Jan;14(1):50-61

Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.devcel.2007.10.021DOI Listing
January 2008

Structural basis of Vta1 function in the multivesicular body sorting pathway.

Dev Cell 2008 Jan;14(1):37-49

Life Sciences Institute and Department of Biological Chemistry, Medical School, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/j.devcel.2007.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775496PMC
January 2008

Structural characterization of the ATPase reaction cycle of endosomal AAA protein Vps4.

J Mol Biol 2007 Nov 29;374(3):655-70. Epub 2007 Sep 29.

Life Sciences Institute and Department of Biological Chemistry, Medical School, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/j.jmb.2007.09.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693005PMC
November 2007