Publications by authors named "Junwei Li"

167 Publications

Scalable Synthesis of WS2 Nanosheets for Alkali-acid Electrocatalytic Sulfion Recycle and H2 Generation.

Angew Chem Int Ed Engl 2021 Jul 21. Epub 2021 Jul 21.

Fujian Institute of Research on the Structure of Matter, Chinese Academy of Science, Institute of Materials, 155 Yangqiao Road West, 350002, Fuzhou, CHINA.

WS 2 nanosheets hold great promise for a variety of applications yet face a grand challenge in implementing large-scale synthesis. We herein report a reliable, scalable, and high-yield (> 93%) synthetic strategy to fabricate WS 2 nanosheets, which exhibit highly desirable electrocatalytic properties toward both alkaline sulfion (S 2- ) oxidation reaction (SOR) and acidic hydrogen evolution reaction (HER), prompting us to develop a hybrid alkali-acid electrochemical cell with the WS 2 nanosheets as bifunctional electrode catalysts of alkaline anodic SOR and acidic cathodic HER, such proof-of-concept device may hold promise for self-powder or low-electricity electrolytic H 2 generation and environmentally friendly recycling of sulfion with enhancing electron utilization efficiency, and thus potentially steering and stepping forward its technoeconomic feasibility.
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http://dx.doi.org/10.1002/anie.202108992DOI Listing
July 2021

Biomechanical study of transsacral-transiliac screw fixation versus lumbopelvic fixation and bilateral triangular fixation for "H"- and "U"-type sacrum fractures with traumatic spondylopelvic dissociation: a finite element analysis study.

J Orthop Surg Res 2021 Jul 3;16(1):428. Epub 2021 Jul 3.

Department of Orthopaedic Surgery, General Hospital of Chinese People's Liberation Army, 28 Fu-Xing Road, 100853, Beijing, People's Republic of China.

Objective: To compare the biomechanical stability of transsacral-transiliac screw fixation and lumbopelvic fixation for "H"- and "U"-type sacrum fractures with traumatic spondylopelvic dissociation.

Methods: Finite element models of "H"- and "U"-type sacrum fractures with traumatic spondylopelvic dissociation were created in this study. The models mimicked the standing position of a human. Fixation with transsacral-transiliac screw fixation, lumbopelvic fixation, and bilateral triangular fixation were simulated. Biomechanical tests of instability were performed, and the fracture gap displacement, anteflexion, rotation, and stress distribution after fixation were assessed.

Results: For H-type fractures, the three kinds of fixation ranked by stability were bilateral triangular fixation > lumbopelvic fixation > transsacral-transiliac screw fixation in the vertical and anteflexion directions, bilateral triangular fixation > transsacral-transiliac S1 and S2 screw fixation > lumbopelvic fixation in rotation. The largest displacements in the vertical, anteflexion, and rotational directions were 0.57234 mm, 0.37923 mm, and 0.13076 mm, respectively. For U-type fractures, these kinds of fixation ranked by stability were bilateral triangular fixation > lumbopelvic fixation > transsacral-transiliac S1 and S2 screw fixation > transsacral-transiliac S1 screw fixation in the vertical, anteflexion, and rotational directions. The largest displacements in the vertical, anteflexion, and rotational directions were 0.38296 mm, 0.33976 mm, and 0.05064 mm, respectively.

Conclusion: All these kinds of fixation met the mechanical criteria for clinical applications. The biomechanical analysis showed better bilateral balance with transsacral-transiliac screw fixation. The maximal displacement for these types of fixation was less than 1 mm. Percutaneous transsacral-transiliac screw fixation can be considered the best option among these kinds of fracture fixation.
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http://dx.doi.org/10.1186/s13018-021-02581-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254325PMC
July 2021

Pre-Degassed Microfluidic Chamber-Based Digital PCR Device for Meat Authentication Applications.

Micromachines (Basel) 2021 Jun 14;12(6). Epub 2021 Jun 14.

Department of Electronic and Information Engineering, Hebei University of Technology, Langfang 065000, China.

Droplet digital polymerase chain reaction (ddPCR) suffers from the need for specific equipment and skilled personnel; thus, we here present a chamber-based digital PCR microfluidic device that is compatible with fluorescence image read-out systems and removes bubbles by a pre-degassed microfluidic device that consists of a pilot channel and micro chamber arrays. Digitalized PCR reagents are introduced into micro chambers, and thermocycles are taken to perform a DNA amplification process. Then, fluorescence images of a micro chamber array are read out and analyzed to obtain the total number of positive chambers. Thereby, the copy numbers of target DNA are calculated for quantitative detections. As a validation, this device is evaluated by the application of meat authentication. We performed dPCR tests using DNA templates extracted from a pure mutton DNA template with different dilutions. Then, the dPCR chip was used to identify the meat authentication using mutton-chicken mixtures with different mass ratios, showing its performance in real biotechnical applications.
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http://dx.doi.org/10.3390/mi12060694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231815PMC
June 2021

A General Self-Sacrifice Template Strategy to 3D Heteroatom-Doped Macroporous Carbon for High-Performance Potassium-Ion Hybrid Capacitors.

Nanomicro Lett 2021 May 29;13(1):131. Epub 2021 May 29.

CAS Key Laboratory of Design and Assembly of Functional Nanostructures, and Fujian Provincial Key Laboratory of Nanomaterials, Fujian Institute of Research On the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, 350002, People's Republic of China.

Potassium-ion hybrid capacitors (PIHCs) tactfully combining capacitor-type cathode with battery-type anode have recently attracted increasing attentions due to their advantages of decent energy density, high power density, and low cost; the mismatches of capacity and kinetics between capacitor-type cathode and battery-type anode in PIHCs yet hinder their overall performance output. Herein, based on prediction of density functional theory calculations, we find Se/N co-doped porous carbon is a promising candidate for K storage and thus develop a simple and universal self-sacrifice template method to fabricate Se and N co-doped three-dimensional (3D) macroporous carbon (Se/N-3DMpC), which features favorable properties of connective hierarchical pores, expanded interlayer structure, and rich activity site for boosting pseudocapacitive activity and kinetics toward K storage anode and enhancing capacitance performance for the reversible anion adsorption/desorption cathode. As expected, the as-assembled PIHCs full cell with a working voltage as high as 4.0 V delivers a high energy density of 186 Wh kg and a power output of 8100 W kg as well as excellent long service life. The proof-of-concept PIHCs with excellent performance open a new avenue for the development and application of high-performance hybrid capacitors.
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http://dx.doi.org/10.1007/s40820-021-00659-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163926PMC
May 2021

Facile Synthesis of P-Doped Carbon Nanosheets as Janus Electrodes of Advanced Potassium-Ion Hybrid Capacitor.

ACS Appl Mater Interfaces 2021 Jun 15;13(25):29511-29521. Epub 2021 Jun 15.

CAS Key Laboratory of Design and Assembly of Functional Nanostructures, and Fujian Provincial Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, Fujian, China.

Potassium-ion hybrid capacitors (PIHCs) shrewdly integrate the merits of the high energy density of battery-type anode and the high power density of capacitor-type cathode, promising prospects for potential application in a diversity of fields. Here, we report the synthesis of P-doped porous carbon nanosheets (P-PCNs) with favorable features as electrochemical storage materials, including ultrahigh specific surface area and rich activity sites. The P-PCN as Janus electrodes show highly attractive electrochemical properties of high capacity and remarkable stability for fast K storage and manifest high capacitance for PF adsorption. The P-PCNs are applied as both anode and cathode materials to set up dual-carbon PIHCs, which show the capability to deliver a high energy/power density (165.2 Wh kg and 5934.4 W kg) as well as remarkable long-life capability.
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http://dx.doi.org/10.1021/acsami.1c04278DOI Listing
June 2021

Herbacetin Broadly Blocks the Activities of CYP450s by Different Inhibitory Mechanisms.

Planta Med 2021 Jun 11. Epub 2021 Jun 11.

School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Herbacetin is a bioactive flavanol compound that has various pharmacological effects. However, the pharmacokinetic characteristics have not been thoroughly investigated. Previously, we screened a natural compound library and identified herbacetin as a potent CYP blocker. Herein, we aimed to mechanistically determine the inhibitory effects of herbacetin on CYP450 and its potential application. A human liver microsome incubation system was developed based on a UPLC-MS/MS method. Moreover, an docking assay and a human CYP recombinase reaction system were developed and used to investigate binding affinity and inhibitory efficacy. Subsequently, the effects of the combination of herbacetin and sorafenib on HepG2 cells were assessed by MTT and immunoblotting assays. The concentration of sorafenib and its main metabolite were measured by UPLC-MS/MS after incubation with or without herbacetin. As a result, we found herbacetin almost completely inhibited the functions of major CYPs at 100 µM. Moreover, through analysis of the structure-activity relationship, we found 4-, 6-, and 8-hydroxyl were essential groups for the inhibitory effects. Herbacetin inhibited CYP3A4, CYP2B6, CYP2C9, and CYP2E1 in a mixed manner, but non-competitively blocked CYP2D6. These results are in good agreement with the recombinase reaction results, with an IC < 10 µM for each tested isoenzyme. Interestingly, the stimulatory effects of sorafenib on HepG2 cell apoptosis were significantly enhanced by combining with herbacetin, which was associated with increased sorafenib exposure. In summary, herbacetin is a potent inhibitor of a wide spectrum of CYP450s, which may enhance the exposure of drugs .
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http://dx.doi.org/10.1055/a-1502-7131DOI Listing
June 2021

Transvaginal natural orifice transluminal endoscopic surgery for uterosacral ligament suspension: pilot study of 35 cases of severe pelvic organ prolapse.

BMC Surg 2021 Jun 8;21(1):286. Epub 2021 Jun 8.

Department of Gynecology, The Obstetrics and Gynecology Hospital of Fudan University, 128 Shenyang RD, Shanghai, 200090, China.

Background: To describe the short-term outcomes of transvaginal natural orifice transluminal endoscopic surgery (vNOTES) for uterosacral ligament suspension (USLS) in patients with severe prolapse.

Methods: This was a retrospective study of patients with severe prolapse (≥ stage 3) who underwent vNOTES for USLS between May 2019 and July 2020. The Pelvic Organ Prolapse Quantification (POP-Q) score, Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire short form (PISQ-12) and Pelvic Floor Inventory-20 (PFDI-20) were used to evaluate physical prolapse and quality of life before and after vNOTES for USLS.

Results: A total of 35 patients were included. The mean operative duration was 111.7 ± 39.4 min. The mean blood loss was 67.9 ± 35.8 ml. Statistically significant differences were observed between before and after vNOTES USLS in Aa (+ 0.6 ± 1.7 versus - 2.9 ± 0.2), Ba (+ 1.9 ± 2.2 versus - 2.9 ± 0.3), C (+ 1.5 ± 2.2 versus - 6.9 ± 0.9), Ap (- 1.4 ± 1.0 versus - 3.0 ± 0.1) and Bp (- 1.1 ± 1.4 versus - 2.9 ± 0.1) (P < 0.05 for all). The mean pre- and postoperative PFDI-20 score was 19.9 ± 6.7 and 3.2 ± 5.4, respectively, and the mean pre- and postoperative PISQ-12 score was 24.8 ± 2.3 and 38.3 ± 4.1, respectively (P < 0.05 for both). During 1-13 months of follow-up, there were no cases of severe complications or recurrence.

Conclusions: vNOTES for USLS may be a feasible technique to manage severe prolapse, with promising short-term efficacy and safety. Larger studies with more patients and longer follow-up periods should be performed to evaluate the long-term efficacy and safety profile of vNOTES for USLS.
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http://dx.doi.org/10.1186/s12893-021-01280-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185939PMC
June 2021

Fluorescent dissolved organic matter facilitates the phytoavailability of copper in the coastal wetlands influenced by artificial topography.

Sci Total Environ 2021 May 26;790:147855. Epub 2021 May 26.

Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, Xiamen University, Xiamen 361102, PR China; State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361102, PR China. Electronic address:

Dissolved organic matter (DOM) is a crucial driver in ecosystem services and a central part of the carbon transport and biological cycle in land-sea interaction. DOM exhibits characteristic environmental behavior in the coastal zone, but its sustainability is affected by expanding artificial topography (AT) construction. It requires combining analyses on AT-induced response of field fluorescent DOM (fDOM) and its quenching pattern under metal-complexation. Herein, we conducted systemic investigations into the spatiotemporal dynamics of fDOM compositions with further in-lab verification to study its Cu-binding capacity. We detected three humid-like fDOM components sensitive to AT. The total fDOM intensity was positively correlated with low molecular weight organic acid (LMWOA) extractable Cu and the Cu pools in above-ground biomass. The enriched fDOM serves as an ecological engineer by increasing the Cu mobility, confirmed by an in-lab fluorescence titration. The application of LMWOA greatly enhanced the intensity of one fDOM component, elevated its conditional stability constant, and decreased its quenched proportion, implying that LMWOA might extract part of Cu from fDOM complexation. The present work provides an "fDOM-LMWOA pump" explanation to suggest that fDOM is a novel ecological regulator on vegetation growth under the AT-induced matter accumulation.
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http://dx.doi.org/10.1016/j.scitotenv.2021.147855DOI Listing
May 2021

Prolonged exposure to the herbicide atrazine suppresses immune cell functions by inducing spleen cell apoptosis in rats.

Ecotoxicol Environ Saf 2021 Sep 2;220:112386. Epub 2021 Jun 2.

School of Nursing, Jilin University, Changchun 130021, Jilin, China. Electronic address:

Atrazine (ATR) is a herbicide used widely worldwide. Because of its prolonged persistence in the environment and accumulation in the body, ATR exposure is a potential threat to human health. Our previous study showed that subacute exposure to ATR suppresses cellular immune function in mice. In this study, the effects of long-term exposure to ATR on rat immunological system function were measured. Four-week-old female Sprague-Dawley (SD) rats were treated with 0.4 μmol/L, 2 μmol/L and 10 μmol/L ATR for 24 weeks. The results showed that the spleen index increased, white blood cells decreased, and monocytes and eosinophils increased. No obvious changes were detected in the numbers of neutrophils and lymphocytes. Th1, Th2, and Th17 cells decreased significantly, while Treg cells increased after long-term ATR exposure. Moreover, serum levels of cytokines, including TNF-α, INF-γ, IL-6, and IL-12, decreased, while IL-1, IL-4, and IL-5 increased. Degenerative changes and cell apoptosis were found in the spleen; Caspase-3 and Caspase-9 were upregulated, and Bcl-2 was downregulated. These results suggested that long-term ATR exposure may inhibit immune system function.
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http://dx.doi.org/10.1016/j.ecoenv.2021.112386DOI Listing
September 2021

Safety and Considerations of the COVID-19 Vaccine Massive Deployment.

Virol Sin 2021 Jun 1. Epub 2021 Jun 1.

Department of Infectious Diseases, The Second Hospital of Nanjing, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210003, China.

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http://dx.doi.org/10.1007/s12250-021-00408-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167387PMC
June 2021

Cadmium disturbs epigenetic modification and induces DNA damage in mouse preimplantation embryos.

Ecotoxicol Environ Saf 2021 Aug 11;219:112306. Epub 2021 May 11.

College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, PR China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, PR China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, PR China. Electronic address:

Cadmium is an environmental pollutant that has extensive deleterious effects on the reproductive system. However, the mechanisms underlying the effects of cadmium on preimplantation embryos are unclear. Here, we used a mouse model to investigate the effects of maternal cadmium (32 mg/l) exposure in drinking water for 2 days on early embryonic development, and studied the mechanisms associated with epigenetic modifications and DNA damage induced by oxidative stress. We observed that maternal cadmium exposure impaired preimplantation embryo development by inducing embryo death, fragmentation, or developmental blockade. After cadmium exposure, the most survived embryos were at the 8-cell stage, which were used for all measurements. Histone acetylation, not methylation, was disturbed by increasing histone deacetylase 1 (HDAC1) levels after cadmium exposure. Cadmium also disrupted DNA methylation of H19; however genomic DNA methylation can be normally reprogrammed in embryos. Furthermore, cadmium increased reactive oxygen species (ROS) levels and DNA damage, and partly inhibited gene expression related to DNA repair. The distribution and activity of mitochondria was increased; therefore, embryos maintain intracellular homeostasis for survival. Collectively, our findings revealed that maternal cadmium exposure impairs preimplantation embryo development by disturbing the epigenetic modification and inducing DNA damage.
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http://dx.doi.org/10.1016/j.ecoenv.2021.112306DOI Listing
August 2021

A Cluster-Based Energy Optimization Algorithm in Wireless Sensor Networks with Mobile Sink.

Sensors (Basel) 2021 Apr 4;21(7). Epub 2021 Apr 4.

School of Artificial Intelligence, Henan University, Kaifeng 475004, China.

Aiming at high network energy consumption and data delay induced by mobile sink in wireless sensor networks (WSNs), this paper proposes a cluster-based energy optimization algorithm called Cluster-Based Energy Optimization with Mobile Sink (CEOMS). CEOMS algorithm constructs the energy density function of network nodes firstly and then assigns sensor nodes with higher remaining energy as cluster heads according to energy density function. Meanwhile, the directivity motion performance function of mobile sink is constructed to enhance the probability of remote sensor nodes being assigned as cluster heads. Secondly, based on Low Energy Adaptive Clustering Hierarchy Protocol (LEACH) architecture, the energy density function and the motion performance function are introduced into the cluster head selection process to avoid random assignment of cluster head. Finally, an adaptive adjustment function is designed to improve the adaptability of cluster head selection by percentage of network nodes death and the density of all surviving nodes of the entire network. The simulation results show that the proposed CEOMS algorithm improves the cluster head selection self-adaptability, extends the network life, reduces the data delay, and balances the network load.
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http://dx.doi.org/10.3390/s21072523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038497PMC
April 2021

Broadband emission GdScAlO:Ce transparent ceramics with a high color rendering index for high-power white LEDs/LDs.

Opt Express 2021 Mar;29(6):9474-9493

The discovery of single structure Ce doped garnet transparent ceramics (TCs) with a broad full width at half maximum (FWHM) is essential to realize a high CRI for high-power white light emitting diodes (LEDs) and laser diodes (LDs). In this work, by utilizing the ion substitution engineering strategy, pure phase GdScAlO:Ce (GSAG:Ce) TC with a broad FWHM of 132.4 nm and a high CRI value of 80.7 was fabricated through the vacuum sintering technique for the first time. The optimized in-line transmittance of TCs was 58.4% @ 800 nm. Notably, the GSAG:Ce TCs exhibited a remarkable red shift from 546 nm to 582 nm, with a high internal quantum efficiency (IQE) of 46.91%. The degraded thermal stability in Ce:GSAG TCs was observed compared with that of Ce:YAG TC, owing to the narrowed band gap of GSAG. Additionally, remote excitation white LEDs/LDs were constructed by combining GSAG:Ce TCs with blue LED chips or laser sources. A tunable color hue from yellow to shinning white was achieved in white LEDs, whereas the acquired CRI and CCT of the white LDs were 69.5 and 7766 K, respectively. This work provides a new perspective to develop TCs with high CRI for their real applications in high-power white LEDs/LDs.
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http://dx.doi.org/10.1364/OE.417464DOI Listing
March 2021

Health risk assessment of heavy metal and its mitigation by glomalin-related soil protein in sediments along the South China coast.

Environ Pollut 2020 Aug 11;263(Pt A):114565. Epub 2020 Apr 11.

Key Laboratory of Ministry of Education for Coastal and Wetland Ecosystems, Xiamen University, Xiamen, 361102, China; State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, 361102, China. Electronic address:

Knowledge regarding the exposure risk of heavy metals in estuarine wetland is important for people (especially fishermen and consumers of local fish) living in the coastal area and the coastal reclamation. Here, we assessed the ecological and human health risks of sediment-associated metals in the large-scale estuary area based on different sediment textures (Mud, Mud-Sand, and Sand). To investigate the potential impact of terrestrial material on the contamination risks, glomalin-related soil protein (GRSP), a recalcitrant soil protein fraction, was used. Results showed that the estuarine sediment texture played a rather important role in the heavy metal distribution, risk assessment, and the metal sequestration capacity of the land-derived GRSP fraction. We found arsenic, Pb, Cd, and Cr had the highest enrichment in the estuarine wetlands by calculating multiple contamination indices, and that confirmed similar findings of heavy metal contents, except Cd. The average pollution load index (PLI) was 1.67 in all the estuarine sediments, indicating multi-element contamination, with the Muddy sediments (PLI = 2.07) significantly higher than the Mud-Sand mixed sediments (PLI = 1.85), and the lowest (0.78 < 1) in the Sandy sediments. The health risk assessment suggested that the potential cancer risk occurred (>1.00E-6) but no obvious non-carcinogenic effects occurred (<1). Arsenic was found to be the primary contributor to non-carcinogenic risk, accounting for 44.2% of hazard index, while Ni is the primary control metal for carcinogenic risk (except arsenic in the Sandy sediments). As a proxy of terrestrial organic matter, GRSP fraction possessed a high sequestration capacity for heavy metal, especially in the Sandy sediments, and it was significantly associated with the mitigation of ecological and health risks, which may provide new insights into the in situ remediation of anoxic estuarine wetlands.
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http://dx.doi.org/10.1016/j.envpol.2020.114565DOI Listing
August 2020

Clinicopathological Characteristics and Treatment Strategies of Triple-Negative Breast Cancer Patients With a Survival Longer than 5 Years.

Front Oncol 2020 1;10:617593. Epub 2021 Feb 1.

Department of Medical Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Purpose: Triple-negative breast cancer (TNBC) is characterized by high malignancy and a poor prognosis. Patients with TNBC who survive longer than 5 years represent a unique portion of the population. This study aimed to analyze the clinicopathological features, explore prognostic factors, and evaluate treatment options for these patients.

Methods: A total of 24,943 TNBC patients were enrolled from the national Surveillance, Epidemiology, and End Results (SEER) database between January 2010 and December 2016. The patients were divided into three groups: group 1, survival time <3 years; group 2, 3-5 years; and group 3, survival time ≥5 years. The overall survival (OS) and breast cancer cause-specific survival (BCSS) were primarily assessed in this study. A propensity score analysis was used to avoid bias caused by the data selection criteria. We used a Cox hazard ratio analysis to determine prognostic factors, which were selected as nomogram parameters to develop a model for predicting patient survival.

Results: Patients who survived longer than 5 years were more likely to be younger than 55 years, Caucasian, and exhibit a lower AJCC stage, N stage, distant metastasis, lymph node (LN) involvement, and tumor size than those with a shorter survival time ( < 0.05). The multivariable Cox regression analysis showed that age, race, tumor size, LN status, and chemotherapy were independent prognostic factors. Subgroup analyses for patients with tumors ≤20 mm displayed a superior OS and BCSS for breast-conserving surgery (BCS) not treated with a mastectomy. BCS provided at least an equivalent prognosis to a mastectomy in patients with tumors larger than 20 mm. A nomogram with a C-index of 0.776 (95% confidence interval: 0.767-0.785) was developed to predict the 3- and 5-year survival probability for the patients with TNBC.

Conclusion: A localized surgical approach may represent a superior choice for TNBC patients with a survival time longer than 5 years. Our study indicated that age, race, tumor size, LN status, and chemotherapy were independent prognostic factors. A prognostic nomogram directly quantified patient risk and was better able to predict long-term survival in TNBC patients.
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http://dx.doi.org/10.3389/fonc.2020.617593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882729PMC
February 2021

VO Nanoparticles Confined in High-Conductivity and High-Throughput Carbon Nanofiber Nanohybrids for Advanced Sodium-Ion Capacitors.

ACS Appl Mater Interfaces 2021 Mar 16;13(8):10001-10012. Epub 2021 Feb 16.

Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Engineering, University of Jinan, Jinan 250002, China.

Electrode materials with high conductivity and high mass transport rate are highly desirable for a variety of electrochemical energy devices but face a grand challenge to be readily prepared yet. Here, we propose the design and preparation of a nanohybrid of VO nanoparticles embedded in a multichannel carbon nanofiber ([email protected]) network with high conductivity and high mass transport. We demonstrate the [email protected] shows superior capability for sodium storage with an excellent capacity of 214.3 mA h g even at 5 A g, thanks to its high conductivity for electron transfer and facilitated mass transportation endowed by the one-dimensional conductive multichannel fiber structure. Such favorable structures and properties in [email protected] enable them to be applied as high-performance anodes of sodium-ion hybrid capacitors (SIHCs), successfully addressing the critical kinetics imbalance between Faradaic anodes and capacitive cathodes for application of SIHCs, which show impressively high energy/power densities along with impressive cycling performance over 10,000 cycles.
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http://dx.doi.org/10.1021/acsami.0c21313DOI Listing
March 2021

Boosting Electroreduction Kinetics of Nitrogen to Ammonia via Tuning Electron Distribution of Single-Atomic Iron Sites.

Angew Chem Int Ed Engl 2021 Apr 5;60(16):9078-9085. Epub 2021 Mar 5.

Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.

Electrocatalytic nitrogen reduction reaction (NRR) plays a vital role for next-generation electrochemical energy conversion technologies. However, the NRR kinetics is still limited by the sluggish hydrogenation process on noble-metal-free electrocatalyst. Herein, we report the rational design and synthesis of a hybrid catalyst with atomic iron sites anchored on a N,O-doped porous carbon (Fe -NO-C) matrix of an inverse opal structure, leading to a remarkably high NH yield rate of 31.9 μg  h  mg and Faradaic efficiency of 11.8 % at -0.4 V for NRR electrocatalysis, outperformed almost all previously reported atomically dispersed metal-nitrogen-carbon catalysts. Theoretical calculations revealed that the observed high NRR catalytic activity for the Fe -NO-C catalyst stemmed mainly from the optimized charge-transfer between the adjacent O and Fe atoms homogenously distributed on the porous carbon support, which could not only significantly facilitate the transportation of N and ions but also effectively decrease the binding energy between the isolated Fe atom and *N intermediate and the thermodynamic Gibbs free energy of the rate-determining step (*N → *NNH).
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http://dx.doi.org/10.1002/anie.202100526DOI Listing
April 2021

Immune-related organizing pneumonitis in non-small cell lung cancer receiving PD-1 inhibitor treatment: A case report and literature review.

J Cancer Res Ther 2020 ;16(7):1555-1559

Department of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, China.

Immune checkpoint blockade with programmed cell death protein-1 (PD-1)/programmed cell death ligand-1 (PD-L1) inhibitors has been standard care for metastatic nonsmall cell lung cancer (NSCLC) and after progression using first-line platinum-containing chemotherapy. Although several management guidelines exist for immune checkpoint inhibitor-induced toxicities, uncommon, complicated, and life-threatening immune-related adverse events remain challenging for oncologists. In this report, we presented a male patient with NSCLC who received pembrolizumab during disease progression. He developed interstitial pembrolizumab-induced organizing pneumonia (OP). The patient received 9 months of anti-PD-1 pembrolizumab when he presented with dry cough and fatigue. The patient developed a solitary nodular lung lesion mimicking a newly occurred metastatic lesion in the lung without a significant circulating tumor marker increase. Sputum analysis was negative for acid-fast bacilli and fungi. A computed tomography-guided percutaneous lung biopsy was conducted and showed alveolar fibrous thickness and various lymphocyte infiltration. Immunotherapy-related OP was identified, and he subsequently responded well to corticosteroids. This case describes a clinical situation, where PD-1-induced OP is radiologically similar to NSCLC disease progression in the lungs. Oncologists should be aware of uncommon pulmonary PD-1/PD-L1 inhibitor toxicity. Lung biopsy may help to distinguish immune-related pneumonitis, lung infections, and progressive nodular lesions.
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http://dx.doi.org/10.4103/jcrt.JCRT_971_20DOI Listing
January 2020

Red mud based passivator reduced Cd accumulation in edible amaranth by influencing root organic matter metabolism and soil aggregate distribution.

Environ Pollut 2021 Apr 2;275:116543. Epub 2021 Feb 2.

Key Laboratory of Environmental Pollution and Health of Guangdong Province, School of Environment, Jinan University, Guangzhou, 510632, China. Electronic address:

Red mud was a highly alkaline hazardous waste, and their resource utilization was a research hotspot. In this study, influencing mechanisms of red mud based passivator on the transformation of Cd fraction in acidic Cd-polluted soil, photosynthetic property, and Cd accumulation in edible amaranth were investigated based on the evaluation of Cd adsorption capacity, root metabolic response, and soil aggregate distribution. Results showed that red mud exhibited good Cd adsorption capacities at about 35 °C and pH 9 in an aqueous solution, and the adsorption behavior of red mud on Cd in rhizosphere soil solution was considered to have some similarity. In the soil-pot trial, red mud application significantly facilitated edible amaranth growth by enhancing the maximum photochemical efficiency and light energy absorption by per unit leaf area by activating more reaction centers. The main mechanisms of rhizosphere soil Cd immobilisation by red mud application included: i) the reduction of mobilized Cd caused by the increasing negative surface charge of soil and precipitation of Cd hydroxides and carbonates at high pH; ii) the increase of organics-Cd complexes caused by the increasing -OH and -COOH amounts adsorbed on the surface of rhizosphere soil after red mud application; and iii) the decrease of available Cd content in soil aggregates caused by the increasing organic matters after red mud application. This study would provide the basis for the safe utilization of red mud remediating acidic Cd-polluted soil.
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http://dx.doi.org/10.1016/j.envpol.2021.116543DOI Listing
April 2021

Eco-friendly flame retardant and dripping-resistant of polyester/cotton blend fabrics through layer-by-layer assembly fully bio-based chitosan/phytic acid coating.

Int J Biol Macromol 2021 Apr 5;175:140-146. Epub 2021 Feb 5.

School of Textile and Garment, Anhui Polytechnic University, Wuhu 241000, China; Technology Public Service Platform for Textile Industry of Anhui Province, Wuhu 241000, China.

Polyester/cotton blend fabrics are widely used in clothing and household textiles which combine the comfort of cotton and excellent mechanical strength of polyester. However, their high flammability due to the special "wick effect" resulting from the different thermal decomposition process of cotton and polyester causes greatly potential fire hazards. In this study, fully bio-based intumescent flame retardant (IFR) coating of chitosan/phytic acid (CS/PA) was layer-by-layer (LBL) assembly constructed on polyester/cotton blend fabrics. The LOI value of polyester/cotton blend fabric which was LBL assembly coated by 20 bilayers CS/PA reached 29.2%. And the dripping of coated fabric was eliminated. The results of cone calorimetry test confirmed CS/PA coating greatly improved the flame retardancy of polyester/cotton blend fabrics. Thermogravimetric analysis (TGA) results showed CS/PA coating changed the thermal decomposition process to promote the char formation of polyester/cotton blend fabrics. CS/PA coating on fabric could form the IFR system which acts through both condensed phase action by the catalysis dehydration reaction to forming stable char and gas phase action by the blowing effect. This research provides a new strategy to eco-friendly flame retardant and dripping-resistant for polyester/cotton blend fabrics by bio-based IFR system through facile LBL assembly method.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.02.023DOI Listing
April 2021

Primary Squamous Cell Carcinoma of the Liver is Rare but Hostile: Case Series and Comprehensive Review of the Literature.

Cancer Manag Res 2021 29;13:829-837. Epub 2021 Jan 29.

Department of Oncology, The First Affiliated Hospital of Shandong First Medical University, Jinan, People's Republic of China.

Primary squamous cell carcinoma (SCC) of the liver is an uncommon cancer type. Only dozens of such cases have been reported in the literature. We reviewed three cases with primary SCC of the liver in a single center from January 2013 to October 2019. One case was positive for hepatitis B infection and simultaneously diagnosed with sigmoid adenocarcinoma and liver cyst. The second patient presented with hepatolithiasis. The remaining one had no history of prior liver insult, hepatic infection or any pre-existing hepatic cysts. Two cases had a long survival of more than one year through chemotherapy, or radical surgery plus transarterial chemoembolization. We also found 25 patients with primary hepatic SCC in the Surveillance, Epidemiology and End Results (SEER) database from 1997 to 2016. The median age was 67 years (range 33-87 years). The median overall survival and disease-specific survival were 7.7 months (range 0.0-76.0 months) and 2.0 months (range 0.0-20.0 months), respectively. Furthermore, patients receiving surgery had a longer median OS (20.0 versus 6.0 months, = 0.016) and DSS (48.0 versus 8.0 months, = 0.03) than those receiving palliative treatment. Only 20% of all cases survived for more than a year. Although primary SCC of the liver has an unfavorable prognosis, radical surgery and systematic treatment might be helpful for clinical management.
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http://dx.doi.org/10.2147/CMAR.S290523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853432PMC
January 2021

A novel chemosensor for the distinguishable detections of Cu and Hg by off-on fluorescence and ratiometric UV-visible absorption.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 5;250:119365. Epub 2021 Jan 5.

Department of Chemistry, Hong Kong Baptist University, Hong Kong, China. Electronic address:

A novel dual-functional chemosensor, derived from the conjugation of rhodamine B with a quinoline derivative (RHQ), was firstly synthesized with high efficiency and cost-effectiveness for the distinguishable detections of Cu and Hg via ring-opening and ring-forming mechanism. The chemosensor exhibits highly selective and distinguishable responses for Cu and Hg in CHCN-HO (4:1, v/v) with off-on fluorescence and ratiometric ultraviolet-visible (UV-Vis) absorption changes. Additionally, Cu is identified by opening a rhodamine spirocycle with a UV-Vis absorption band, at around 560 nm and fluorescence turn-on. Interestingly, Hg is discerned by opening the rhodamine spirocycle and by generating a new special cycle for the quinoline unit. Resultantly, there were two UV-Vis absorption bands at around 365 nm and 560 nm, which were accompanied by fluorescence turn-on. Moreover, the chemosensor can quantitatively detect Cu and Hg by off-on fluorescence and ratiometric UV-Vis absorption changes, respectively. Furthermore, the chemosensor with low cytotoxicity could be successfully administered to monitor Cu and Hg in living cells. This work may pay the way for the development of dual-functional chemosensor for quantificationally detecting metal ions in environmental and biological systems.
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http://dx.doi.org/10.1016/j.saa.2020.119365DOI Listing
April 2021

Robust Visual Tracking Based on Adaptive Multi-Feature Fusion Using the Tracking Reliability Criterion.

Sensors (Basel) 2020 Dec 14;20(24). Epub 2020 Dec 14.

School of Electrical Engineering, North China University of Water Resources and Electric Power, Zhengzhou 450000, China.

Multi-resolution feature fusion DCF (Discriminative Correlation Filter) methods have significantly advanced the object tracking performance. However, careless choice and fusion of sample features make the algorithm susceptible to interference, leading to tracking failure. Some trackers embed the re-detection module to remedy tracking failures, yet distinguishing ability and stability of the sample features are scarcely considered when training the detector, resulting in low effectiveness detection. Firstly, this paper proposes a criterion of feature tracking reliability and conduct a novel feature adaptive fusion framework. The feature tracking reliability criterion is proposed to evaluate the robustness and distinguishing ability of the sample features. Secondly, a re-detection module is proposed to further avoid tracking failures and increase the accuracy of target re-detection. The re-detection module consists of multiple SVM detectors trained by different sample features. When the tracking fails, the SVM detector trained by the most reliable sample feature will be activated to recover the target and adjust the target position. Finally, comparison experiments on OTB2015 and UAV123 databases demonstrate the accuracy and robustness of the proposed method.
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http://dx.doi.org/10.3390/s20247165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764914PMC
December 2020

Analytical and Experimental Investigation of Temporal Interference for Selective Neuromuscular Activation.

IEEE Trans Neural Syst Rehabil Eng 2020 12 28;28(12):3100-3112. Epub 2021 Jan 28.

This article presents an analytical method that offers both spectral and spatial information to predict local electric fields capable of driving neural activities for neuromuscular activation, and the findings of an experimental investigation on a common strategy utilizing multiple high-frequency (HF) electric fields to create an interference to recruit neural firing at depth. By introducing a cut-off frequency [Formula: see text] too high to recruit neural firing in a frequency-based field descriptor, the analytical method offers an effective means to position a focused temporal interference (TI) without mechanically moving the electrodes. The experiment, which was conducted on both forearms of five healthy volunteers, validates the feasibility of the method for selective neuromuscular stimulation, where three nerve/muscles that control human fingers were independently stimulated with two current channels. The numerical and experimental findings demonstrate that the frequency-based method overcomes several limitations associated with surface-based electrical stimulation.
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http://dx.doi.org/10.1109/TNSRE.2020.3038025DOI Listing
December 2020

Hierarchical Multicavity Nitrogen-Doped Carbon Nanospheres as Efficient Polyselenide Reservoir for Fast and Long-Life Sodium-Selenium Batteries.

Small 2020 Dec 4;16(48):e2005534. Epub 2020 Nov 4.

CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Provincial Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, 350002, China.

Sodium-selenium (Na-Se) battery has been emerging as one of the most prospective energy storage systems owing to their high volumetric energy density and cost effectiveness. Nevertheless, the shuttle effect of sodium polyselenide (NaPSe) and sluggish electrochemical reaction kinetics present the main bottlenecks for its practical implementation. Herein, a new Se host of 3D nitrogen-doped hierarchical multicavity carbon nanospheres (3D NHMCs) is designed and synthesized via a facile self-sacrifice templating strategy. The 3D NHMCs are verified to hold a favorable structure of a hollow macropore core and numerous micro/mesopores hollow shell for hosting Se, which can not only maximize Se utilization and alleviate the volumetric expansion but also promote the electrical/ionic conductivity and electrolyte infiltration. Moreover, the abundant self-functionalized surfaces as an efficient NaPSe scavenger via robust physical-chemical dual blocking effects demonstrate high-efficiency in situ anchoring-diffusion-conversion of NaPSe, rendering rapid reaction kinetics and remarkable suppressive shuttle effect, as evidenced by systematic experimental analysis and density functional theory calculations. As a result, the high-Se-loading 3D NHMCs/Se cathode exhibits an ultrahigh volumetric capacity (863 mAh cm ) and rate capability (377 mAh g at 20 C) and unexceptionable stability over 2000 cycles at 2 C.
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http://dx.doi.org/10.1002/smll.202005534DOI Listing
December 2020

Blockade of IL-33 signalling attenuates osteoarthritis.

Clin Transl Immunology 2020 23;9(10):e1185. Epub 2020 Oct 23.

The Institute of Ageing and Chronic Disease University of Liverpool Liverpool UK.

Objectives: Osteoarthritis (OA) is the most common form of arthritis characterised by cartilage degradation, synovitis and pain. Disease modifying treatments for OA are not available. The critical unmet need is to find therapeutic targets to reduce both disease progression and pain. The cytokine IL-33 and its receptor ST2 have been shown to play a role in immune and inflammatory diseases, but their role in osteoarthritis is unknown.

Methods: Non-OA and OA human chondrocytes samples were examined for IL-33 and ST2 expression. Novel inducible cartilage specific knockout mice (IL-33) and inducible fibroblast-like synoviocyte knockout mice (IL-33) were generated and subjected to an experimental OA model. In addition, wild-type mice were intra-articularly administered with either IL-33- or ST2-neutralising antibodies during experimental OA studies.

Results: IL-33 and its receptor ST2 have increased expression in OA patients and a murine disease model. Administering recombinant IL-33 increased OA and pain . Synovial fibroblast-specific deletion of IL-33 decreased synovitis but did not impact disease outcomes, whilst cartilage-specific deletion of IL-33 improved disease outcomes . Blocking IL-33 signalling also reduced the release of cartilage-degrading enzymes in human and mouse chondrocytes. Most importantly, we show the use of monoclonal antibodies against IL-33 and ST2 attenuates both OA and pain .

Conclusion: Overall, our data reveal blockade of IL-33 signalling as a viable therapeutic target for OA.
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http://dx.doi.org/10.1002/cti2.1187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587452PMC
October 2020

Mitigating NO emissions from an ammonia-fueled micro-power system with a perforated plate implemented.

J Hazard Mater 2021 Jan 6;401:123848. Epub 2020 Sep 6.

School of Aerospace Engineering, Beijing Institute of Technology, Beijing, 100083, China.

In this work, three-dimensional numerical simulations with a simplified reaction mechanism are conducted to investigate the effect of implementing a perforated plate in an ammonia-fueled micro-power systems on the NO emission behavior. Detailed analyses on 1) the perforated plate hole dimensionless width w, dimensionless location l as well as the material property are performed. Results show that with an optimized perforated plate implemented, the NO emission is reduced by up to 73.3 % compared to those in the absence of perforated plates. The decrease is mainly due to the formation of a recirculation zone with a low flame temperature. Increasing w is shown to play a positive role in minimizing the NO generation, while l leads to a reverse trend resulting from the size variation of the recirculation zone. In contrast, the plate material has a negligible effect on NO emissions. It is also shown that the pressure loss P is varied non-monotonically with l, but monotonically with w and the NH volumetric flow rate. Furthermore, the conjugate heat transfer between the plate and combustion products has a certain impact on P. The present work shed lights on reducing NO emissions by implementing a well-designed perforated plate for practical micro-power systems.
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http://dx.doi.org/10.1016/j.jhazmat.2020.123848DOI Listing
January 2021

Transvaginal natural orifice transluminal endoscopic surgery (vNOTES) hysterectomy for uterus weighing ≥1 kg.

BMC Surg 2020 Oct 12;20(1):234. Epub 2020 Oct 12.

Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, 128 Shenyang Road, Shanghai, 200090, China.

Background: The transvaginal natural orifice transluminal endoscopic surgery (vNOTES) applied in gynecology has been developed recent years and been evolving. In this study, we aimed to evaluate the feasibility and effect of the vNOTES hysterectomy for uterus ≥1 kilogram (kg).

Methods: From January 2019 to March 2020, patients with benign indications in cases of uterus weighing ≥1 kg, underwent vNOTES hysterectomy were studied retrospectively. The patients' demographics, indications for surgery, operation outcomes and follow-up details were recorded.

Results: 39 patients were performed vNOTES hysterectomy for large uterus (mean weight 1141.8 gram, range from 1000 to 1720), indications for surgery included bulky uterine myomas or adenomysosis. The mean age was 48 years (range 42-66) and mean BMI was 24 kg/m (range 18.4-38). Mean operating time was 123.3 min (rang 40-400) and the mean estimated blood loss was 206.7 milliliters  (range 10-1300). The mean pain assessment was 2.1 (range 0-5). The mean length of stay was 2.4 nights (1-11). 1 patient experienced ureteral injury and was performed ureteral anastomosis. 3 patients were converted to vaginal-assisted trans-umbilicus single-port laparoscopy. The learning curve was analyzed to show that 20 cases were needed to achieve proficiency in vNOTES hysterectomy for large uterus ≥1 kg.

Conclusion: Our preliminary experience suggested that vNOTES hysterectomy for large uterus weighing ≥1 kg was feasible and safe, meanwhile this procedure had the advantages of all the minimal invasive approach such as fast recovery and aesthetic advantage.
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http://dx.doi.org/10.1186/s12893-020-00897-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552525PMC
October 2020

T17 cells…Sorting the good out from the bad.

Signal Transduct Target Ther 2020 09 19;5(1):207. Epub 2020 Sep 19.

The Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, L7 8TX, UK.

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http://dx.doi.org/10.1038/s41392-020-00316-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502076PMC
September 2020

Protective effects of dexmedetomidine on hypoxia/reoxygenation injury in cardiomyocytes by regulating the CHOP signaling pathway.

Mol Med Rep 2020 Oct 19;22(4):3307-3315. Epub 2020 Aug 19.

Department of Anesthesiology, The Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha, Hunan 410005, P.R. China.

Hypoxia/reoxygenation (H/R) injury in myocardial cells occurs frequently during cardiac surgery and affects the prognosis of patients. The present study aimed to investigate the protective effects of dexmedetomidine (Dex) on H/R injury and its association with the C/EBP‑homologous protein (CHOP) signaling pathway. An H/R model was constructed in H9C2 cells to investigate the effects of Dex on H/R injury. Cell viability, apoptosis and lactate dehydrogenase (LDH) levels were determined by MTT, flow cytometry and 2,4‑dinitrophenylhydrazine colorimetric assays, respectively. The expression levels of inflammatory factors were measured by reverse transcription‑quantitative PCR (RT‑qPCR), and CHOP and glucose‑regulated protein‑78 (Grp78) expression levels were detected by RT‑qPCR and western blotting. CHOP was overexpressed or knocked down to detect the cell viability, apoptosis, LDH level and the expression levels of inflammatory factors and Grp78. The results demonstrated that in the H/R group, cell viability was lower and apoptosis was higher, and that higher levels of LDH and inflammatory factors were present compared with those in the Dex+H/R group. Silencing of CHOP significantly reversed the H/R‑reduced cell viability, high apoptotic rate and LDH levels, as well as the elevated expression levels of inflammatory factors and Grp78 caused by H/R injury, whereas the overexpression of CHOP inhibited cell viability and promoted apoptosis, elevated LDH level and expression of inflammatory factors and Grp78 compared with the negative control. Additionally, pretreatment with Dex significantly alleviated the H/R injury; thus, Dex may protect H9C2 cells against H/R induced cell injury, possibly by suppressing the CHOP signaling pathway.
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http://dx.doi.org/10.3892/mmr.2020.11442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453597PMC
October 2020
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