Publications by authors named "Junqing Zhang"

93 Publications

Comparative analysis of Bioactive Constituents and Pharmacological Activities from different parts of Nauclea officinalis.

Biomed Chromatogr 2021 Jul 12:e5214. Epub 2021 Jul 12.

Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, China.

The stem of Nauclea officinalis have been utilized as a crude drug in China, so other parts of Nauclea officinalis are abandoned, resulting in a waste of traditional Chinese medicine resources. To determine the distribution and content of the alkaloids, phenolic acids and iridoid in different organs (stem, branch, leaf and bark) of this plant, a reliable method has been established using LC-MS/MS. Nine constituents, namely strictosamide, vincosamide, chlorogenic acid, sweroside, naucleamide B, protocatechuic acid, pumiloside, vanillic acid and cryptochlorogenic acid were simultaneously determined in six minutes. Meanwhile, the antipyretic, anti-inflammatory and analgesic activities were evaluated for comparative analysis of the pharmacological activity in different parts from Nauclea officinalis. The results showed that the content of active components in other organs of Nauclea officinalis was higher than that in stems, and pharmacological effects of branches and leaves were also better. The established approach could be helpful for the quality control of Nauclea officinalis, and also provide necessary information for the rational utilization of Nauclea officinalis resources.
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http://dx.doi.org/10.1002/bmc.5214DOI Listing
July 2021

Herb-drug interaction in the protective effect of against gastric injury induced by indomethacin based on pharmacokinetic, tissue distribution and excretion studies in rats.

J Pharm Anal 2021 Apr 6;11(2):200-209. Epub 2020 Jun 6.

Key Laboratory of Tropical Translation Medicine of Ministry of Education; Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs; School of Pharmacy, Hainan Medical University, Haikou, 571199, China.

Hance of the Chinese traditional herb for the treatment of emesis, abdominal pain and diarrhea has been used to counteract gastric disease induced by indomethacin in rats without obvious side effects. However, the role of herb-drug interaction between indomethacin and based on pharmacokinetic, tissue distribution and excretion still remains unknown. In this study, an ultra-fast liquid-tandem mass spectrometry (UFLC-MS/MS) method was developed for simultaneous determination of indomethacin and its three metabolites, O-desmethylindomethacin (ODI), deschlorobenzoylindomethacin (NDI) and indomethacin acyl-β-D-glucuronide (IDAβG) by oral administration of indomethacin solution with and without the ethanolic extract of and applied to comparative pharmacokinetic, tissue distribution and excretion studies. Our results clarified that oral administration of produced significant alterations in the pharmacokinetic parameters of indomethacin. And the pharmacokinetic interaction between indomethacin and reduced the systemic exposure of indomethacin and increased its elimination. Tissue distribution results demonstrated that co-administration of could not reduce the accumulation of indomethacin in the target tissue of the stomach, but could accelerate the excretions of indomethacin and its three metabolites including ODI, NDI and IDAβG in the bile and feces of rats in the excretion study. Therefore, might have a gastrointestinal protective effect through the interaction role with indomethacin based on the pharmacokinetics and excretion in rats.
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http://dx.doi.org/10.1016/j.jpha.2020.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116206PMC
April 2021

Glycosylation of Anti-Thyroglobulin IgG1 and IgG4 Subclasses in Thyroid Diseases.

Eur Thyroid J 2021 Apr 27;10(2):114-124. Epub 2020 Aug 27.

Department of Endocrinology, Peking University First Hospital, Beijing, China.

Objective: Thyroglobulin antibodies (TgAb), principally comprising immunoglobulin G (IgG), are frequently found in healthy individuals. Previously, we showed that the glycosylation levels of TgAb IgG differed across various thyroid diseases, suggesting an important role of glycosylation on antibodies in the pathogenesis of thyroid diseases. Since IgG1 and IgG4 are the primary TgAb IgG subclasses, this study aimed to investigate the glycosylation of TgAb IgG1 and IgG4 subclasses in thyroid diseases.

Methods: TgAb IgG was purified by affinity chromatography from the serum of patients with Hashimoto's thyroiditis (HT) ( = 16), Graves' disease (GD) ( = 8), papillary thyroid carcinoma (PTC) ( = 6), and PTC with histological lymphocytic thyroiditis (PTC-T) ( = 9) as well as healthy donors ( = 10). TgAb IgG1 and IgG4 concentrations were determined by enzyme-linked immunosorbent assay, and a lectin microassay was used to assess TgAb IgG1 and IgG4 glycosylation.

Results: Significantly elevated mannose, sialic acid, and galactose levels on TgAb IgG1 were found in HT and PTC patients compared to GD patients and healthy controls (all < 0.05). The mannose, sialic acid, and core fucose levels on TgAb IgG1 in PTC-T patients were higher than in healthy controls (all < 0.05). Additionally, TgAb IgG1 from PTC-T patients exhibited lower sialylation than that from patients with PTC and higher fucosylation than that from patients with HT (both < 0.05). However, TgAb IgG4 glycosylation did not differ among the five groups ( < 0.05).

Conclusion: Our study describes different distributions of TgAb IgG1 glycosylation in various thyroid diseases. The aberrantly increased glycosylation levels of TgAb IgG1 observed in HT, PTC, and PTC-T might be indicative of immune disorders and participate in the pathogenesis of these diseases.
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http://dx.doi.org/10.1159/000507699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077608PMC
April 2021

A multiplex PCR amplicon sequencing assay to screen genetic hearing loss variants in newborns.

BMC Med Genomics 2021 02 27;14(1):61. Epub 2021 Feb 27.

BGI Education Center, University of Chinese Academy of Sciences, BGI Park, No.21 Hongan 3rd Street, Yantian District, Shenzhen, 518083, China.

Background: Congenital hearing loss is one of the most common birth defects. Early identification and management play a crucial role in improving patients' communication and language acquisition. Previous studies demonstrated that genetic screening complements newborn hearing screening in clinical settings.

Methods: We developed a multiplex PCR amplicon sequencing assay to sequence the full coding region of the GJB2 gene, the most pathogenic variants of the SLC26A4 gene, and hotspot variants in the MT-RNR1 gene. The sensitivity, specificity, and reliability were validated via samples with known genotypes. Finally, a pilot study was performed on 300 anonymous dried blood samples.

Results: Of 103 samples with known genotypes, the multiplex PCR amplicon sequencing assay accurately identified all the variants, demonstrating a 100% sensitivity and specificity. The consistency is high in the analysis of the test-retest reliability and internal consistency reliability. In the pilot study, 12.3% (37/300) of the newborns were found to carry at least one pathogenic variant, including 24, 10, and 3 from the GJB2, SLC26A4, and MT-RNR1 gene, respectively. With an allele frequency of 2.2%, the NM_004004.6(GJB2):c.109G>A was the most prevalent variant in the study population.

Conclusion: The multiplex PCR amplicon sequencing assay is an accurate and reliable test to detect hearing loss variants in the GJB2, SLC26A4, and MT-RNR1 genes. It can be used to screen genetic hearing loss in newborns.
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http://dx.doi.org/10.1186/s12920-021-00906-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913202PMC
February 2021

Neutrophil-Lymphocyte Ratio as an Initial Screening Biomarker for Differential Diagnosis of Cushing's Syndrome from Nonfunctional Adenoma in Patients with an Adrenal Mass.

Biomed Res Int 2021 15;2021:6635594. Epub 2021 Feb 15.

Department of Endocrinology, Peking University First Hospital, No. 8 Xishiku Street, Beijing 100034, China.

Objective: Assessing excess adrenal hormones is important in patients with adrenal mass. Current screening tests for excess cortisol hormones are complex, so it cannot be done sometimes due to the limited medical resources. The aim of the study was to evaluate whether the neutrophil-lymphocyte ratio (NLR) can be used as an initial screening biomarker for Cushing's syndrome (CS) in patients with an adrenal mass.

Methods: This retrospective study included a total of 185 patients with CS and 185 patients with nonfunctional adrenal adenoma (matched 1 : 1 by sex, body mass index, and discharge date). The NLR was compared between the two groups. The association between NLR and serum and urinary cortisol concentrations was analyzed, and an NLR cut-off value for CS screening was calculated.

Results: NLR (3.38 (2.33, 5.45) vs. 2.13 (1.74, 3.00), < 0.001) was significantly higher in the CS group than in the nonfunctional adenoma group. In CS patients, the NLR was positively associated with serum cortisol concentrations at 8 am, with 24-hour urine free cortisol and with serum cortisol after a 1 mg dexamethasone suppression test ( < 0.001 each). An NLR cut-off of 2.2 had a sensitivity of 80.0% and a specificity of 54.05%. The weighted Youden index for the NLR was similar to that of the 24-hour urine free cortisol and late-night serum cortisol tests, which are recommended initial tests for CS diagnosis.

Conclusion: The NLR may be useful for initial screening for CS among patients with an adrenal mass as an easy and convenient marker.
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http://dx.doi.org/10.1155/2021/6635594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899776PMC
June 2021

Delayed diagnosis of multiple endocrine neoplasia type 1 during pregnancy: a case report.

QJM 2021 Jan 18. Epub 2021 Jan 18.

Department of Endocrinology, Peking University First Hospital, Beijing, China.

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http://dx.doi.org/10.1093/qjmed/hcab004DOI Listing
January 2021

Resveratrol attenuates dapagliflozin-induced renal gluconeogenesis activating the PI3K/Akt pathway and suppressing the FoxO1 pathway in type 2 diabetes.

Food Funct 2021 Feb;12(3):1207-1218

Endocrinology, Peking University First Hospital, Beijing 100034, China.

Dapagliflozin alleviates hyperglycemia by increasing glycosuria, but it induces renal gluconeogenesis, thus neutralizing its efficacy. Resveratrol (Rsv), a natural polyphenolic chemical, improves insulin sensitivity in type 2 diabetes (T2D). Here, we investigated the regulatory effects and underlying mechanisms of Rsv on dapagliflozin-induced renal gluconeogenesis. Male ob/ob mice were given the vehicle (HF), dapagliflozin (1 mg kg-1), Rsv (10 mg kg-1), or dapagliflozin and Rsv combination for 10 weeks. Glucose metabolism was evaluated by glucose and pyruvate tolerance tests. HK-2 cells (human renal proximal tubule cells) were treated with dapagliflozin (1 μmol L-1) for 2 h and further incubated with Rsv (10 μmol L-1) for 12 h. The effects of Rsv on gluconeogenesis and insulin signaling were assessed. Dapagliflozin treatment increased glucose production in HK-2 cells and lowered blood glucose and induced gluconeogenesis in ob/ob mice. After Rsv treatment, the enhanced glucose production and gluconeogenesis were alleviated. The upregulated mRNA and protein expression of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) and the activation of the forkhead transcription factor O1 (FoxO1) protein in the dapagliflozin group were attenuated by Rsv administration. Rsv also improved renal insulin signaling by increasing PI3K and Akt phosphorylation. The PI3K inhibitor LY294002 dramatically decreased the p-Akt expression and activated FoxO1 by dephosphorylation, thus diminishing the inhibitory effects of Rsv on dapagliflozin-induced PEPCK and G6Pase expression. The data showed the mechanisms of Rsv in attenuating dapagliflozin-induced renal gluconeogenesis via activating the PI3K/Akt pathway and further suppressing FoxO1 activation, suggesting a potential intervention to achieve better glucose-lowering effects for SGLT2 inhibitors in T2D therapy.
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http://dx.doi.org/10.1039/d0fo02387fDOI Listing
February 2021

A novel GNAS mutation in pseudohypoparathyroidism type 1a in a Chinese man presented with recurrent seizure: a case report.

BMC Endocr Disord 2021 Jan 9;21(1):12. Epub 2021 Jan 9.

Department of Endocrinology, Peking University First Hospital, Beijing, China.

Background: Pseudohypoparathyroidism is a rare genetic disease characterized by hypocalcaemia and hyperphosphataemia due to the defect to the guanine nucleotide-binding protein alpha subunit (GNAS) gene. Patients with pseudoparathyroidism type 1a and 1c could manifest Albright's hereditary osteodystrophy and multiple hormone resistance including gonadotropin and thyroid stimulating hormone.

Case Presentation: Here we report a Chinese man who presented with fatigue, recurrent seizure and Albright's hereditary osteodystrophy. His genetic study revealed a heterozygote mutation in the GNAS gene [NM_000516.4(GNAS): c2787_2788del (p.Val930AspfsTer12)]. After calcium and calcitriol supplement, his seizures achieved partially remission.

Conclusions: We report a case of PHP1a or 1c with a novel frameshift mutation in GNAS gene in a patient presenting with AHO, as well as TSH and partial gonadotropin resistance. This mutation in this case has not been reported in literature and adds to the spectrum of genetic mutations related to PHP.
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http://dx.doi.org/10.1186/s12902-020-00651-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796383PMC
January 2021

Toxic epidermal necrolysis after therapeutic plasma exchange in pediatric lupus patients and associated risk factors analysis.

Lupus 2021 Mar 7;30(3):465-472. Epub 2021 Jan 7.

Department of pediatric nephrology, West China Second Hospital of Sichuan University, Sichuan, China.

Background: Therapeutic plasma exchange (TPE) is an effective means of treating systemic lupus erythematosus in children and is safe for most pediatric patients with systemic lupus erythematosus, but severe complications such as toxic epidermal necrolysis (TEN) may occur, which is a life-threatening condition.

Methods: In this study, three systemic lupus erythematosus (SLE) children developed toxic epidermal necrolysis after TPE. We analyzed their medical history, clinical manifestations, SLEDAI scores, and immunological characteristics, compared to 117 cases of SLE patients without TEN after TPE, trying to find the possible risk factors.

Results: The three children with TEN after plasma exchange appeared to have a higher proportion of male (male: female = 2:1), fever (100% Vs 32.5%), erythema on the cheek (100% Vs 54.7%), itching rash (100% Vs 54.7%), ruptured rash (100% Vs 54.7%), oral ulcer (100% Vs 54.7%) and higher LDH level (1826.0 ± 1113.1 Vs 721.1 ± 799.5 U/L), but lower white blood cell count (5.5 ± 3.3 Vs 7.2 ± 4.2 × 10/L), neutrophil count (4.7 ± 3.7 Vs 5.2 ± 3.6 × 10/L), lymphocyte count (0.6 ± 0.5 Vs 1.5 ± 0.8 × 10/L), platelet count (133.7 ± 58.1 Vs 178.5 ± 103.1 × 10/L) and C-reactive protein (all normal Vs 47.9% elevated). Autoantibody spectrum revealed that positive anti-SSA seemed more common (100% Vs 42.7%) in the three children. Relative risk analysis revealed that male (OR 21.4, 95%CI 1.78-257.186), ruptured skin rash (OR 56.5, 95%CI 4.199-760.196) and rash with itching (OR 24, 95%CI 1.98-290.896) are the risk factors of SLE patients developing TEN after plasma exchange.

Conclusions: We should pay particular attention to TEN after plasma exchange in SLE patients (3/120, 2.5%). This condition may be related to male, ruptured skin rash and rash with itching. For SLE patients with risk factors. We should arrange plasmapheresis more carefully.
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http://dx.doi.org/10.1177/0961203320981128DOI Listing
March 2021

Prevalence of Depression and Anxiety Symptoms of High School Students in Shandong Province During the COVID-19 Epidemic.

Front Psychiatry 2020 21;11:570096. Epub 2020 Dec 21.

School of Mental Health, Jining Medical University, Jining, China.

The coronavirus disease 2019 (covid-19) has brought physical risks as well as psychological challenges to the whole world. High school students are a special group suffering from both the academic pressure and the threat of the epidemic. The present study aims to conduct an online survey to investigate the psychological status of high school students in Shandong Province. Using a web-based cross-sectional survey, data was collected from 1,018 voluntary high school students assessed with demographic information, the Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder-7 (GAD-7) and a self-designed online-study effect survey. Correlation analysis was performed to explore the relationships between depression symptoms, anxiety symptoms, and study effect. The prevalence of depressive symptoms, anxiety symptoms, and a combination of depressive and anxiety symptoms was 52.4, 31.4, and 26.8%, respectively, among high school students in Shandong Province during the COVID-19 epidemic. And from moderate to severe severity level, the rates of depressive symptoms and anxious symptoms were 17.6 and 4.6%. Female students exhibited a higher rate and severity of mental symptoms than male, and grade one senior high school students got a higher rate and severity of mental symptoms than the other two grades. Nearly half of the students were not satisfied with their online-study effect. The PHQ-9 score had a strong positive correlation with the GAD-7 score. Both the PHQ-9 score the GAD-7 score had a negative correlation with the study-effect survey score. Quite a number of high school students suffered from depression and anxiety symptoms during the COVID-19 epidemic. Sufficient attentions should be paid, and necessary supports should be provided, to protect the mental health of this special group.
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http://dx.doi.org/10.3389/fpsyt.2020.570096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779476PMC
December 2020

IgG4 immunohistochemistry in Riedel's thyroiditis and the recommended criteria for diagnosis: A case series and literature review.

Clin Endocrinol (Oxf) 2021 May 21;94(5):851-857. Epub 2020 Dec 21.

Department of Endocrinology, Peking University First Hospital, Beijing, China.

Objective: Riedel's thyroiditis (RT) is a very rare chronic fibrosing thyroiditis that is often associated with multifocal fibrosclerosis. Although the relationship of RT and IgG4-related disease (IgG4-RD) has been suggested, the expression of IgG and IgG4 in thyroid tissues of patients with RT has seldom been studied.

Design: A case series and literature review.

Patients And Measurements: We searched our hospital's pathology database and identified five cases of RT between 2000 and 2019. The expression levels of IgG4 and IgG in thyroid tissues were detected by immunohistochemistry. We also performed a literature search of the electronic databases PubMed/MEDLINE, Web of Science and China National Knowledge Internet (CNKI). Eight papers were included in this study.

Results: According to immunohistochemistry, the numbers of IgG4+ plasma cells per high-power field (HPF) of the five RT patients at our hospital were 80, 8, 50, 10 and 22, and the respective IgG4+/IgG+ ratios were 76%, 80%, 43%, 19% and 28%. In the literature, 15 RT patients with confirmed IgG4 and IgG immunohistochemical findings were identified. Only seven of them fulfilled the IgG4-RD diagnostic criteria in terms of immunohistochemistry (IgG4+ > 10/HPF, IgG4+/IgG+ > 40%). In order to ensure that most RT cases can meet the IgG4 immunohistochemical criteria, an organ-specific cut-off value (≥10 IgG4+ plasma cells/HPF and ≥ an IgG4+/IgG ratio of 20%) was finally selected in our study.

Conclusion: Our findings of IgG4 expression in patients with RT suggest that a cut-off of 10 IgG4+ plasma cells/HPF and an IgG4+/IgG ratio of 20% are more suitable diagnostic criteria for RT in IgG4-RD.
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http://dx.doi.org/10.1111/cen.14390DOI Listing
May 2021

Rational molecular design of a reversible BODIPY-Based fluorescent probe for real-time imaging of GSH dynamics in living cells.

Biosens Bioelectron 2021 Mar 27;175:112866. Epub 2020 Nov 27.

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Key Laboratory of Functional Polymer Materials of Ministry of Education, Nankai University, Tianjin, 300071, PR China. Electronic address:

Marring the reversible covalent chemistry with BODIPY dye, which is a superfamily of fluorophores with striking photophysical performances, would enable a panel of diverse dynamic fluorescent probes for biomedical applications. Herein we show that structural manipulation of BODIPY allows rational tuning of α-site or meso-site activation as well as the spectral response toward nucleophiles. By rational molecular design, we have obtained a highly specific and reversible GSH probe, BD-GSH, which exhibits a tremendously fast and dynamic fluorescence response within the wide physiological GSH concentration range of 0-8 mM. We successfully applied BD-GSH to real-time imaging of intracellular GSH dynamics in different cell lines. In light of the remarkable photophysical properties and synthesis flexibility of BODIPY dyes, the current findings will help to design more reversible BODIPY-based fluorescent probes targeting various bio-species.
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http://dx.doi.org/10.1016/j.bios.2020.112866DOI Listing
March 2021

Expert consensus workshop report: Guidelines for thermal ablation of thyroid tumors (2019 edition).

J Cancer Res Ther 2020 Sep;16(5):960-966

Department of Ultrasound, Chinese PLA General Hospital, China.

As a treatment option for cancer, thermal ablation has satisfactory effects on many types of solid tumors (such as liver and renal cancers). However, its clinical applications for the treatment of thyroid nodules and metastatic cervical lymph nodes are still under debate both in China and abroad. In 2015, the "Zhejiang Expert consensus on thermal ablation for thyroid benign nodules, microcarcinoma, and metastatic cervical lymph nodes (2015 edition)," was released by the Thyroid Cancer Committee of Zhejiang Anti-Cancer Association, China. To further standardize the application of thermal ablation for thyroid tumors, the Thyroid Tumor Ablation Experts Group of Chinese Medical Doctor Association has organized many seminars and finally produced a consensus to formulate the "Expert consensus workshop report: Guidelines for thermal ablation of thyroid tumors (2019 edition)."
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http://dx.doi.org/10.4103/jcrt.JCRT_558_19DOI Listing
September 2020

The short-term effect of PM/O on daily mortality from 2013 to 2018 in Hefei, China.

Environ Geochem Health 2021 Jan 12;43(1):153-169. Epub 2020 Aug 12.

Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China.

This research intends to explore the short-term impacts of PM/O on daily death in Hefei from 2013 to 2018. Data on daily death of Hefei residents, meteorological factors, and air pollutants were collected from Jan 1, 2013, to Dec 31, 2018. The correlation between PM/O and daily death in Hefei during the research period was studied by time series analysis. From 2013 to 2018, there were 61,683 non-accidental deaths, including 27,431 cardiovascular deaths, 5587 respiratory deaths, 20,921 malignant tumor deaths, and 1674 diabetes deaths, in Hefei. Annual mean concentrations of PM, PM, NO, SO, CO, and O in Hefei were 66.18, 92.37, 39.75, 15.39, 930, and 79.08 μg m, respectively. An increase of 10 μg m in PM was related with 0.53% (95% CI 0.31-0.75%), 0.93% (95% CI 0.60-1.26%), 0.90% and (95% CI 0.23-1.57%) increase in non-accidental, cardiovascular and respiratory diseases mortality, respectively. The association between ozone and mortality was not significant. In cold seasons, PM had a stronger effect on the deaths resulting from non-accidental, cardiovascular, and respiratory diseases. The effect of O on deaths was not significantly different between the cold season and the warm season. Women and the elders (over 65 years) were at high risk of being affected by PM/O. Short-term exposure to PM was positively correlated with increased deaths due to non-accidental, cardiovascular and respiratory diseases in Hefei. Females and elders were more vulnerable to PM/O exposure. No significant associations were observed between ozone and deaths from non-accidental, cardiovascular, respiratory, malignant tumors, and diabetes diseases.
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http://dx.doi.org/10.1007/s10653-020-00689-xDOI Listing
January 2021

The use of doxazosin before adrenalectomy for pheochromocytoma: is the duration related to intraoperative hemodynamics and postoperative complications?

Int Urol Nephrol 2020 Nov 3;52(11):2079-2085. Epub 2020 Jul 3.

Department of Urology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, 100034, China.

Purpose: No conclusion exists for the optimum duration of preoperative administration of doxazosin (DOX) before adrenalectomy for pheochromocytoma. The purpose of this study is to investigate whether perioperative hemodynamics and postoperative outcomes are related to the duration of DOX administration.

Methods: In total, 132 patients managed preoperatively with single α-receptor blocker DOX were enrolled. All patients underwent adrenalectomy for pheochromocytoma in the Department of Urology, Peking University First Hospital, between January 2001 and July 2019. Patients were divided into three groups based on the duration of preoperative administration of DOX: group A (≤14 days), group B (15-30 days), and group C (>30 days). Patient and tumor characteristics, intraoperative hemodynamics, and postoperative outcomes were recorded and compared.

Results: These patients included 57 men and 75 women, with an average age of 48 years. Clinical characteristics, preoperative hemodynamics, medicine management and surgical approaches were comparable between the three groups. Among the three groups, we found that group C (>30 days) had the lowest intraoperative minimum heart rate [group A vs. group B vs. group C = 60 (52-67) vs. 59 (50-61) vs. 51.5 (50-58.75), p = 0.024] and highest risk of postoperative hypotension requiring vasopressor support [group A vs. group B vs. group C = 14 (20.3%) vs. 12 (27.9%) vs. 10 (50.0%), p = 0.032].

Conclusion: The current study indicated that preoperative management of pheochromocytoma with single α-receptor blocker DOX for more than 30 days after final dose adjustment might lead to intraoperative bradycardia and more postoperative hypotension requiring vasopressor support. Thus, our study does not support long-term (over 30 days) preoperative administration of pheochromocytoma with single α-receptor blocker DOX in the final dose.
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http://dx.doi.org/10.1007/s11255-020-02539-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575471PMC
November 2020

Maternal high-fat diet regulates glucose metabolism and pancreatic β cell phenotype in mouse offspring at weaning.

PeerJ 2020 22;8:e9407. Epub 2020 Jun 22.

Department of Endocrinology, Peking University First Hospital, Beijing, China.

Background: Maternal malnutrition is a critical factor in determining the risk of obesity and glucose intolerance in offspring. However, little is known about the effects of a maternal high-fat diet (HFD) on the β cell phenotype in offspring, which is a major factor in glucose homeostasis, especially during the early life of offspring.

Methods: Dams were randomly fed a HFD (60% kcal from fat) or a chow diet before pregnancy and during gestation and lactation. Glucose metabolism and the β cell phenotype were assessed in male offspring at weaning.

Results: Dams fed a HFD showed impaired glucose tolerance. A HFD predisposed the offspring to increased impairment of metabolic health, including obesity, glucose intolerance and insulin resistance, compared with offspring from chow diet-fed dams. Furthermore, increased islet sizes and islet densities were observed in male offspring from HFD-fed dams at weaning. There were increases in the insulin-positive area, β cell mass and β cell proliferation in male offspring from HFD-fed dams at weaning age. Next, we further determined whether a maternal HFD could affect β cell apoptosis in mouse offspring and found that there was no significant change in β cell apoptosis between the HFD and control groups.

Conclusion: Our study is novel in showing that a maternal HFD predisposes offspring to impaired glucose metabolism and has a profound effect on β cell mass and proliferation in offspring mice, which is observed in mice as early as at weaning age. However, further study to clarify the underlying mechanisms is warranted.
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http://dx.doi.org/10.7717/peerj.9407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316079PMC
June 2020

The clinical characteristics and outcomes of patients with diabetes and secondary hyperglycaemia with coronavirus disease 2019: A single-centre, retrospective, observational study in Wuhan.

Diabetes Obes Metab 2020 08 17;22(8):1443-1454. Epub 2020 Jun 17.

Geriatrics Department, Peking University First Hospital, Beijing, China.

Aim: To explore whether coronavirus disease 2019 (COVID-19) patients with diabetes and secondary hyperglycaemia have different clinical characteristics and prognoses than those without significantly abnormal glucose metabolism.

Materials And Methods: We retrospectively analysed 166 COVID-19 patients at Tongji Hospital (Wuhan) from 8 February to 21 March 2020. Clinical characteristics and outcomes (as of 4 April 2020) were compared among control (group 1), secondary hyperglycaemia (group 2: no diabetes history, fasting plasma glucose levels of ≥7.0 mmol/L once and HbA1c values <6.5%) and patients with diabetes (group 3).

Results: Compared with group 1, groups 2 and 3 had higher rates of leukocytosis, neutrophilia, lymphocytopenia, eosinopenia and levels of hypersensitive C-reactive protein, ferritin and d-dimer (P < .05 for all). Group 2 patients had higher levels of lactate dehydrogenase, prevalence of liver dysfunction and increased interleukin-8 (IL-8) than those in group 1, and a higher prevalence of increased IL-8 was found in group 2 than in group 3 (P < .05 for all). The proportions of critical patients in groups 2 and 3 were significantly higher compared with group 1 (38.1%, 32.8% vs. 9.5%, P < .05 for both). Groups 2 and 3 had significantly longer hospital stays than group 1, which was nearly 1 week longer. The composite outcomes risks were 5.47 (1.56-19.82) and 2.61 (0.86-7.88) times greater in groups 2 and 3 than in group 1.

Conclusions: Hyperglycaemia in both diabetes and secondary hyperglycaemia patients with COVID-19 may indicate poor prognoses. There were differences between patients with secondary hyperglycaemia and those with diabetes. We recommend that clinicians pay more attention to the blood glucose status of COVID-19 patients, even those not diagnosed with diabetes before admission.
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http://dx.doi.org/10.1111/dom.14086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273002PMC
August 2020

Effectiveness and safety of pulsatile intravenous insulin therapy for the improvement of respiratory quotient in Chinese patients with diabetes mellitus.

Exp Ther Med 2020 Apr 27;19(4):3069-3075. Epub 2020 Feb 27.

Department of Endocrinology, Peking University First Hospital, Beijing 100034, P.R. China.

Pulsatile intravenous insulin therapy (PIVIT) is a means of imitating naturally occurring insulin pulses artificially. It is thought to improve carbohydrate metabolism, which can be assessed using the respiratory quotient (RQ). The aim of this present study was to assess the efficacy and safety of PIVIT for the improvement of RQ in Chinese patients with diabetes mellitus (DM). This 12-week, multi-center, prospective, randomized, open-label, parallel-group study involved 110 DM patients (both type 1 and type 2) whose RQ was <0.8. Of these, 53 patients formed the control group, in which standard anti-diabetic therapy was maintained, and 54 patients formed the treatment group, which underwent weekly PIVIT in addition to the administration of standard anti-diabetic therapy. RQ was evaluated monthly in control subjects, and before and after every PIVIT treatment in the treatment group. After weekly PIVIT for 12 weeks, the mean RQ increased from 0.70 to 0.90 in the treatment group, but did not change in the control group. The percentage of subjects reporting adverse events (AEs) was 31.5% (17/54) in the treatment group and 9.43% (5/53) in the control group (P=0.0053). The most frequently reported AE (by 12 subjects) was a gastroenteric reaction when these individuals were receiving 50% glucose during the PIVIT treatment. The majority of AEs were mild and did not interfere with the ongoing treatment. Thus, PIVIT can be viewed as tolerated and effective for the improvement of RQ in Chinese DM patients. This study was retrospectively registered with the Chinese Clinical Trial Registry (http://www.chictr.org.cn) on November 13th 2019 (registration no. ChiCTR1900027510).
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http://dx.doi.org/10.3892/etm.2020.8563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086298PMC
April 2020

Thrombotic thrombocytopenic purpura with reversible splenial lesion syndrome: a case report.

BMC Neurol 2020 Apr 6;20(1):122. Epub 2020 Apr 6.

The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

Background: Reversible splenial lesion syndrome (RESLES) is known to cause severe psychiatric symptoms but is also a very rare clinical disease in which the specific aetiology is unknown. According to current reports, there are major causes of the disease, including viral or bacterial infection, epilepsy, anti-epileptic drug withdrawal, high-altitude cerebral oedema, and metabolic disorders such as hypoglycaemia and hypernatraemia. In this article, we report a patient with thrombotic thrombocytopenic purpura (TTP) who presented with RESLES.

Case Presentation: A 34-year-old female patient who presented with fever and progression of disorder of consciousness was eventually diagnosed with RESLES based on brain imaging. Moreover, clinical features and peripheral smears demonstrating schistocytes and thrombocytopenia confirmed a diagnosis of TTP. RESLES can be improved by plasma exchange therapy.

Conclusion: This rare case highlights the occurrence of RESLES as a presenting feature of the expanding list of unusual neurological manifestations of TTP.
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http://dx.doi.org/10.1186/s12883-020-01696-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133000PMC
April 2020

2.5D multizone reproduction using weighted mode matching: Performance analysis and experimental validation.

J Acoust Soc Am 2020 Mar;147(3):1404

Center of Intelligent Acoustics and Immersive Communications, School of Marine Science and Technology, Northwestern Polytechnical University, Xi'an Shaanxi 710072, China.

Mode-matching based multizone reproduction has been mainly focused on a purely two-dimensional (2D) theory, where infinite-long 2D secondary sources are assumed for 2D multizone reproduction. Its extension to the three-dimensional (3D) case requires more secondary sources and a higher computational complexity. This work investigates a more practical setup to use 3D sound sources as secondary sources for multizone reproduction in a 2D horizontal plane, i.e., 2.5D multizone reproduction. A weighted mode-matching approach is proposed to solve the dimensionality mismatch between the 2D desired sound field and 3D reproduced sound field. The weighting is based on an integral of Bessel-spherical harmonic modes over the entire control region. A detailed analysis of the weighting function is provided to show that the proposed method controls all the reproduction modes present on the 2D plane to minimize the reproduction error. The method is validated in both simulation-based and hardware-based experiments. The results demonstrate that in comparison with the conventional sectorial mode-matching method, the proposed approach can achieve more accurate reproduction over a wide frequency range and a large control region.
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http://dx.doi.org/10.1121/10.0000797DOI Listing
March 2020

Response surface methodology for the fermentation of polysaccharides from Auricularia auricula using Trichoderma viride and their antioxidant activities.

Int J Biol Macromol 2020 Jul 26;155:393-402. Epub 2020 Mar 26.

School of Pharmacy, Hainan Medical University, Haikou, Hainan 570100, China; Hainan Provincial Key Laboratory of R & D on Tropical Herbs, Haikou, Hainan 570100, China; Key Laboratory of Tropical Translational Medicine of Ministry of Education, Haikou, Hainan 570100, China. Electronic address:

Fermentation technology was used to improve the antioxidant activities of Auricularia auricula polysaccharide (AAP). Response surface methodology (RSM) was used to optimize the fermentation conditions. The effects of 4 independent factors: water content (X: 40-80%), inoculation amount (X: 2-20%), temperature (X: 24-32 °C), and time (X: 4-6 d) on the biological degradation efficiency were evaluated. The RSM results showed that the optimal fermentation conditions were: X: 61.7%, X: 12.4%, X: 31.0 °C, X: 5.5 d. Verification tests showed no significant differences between the practical and the predictive values for each response. Under the optimal conditions, the degradation rate was 26.89 ± 0.14%, without significant differences with the predicted value (27.03%). The degradation products were classified to different molecular weight (M) polysaccharide fragments using membrane separation technology. The FT-IR analysis and monosaccharide composition analysis of degraded AAP (D-AAP-VI) showed that D-AAP-VI was a furan type polysaccharide, which was different from the total AAP (pyran type). In addition, compared to total AAP, the antioxidant activities in vitro of D-AAP-VI were significantly improved (p < 0.05) and D-AAP-VI showed the strongest antioxidant activity. These results indicated that biological degradation may be a suitable way to improve the antioxidant activities of natural polysaccharides.
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http://dx.doi.org/10.1016/j.ijbiomac.2020.03.183DOI Listing
July 2020

Long-Term Postpartum Outcomes of Insulin Resistance and -cell Function in Women with Previous Gestational Diabetes Mellitus.

Int J Endocrinol 2020 26;2020:7417356. Epub 2020 Feb 26.

Department of Endocrinology and Metabolism, Peking University First Hospital, Beijing 100034, China.

Aims: The objective of the present study was to explore the long-term postpartum glucose metabolism in women with previous GDM, and study the mechanism of hyperglycemia from gestation to postpartum by investigating the postpartum insulin resistance and insulin secretion.

Methods: A total of 321 females with previous GDM were followed up once during 1- to 6-years postpartum. Characteristics during pregnancy, perinatal period, and postpartum were compared between postpartum NGT and hyperglycemic women. HOMA-IR and HOMA- were used to assess insulin resistance and insulin secretion levels with different glucose statuses.

Results: The prevalence of postpartum hyperglycemia had a fluctuant increase from 25.9% at 1 year, to 53.7% at 5 year. 75 g OGTT 2 hPG during pregnancy was an independent predictor of postpartum hyperglycemia with an OR of 2.15 (95% CI 1.245, 3.722) (=0.006). After ROC analysis, the best equilibrium between sensitivity (70.3%) and specificity (60.4%) for 2 hPG was 9.03 mmol/L. HOMA-IR was increased in postpartum normal glucose tolerance (NGT), prediabetes, and T2DM (1.64 vs. 2.14 vs. 4.27, =0.006). After ROC analysis, the best equilibrium between sensitivity (70.3%) and specificity (60.4%) for 2 hPG was 9.03 mmol/L. HOMA-IR was increased in postpartum normal glucose tolerance (NGT), prediabetes, and T2DM (1.64 vs. 2.14 vs. 4.27, were used to assess insulin resistance and insulin secretion levels with different glucose statuses. =0.006). After ROC analysis, the best equilibrium between sensitivity (70.3%) and specificity (60.4%) for 2 hPG was 9.03 mmol/L. HOMA-IR was increased in postpartum normal glucose tolerance (NGT), prediabetes, and T2DM (1.64 vs. 2.14 vs. 4.27, were used to assess insulin resistance and insulin secretion levels with different glucose statuses.

Conclusions: 75 g OGTT 2h PG during pregnancy higher than 9.03 mmol/L is regarded as an independent risk factor of postpartum hyperglycemia. Insulin resistance with insufficient insulin secretion compensation is still common phenomenon during long-term postpartum. Women with heavier insulin resistance in the postpartum period are more likely develop prediabetes, while decreased -cell function contributes more to T2DM development. were used to assess insulin resistance and insulin secretion levels with different glucose statuses.
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http://dx.doi.org/10.1155/2020/7417356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061142PMC
February 2020

Aberrant expression of miR-214 is associated with obesity-induced insulin resistance as a biomarker and therapeutic.

Diagn Pathol 2020 Feb 24;15(1):18. Epub 2020 Feb 24.

Department of Endocrinology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, 100034, China.

Background: Insulin resistance (IR) in obesity is associated with the occurrence of metabolic and cardiovascular diseases. Dipepidyl peptidase 4 (DPP4) plays a pivotal role during the development of IR, and was found to be a target gene of microRNA-214 (miR-214) in our study. This study sought to assess the expression and clinical value of miR-214 in obese patients with IR, and investigate its therapeutic potential in obese rats and adipocytes with IR.

Methods: Serum expression of miR-214 in obese patients with or without IR was estimated by quantitative real-time-PCR. A receiver operating characteristic curve was plotted to evaluate the diagnostic value of miR-214 in the patients. Obesity-induced IR animal and cell models were constructed, and the therapeutic ability of miR-214 was explored.

Results: Serum expression of miR-214 was decreased in obese patients compared with the healthy controls, and the lowest expression was observed in the cases with IR. Downregulation of miR-214 was significantly correlated with the serum DPP4 levels and HOMA-IR of the patients upon IR conditions, and was demonstrated to perform diagnostic accuracy for distinguishing obese patients with IR from those without IR. In obesity-associated IR animal and cell models, the downregulation of miR-214 was also been detected. According to the measurement of glucose and insulin tolerance and glucose uptake abilities, we found that the overexpression of miR-214 could be used to alleviate IR in the IR models, especially when collaboratively used with DPP4 inhibitor vildagliptin.

Conclusion: All data revealed that miR-214, as a regulator of DPP4, is decreased in obese patients with IR and may serve as a diagnostic biomarker. The upregulation of miR-214 could improve IR in obese rats and adipocytes, indicating that miR-214 has the therapeutic potential for obesity and IR.
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http://dx.doi.org/10.1186/s13000-019-0914-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041268PMC
February 2020

Isolation, structural characterization and bioactivities of polysaccharides and its derivatives from Auricularia-A review.

Int J Biol Macromol 2020 May 7;150:102-113. Epub 2020 Feb 7.

Department of Food Science, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, Heilongjiang 150010, China.

Auricularia mushrooms are known for their bioactive compounds, mostly polysaccharides, which have numerous biological activities, such as antioxidant, antitumor, immunomodulatory, hyperlipidemic, antidiabetic, anticoagulant and hepatoprotective effects. Over the past decades, there has been a consistent focus on the isolation, chemical properties and bioactivities of polysaccharides from Auricularia. This review will cover what is known about Auricularia polysaccharides (AP) especially for several common species, including A. auricula-judae, A. auricula, A. polytricha, and A. cornea var. Li. The isolation and purifications, structural characterizations, chemical modifications, and biological activities of these AP and their derivatives will be discussed, thus to provide a foundation for the further investigation, production, and application of AP as functional foods and therapeutic agents.
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http://dx.doi.org/10.1016/j.ijbiomac.2020.02.054DOI Listing
May 2020

Selection of the Reference Gene for Expression Normalization in s L. under Abiotic Stress and Hormone Treatment.

Genes (Basel) 2020 01 23;11(2). Epub 2020 Jan 23.

Department of Resources Science of Traditional Chinese Medicines and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China.

s L. is an important medical plant that produces analgesic drugs used for the pain caused by cancers and surgeries. Recent studies have focused on the expression genes involved in analgesic drugs biosynthesis, and the real-time quantitative polymerase chain reaction (RT-qPCR) technique is the main strategy. However, no reference genes have been reported for gene expression normalization in s. Herein, nine reference genes (actin (), glyceraldehyde-3-phosphate dehydrogenase (), cyclophilin 2 (), elongation factor 1-alpha (-), glyceraldehyde-3-phosphate dehydrogenase 2, cytosolic (), nuclear cap-binding protein subunit 2 (), protein phosphatase 2A (), TIP41-like protein (), and tubulin beta chain ()) of were selected and analyzed under five different treatments (cold, drought, salt, heavy metal, and hormone stress). Then, BestKeeper, NormFinder, geNorm, and RefFinder were employed to analyze their gene expression stability. The results reveal that is the most stable reference gene under various experimental conditions. The work described here is the first report regarding on reference gene selection in which could be used for the accurate normalization of the gene expression involved in analgesic drug biosynthesis.
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http://dx.doi.org/10.3390/genes11020124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074096PMC
January 2020

The truncated E protein of DTMUV provide protection in young ducks.

Vet Microbiol 2020 Jan 13;240:108508. Epub 2019 Nov 13.

State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510006, PR China. Electronic address:

Duck Tembusu virus (DTMUV) is a major pathogen of duck industry in China. In the current study, we generated different constructs containing envelope (E) protein, pre-membrane-envelope (prM-E) protein, and C-terminally truncated E protein of the DTMUV. The constructed proteins could induce specific antibody responses in young ducks. When ducklings were immunized with the constructed proteins, they were 100% protected against DTMUV infection. Furthermore, the fluorescent signal of the truncated E protein was stronger than other constructed proteins, when Bac-to-Bac baculovirus expression system was applied. Our data demonstrated that the truncated E protein used in the current study could be applied as a potential vaccine candidate to control DTMUV infection in young ducks.
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http://dx.doi.org/10.1016/j.vetmic.2019.108508DOI Listing
January 2020

Dysregulation of DPP4 Is Associated with the AMPK/JAK2/STAT3 Pathway in Adipocytes Under Insulin Resistance Status and Liraglutide Intervention.

Diabetes Metab Syndr Obes 2019 11;12:2635-2644. Epub 2019 Dec 11.

Department of Endocrinology, Peking University First Hospital, Beijing 100034, People's Republic of China.

Purpose: Dipeptidyl peptidase 4 (DPP4) is one of the newly identified adipokines, which acts as paracrine in adipose tissue and as endocrine hormones in the liver, muscles and central nervous system. Expression of DPP4 was significantly upregulated in obese patients upon insulin resistance (IR) conditions, but the mechanism underlying the dysregulation of DPP4 remains unclear. This study aimed to investigate the DPP4 expression in adipose tissue and adipocytes under IR conditions or with liraglutide intervention, and explore the potential molecular mechanisms.

Methods: Obesity-associated IR animal and cell models were, respectively, constructed by using high-fat diet and palmitic acid (PA) stimulation. Expression of DPP4 in adipose tissues and adipocytes was estimated by quantitative real-time RT-PCR and Western-blot. Effects of the AMPK/JAK2/STAT3 pathway on DPP4 were examined by regulating the activity of AMPK and the JAK2/STAT signaling. The therapeutic efficacy of liraglutide in the IR models was evaluated, and its regulatory effects on DPP4 expression and the underlying molecular mechanisms were explored.

Results: The expression of DPP4 was markedly upregulated in both the animal and cell IR models. In the adipocyte, DPP4 expression was found to be suppressed by the activation of AMPK, and this inhibition effect was mediated by the JAK2/STAT3 signaling. Moreover, liraglutide could alleviate the obesity-induced IR, and led to the downregulation of DPP4 in IR animal and cell models. Liraglutide intervention resulted in the activation of AMPK and deactivation of the JAK2/STAT3 signaling in the adipocytes.

Conclusion: Taken together, the expression of DPP4 is upregulated in adipose tissues and adipocytes upon IR conditions, but is reduced after liraglutide intervention. The dysregulation of DPP4 in the adipocytes may be performed by the AMPK/JAK2/STAT3 pathway.
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http://dx.doi.org/10.2147/DMSO.S229838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911808PMC
December 2019

Biodegradation of polyethylene microplastic particles by the fungus Aspergillus flavus from the guts of wax moth Galleria mellonella.

Sci Total Environ 2020 Feb 5;704:135931. Epub 2019 Dec 5.

Department of Resources Science of Traditional Chinese Medicines and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, PR China. Electronic address:

Polyethylene (PE) products are widely used in daily life, agriculture, and industry because of their convenience and economic value. However, PE is one of the polymer materials remarkably resistant to degradation. Current methods of plastic waste disposal pose a threat to the environment and produce microplastic particles (MPP), which becomes a global environmental concern because of its accumulation. In this study, a PE-degrading fungus Aspergillus flavus named PEDX3, was isolated from the gut contents of wax moth Galleria mellonella. The results indicated that high-density polyethylene (HDPE) MPP was degraded into the MPP with a lower molecular weight by strain PEDX3 after 28 days incubation. In addition, Fourier Transform - Infrared Spectroscopy (FT-IR) results showed the appearance of carbonyl groups and ether groups of MPP, which also validated the degradation of PE. Furthermore, the potential degradation enzymes were investigated by Reverse Transcription-Polymerase Chain Reaction (RT-PCR). Finally, two laccase-like multicopper oxidases (LMCOs) genes, AFLA_006190 and AFLA_053930, displayed up-regulated expression during the degradation process, which may be the candidate PE-degrading enzymes. These results have demonstrated that the A. flavus strain PEDX3 has an ability to degrade microplastic particles and the two PE-degrading enzymes provide a promising application for the PE MPP remediation.
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http://dx.doi.org/10.1016/j.scitotenv.2019.135931DOI Listing
February 2020

Strong optical response and light emission from a monolayer molecular crystal.

Nat Commun 2019 12 6;10(1):5589. Epub 2019 Dec 6.

National Laboratory of Solid State Microstructures, School of Electronic Science and Engineering, and Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing, 210093, China.

Excitons in two-dimensional (2D) materials are tightly bound and exhibit rich physics. So far, the optical excitations in 2D semiconductors are dominated by Wannier-Mott excitons, but molecular systems can host Frenkel excitons (FE) with unique properties. Here, we report a strong optical response in a class of monolayer molecular J-aggregates. The exciton exhibits giant oscillator strength and absorption (over 30% for monolayer) at resonance, as well as photoluminescence quantum yield in the range of 60-100%. We observe evidence of superradiance (including increased oscillator strength, bathochromic shift, reduced linewidth and lifetime) at room-temperature and more progressively towards low temperature. These unique properties only exist in monolayer owing to the large unscreened dipole interactions and suppression of charge-transfer processes. Finally, we demonstrate light-emitting devices with the monolayer J-aggregate. The intrinsic device speed could be beyond 30 GHz, which is promising for next-generation ultrafast on-chip optical communications.
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http://dx.doi.org/10.1038/s41467-019-13581-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897925PMC
December 2019

Study on the association between ambient air pollution and daily cardiovascular death in Hefei, China.

Environ Sci Pollut Res Int 2020 Jan 4;27(1):547-561. Epub 2019 Dec 4.

Department of Occupational and Environmental Health, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230000, Anhui, China.

Cardiovascular disease has always been the most serious public health problem in China. Although many studies have found that the risk of death caused by cardiovascular disease is related to air pollutants, the existing results are still inconsistent. The aim of this study was to investigate the effects of air pollutants on the risk of daily cardiovascular deaths in Hefei, China. Daily data on cardiovascular deaths, daily air pollutants, and meteorological factors from 2007 to 2016 were collected in this study. A time-series study design using a distributed lag nonlinear model was employed to evaluate the association between air pollutants and cardiovascular deaths. First, a single air pollutant model was established based on the minimum value of Akaike information criterion (AIC), and the single day lag effects and multi-day lag effects were discussed separately. Then, two-pollutant models were fitted. Subgroup analyses were conducted by gender (male and female), age (< 65 age and ≥ 65 age), and disease type (ischemic heart disease and cerebral vascular disease). There were 34,500 cases of cardiovascular deaths during the period 2007-2016, and the average concentrations of air pollutants (PM, SO, NO, PM, CO, O) were 106.11, 20.34, 30.49, 72.59, 958.7, and 67.88 μg/m, respectively. An increase of interquartile range (IQR) in PM, SO, NO, PM, CO, and O were associated with an increase of 4.34% (95%CI 1.54~7.23%) at lag 0-6, 5.79% (95%CI 2.43~9.27%) at lag 0-5, 4.47% (95%CI 1.64~7.37%) at lag 0-5, 3.14% (95%CI 0.03~6.36%) at lag 0-4, 3.11% (95%CI 0.21~6.10%) at lag 0-3, and 8.17% (95%CI 1.89~14.84%) at lag 0-5 in cardiovascular deaths, respectively. Females, older group (≥ 65 years) and deaths from cerebral vascular disease were more vulnerable to air pollution than males, younger individuals (< 65 years) and deaths from ischemic heart disease. Our results suggest that air pollution increased the risk of cardiovascular deaths in Hefei. These findings can provide evidence for effective air quality interventions in Hefei.
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http://dx.doi.org/10.1007/s11356-019-06867-4DOI Listing
January 2020