Publications




Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain.
Proc Natl Acad Sci U S A 2017 Mar 21;114(10):E1996-E2005. Epub 2017 Feb 21.
The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205;


C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles.
Cell 2016 Oct;167(3):774-788.e17
Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Howard Hughes Medical Institute, Department of Cell and Molecular Biology, St Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

Enhanced Purification of Ubiquitinated Proteins by Engineered Tandem Hybrid Ubiquitin-binding Domains (ThUBDs).
Mol Cell Proteomics 2016 Apr;15(4):1381-96
From the ‡State Key Laboratory of Proteomics, National Engineering Research Center for Protein Drugs, Beijing Proteome Research Center, National Center for Protein Sciences Beijing, Beijing Institute of Radiation Medicine, Beijing 102206,China; the ¶School of Basic Medical Science, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery of Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China;

Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination.
J Mol Biol 2016 Mar 22;428(6):1256-1271. Epub 2015 Oct 22.
Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Electronic address:




Systematic optimization of long gradient chromatography mass spectrometry for deep analysis of brain proteome.
J Proteome Res 2015 Feb 12;14(2):829-38. Epub 2014 Dec 12.
Department of Structural Biology, ‡St. Jude Proteomics Facility, and §̂Department of Developmental Neurobiology, St. Jude Children's Research Hospital , 262 Danny Thomas Place, Memphis, Tennessee 38105, United States.

Altered ubiquitin causes perturbed calcium homeostasis, hyperactivation of calpain, dysregulated differentiation, and cataract.
Proc Natl Acad Sci U S A 2015 Jan 12;112(4):1071-6. Epub 2015 Jan 12.
Laboratory for Nutrition and Vision Research, US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111; Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 7610001, Israel

JUMP: a tag-based database search tool for peptide identification with high sensitivity and accuracy.
Mol Cell Proteomics 2014 Dec 8;13(12):3663-73. Epub 2014 Sep 8.
From the ‡St. Jude Proteomics Facility, St. Jude Children's Research Hospital, Memphis, Tennessee 38105; §Departments of Structural Biology and Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105;

Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing.
Genes Dev 2014 Jun 19;28(11):1191-203. Epub 2014 May 19.
Division of Hematology/Oncology, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA;

A nano ultra-performance liquid chromatography-high resolution mass spectrometry approach for global metabolomic profiling and case study on drug-resistant multiple myeloma.
Anal Chem 2014 Apr 20;86(7):3667-75. Epub 2014 Mar 20.
Departments of †Structural Biology and Developmental Neurobiology and ‡St. Jude Proteomics Facility, St. Jude Children's Research Hospital , 262 Danny Thomas Place, Memphis, Tennessee 38105, United States.


Regulation of behavioral circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2.
Biol Open 2012 Aug 28;1(8):789-801. Epub 2012 Jun 28.
Polypeptide Laboratory, Department of Medicine, McGill University and McGill University Health Centre Research Institute , Montréal, QC H3A 2B2 , Canada.



Phosphoproteomic analysis reveals site-specific changes in GFAP and NDRG2 phosphorylation in frontotemporal lobar degeneration.
J Proteome Res 2010 Dec 22;9(12):6368-79. Epub 2010 Oct 22.
Department of Neurology, the Center for Neurodegenerative Diseases, Laboratory Medicine, and Proteomics Service Center, Emory University School of Medicine, Atlanta, Georgia 30322, United States.

Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation.
Mol Cell 2010 Jul;39(2):222-33
Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, USA.


Identification and characterization of neuronal mitogen-activated protein kinase substrates using a specific phosphomotif antibody.
Mol Cell Proteomics 2009 Apr 3;8(4):681-95. Epub 2008 Dec 3.
The Picower Institute for Learning and Memory, Howard Hughes Medical Institute, RIKEN-MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Polyubiquitination of prolactin receptor stimulates its internalization, postinternalization sorting, and degradation via the lysosomal pathway.
Mol Cell Biol 2008 Sep 23;28(17):5275-87. Epub 2008 Jun 23.
Department of Animal Biology and Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, 380 S. Philadelphia, PA 19104-4539, USA.

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