Publications by authors named "Junjie Wang"

539 Publications

Formation and influence factors of halonitromethanes in chlorination of nitro-aromatic compounds.

Chemosphere 2021 Sep 5;278:130497. Epub 2021 Apr 5.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, 210023, China. Electronic address:

Halonitromethanes (HNMs), typical nitrogenous disinfection byproducts generated during disinfection of chlorination and chloramination, are widely detected in drinking water. This study investigated the formation of two dominant HNMs, trichloronitromethane (TCNM) and dichloronitromethane (DCNM) during chlorination/chloramination of ten nitro-aromatic compounds (NACs), including six aromatic mono-nitro compounds, three aromatic di-nitro compounds and one aromatic tri-nitro compound. The results showed that 2-nitrophenol and 3-nitrophenol could be the main precursors of TCNM and DCNM, and the yields of TCNM were one order of magnitude higher than that of DCNM. HNMs formation in chlorination was much higher than that in chloramination. However, HNMs were hardly produced during chlorination and chloramination of the other eight NACs. In chlorination of 2-nitrophenol, a pH range of 5.0-7.0 facilitated the TCNM formation. Besides, the concentration of ferric and manganese ions had different influences on TCNM formation. While the concentration ranges were 0-2 mg/L, ferric ion significantly decreased TCNM formation but manganese ion had not any influence on TCNM formation. Contrary to a previous finding, nitrite significantly reduced TCNM formation, which implied that nitrite has different effects on TCNM formation from various precursors. Moreover, dissolved organic matter (DOM, 0-5 mg/L as C) significantly influenced the formation of TCNM in chlorination of 2-nitrophenol despite the low TCNM formation in chlorination of DOM. Several chlorinated intermediates were detected and identified as mono/di/tri-chloro-2-nitrophenol during chlorination of 2-nitrophenol. It is effectively to reduce the production of TCNM and DCNM formation from chlorination of 2-nitrophenol by controlling disinfection conditions in drinking water.
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http://dx.doi.org/10.1016/j.chemosphere.2021.130497DOI Listing
September 2021

Abnormality of subcortical volume and resting functional connectivity in adolescents with early-onset and prodromal schizophrenia.

J Psychiatr Res 2021 Jun 4;140:282-288. Epub 2021 Jun 4.

Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, China; Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China; Department of Mental Health, Shanxi Medical University, Taiyuan, China. Electronic address:

Objective: Studies have found that there may be qualitative changes in brain structure and function in adolescents with early-onset schizophrenia (EOS) and prodromal schizophrenia (PDS). However, the abnormal brain structure and function of adolescents with EOS and PDS have received little attention, and their underlying neural mechanisms are still unknown.

Methods: In this study, structural and resting-state functional magnetic resonance imaging (fMRI) were used to compare the subcortical volume and functional connectivity (FC) among EOS, PDS, and a control group. The Positive and Negative Symptom Scale (PNASS) questionnaire was used for clinical evaluation. Structural MRI was used to calculate cortical-based morphological volume and subcortical volume, and resting-state fMRI was used to analyze seed-based FC.

Results: Structural MRI analyses showed that the gray matter volume of the hippocampus in EOS was significantly smaller than that in the control group, and the gray matter volume of the hippocampus, amygdala, and caudate nucleus in PDS was significantly smaller than that in the control group. Additionally, correlation analysis showed that the gray matter volume of the hippocampus was significantly negatively correlated with the negative symptom score of PANSS in EOS. When the hippocampus was used as the seed, fMRI analysis found that the FC between the hippocampus and the posterior cingulate gyrus and precuneus in EOS was significantly weaker than that in the control group.

Conclusion: Our results indicate that the brain structure and function are abnormal in EOS and PDS, with abnormalities mainly concentrated in the limbic system, including the hippocampus, amygdala, caudate nucleus, cingulate gyrus, and precuneus. These findings provide a new direction for early intervention and improvement of the prognosis of schizophrenic patients.
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http://dx.doi.org/10.1016/j.jpsychires.2021.05.052DOI Listing
June 2021

The accuracy and dosimetric analysis of 3D-printing non-coplanar template-assisted iodine-125 seed implantation for recurrent chest wall cancer.

J Contemp Brachytherapy 2021 Jun 18;13(3):273-279. Epub 2021 May 18.

Department of Radiation Oncology, Peking University Third Hospital, Beijing, China.

Purpose: To investigate the accuracy and dosimetry of 3D-printing non-coplanar template (3D-PNCT)-assisted computed tomography (CT)-guided iodine-125 seed implantation (I-SI) for recurrent chest wall cancer (rCWC).

Material And Methods: This was a retrospective study of 19 patients with 22 rCWC treated with 3D-PNCT-assisted CT-guided I-SI, from Mar 2017 to Mar 2020 in our institute.

Results: Mean needle entrance deviation was 4.50 ±2.70 mm, mean angular deviation was 3.40 ±3.10 degrees, and mean depth deviation was 5.20 ±5.20 mm. No significant difference was found for dosimetric parameters (except conformity index) between pre-plan and post-plan; D, D, V, V, and V were 157.74 ±24.23 and 151.71 ±33.62 ( = 0.228), 85.36 ±34.09 and 70.46 ±23.48 ( = 0.067), 0.93 ±0.04 and 0.90 ±0.07 ( = 0.068), 0.64 ±0.16 and 0.64 ±0.16 ( = 0.984), and 0.35 ±0.17 and 0.37 ±0.18 ( = 0.382) for pre-plan and post-plan, respectively. Conformity index, external index, and homogeneity index were 0.57 ±0.16 and 0.52 ±0.15 ( = 0.007), 0.73 ±0.55 and 0.79 ±0.53 ( = 0.096), and 0.31 ±0.15 and 0.30 ±0.14 ( = 0.504) for pre-plan and post-plan, respectively. Median follow-up time was 8 months (range, 3-30 months). Complete response was observed in 4/22 (18.1%), partial response in 13/22 (59.1%), stable disease in 4/22 (18.1%), and progression disease in 1/22 (4.5%) of the cancers. Among patients with pain before I-SI, pain relief rate was 87.5% (7/8). No peri-operative complications of more than grade 2 were observed.

Conclusions: 3D-PNCT-assisted CT-guided I-SI may be safe and feasible as palliative therapy for non-surgical candidates and painful patients with rCWC.
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http://dx.doi.org/10.5114/jcb.2021.106250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170518PMC
June 2021

Logistic regression analysis on risk factors of augmented vertebra recompression after percutaneous vertebral augmentation.

J Orthop Surg Res 2021 Jun 11;16(1):374. Epub 2021 Jun 11.

Department of Spinal Surgery, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310005, Zhejiang, People's Republic of China.

Objective: To explore the high-risk factors of augmented vertebra recompression after percutaneous vertebral augmentation (PVA) in the treatment of osteoporotic vertebral compression fracture (OVCF) and analyze the correlation between these factors and augmented vertebra recompression after PVA.

Methods: A retrospective analysis was conducted on 353 patients who received PVA for a single-segment osteoporotic vertebral compression fracture from January 2017 to December 2018 in our department according to the inclusion criteria. All cases meeting the inclusion and exclusion criteria were divided into two groups: 82 patients in the recompression group and 175 patients in the non-compression group. The following covariates were reviewed: age, gender, body mass index (BMI), injured vertebral segment, bone mineral density (BMD) during follow-up, intravertebral cleft (IVC) before operation, selection of surgical methods, unilateral or bilateral puncture, volume of bone cement injected, postoperative leakage of bone cement, distribution of bone cement, contact between the bone cement and the upper or lower endplates, and anterior height of injured vertebrae before operation, after surgery, and at the last follow-up. Univariate analysis was performed on these factors, and the statistically significant factors were substituted into the logistic regression model to analyze their correlation with the augmented vertebra recompression after PVA.

Results: A total of 257 patients from 353 patients were included in this study. The follow-up time was 12-24 months, with an average of 13.5 ± 0.9 months. All the operations were successfully completed, and the pain of patients was relieved obviously after PVA. Univariate analysis showed that in the early stage after PVA, the augmented vertebra recompression was correlated with BMD, surgical methods, volume of bone cement injected, preoperative IVC, contact between bone cement and the upper or lower endplates, and recovery of anterior column height. The difference was statistically significant (P < 0.05). Among them, multiple factors logistic regression elucidated that more injected cement (P < 0.001, OR = 0.558) and high BMD (P = 0.028, OR = 0.583) were negatively correlated with the augmented vertebra recompression after PVA, which meant protective factors (B < 0). Preoperative IVC (P < 0.001, OR = 3.252) and bone cement not in contact with upper or lower endplates (P = 0.006, OR = 2.504) were risk factors for the augmented vertebra recompression after PVA. The augmented vertebra recompression after PVP was significantly less than that of PKP (P = 0.007, OR = 0.337).

Conclusions: The augmented vertebra recompression after PVA is due to the interaction of various factors, such as surgical methods, volume of bone cement injected, osteoporosis, preoperative IVC, and whether the bone cement is in contact with the upper or lower endplates.
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http://dx.doi.org/10.1186/s13018-021-02480-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8194186PMC
June 2021

Oral squamous cell carcinoma (OSCC)-derived exosomal MiR-221 targets and regulates phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) to promote human umbilical vein endothelial cells migration and tube formation.

Bioengineered 2021 Dec;12(1):2164-2174

Medical Centre of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, China.

Oral squamous cell carcinoma (OSCC) is the most common tumor of the oral cavity. Studies have shown that exosomal miRNAs from cancer cells play an important role in mediating the cellular environment. The objective was to investigate the effect of OSCC-derived exosomes microRNA-221 (miR-221) in OSCC. We used quantitative real-time PCR (qRT-PCR) and western blotting to determine PIK3R1 and miR-221 expressions in OSCC tissue or peripheral blood serum. Exosomes of OSCC cell line CAL27 were extracted and characterized. Exosomal miR-221 expression was detected by qRT-PCR. Dual-luciferase was performed to validate the targeted regulatory relationship of miR-221 on PIK3R1. Transwell and tube formation assay were applied to detect the effect of OSCC-derived exosomal miR-221 on HUVEC migration and angiogenesis. qRT-PCR confirmed that PIK3R1 expression was downregulated in OSCC tissue and cell line, while miR-221 expression was upregulated. miR-221 expression in OSCC cell line-derived exosome elevated. miR-221 could target and negatively regulate PIK3R1 expression. In addition, OSCC-derived miR-221 could promote HUVEC migration and angiogenesis. In conclusion, OSCC-derived exosomal miR-221 could target and negatively regulate PIK3R1 expression, as well as promote vascular endothelial cell migration and angiogenesis.
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http://dx.doi.org/10.1080/21655979.2021.1932222DOI Listing
December 2021

Electron-Deficient-Type Electride CaPb: Extension of Electride Chemical Space.

J Am Chem Soc 2021 Jun 7;143(23):8821-8828. Epub 2021 Jun 7.

Materials Research Center for Element Strategy, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan.

Electrides have been identified so far by two major routes: one is conversion of elemental metals and stoichiometric compounds by high pressure; the other is to search for electron-rich compounds, and this approach is more general. In contrast, few electron-deficient structures in existing databases have been revealed as potential electride candidates. In this work, we found an electron-deficient compound CaPb could be transformed into electrides upon applying external pressure or strain along the -axis, which induces the electron immigration from Pb to interstitial sites. Furthermore, the electron doping via Hf substitution of Ca atoms for CaPb was found to be capable of tuning the interstitial electron density under ambient pressure, resulting in a new stable ternary electride CaHfPb, Hf-substituted CaPb. The electron-deficient electride discovered here is of novel type and can largely expand the research scope of electrides. Considering a recently reported neutral electride NaN and the present finding, it is now clarified that electrides can be identified irrespective of stoichiometry (electron-rich, -neutral, or -poor) for compounds.
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http://dx.doi.org/10.1021/jacs.1c03278DOI Listing
June 2021

High-Pressure Phase Diagram of the Ti-O System.

J Phys Chem Lett 2021 Jun 4:5486-5493. Epub 2021 Jun 4.

Skolkovo Institute of Science and Technology, 3 Nobel Street, Moscow 143026, Russia.

Titanium oxides are technologically important compounds. The chemistry of the Ti-O system is quite rich, largely because of the multiple oxidation states that titanium atoms can take. In this work, using a combination of variable-composition evolutionary crystal structure prediction (USPEX code) and data mining (Materials Project), we predicted all of the stable titanium oxides in the pressure range 0-200 GPa and found that 27 compounds can be stable at different pressures. We resolved contradictions between previous works and predicted four hitherto-unknown stable phases: 2/-TiO, 4/-TiO, 2-TiO, and 3̅-TiO. We also showed that the high-pressure 6̅2-TiO phase is an electride.
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http://dx.doi.org/10.1021/acs.jpclett.1c01133DOI Listing
June 2021

Effects of ZnMgO Electron Transport Layer on the Performance of InP-Based Inverted Quantum Dot Light-Emitting Diodes.

Nanomaterials (Basel) 2021 May 9;11(5). Epub 2021 May 9.

State Key Laboratory of Luminescent Materials and Devices, Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology, Guangzhou 510640, China.

An environment-friendly inverted indium phosphide red quantum dot light-emitting diode (InP QLED) was fabricated using Mg-doped zinc oxide (ZnMgO) as the electron transport layer (ETL). The effects of ZnMgO ETL on the performance of InP QLED were investigated. X-ray diffraction (XRD) analysis indicated that ZnMgO film has an amorphous structure, which is similar to zinc oxide (ZnO) film. Comparison of morphology between ZnO film and ZnMgO film demonstrated that Mg-doped ZnO film remains a high-quality surface (root mean square roughness: 0.86 nm) as smooth as ZnO film. The optical band gap and ultraviolet photoelectron spectroscopy (UPS) analysis revealed that the conduction band of ZnO shifts to a more matched position with InP quantum dot after Mg-doping, resulting in the decrease in turn-on voltage from 2.51 to 2.32 V. In addition, the ratio of irradiation recombination of QLED increases from 7% to 25% using ZnMgO ETL, which can be attributed to reduction in trap state by introducing Mg ions into ZnO lattices. As a result, ZnMgO is a promising material to enhance the performance of inverted InP QLED. This work suggests that ZnMgO has the potential to improve the performance of QLED, which consists of the ITO/ETL/InP QDs/TCTA/MoO/Al, and Mg-doping strategy is an efficient route to directionally regulate ZnO conduction bands.
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http://dx.doi.org/10.3390/nano11051246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151885PMC
May 2021

Comparative population genomics dissects the genetic basis of seven domestication traits in jujube.

Hortic Res 2020 Jun 1;7(1):89. Epub 2020 Jun 1.

College of Life Sciences, Luoyang Normal University, Luoyang, 471934, China.

Jujube (Ziziphus jujuba Mill.) is an important perennial fruit tree with a range of interesting horticultural traits. It was domesticated from wild jujube (Ziziphus acidojujuba), but the genomic variation dynamics and genetic changes underlying its horticultural traits during domestication are poorly understood. Here, we report a comprehensive genome variation map based on the resequencing of 350 accessions, including wild, semi-wild and cultivated jujube plants, at a >15× depth. Using the combination of a genome-wide association study (GWAS) and selective sweep analysis, we identified several candidate genes potentially involved in regulating seven domestication traits in jujube. For fruit shape and kernel shape, we integrated the GWAS approach with transcriptome profiling data, expression analysis and the transgenic validation of a candidate gene to identify a causal gene, ZjFS3, which encodes an ethylene-responsive transcription factor. Similarly, we identified a candidate gene for bearing-shoot length and the number of leaves per bearing shoot and two candidate genes for the seed-setting rate using GWAS. In the selective sweep analysis, we also discovered several putative genes for the presence of prickles on bearing shoots and the postharvest shelf life of fleshy fruits. This study outlines the genetic basis of jujube domestication and evolution and provides a rich genomic resource for mining other horticulturally important genes in jujube.
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http://dx.doi.org/10.1038/s41438-020-0312-6DOI Listing
June 2020

Heart Rate Fluctuation and Mortality in Critically Ill Myocardial Infarction Patients: A Retrospective Cohort Study.

Front Cardiovasc Med 2021 14;8:577742. Epub 2021 May 14.

Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.

Whether heart rate (HR) fluctuation after admission has an impact on the outcomes of critically ill myocardial infarction (MI) patients in intensive care unit remains unknown. A total of 2,031 MI patients were enrolled from the Medical Information Mart for Intensive Care (MIMIC-III) database. HR fluctuation was calculated as the maximum HR minus the minimum HR in the initial 24 h after admission. Participants were divided into 3 groups, namely, low HR fluctuation [<30 beats per minute (bpm)], medium HR fluctuation (30-49 bpm), and high HR fluctuation (≥ 50 bpm). The main outcomes were 30-day and 1-year mortality. Cox regression and restricted cubic spline model were used. Each 10-bpm increase in HR fluctuation was associated with a higher risk of 30-day mortality and 1-year mortality, with adjusted hazard ratios of 1.122 (95% CI, 1.083-1.162) and 1.107 (95% CI, 1.074-1.140), respectively. Compared with the low HR fluctuation group, the high HR fluctuation group suffered a significantly higher risk of mortality after adjustment, with hazard ratios of 2.156 (95% CI, 1.483-3.134) for 30-day mortality and 1.796 (95% CI, 1.354-2.381) for 1-year mortality. A typical J-type curve was observed in restricted cubic splines for the association between HR fluctuation and 30-day or 1-year mortality of MI patients, with the lowest risk on the HR fluctuation of 30 bpm. Sensitivity analyses emphasized the robustness of our results. This retrospective cohort study revealed an independent positive association between HR fluctuation and 30-day and 1-year mortality in critically ill MI patients, which warrants further investigation.
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http://dx.doi.org/10.3389/fcvm.2021.577742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160095PMC
May 2021

Accuracy and dosimetric parameters comparison of 3D-printed non-coplanar template-assisted computed tomography-guided iodine-125 seed ablative brachytherapy in pelvic lateral recurrence of gynecological carcinomas.

J Contemp Brachytherapy 2021 Feb 18;13(1):39-45. Epub 2021 Feb 18.

Department of Radiation Oncology, Peking University 3rd Hospital, Beijing, China.

Purpose: To investigate the accuracy of needle distribution and dosimetric parameter differences of 3D-printing non-coplanar template (3D-PNCT)-assisted computed tomography (CT)-guided iodine-125 seed ablative brachytherapy (I-SAB) in gynecological cancer patients with non-central pelvic recurrence between pre-operative plan and post-operative plan.

Material And Methods: Thirty-eight patients with forty-one non-central pelvic recurrent gynecological carcinomas after radiotherapy were enrolled in this study. All patients received 3D-PNCT-assisted CT-guided I-SAB from January 2016 to January 2019. The position, angle, and depth of seed needles were measured in both pre-operative plan and intra-operative real-time plan in brachytherapy treatment planning system (B-TPS). Dosimetric parameters of D, D, V, V, and V as well as quality parameters of conformal index (CI), external index (EI), and homogeneity index (HI) were compared between pre-operative plan and post-operative plan. Peri-operation complications and radiation-related toxicity were assessed.

Results: Median follow-up time was 12 months (range, 5-34 months). Prescribed dose was 100-170 Gy (median, 120 Gy). Radioactivity of I seed was 0.4-0.7 mCi (median, 0.55 mCi). Mean depth deviation for 499 needles was 0.8 ±1.0 cm. Mean angular deviation was 2.2 2.1 degrees. Mean tip distance deviation of needles was 0.4 ±0.3 cm. There were significant differences between pre-operative and post-operative plans in CI ( = 0.001) and EI ( = 0.005). No significant differences were shown in D, D, V, V, V, and HI between pre-operative and post-operative plans. Only few patients suffered from ≤ grade 2 toxicities.

Conclusions: 3D-PNCT-assisted CT-guided I-SAB is safe and feasible for non-central pelvic recurrence of gynecological cancer. All complications are tolerable and mild.
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http://dx.doi.org/10.5114/jcb.2021.103585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117710PMC
February 2021

Dosimetric comparison of computed tomography-guided iodine-125 seed implantation assisted with and without three-dimensional printing non-coplanar template in locally recurrent rectal cancer: a propensity score matching study.

J Contemp Brachytherapy 2021 Feb 18;13(1):18-23. Epub 2021 Feb 18.

Department of Radiation Oncology, Peking University Third Hospital, Beijing, People's Republic of China.

Purpose: To compare post-implant dosimetric parameters of computed tomography (CT)-guided radioactive iodine-125 (I) seed (RIS) implantation assisted with and without three-dimensional printing non-coplanar template (3D-PNCT) in locally recurrent rectal cancer (LRRC).

Material And Methods: One hundred and fifty-five LRRC patients treated by CT-guided RIS implantation assisted with or without 3D-PNCT from October 2003 to May 2019 were included in this study. Propensity score matching (PSM) method (1 : 1) was used to adjust for differences between the 3D-group (with 3D-PNCT) and the CT-group (without 3D-PNCT). After PSM, dosimetric parameters [D (dose that covered 90% of target volume), D (dose that covered 100% of target volume), V (percentage of gross tumor volume (GTV) receiving 100% of prescription dose), V (percentage of GTV receiving 150% of prescription dose), HI (homogeneity index), CI (conformity index), and EI (external index)] of the two groups were compared.

Results: After PSM, 45 pairs of matched cases were selected for analysis and differences in variables between the two groups were balanced. For the 3D-group, median values of D, D, V, V, EI, and HI were 142.6 Gy (73.7-218.2 Gy), 73.7 Gy (26.2-169.3 Gy), 94.1% (74.3-100%), 71.8% (35.4-98.3%), 0.7 (0.1-30.7), and 0.20 (0-0.60), respectively, and corresponding values were 119.9 Gy (39.8-159.3 Gy), 47.0 Gy (13.0-200.9 Gy), 89.9% (38.6-100%), 62.8% (14.8-100%), 0.39 (0-11.01), and 0.30 (0-0.95), respectively, for the CT-group. Parameters including D, D, V, V, and EI in the 3D-group were significantly higher than those in the CT-group ( < 0.001, < 0.001, < 0.001, < 0.001, and = 0.006, respectively).

Conclusions: 3D-PNCT can improve the accuracy of radioactive seed implantation by increasing the dose delivered to the tumor and reducing the number of "cold" spots of dose.
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http://dx.doi.org/10.5114/jcb.2021.103582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117706PMC
February 2021

Simulation Verification of Barrierless HONO Formation from the Oxidation Reaction System of NO, Cl, and Water in the Atmosphere.

Environ Sci Technol 2021 Jun 21;55(12):7850-7857. Epub 2021 May 21.

Environment Research Institute, Shandong University, Qingdao 266237, P. R. China.

Nitrous acid (HONO) is a major source of hydroxyl (OH) radicals, and identifying its source is crucial to atmospheric chemistry. Here, a new formation route of HONO from the reaction of NO with Cl radicals with the aid of one or two water molecules [(Cl) (NO) (HO) ( = 1-2)] as well as on the droplet surface was found by Born-Oppenheimer molecular dynamic simulation and metadynamic simulation. The (Cl) (NO) (HO) (monohydrate) system exhibited a free-energy barrier of approximately 0.95 kcal mol, whereas the (Cl) (NO) (HO) (dihydrate) system was barrierless. For the dihydrate system and the reaction of NO with Cl radicals on the droplet surface, only one water molecule participated in the reaction and the other acted as the "solvent" molecule. The production rates of HONO suggested that the monohydrate system ([NO] = 8.56 × 10 molecule cm, [Cl] = 8.00 × 10 molecule cm, [HO] = 5.18 × 10 molecule cm) could account for 40.3% of the unknown HONO production rate () at site 1 and 53.8% of at site 2 in the East China Sea. This study identified the importance of the reaction system of NO, Cl, and water molecules in the formation of HONO in the marine boundary layer region.
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http://dx.doi.org/10.1021/acs.est.1c01773DOI Listing
June 2021

Correction: Discovery of intrinsic two-dimensional antiferromagnets from transition-metal borides.

Nanoscale 2021 Jun;13(21):9889

State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, People's Republic of China.

Correction for 'Discovery of intrinsic two-dimensional antiferromagnets from transition-metal borides' by Shiyao Wang et al., Nanoscale, 2021, 13, 8254-8263, DOI: 10.1039/D1NR01103K.
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http://dx.doi.org/10.1039/d1nr90110aDOI Listing
June 2021

BN and BN Monolayers with High Carrier Mobility and Excellent Optical Performance.

J Phys Chem Lett 2021 May 17;12(20):4823-4832. Epub 2021 May 17.

Materials Research Center for Element Strategy, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan.

An evolutionary search algorithm was combined with density functional theory (DFT) calculations to predict a series of 2-D BN (1 < / ≤ 2). Particularly, BN and BN monolayers have sufficiently low formation enthalpy and excellent dynamic stability that make them promising for synthesis in experiments. Electronic structure calculations reveal that BN and BN monolayers possess an indirect band gap of 1.99 eV and a direct band gap of 2.40 eV, respectively. The calculated absorption coefficients for BN and BN monolayers are significantly improved in the low end of the visible region compared with that of 2-D h-BN. Moreover, our calculations reveal that both BN and BN monolayers have high electron carrier mobilities. The narrow band gaps, high carrier mobilities, strong near-ultraviolet absorption, and high synthesis possibility of BN and BN monolayers render them promising new materials for application in novel electronics and environmentally benign solar energy conversion.
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http://dx.doi.org/10.1021/acs.jpclett.1c00913DOI Listing
May 2021

Large HDL combined with inflammatory factors as superior predictors for coronary artery disease than small HDL.

Ann Transl Med 2021 Apr;9(8):672

Cardiovascular Medicine Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Background: This study investigated whether combinations of high-density lipoprotein (HDL) subfractions and inflammatory markers would add value to coronary artery disease (CAD) prediction.

Methods: Non-CAD subjects (n=245) were stratified into low/moderate/high-Framingham risk (L/M/H-FR) groups and 180 CAD patients were enrolled. Levels of HDL-C, HDL, HDL, monocyte chemoattractant protein-1 (MCP-1), and high-sensitivity C-reactive protein (hsCRP) were measured. Multivariable logistic models for CAD were estimated with a single parameter or all parameters together after adjustment for conventional risk factors (CRFs), and Z statistics, net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were used to compare discrimination among different models.

Results: The results show that HDL-C, HDL and HDL gradually decreased, while MCP-1 and hsCRP gradually increased from L/M/H-FR to the CAD group. When applying a single factor in the CRFs-adjusted models, HDL-C (OR 0.011, 95% CI, 0.002-0.071, P<0.05) and HDL (OR 0.000072, 95% CI, 0.000001-0.004, P<0.05), but not HDL, were significantly related to CAD risk. Only HDL (OR 0.000072, 95% CI, 0.000001-0.004, P<0.001) remained significant when applying all HDL parameters. In the model including all HDL and inflammatory parameters, HDL (OR 0.001, 95% CI, 0.000027-0.051), MCP-1 (OR 1.066, 95% CI, 1.039-1.094), and hsCRP (OR 1.130, 95% CI, 1.041-1.227) showed significant differences (all P<0.05). This combined model showed improved discrimination over the models with a single factor (P<0.05) or all HDL parameters (Z=3.299, NRI =0.179, IDI =0.081, P<0.001).

Conclusions: Large HDL is superior to small HDL in the inverse association with CAD. The combination of HDL, MCP-1, and hsCRP with CRFs provides an optimal prediction for CAD.
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http://dx.doi.org/10.21037/atm-21-948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106016PMC
April 2021

Facile synthesis of an aggregation-induced emission (AIE) active imidazoles for sensitive detection of trifluralin.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Oct 27;259:119880. Epub 2021 Apr 27.

Guangxi Key Laboratory of Electrochemical and Magneto-chemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, Guangxi 541006, PR China; National Engineering and Technology Research Center for Colloidal Materials, Shandong University, Jinan, Shandong 250100, PR China. Electronic address:

A novel imidazoles fluorescent probe (2) was synthesized from vanillin, o-phenylenediamine, and N,N-diphenylcarbamyl chloride. Its structure was characterized by fluorescence spectra, UV-Vis spectra, H NMR, C NMR, and high-resolution mass spectrometry (HRMS). Moreover, its aggregation-induced emission (AIE) feature was investigated in THF/MeOH solution. Furthermore, the fluorescence quenching experimental results suggest that compound 2 is the potential fluorescent probe of small organic molecules showing high selectivity and sensitivity for nitroaromatic compounds. In addition, the probe could be applied in the determination of trifluralin with fast response and stability. The fluorescence response of the probe exhibited a good linear correlation with the concentration of trifluralin ranging from 10 to 100 μM, and the limit of detection (LOD) was as low as 5.066 μM. Finally, the probe was successfully utilized to determine the amount of trifluralin in real samples, and the recoveries were 91.1% to 111.2%, indicating the applicability and reliability of the probe.
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http://dx.doi.org/10.1016/j.saa.2021.119880DOI Listing
October 2021

Nanoparticle-based approaches to target the lymphatic system for antitumor treatment.

Cell Mol Life Sci 2021 May 8. Epub 2021 May 8.

School of Biomedical Engineering, Hainan University, Haikou, 570228, Hainan, China.

Immunotherapies have been established as safe and efficient modalities for numerous tumor treatments. The lymphatic system, which is an important system, can modulate the immune system via a complex network, which includes lymph nodes, vessels, and lymphocytes. With the deepening understanding of tumor immunology, a plethora of immunotherapies, which include vaccines, photothermal therapy, and photodynamic therapy, have been established for antitumor treatments. However, the deleterious off-target effects and nonspecific targeting of therapeutic agents result in low efficacy of immunotherapy. Fortunately, nanoparticle-based approaches for targeting the lymphatic system afford a unique opportunity to manufacture drugs that can simultaneously tackle both aspects, thereby improving tumor treatments. Over the past decades, great strides have been made in the development of DC vaccines and nanomedicine as antitumor treatments in the field of lymphatic therapeutics and diagnosis. In this review, we summarize the current strategies through which nanoparticle technology has been designed to target the lymphatic system and describe applications of lymphatic imaging for the diagnosis and image-guided surgery of tumor metastasis. Moreover, improvements in the tumor specificity of nanovaccines and medicines, which have been realized through targeting or stimulating the lymphatic system, can provide amplified antitumor immune responses and reduce side effects, thereby promoting the paradigm of antitumor treatment into the clinic to benefit patients.
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http://dx.doi.org/10.1007/s00018-021-03842-6DOI Listing
May 2021

Use of a Double Reverse Traction Repositor versus a Traction Table for the Treatment of Intertrochanteric Femur Fractures: A Comparative Study.

Orthop Surg 2021 May 5. Epub 2021 May 5.

Department of Orthopaedic Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.

Objective: The aim of the present study was to compare the clinical results for unstable femoral intertrochanteric fractures treated with a double reverse traction repositor (DRTR) and those treated using a traction table with the Asia proximal femoral nail antirotation (PFNA-II).

Methods: A retrospective study was performed including 95 patients with AO/OTA type 31-A2 and 31-A3 unstable femoral intertrochanteric fractures who underwent DRTR or traction table-facilitated PFNA-II nailing from April 2015 to December 2018 in our traumatic center. Demographics, duration of operation, blood loss, part loading time after surgery, fracture healing time, and early and late complications were assessed. Clinical and radiological outcomes were collected to compare the differences between the two groups.

Results: A total of 95 unstable intertrochanteric fracture patients treated with the PFNA-II were analyzed. Of these cases, 56 patients were treated with a DRTR and the other 39 patients were treated using a traction table to achieve fracture reduction. No patients died during surgery and hospitalization. There were no significant differences in respect to demographics and fracture characteristics of cases enrolled. The total operative time was significantly longer in the traction table group than in the DRTR group (72.5 ± 6.1 min for the traction table and 63.0 ± 4.1 min for the DRTR group, P < 0.001). No significant differences were observed in intraoperative blood loss and duration of hospitalization. The periods of follow up ranged from 12 to 31 months among all patients. At the last follow up, the Harris hip score (HHS) in the DRTR group was excellent in 10 patients (17.9%), good in 36 (64.3%), fair in 8 (14.3%), and poor in 2 (3.6%). These scores were comparable to those in the traction table group, which were: excellent in 8 patients (20.5%), good in 24 (61.5%), fair in 6 (15.4%), and poor in 1 (2.6%). Regarding the radiological evaluation, excellent rates of reduction rate were achieved in 39 cases (69.6%) in the DRTR group, which was comparable to 19 cases (48.7%) in the traction table group. In addition, the mean fracture healing time after surgery was 20.6 ± 2.3 weeks in the DRTR group and 21.4 ± 3.4 weeks in the traction table group, which did not reach a significant difference (P = 0.18). During the follow up, 6 cases of thigh pain, 4 cases of deep vein thrombosis, and 1 case of fracture of the anterior superior iliac spine were reported in the DRTR group. In the traction table group, there were 2 cases of deep vein thrombosis and 3 cases of thigh pain.

Conclusion: When using the PFNA-II for unstable intertrochanteric fractures, the DRTR was superior to the traction table in respect to operative time and duration of patient position, despite an additional ipsilateral anterior superior iliac spine (ASIS) incision and drilling of the ASIS and the femur condyle.
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http://dx.doi.org/10.1111/os.12956DOI Listing
May 2021

A Preliminary Characterization of Canonicalized and Non-Canonicalized Section Headers Across Variable Clinical Note Types.

AMIA Annu Symp Proc 2020 25;2020:1268-1276. Epub 2021 Jan 25.

Biostatistics, Epidemiology & Informatics, University of Pennsylvania, Philadelphia, PA.

In the electronic health record, the majority of clinically relevant information is stored within clinical notes. Most clinical notes follow a set organizational structure composed of canonicalized section headers that facilitate clinical review and information gathering. Standardized section header terminologies such as the SecTag terminology permit the identification and standardization of headers to a canonicalized form. Although the SecTag terminology has been evaluated extensively for history & physical notes, the coverage of canonical section header terms has not been assessed across other note types. For this pilot study, we conducted a coverage study and characterization of canonical section headers across 5 common, clinical note types and a generalizability study of canonical section headers detected within two types of clinical notes from Penn Medicine.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075444PMC
June 2021

Postoperative bisphosphonate do not significantly alter the fusion rate after lumbar spinal fusion: a meta-analysis.

J Orthop Surg Res 2021 Apr 29;16(1):284. Epub 2021 Apr 29.

Shanxi Bethune Hospital, Shanxi Academy of Medical Science, No. 99, Longcheng Street, Taiyuan, 030032, Shanxi Province, China.

Background: To evaluate the effect of postoperative BP treatment on improving the fusion rate after lumbar spinal fusion surgery by performing a meta-analysis of randomized controlled trials (RCTs) and other comparative cohort studies.

Methods: A comprehensive search of PubMed, EMBASE, the Web of Science, and the Cochrane Central Register of Controlled Trials was performed for RCTs and other comparative cohort studies on the effect of BP treatment on improving the fusion rate after lumbar spinal fusion surgery. The primary outcome measures were the number of patients with bone formation grades A, B, and C at 12 months of follow-up; fusion rates at 12 and 24 months of follow-up; vertebral compression fracture (VCF) at 12 and 24 months of follow-up; pedicle screw loosening at 24 months of follow-up; and cage subsidence, the Oswestry disability index (ODI), and the visual analogue score (VAS) at 12 months of follow-up. The final search was performed in July 2020.

Results: Seven studies with 401 patients were included. Compared with the placebo, BP treatment did not significantly alter the number of patients with bone formation grades A, B, and C, or the VAS at the 12-month follow-up or the fusion rates at the 12- and 24-month follow-ups. In addition, compared with the placebo, BPs significantly reduced the risks of VCF at the 12- and 24-month follow-ups, pedicle screw loosening at the 24-month follow-up, and cage subsidence and the ODI at the 12-month follow-up.

Conclusions: Postoperative BPs do not clearly improve bone formation and the fusion rate, but they reduce VCF, cage subsidence, and loosening of pedicle screws after lumbar fusion surgery compared with the control treatment.
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http://dx.doi.org/10.1186/s13018-021-02444-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082634PMC
April 2021

An organophotoredox-catalyzed C(sp)-N cross coupling reaction of cyclic aldimines with cyclic aliphatic amines.

Org Biomol Chem 2021 Apr;19(16):3595-3600

College of Chemistry, Zhengzhou University, Zhengzhou, Henan 450052, China. and Henan Key Laboratory of Biomolecular Recognition and Sensing, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, Henan 476000, China.

An organophotocatalyzed C(sp2)-H/N-H cross-dehydrogenative coupling of cyclic aldimines with aliphatic amines has been developed, which represents the first example of visible-light-induced C-H amination of N-sulfonylated imines. This methodology enables the streamline assembly of amine derivatives via radical mediated C-N bond formation. The current protocol features transition-metal-free, mild conditions, good functional group tolerance and good yields.
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http://dx.doi.org/10.1039/d1ob00223fDOI Listing
April 2021

Morphological Irregularity of Unruptured Intracranial Aneurysms is More Related with Aneurysm Size Rather Than Cerebrovascular Atherosclerosis: A Case-Control Study.

Clin Interv Aging 2021 20;16:665-674. Epub 2021 Apr 20.

Department of Neurosurgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China; Graduate School of Peking Union Medical College, Beijing, People's Republic of China.

Objective: It remains unclear whether irregular morphological features of intracranial aneurysms (IAs) are associated with atherosclerosis. We investigated the effect of cerebrovascular atherosclerosis stenosis (CAS) on irregular morphology of IAs.

Patients And Methods: This single-center case-control study included consecutive patients with IAs at our institution from September 2011 to September 2018. Cases were patients with irregular IAs, and age- and location-matched controls were patients with regular IAs. Conditional logistic regression models were used to assess the relationship between angiographic variables of CAS and aneurysmal irregularity.

Results: A total of 140 cases of irregular IAs and 140 controls were included in the analysis. Sixteen patients with irregular IAs (11.4%) and eleven patients with regular IAs (7.9%) had >50% parent artery stenosis; however, the differences were not statistically significant between these two groups. In addition, no significant between-group differences were observed in distributions of the cerebrovascular stenosis, number of arterial stenoses, and location of the stenosis. In the final adjusted conditional logistic regression model, only aneurysm size (≥7 mm) was significantly associated with irregular IA morphology ( = 0.022). Moreover, 89 cases of irregular IAs and 89 controls were included in the analysis of unruptured IAs (UIAs). In the final adjusted conditional logistic regression model, only aneurysm size (≥7 mm) was significantly associated with irregular UIA morphology ( = 0.020).

Conclusion: Our findings indicate that the morphological irregularity of unruptured intracranial aneurysms is more related with aneurysm size rather than cerebrovascular atherosclerosis. Further studies are needed to use prospective data to identify causative factors responsible for aneurysmal irregularity.
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http://dx.doi.org/10.2147/CIA.S301326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069126PMC
June 2021

[Expert Consensus for Thermal Ablation of Pulmonary Subsolid Nodules (2021 Edition)].

Zhongguo Fei Ai Za Zhi 2021 May 26;24(5):305-322. Epub 2021 Apr 26.

Department of Oncology, Tengzhou Central People's Hospital, Tengzhou 277500, China.

"The Expert Group on Tumor Ablation Therapy of Chinese Medical Doctor Association, The Tumor Ablation Committee of Chinese College of Interventionalists, The Society of Tumor Ablation Therapy of Chinese Anti-Cancer Association and The Ablation Expert Committee of the Chinese Society of Clinical Oncology" have organized multidisciplinary experts to formulate the consensus for thermal ablation of pulmonary subsolid nodules or ground-glass nodule (GGN). The expert consensus reviews current literatures and provides clinical practices for thermal ablation of GGN. The main contents include: (1) clinical evaluation of GGN, (2) procedures, indications, contraindications, outcomes evaluation and related complications of thermal ablation for GGN and (3) future development directions.
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http://dx.doi.org/10.3779/j.issn.1009-3419.2021.101.14DOI Listing
May 2021

Discovery of intrinsic two-dimensional antiferromagnets from transition-metal borides.

Nanoscale 2021 May;13(17):8254-8263

State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, People's Republic of China.

Intrinsic two-dimensional (2D) magnets are promising materials for developing advanced spintronic devices. A few have already been synthesized from the exfoliation of van der Waals magnetic materials. In this work, by using ab initio calculations and Monte Carlo simulation, a series of 2D MBs (M = Cr, Mn or Fe; B = boron) are predicted possessing robust magnetism, sizeable magnetic anisotropy energy, and excellent structural stability. These 2D MBs can be respectively synthesized from non-van der Waals compounds with low separation energies such as Cr2AlB2, Mn2AlB2, and Fe2AlB2. 2D CrB is a ferromagnetic (FM) metal with a weak in-plane magnetic anisotropy energy of 23.6 μeV per atom. Metallic 2D MnB and FeB are Ising antiferromagnets with an out-of-plane magnetic easy axis and robust magnetic anisotropy energies up to 222.7 and 482.2 μeV per atom, respectively. By using Monte Carlo simulation, the critical temperatures of 2D CrB, MnB, and FeB were calculated to be 440 K, 300 K, and 320 K, respectively. Our study found that the super-exchange interaction plays the dominant role in determining the long-range magnetic ordering of 2D MBs. Moreover, most functionalized 2D MBTs (T = O, OH or F) are predicted to have AFM ground states. Alternating transition metals or functional groups can significantly modulate the magnetic ground state and critical temperature of 2D MBTs. This study suggests that the 2D MBs and MBTs are promising metallic 2D magnets for spintronic applications.
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http://dx.doi.org/10.1039/d1nr01103kDOI Listing
May 2021

The Accuracy of Individualized 3D-Printing Template-Assisted I Radioactive Seed Implantation for Recurrent/Metastatic Head and Neck Cancer.

Front Oncol 2021 31;11:664996. Epub 2021 Mar 31.

Department of Radiation Oncology, Peking University Third Hospital, Beijing, China.

Purpose: To evaluate the accuracy of individualized 3D-printing template-assisted I radioactive seed implantation (3D-PT assisted I RSI) for recurrent/metastatic head and neck cancer.

Materials And Methods: From February 2017 to January 2020, clinical data of 41 patients (mean age, 58.5 ± 16.1 years; 28 males) with recurrent (48.8%)/metastatic (51.2%) head and neck cancer underwent individualized 3D-PT assisted I RSI under CT guidance in a single institute were retrospectively reviewed. Total 430 seed needles [mean, 10.5 (range 3-17) per patient] were inserted.

Results: All seed needles were inserted manually in a single attempt with the technical success rate of 100% without major perioperative complications. The mean needle's entrance deviation was 0.090 cm (95% Confidence Interval, 0.081-0.098). The mean intraoperative depth and angle of the needle were consistent with that of planned (6.23 ± 0.24 vs. 6.21 ± 0.24 cm, p = 0.903; 83.14 ± 3.64 vs. 83.09 ± 3.66 degrees, p = 0.985, respectively). The mean deviation between the needle's planned and intraoperative depth and angle was 0.168 ± 0.024 cm and 1.56 ± 0.14 degrees, respectively. The postoperative dosimetry parameters, including D90, D100, V100, V150, V200, conformity index, external index, and homogeneity index, were all well-coordinated with planned dosimetry without significant difference (p = 0.515, 0.662, 0.958, 0.865, 0.872, 0.278, 0.456, and 0.989, respectively).

Conclusions: Within the limitation of this study, individualized 3D-PT assisted I RSI may be accurate in obtaining favorable postoperative dosimetry for patients with recurrent/metastatic head and neck cancer.

Clinical Trial Registration: [website], identifier [registration number].
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http://dx.doi.org/10.3389/fonc.2021.664996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045752PMC
March 2021

MXene-based enzymatic sensor for highly sensitive and selective detection of cholesterol.

Biosens Bioelectron 2021 Jul 15;183:113243. Epub 2021 Apr 15.

Guangxi Key Laboratory of Electrochemical and Magneto-chemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, Guangxi, 541006, PR China; National Engineering and Technology Research Center for Colloidal Materials, Shandong University, Jinan, Shandong, 250100, PR China. Electronic address:

In this work, the synthesized MXene (TiCT) exhibited large specific area, biocompatibility, excellent electronic conductivity, and good dispersion in aqueous phase. The Chit/ChOx/TiCT nanocomposite was prepared through the continuous self-assembled process. Its structure is characterized by scanning electron microscopy (SEM), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV). Moreover, the biosensor for cholesterol detection was fabricated via a one-step dip-coating method. Chit andTiCT act as a support matrix to immobilize ChOx enzyme, and also play a role in increasing the electrical conductivity. Meanwhile, the addition of redox mediator (Fe(CN)) facilitates the electron transport from the analyte to the modified electrode in the oxidation of cholesterol. The DPV response exhibited an increase in current with increasing cholesterol concentration. Under the optimum conditions, the DPV response of the biosensor indicated a good linear relationship with the concentration of cholesterol ranging from 0.3 to 4.5 nM with a low detection limit of 0.11 nM, and a high sensitivity of 132.66 μA nM cm. In addition, with favorable selectivity and stability, the biosensor has been used to detect cholesterol in real samples and the results demonstrate that the biosensor has excellent practicability.
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http://dx.doi.org/10.1016/j.bios.2021.113243DOI Listing
July 2021

Nanobody Repertoires for Exposing Vulnerabilities of SARS-CoV-2.

bioRxiv 2021 Apr 10. Epub 2021 Apr 10.

Despite the great promise of vaccines, the COVID-19 pandemic is ongoing and future serious outbreaks are highly likely, so that multi-pronged containment strategies will be required for many years. Nanobodies are the smallest naturally occurring single domain antigen binding proteins identified to date, possessing numerous properties advantageous to their production and use. We present a large repertoire of high affinity nanobodies against SARS-CoV-2 Spike protein with excellent kinetic and viral neutralization properties, which can be strongly enhanced with oligomerization. This repertoire samples the epitope landscape of the Spike ectodomain inside and outside the receptor binding domain, recognizing a multitude of distinct epitopes and revealing multiple neutralization targets of pseudoviruses and authentic SARS-CoV-2, including in primary human airway epithelial cells. Combinatorial nanobody mixtures show highly synergistic activities, and are resistant to mutational escape and emerging viral variants of concern. These nanobodies establish an exceptional resource for superior COVID-19 prophylactics and therapeutics.
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http://dx.doi.org/10.1101/2021.04.08.438911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043454PMC
April 2021

Minimum heart rate and mortality in critically ill myocardial infarction patients: an analysis of the MIMIC-III database.

Ann Transl Med 2021 Mar;9(6):496

Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.

Background: Low minimum heart rate (MHR) is common in critically ill myocardial infarction (MI) patients. However, the association between MHR and the mortality of critically ill MI patients remains unclear.

Methods: In this retrospective cohort study, a total of 2,031 critically ill MI patients were enrolled from the Medical Information Mart for Intensive Care (MIMIC)-III database. Patients were divided into a low MHR group [MHR <60 beats per minute (bpm)] and a high MHR group (MHR ≥60 bpm). A Cox proportional hazard model was used to elucidate the association between these two groups and the mortality of MI patients. The association between mortality and MHR as a continuous variable was analyzed non-parametrically using restricted cubic splines. Sensitivity analyses were conducted to determine the impact of different admission heart rate, hypertension, atrial fibrillation, and vasopressor use on our results.

Results: MI patients in the low MHR group had higher 30-day and 1-year mortality than those in the high MHR group (20.59% 10.91%, P<0.001 and 29.76% 19.31%, P<0.001, respectively). After adjustment, the low MHR group was significantly correlated with 30-day mortality [hazard ratio, 1.779, 95% confidence interval (CI), 1.400-2.261, P<0.001] and 1-year mortality (hazard ratio, 1.537, 95% CI, 1.272-1.859, P<0.001). This correlation remained remarkable in patients with low or high admission heart rate, with or without hypertension, and with or without atrial fibrillation. An apparent L-curve relationship was observed between the 30-day mortality or 1-year mortality and MHR as a continuous variable.

Conclusions: MHR under 60 bpm may be associated with a higher risk for both 30-day and 1-year mortality in critically ill MI patients. These findings highlight the possibility of MHR as an early risk indicator and potential therapeutic target for mortality in critically ill MI patients, which warrants further investigation.
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http://dx.doi.org/10.21037/atm-21-992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039698PMC
March 2021

Incidence and prognostic factors of primary thyroid lymphoma and construction of prognostic models for post-chemotherapy and postoperative patients: a population-based study.

BMC Endocr Disord 2021 Apr 13;21(1):68. Epub 2021 Apr 13.

Department of Pathology, Wannan Medical College, Wenchang West Road 22, Wuhu, Anhui, China.

Background: Primary thyroid lymphoma (PTL) is a rare thyroid malignancy, there are few large sample studies on PTL and no standardized treatment regimen has been established due to the rarity. The aims of this study were to explore the incidence and prognostic factors of PTL and construct visual prognostic prediction models for post-chemotherapy and postoperative patients.

Methods: The incidence of PTL in 1975-2017 was extracted from the US Surveillance, Epidemiology, and End Results (SEER) database, then assessed using joinpoint regression software. A total of 1616 eligible PTL patients diagnosed in 1998-2016 were brought into prognostic analysis. Multivariate Cox regression analyses were carried out to reveal independent prognostic elements for overall survival (OS) and cancer-specific survival (CSS).

Results: PTL incidence showed a relatively steady increase in 1975-1994, which annual percent change (APC) was 4.0%, and steady decreasing in 1994-2017(APC - 2.4%). Age, marital status, lymphoma Ann Arbor stage, histological subtypes, surgery, chemotherapy, and radiation were significantly correlated to OS and CSS. Nomograms were constructed to predict OS and CSS in post-chemotherapy and postoperative PTL patients separately, and were verified to have good reliability.

Conclusions: The incidence of PTL increased and subsequently decreased. We revealed the prognostic implications and constructed reliable nomograms for post-chemotherapy and postoperative PTL patients.
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http://dx.doi.org/10.1186/s12902-021-00732-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045392PMC
April 2021