Publications by authors named "Jung-Hyun Shim"

100Publications

Targeted inhibition of c-MET by podophyllotoxin promotes caspase-dependent apoptosis and suppresses cell growth in gefitinib-resistant non-small cell lung cancer cells.

Phytomedicine 2020 Sep 25;80:153355. Epub 2020 Sep 25.

Department of Pharmacy, College of Pharmacy, Mokpo National University, Jeonnam 58554, Republic of Korea; China-US (Henan) Hormel Cancer Institute, Zhengzhou, Henan, 450008, P.R. China; Department of Biomedicine, Health & Life Convergence Sciences, BK21 Four, College of Pharmacy, Mokpo National University, Jeonnam 58554, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2020.153355DOI Listing
September 2020

Alternative Options for Skin Cancer Therapy via Regulation of AKT and Related Signaling Pathways.

Int J Mol Sci 2020 Sep 18;21(18). Epub 2020 Sep 18.

Department of Pharmacy, College of Pharmacy, Mokpo National University, Jeonnam 58554, Korea.

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http://dx.doi.org/10.3390/ijms21186869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560163PMC
September 2020

Picropodophyllotoxin, an Epimer of Podophyllotoxin, Causes Apoptosis of Human Esophageal Squamous Cell Carcinoma Cells Through ROS-Mediated JNK/P38 MAPK Pathways.

Int J Mol Sci 2020 Jun 30;21(13). Epub 2020 Jun 30.

Department of Dental Pharmacology, School of Dentistry and Institute of Oral Bioscience, BK21 Plus, Jeonbuk National University, Jeonju 54896, Korea.

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http://dx.doi.org/10.3390/ijms21134640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369713PMC
June 2020

Xanthohumol Inhibits the Growth of Keratin 18-Overexpressed Esophageal Squamous Cell Carcinoma and .

Front Cell Dev Biol 2020 19;8:366. Epub 2020 May 19.

Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.

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http://dx.doi.org/10.3389/fcell.2020.00366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248302PMC
May 2020

Janus kinase 2 inhibition by Licochalcone B suppresses esophageal squamous cell carcinoma growth.

Phytother Res 2020 Aug 6;34(8):2032-2043. Epub 2020 Mar 6.

Department of Pharmacy, College of Pharmacy, Mokpo National University, Muan-gun, Republic of Korea.

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http://dx.doi.org/10.1002/ptr.6661DOI Listing
August 2020

Licochalcone C induces cell cycle G1 arrest and apoptosis in human esophageal squamous carcinoma cells by activation of the ROS/MAPK signaling pathway.

J Chemother 2020 May 3;32(3):132-143. Epub 2020 Feb 3.

Department of Pharmacy, College of Pharmacy, Mokpo National University, Jeonnam, Republic of Korea.

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http://dx.doi.org/10.1080/1120009X.2020.1721175DOI Listing
May 2020

(S)-10-Hydroxycamptothecin Inhibits Esophageal Squamous Cell Carcinoma Growth In Vitro and In Vivo Via Decreasing Topoisomerase I Enzyme Activity.

Cancers (Basel) 2019 Dec 6;11(12). Epub 2019 Dec 6.

Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.

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http://dx.doi.org/10.3390/cancers11121964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966462PMC
December 2019

Licochalcone H Synthesized by Modifying Structure of Licochalcone C Extracted from Glycyrrhiza inflata Induces Apoptosis of Esophageal Squamous Cell Carcinoma Cells.

Cell Biochem Biophys 2020 Mar 9;78(1):65-76. Epub 2019 Nov 9.

Department of Pharmacy, College of Pharmacy, Mokpo National University, Jeonnam, 58554, Republic of Korea.

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http://dx.doi.org/10.1007/s12013-019-00892-3DOI Listing
March 2020

Dual inhibition of EGFR and MET by Echinatin retards cell growth and induces apoptosis of lung cancer cells sensitive or resistant to gefitinib.

Phytother Res 2020 Feb 7;34(2):388-400. Epub 2019 Nov 7.

Department of Pharmacy, Mokpo National University, Jeonnam, 58554, Republic of Korea.

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http://dx.doi.org/10.1002/ptr.6530DOI Listing
February 2020

Licochalcone B inhibits growth and induces apoptosis of human non-small-cell lung cancer cells by dual targeting of EGFR and MET.

Phytomedicine 2019 Oct 5;63:153014. Epub 2019 Jul 5.

Department of Pharmacy, College of Pharmacy, Mokpo National University, Jeonnam 58554, Republic of Korea; China-US (Henan) Hormel Cancer Institute, Zhengzhou, Henan 450008, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2019.153014DOI Listing
October 2019

Deoxypodophyllotoxin Exerts Anti-Cancer Effects on Colorectal Cancer Cells Through Induction of Apoptosis and Suppression of Tumorigenesis.

Int J Mol Sci 2019 May 28;20(11). Epub 2019 May 28.

College of Pharmacy and Research Institute of Life and Pharmaeutical Sciences, Sunchon National University, 255 Jungang-ro, Sunchon, Jeonnam 57922, Korea.

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http://dx.doi.org/10.3390/ijms20112612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601030PMC
May 2019

Cell growth inhibition by 3-deoxysappanchalcone is mediated by directly targeting the TOPK signaling pathway in colon cancer.

Phytomedicine 2019 Aug 31;61:152813. Epub 2018 Dec 31.

Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China; China-US (Henan) Hormel Cancer Institute, No.127, Dongming Road, Jinshui District, Zhengzhou, Henan, 450008, China; The Collaborative Innovation Center of Henan Province for Cancer Chemoprevention, Zhengzhou, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09447113183063
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http://dx.doi.org/10.1016/j.phymed.2018.12.036DOI Listing
August 2019

Targeting ROCK/LIMK/cofilin signaling pathway in cancer.

Arch Pharm Res 2019 Jun 27;42(6):481-491. Epub 2019 Apr 27.

China-US (Henan) Hormel Cancer Institute, No.127, Dongming Road, Jinshui District, Zhengzhou, 450008, Henan, China.

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http://dx.doi.org/10.1007/s12272-019-01153-wDOI Listing
June 2019

Identification and Extraction Optimization of Active Constituents in Seib ex TANAKA Peel and Its Biological Evaluation.

Molecules 2019 Feb 14;24(4). Epub 2019 Feb 14.

Department of Pharmacy, College of Pharmacy, Mokpo National University, Muan, Jeonnam 58554, Korea.

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http://dx.doi.org/10.3390/molecules24040680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412224PMC
February 2019

Ethanol Extract of Leaf Ameliorates Hyperuricemia in Mice via Inhibition of Hepatic and Serum Xanthine Oxidase Activity.

Evid Based Complement Alternat Med 2018 2;2018:8037925. Epub 2018 Dec 2.

Department of Pharmacy, College of Pharmacy, Mokpo National University, Muan, Jeonnam 58554, Republic of Korea.

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https://www.hindawi.com/journals/ecam/2018/8037925/
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http://dx.doi.org/10.1155/2018/8037925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304516PMC
December 2018

JAK2 regulation by licochalcone H inhibits the cell growth and induces apoptosis in oral squamous cell carcinoma.

Phytomedicine 2019 Jan 18;52:60-69. Epub 2018 Sep 18.

Department of Pharmacy, College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam 58554, Republic of Korea; The China-US (Henan) Hormel Cancer Institute, Zhengzhou, Henan 450008, P.R. China. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2018.09.180DOI Listing
January 2019

Licochalcone H induces the apoptosis of human oral squamous cell carcinoma cells via regulation of matrin 3.

Oncol Rep 2019 Jan 11;41(1):333-340. Epub 2018 Oct 11.

Department of Dental Pharmacology, School of Dentistry and Institute of Oral Bioscience, BK21 Plus, Chonbuk National University, Jeonju, Jeollabuk 54896, Republic of Korea.

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http://www.spandidos-publications.com/10.3892/or.2018.6784
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http://dx.doi.org/10.3892/or.2018.6784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278573PMC
January 2019

Licochalcone C induced apoptosis in human oral squamous cell carcinoma cells by regulation of the JAK2/STAT3 signaling pathway.

J Cell Biochem 2018 12 20;119(12):10118-10130. Epub 2018 Aug 20.

Department of Dental Pharmacology, School of Dentistry and Institute of Oral Bioscience, BK21 Plus, Chonbuk National University, Jeonju, Republic of Korea.

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http://doi.wiley.com/10.1002/jcb.27349
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http://dx.doi.org/10.1002/jcb.27349DOI Listing
December 2018

Licochalcone D directly targets JAK2 to induced apoptosis in human oral squamous cell carcinoma.

J Cell Physiol 2019 02 2;234(2):1780-1793. Epub 2018 Aug 2.

Department of Pharmacy, College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Muan County, Republic of Korea.

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http://dx.doi.org/10.1002/jcp.27050DOI Listing
February 2019

Oridonin induces apoptosis in oral squamous cell carcinoma probably through the generation of reactive oxygen species and the p38/JNK MAPK pathway.

Int J Oncol 2018 May 16;52(5):1749-1759. Epub 2018 Mar 16.

Department of Pharmacy, College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam 58554, Republic of Korea.

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http://www.spandidos-publications.com/10.3892/ijo.2018.4319
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http://dx.doi.org/10.3892/ijo.2018.4319DOI Listing
May 2018

Natural Compound Licochalcone B Induced Extrinsic and Intrinsic Apoptosis in Human Skin Melanoma (A375) and Squamous Cell Carcinoma (A431) Cells.

Phytother Res 2017 Dec 13;31(12):1858-1867. Epub 2017 Oct 13.

Department of Pharmacy, College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam, 534-729, Korea.

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http://dx.doi.org/10.1002/ptr.5928DOI Listing
December 2017

Role of Protein Kinases and Their Inhibitors in Radiation Response of Tumor Cells.

Curr Pharm Des 2017 11;23(29):4259-4280

New Drug Development Center, DGMIF, 80 Chumbok-ro, Dong-gu, Daegu 41061, Korea.

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http://dx.doi.org/10.2174/1381612823666170608084355DOI Listing
November 2017

Effects of Cellular 11β-hydroxysteroid Dehydrogenase 1 on LPS-induced Inflammatory Responses in Synovial Cell Line, SW982.

Immune Netw 2017 Jun 20;17(3):171-178. Epub 2017 Jun 20.

Department of Pharmacy, College of Pharmacy, Mokpo National University, Mokpo 58554, Korea.

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http://dx.doi.org/10.4110/in.2017.17.3.171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484647PMC
June 2017

Licochalcone A Suppresses Specificity Protein 1 as a Novel Target in Human Breast Cancer Cells.

J Cell Biochem 2017 12 12;118(12):4652-4663. Epub 2017 Jun 12.

Department of Pharmacy, College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam, 534-729, Republic of Korea.

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http://dx.doi.org/10.1002/jcb.26131DOI Listing
December 2017

Identification of the biologically active constituents of Camellia japonica leaf and anti-hyperuricemic effect in vitro and in vivo.

Int J Mol Med 2017 Jun 3;39(6):1613-1620. Epub 2017 May 3.

Department of Pharmacy, College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Muan, Jeonnam 58554, Republic of Korea.

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https://www.spandidos-publications.com/10.3892/ijmm.2017.297
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http://dx.doi.org/10.3892/ijmm.2017.2973DOI Listing
June 2017

Antitumorigenic effect of atmospheric-pressure dielectric barrier discharge on human colorectal cancer cells via regulation of Sp1 transcription factor.

Sci Rep 2017 02 22;7:43081. Epub 2017 Feb 22.

Department of Applied Plasma Engineering, Chonbuk National University, 567 Baekje-daero, Jeonju, Jeollabuk-do, Republic of Korea.

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http://dx.doi.org/10.1038/srep43081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320527PMC
February 2017

Rhein exhibits antitumorigenic effects by interfering with the interaction between prolyl isomerase Pin1 and c-Jun.

Oncol Rep 2017 Mar 7;37(3):1865-1872. Epub 2017 Feb 7.

Department of Pharmacy, College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam 58554, Republic of Korea.

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http://dx.doi.org/10.3892/or.2017.5434DOI Listing
March 2017

Cytoprotective effects of esculetin against oxidative stress are associated with the upregulation of Nrf2-mediated NQO1 expression via the activation of the ERK pathway.

Int J Mol Med 2017 Feb 16;39(2):380-386. Epub 2016 Dec 16.

Department of Biochemistry, Dongeui University College of Korean Medicine, Busan 614‑052, Republic of Korea.

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http://dx.doi.org/10.3892/ijmm.2016.2834DOI Listing
February 2017

Esculetin exerts anti-proliferative effects against non-small-cell lung carcinoma by suppressing specificity protein 1 in vitro.

Gen Physiol Biophys 2017 Jan 30;36(1):31-39. Epub 2016 Nov 30.

Department of Dental Pharmacology, School of Dentistry, BK21 Plus, Chonbuk National University, Jeonju, Republic of Korea.

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http://dx.doi.org/10.4149/gpb_2016024DOI Listing
January 2017

Proteomic Assessment of the Relevant Factors Affecting Pork Meat Quality Associated with Muscles in Duroc Pigs.

Asian-Australas J Anim Sci 2016 Nov 30;29(11):1653-1663. Epub 2016 Mar 30.

Department of Dental Pharmacology, School of Dentistry and Institute of Dental Bioscience, BK21 plus, Chonbuk National University, Jeonju 651-756, Korea.

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http://dx.doi.org/10.5713/ajas.16.0050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088387PMC
November 2016

Kahweol induces apoptosis by suppressing BTF3 expression through the ERK signaling pathway in non-small cell lung cancer cells.

Int J Oncol 2016 Dec 12;49(6):2294-2302. Epub 2016 Oct 12.

Department of Dental Pharmacology, School of Dentistry, BK21 Plus, Chonbuk National University, Jeonju, Jeolla 561‑756, Republic of Korea.

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http://dx.doi.org/10.3892/ijo.2016.3727DOI Listing
December 2016

Manumycin A induces apoptosis in malignant pleural mesothelioma through regulation of Sp1 and activation of the mitochondria-related apoptotic pathway.

Oncol Rep 2016 Jul 10;36(1):117-24. Epub 2016 May 10.

Department of Pharmacy, College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam 534-729, Republic of Korea.

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http://dx.doi.org/10.3892/or.2016.4801DOI Listing
July 2016

Licochalcone B induces apoptosis of human oral squamous cell carcinoma through the extrinsic- and intrinsic-signaling pathways.

Int J Oncol 2016 Apr 1;48(4):1749-57. Epub 2016 Feb 1.

Department of Pharmacy, College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam 534-729, Republic of Korea.

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http://dx.doi.org/10.3892/ijo.2016.3365DOI Listing
April 2016

HPLC Analysis, Optimization of Extraction Conditions and Biological Evaluation of Corylopsis coreana Uyeki Flos.

Molecules 2016 Jan 15;21(1):94. Epub 2016 Jan 15.

Department of Pharmacy, College of Pharmacy, Mokpo National University, Muan, Jeonnam 534-729, Korea.

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http://dx.doi.org/10.3390/molecules21010094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273307PMC
January 2016

β-lapachone suppresses the proliferation of human malignant melanoma cells by targeting specificity protein 1.

Oncol Rep 2016 Feb 20;35(2):1109-16. Epub 2015 Nov 20.

Department of Dental Pharmacology, School of Dentistry and Institute of Oral Bioscience, BK21 Plus, Chonbuk National University, Jeonju 561-756, Republic of Korea.

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http://dx.doi.org/10.3892/or.2015.4439DOI Listing
February 2016

Esculetin Induces Apoptosis Through EGFR/PI3K/Akt Signaling Pathway and Nucleophosmin Relocalization.

J Cell Biochem 2016 May 18;117(5):1210-21. Epub 2015 Oct 18.

Department of Dental Pharmacology, School of Dentistry, BK21 Plus, Chonbuk National University, Jeonju, Republic of Korea.

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http://doi.wiley.com/10.1002/jcb.25404
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http://dx.doi.org/10.1002/jcb.25404DOI Listing
May 2016

Manumycin A from a new Streptomyces strain induces endoplasmic reticulum stress-mediated cell death through specificity protein 1 signaling in human oral squamous cell carcinoma.

Int J Oncol 2015 11 8;47(5):1954-62. Epub 2015 Sep 8.

Department of Pharmacy, College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam 534-729, Republic of Korea.

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http://dx.doi.org/10.3892/ijo.2015.3151DOI Listing
November 2015

Beta-Lapachone Suppresses Non-small Cell Lung Cancer Proliferation through the Regulation of Specificity Protein 1.

Biol Pharm Bull 2015 ;38(9):1302-8

Department of Dental Pharmacology, School of Dentistry and Institute of Oral Bioscience, BK21 plus, Chonbuk National University.

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http://dx.doi.org/10.1248/bpb.b15-00159DOI Listing
June 2016

Esculetin, a Coumarin Derivative, Exhibits Anti-proliferative and Pro-apoptotic Activity in G361 Human Malignant Melanoma.

J Cancer Prev 2015 Jun;20(2):106-12

Department of Dental Pharmacology, School of Dentistry and Institute of Oral Bioscience, BK21 Plus, Chonbuk National University, Jeonju, Chungnam National University, Daejeon, Korea.

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http://dx.doi.org/10.15430/JCP.2015.20.2.106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492354PMC
June 2015

International ring trial for the validation of an event-specific Golden Rice 2 quantitative real-time polymerase chain reaction method.

J Agric Food Chem 2015 May 13;63(20):4954-65. Epub 2015 May 13.

†Molecular Biology and Genomics Unit, Institute for Health and Consumer Protection, European Commission Joint Research Centre, Via E. Fermi 2749, 21027 Ispra, Varese, Italy.

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http://dx.doi.org/10.1021/acs.jafc.5b00951DOI Listing
May 2015

Downregulation of Sp1 is involved in β-lapachone-induced cell cycle arrest and apoptosis in oral squamous cell carcinoma.

Int J Oncol 2015 20;46(6):2606-12. Epub 2015 Apr 20.

Department of Oral Pharmacology, School of Dentistry and Institute of Oral Bioscience, BK21 plus, Chonbuk National University, Jeonju 561-756, Republic of Korea.

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http://dx.doi.org/10.3892/ijo.2015.2972DOI Listing
February 2016

Multifunctional effects of honokiol as an anti-inflammatory and anti-cancer drug in human oral squamous cancer cells and xenograft.

Biomaterials 2015 16;53:274-84. Epub 2015 Mar 16.

Department of Oral Pharmacology, School of Dentistry and Institute of Dental Bioscience, BK21 Plus, Chonbuk National University, Jeonju 651-756, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2015.02.091DOI Listing
January 2016

Mechanism underlying renal failure caused by pathogenic infection.

Biomed Rep 2015 Mar 24;3(2):179-182. Epub 2014 Nov 24.

Department of Oral Pharmacology, School of Dentistry and Institute of Oral Bioscience, BK21 plus, Chonbuk National University, Jeonju, Republic of Korea.

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http://dx.doi.org/10.3892/br.2014.393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360833PMC
March 2015

Quercetin Induces Antiproliferative Activity Against Human Hepatocellular Carcinoma (HepG2) Cells by Suppressing Specificity Protein 1 (Sp1).

Drug Dev Res 2015 Feb 25;76(1):9-16. Epub 2015 Jan 25.

Department of Oral Pharmacology, School of Dentistry and Institute of Oral Bioscience, BK21 plus, Chonbuk National University, Jeonju, 651-756.

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http://doi.wiley.com/10.1002/ddr.21235
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http://dx.doi.org/10.1002/ddr.21235DOI Listing
February 2015

Development, optimization, and single laboratory validation of an event-specific real-time PCR method for the detection and quantification of Golden Rice 2 using a novel taxon-specific assay.

J Agric Food Chem 2015 Feb 6;63(6):1711-21. Epub 2015 Feb 6.

Molecular Biology and Genomics Unit, Institute for Health and Consumer Protection, European Commission Joint Research Centre , Via E. Fermi 2749, 21027 Ispra (VA), Italy.

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http://dx.doi.org/10.1021/jf505516yDOI Listing
February 2015

Licochalcone A induces apoptosis in malignant pleural mesothelioma through downregulation of Sp1 and subsequent activation of mitochondria-related apoptotic pathway.

Int J Oncol 2015 Mar 13;46(3):1385-92. Epub 2015 Jan 13.

Natural Medicine Research Institute, Department of Pharmacy, College of Pharmacy, Mokpo National University, Jeonnam 534-729, Republic of Korea.

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http://dx.doi.org/10.3892/ijo.2015.2839DOI Listing
March 2015

Apoptotic effects of 7,8-dihydroxyflavone in human oral squamous cancer cells through suppression of Sp1.

Oncol Rep 2015 Feb 27;33(2):631-8. Epub 2014 Nov 27.

Natural Medicine Research Institute, Department of Pharmacy, College of Pharmacy, Mokpo National University, Muan-gun, Jeonnam 534-729, Republic of Korea.

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http://dx.doi.org/10.3892/or.2014.3632DOI Listing
February 2015

Esculetin (6,7-dihydroxycoumarin): a potential cancer chemopreventive agent through suppression of Sp1 in oral squamous cancer cells.

Int J Oncol 2015 Jan 7;46(1):265-71. Epub 2014 Oct 7.

Department of Oral Pharmacology, School of Dentistry and Institute of Oral Bioscience, BK21 plus, Chonbuk National University, Jeonju 651-756, Republic of Korea.

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http://dx.doi.org/10.3892/ijo.2014.2700DOI Listing
January 2015

Cordyceptin induces apoptosis through repressing hTERT expression and inducing extranuclear export of hTERT.

J Biosci Bioeng 2015 Mar 2;119(3):351-7. Epub 2014 Oct 2.

Department of Biochemistry, Dongeui University College of Korean Medicine, Busan 614-052, Republic of Korea; Anti-Aging Research Center & Blue-Bio Industry RIC, Dongeui University, Busan 614-714, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jbiosc.2014.08.008DOI Listing
March 2015

Anti-proliferative properties of kahweol in oral squamous cancer through the regulation specificity protein 1.

Phytother Res 2014 Dec 8;28(12):1879-86. Epub 2014 Sep 8.

Department of Oral Pharmacology, School of Dentistry and Institute of Oral Bioscience, BK21 plus, Chonbuk National University, Jeonju, 651-756, Korea.

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http://dx.doi.org/10.1002/ptr.5217DOI Listing
December 2014

Phosphorylation of PrxII promotes JNK-dependent apoptosis in adult cloned pig kidney.

Int J Biochem Cell Biol 2014 Aug 5;53:352-60. Epub 2014 Jun 5.

Department of Oral Pharmacology, School of Dentistry, Brain Korea 21 Plus Project, Chonbuk National University, Jeonju, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2014.05.039DOI Listing
August 2014

Licochalcone A, a natural chalconoid isolated from Glycyrrhiza inflata root, induces apoptosis via Sp1 and Sp1 regulatory proteins in oral squamous cell carcinoma.

Int J Oncol 2014 Aug 23;45(2):667-74. Epub 2014 May 23.

Natural Medicine Research Institute, Department of Pharmacy, College of Pharmacy, Mokpo National University, Jeonnam 534-729, Republic of Korea.

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http://dx.doi.org/10.3892/ijo.2014.2461DOI Listing
August 2014

Chemical regulation of signaling pathways to programmed necrosis.

Arch Pharm Res 2014 Jun 10;37(6):689-97. Epub 2014 Apr 10.

College of Pharmacy, Keimyung University, 1000 Sindang-dong, Dalseo-gu, Daegu, 704-701, South Korea.

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http://dx.doi.org/10.1007/s12272-014-0385-6DOI Listing
June 2014

Specificity protein 1 is a novel target of 2,4-bis (p-hydroxyphenyl)-2-butenal for the suppression of human oral squamous cell carcinoma cell growth.

J Biomed Sci 2014 Jan 15;21. Epub 2014 Jan 15.

Department of Pharmacy, College of Pharmacy, Mokpo National University, 1666 Youngsan-ro, Muan-gun, Jeonnam 534-729, Republic of Korea.

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http://dx.doi.org/10.1186/1423-0127-21-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928619PMC
January 2014

Cystic giant sacral schwannoma mimicking aneurysmal bone cyst : a case report and review of literatures.

J Korean Neurosurg Soc 2013 Oct 31;54(4):350-4. Epub 2013 Oct 31.

Department of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

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http://dx.doi.org/10.3340/jkns.2013.54.4.350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841281PMC
October 2013

COT phosphorylates prolyl-isomerase Pin1 to promote tumorigenesis in breast cancer.

Mol Carcinog 2015 Jun 22;54(6):440-8. Epub 2013 Nov 22.

College of Pharmacy, Chosun University, Gwangju, South Korea.

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http://dx.doi.org/10.1002/mc.22112DOI Listing
June 2015

Resveratrol contributes to chemosensitivity of malignant mesothelioma cells with activation of p53.

Food Chem Toxicol 2014 Jan 14;63:153-60. Epub 2013 Nov 14.

Soonchunhyung Environmental Health Center for Asbestos, College of Medicine, Soonchunhyang University, Cheonan Hospital, Cheonan 330-930, Republic of Korea; Department of Pediatrics, Soonchunhyang University Cheonan Hospital, Cheonan 330-721, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2013.11.004DOI Listing
January 2014

Anti-proliferative effect of honokiol in oral squamous cancer through the regulation of specificity protein 1.

Int J Oncol 2013 Oct 22;43(4):1103-10. Epub 2013 Jul 22.

Department of Oral Pharmacology, School of Dentistry and Institute of Dental Bioscience, BK21 project, Chonbuk National University, Jeonju, Republic of Korea.

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http://dx.doi.org/10.3892/ijo.2013.2028DOI Listing
October 2013

The HDAC inhibitor, panobinostat, induces apoptosis by suppressing the expresssion of specificity protein 1 in oral squamous cell carcinoma.

Int J Mol Med 2013 Oct 18;32(4):860-6. Epub 2013 Jul 18.

Department of Oral Pharmacology, School of Dentistry and Institute of Dental Bioscience, BK21 project, Chonbuk National University, Jeonju 651-756, Republic of Korea.

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http://dx.doi.org/10.3892/ijmm.2013.1451DOI Listing
October 2013

Distinctive roles of receptor-interacting protein kinases 1 and 3 in caspase-independent cell death of L929.

Cell Biochem Funct 2014 Jan 15;32(1):62-9. Epub 2013 Apr 15.

College of Pharmacy, Keimyung University, Daegu, South Korea.

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http://dx.doi.org/10.1002/cbf.2972DOI Listing
January 2014

Downregulation of Sp1 is involved in honokiol-induced cell cycle arrest and apoptosis in human malignant pleural mesothelioma cells.

Oncol Rep 2013 Jun 20;29(6):2318-24. Epub 2013 Mar 20.

Department of Dental Pharmacology, School of Dentistry, Brain Korea 21 Project, Chonbuk National University, Jeonju 561‑756, Republic of Korea.

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https://www.spandidos-publications.com/10.3892/or.2013.2353
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http://dx.doi.org/10.3892/or.2013.2353DOI Listing
June 2013

Two novel QTLs regulate internode elongation in deepwater rice during the early vegetative stage.

Breed Sci 2012 Jun 19;62(2):178-85. Epub 2012 Jun 19.

Bioscience and Biotechnology Center, Nagoya University , Furo, Chikusa, Nagoya, Aichi 464-8601, Japan.

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http://dx.doi.org/10.1270/jsbbs.62.178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405962PMC
June 2012

Role of transcription factor Sp1 in the quercetin-mediated inhibitory effect on human malignant pleural mesothelioma.

Int J Mol Med 2012 Oct 24;30(4):835-41. Epub 2012 Jul 24.

Department of Dental Pharmacology, School of Dentistry, Brain Korea 21 Project, Chonbuk National University, Jeonju 561-756, Republic of Korea.

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https://www.spandidos-publications.com/10.3892/ijmm.2012.107
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http://dx.doi.org/10.3892/ijmm.2012.1075DOI Listing
October 2012

Althaea rosea Cavanil and Plantago major L. suppress neoplastic cell transformation through the inhibition of epidermal growth factor receptor kinase.

Mol Med Rep 2012 Oct 4;6(4):843-7. Epub 2012 Jul 4.

Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 project, Chonbuk National University, Jeonju 561-756, Republic of Korea.

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http://dx.doi.org/10.3892/mmr.2012.977DOI Listing
October 2012

Natural diterpenes from coffee, cafestol and kahweol induce apoptosis through regulation of specificity protein 1 expression in human malignant pleural mesothelioma.

J Biomed Sci 2012 Jun 26;19:60. Epub 2012 Jun 26.

Department of Biochemistry, College of Medicine, Soonchunhyang University, Ssangyong-dong, Seobuk-gu, Cheonan, Choongnam 331-090, Republic of Korea.

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http://dx.doi.org/10.1186/1423-0127-19-60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431247PMC
June 2012

In vitro apoptotic effects of methanol extracts of Dianthus chinensis and Acalypha australis L. targeting specificity protein 1 in human oral cancer cells.

Head Neck 2013 Jul 25;35(7):992-8. Epub 2012 Jun 25.

Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, BK21 Project, Chonbuk National University, Jeonju, Republic of Korea.

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http://dx.doi.org/10.1002/hed.23072DOI Listing
July 2013

TPA-induced cell transformation provokes a complex formation between Pin1 and 90 kDa ribosomal protein S6 kinase 2.

Mol Cell Biochem 2012 Aug 5;367(1-2):85-92. Epub 2012 May 5.

Department of Pharmacy, Keimyung University, Dalseo-gu, Taegu, Republic of Korea.

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http://dx.doi.org/10.1007/s11010-012-1322-yDOI Listing
August 2012

The flavonoid resveratrol suppresses growth of human malignant pleural mesothelioma cells through direct inhibition of specificity protein 1.

Int J Mol Med 2012 Jul 23;30(1):21-7. Epub 2012 Apr 23.

Department of Biochemistry, College of Medicine, Soonchunhyang University, Cheonan 330-090, Republic of Korea.

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http://dx.doi.org/10.3892/ijmm.2012.978DOI Listing
July 2012

Hesperidin Induces Apoptosis by Inhibiting Sp1 and Its Regulatory Protein in MSTO-211H Cells.

Biomol Ther (Seoul) 2012 May;20(3):273-9

Department of Biochemistry, College of Medicine, Soonchunhyang University.

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http://dx.doi.org/10.4062/biomolther.2012.20.3.273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794523PMC
May 2012

Phosphoinositol 3-kinase, a novel target molecule for the inhibitory effects of juglone on TPA-induced cell transformation.

Int J Mol Med 2012 Jul 10;30(1):8-14. Epub 2012 Apr 10.

Department of Oral Pharmacology, School of Dentistry and Institute of Oral Bioscience, BK21 Project, Chonbuk National University, Jeonju, Republic of Korea.

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http://dx.doi.org/10.3892/ijmm.2012.969DOI Listing
July 2012

Solitary osteochondroma of the twelfth rib with intraspinal extension and cord compression in a middle-aged patient.

BMC Musculoskelet Disord 2012 Apr 13;13:57. Epub 2012 Apr 13.

Department of Neurosurgery, The Leon Wiltse Memorial Hospital, Suwon, Korea.

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http://dx.doi.org/10.1186/1471-2474-13-57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353156PMC
April 2012

Paraplegia due to Missed Thoracic Meningioma after Laminotomy for Lumbar Spinal Stenosis: Report of Two Cases.

Asian Spine J 2011 Dec 28;5(4):253-7. Epub 2011 Nov 28.

Department of Orthopaedic Surgery, Daegu Catholic University Medical Center, Catholic University of Daegu School of Medicine, Daegu, Korea.

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http://asianspinejournal.org/journal/view.php?doi=10.4184/as
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http://dx.doi.org/10.4184/asj.2011.5.4.253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230654PMC
December 2011

Reactive oxygen species and PI3K/Akt signaling play key roles in the induction of Nrf2-driven heme oxygenase-1 expression in sulforaphane-treated human mesothelioma MSTO-211H cells.

Food Chem Toxicol 2012 Feb 14;50(2):116-23. Epub 2011 Oct 14.

Soonchunhyung Environmental Health Center for Asbestos-related Disease, College of Medicine, Soonchunhyang University, Cheonan Hospital, Cheonan 330-090, Republic of Korea.

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http://dx.doi.org/10.1016/j.fct.2011.10.035DOI Listing
February 2012

Epigallocatechin-gallate suppresses tumorigenesis by directly targeting Pin1.

Cancer Prev Res (Phila) 2011 Sep 12;4(9):1366-77. Epub 2011 Jul 12.

The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-11-0301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244823PMC
September 2011

Chemopreventive effects of synthetic C-substituted diindolylmethanes originating from cruciferous vegetables in human oral cancer cells.

Eur J Cancer Prev 2011 Sep;20(5):417-25

Department of Oral Pathology, School of Dentistry, Chonbuk National University, Republic of Korea.

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http://dx.doi.org/10.1097/CEJ.0b013e32834473c3DOI Listing
September 2011

Apoptotic effect of tolfenamic acid in androgen receptor-independent prostate cancer cell and xenograft tumor through specificity protein 1.

Cancer Sci 2011 Apr 17;102(4):742-8. Epub 2011 Feb 17.

Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 Project, Chonbuk National University, Jeon-ju, Korea.

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http://dx.doi.org/10.1111/j.1349-7006.2011.01871.xDOI Listing
April 2011

Chemopreventive effect of tolfenamic acid on KB human cervical cancer cells and tumor xenograft by downregulating specificity protein 1.

Eur J Cancer Prev 2011 Mar;20(2):102-11

Departments of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, BK21 Project, Chonbuk National University, Jeonju, Republic of Korea.

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http://dx.doi.org/10.1097/CEJ.0b013e328341e38fDOI Listing
March 2011

Apoptotic Effect of Tolfenamic Acid in KB Human Oral Cancer Cells: Possible Involvement of the p38 MAPK Pathway.

J Clin Biochem Nutr 2010 Jul 17;47(1):74-80. Epub 2010 Jun 17.

Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 project, Chonbuk National University, Jeonju 561-756, Republic of Korea.

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http://dx.doi.org/10.3164/jcbn.10-02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901767PMC
July 2010

Histone XH2AX is required for Xenopus anterior neural development: critical role of threonine 16 phosphorylation.

J Biol Chem 2010 Sep 16;285(38):29525-34. Epub 2010 Jul 16.

Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA.

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http://dx.doi.org/10.1074/jbc.M110.127233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937984PMC
September 2010

Downregulation of immune response by the human cytokines Interleukin-32alpha and beta in cell-mediated rejection.

Cell Immunol 2010 11;264(1):47-53. Epub 2010 Jun 11.

Department of Oral Pharmacology, School of Dentistry, Brain Korea 21 Project, Chonbuk National University, Jeonju, Republic of Korea.

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http://dx.doi.org/10.1016/j.cellimm.2010.04.010DOI Listing
September 2010