Publications by authors named "Jung Weon Lee"

100Publications

Metastatic behavior analyses of tetraspanin TM4SF5-expressing spheres in three-dimensional (3D) cell culture environment.

Authors:
Dae-Geun Song Eunmi Kim Jung Weon Lee

Arch Pharm Res 2020 Nov 21;43(11):1162-1172. Epub 2020 Nov 21.

Department of Pharmacy, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 08826, Korea.

View Article and Find Full Text PDF
November 2020

Differential TM4SF5-mediated SIRT1 modulation and metabolic signaling in nonalcoholic steatohepatitis progression.

Authors:
Jihye Ryu Eunmi Kim Min-Kyung Kang Dae-Geun Song Eun-Ae Shin Haesong Lee Jae Woo Jung Seo Hee Nam Ji Eon Kim Hye-Jin Kim Taekwon Son Semi Kim Hwi Young Kim Jung Weon Lee

J Pathol 2021 Jan 22;253(1):55-67. Epub 2020 Oct 22.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Republic of Korea.

View Article and Find Full Text PDF
January 2021

A neural circuit mechanism for mechanosensory feedback control of ingestion.

Authors:
Dong-Yoon Kim Gyuryang Heo Minyoo Kim Hyunseo Kim Ju Ae Jin Hyun-Kyung Kim Sieun Jung Myungmo An Benjamin H Ahn Jong Hwi Park Han-Eol Park Myungsun Lee Jung Weon Lee Gary J Schwartz Sung-Yon Kim

Nature 2020 04 8;580(7803):376-380. Epub 2020 Apr 8.

Institute of Molecular Biology and Genetics, Seoul National University, Seoul, South Korea.

View Article and Find Full Text PDF
April 2020

Tetrahydrobenzimidazole TMQ0153 triggers apoptosis, autophagy and necroptosis crosstalk in chronic myeloid leukemia.

Authors:
Sungmi Song Jin-Young Lee Ludmila Ermolenko Aloran Mazumder Seungwon Ji Heeju Ryu HyeJin Kim Dong-Wook Kim Jung Weon Lee Mario Dicato Christo Christov Michael Schnekenburger Claudia Cerella Déborah Gérard Barbora Orlikova-Boyer Ali Al-Mourabit Marc Diederich

Cell Death Dis 2020 02 7;11(2):109. Epub 2020 Feb 7.

College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08626, Korea.

View Article and Find Full Text PDF
February 2020

Amino acid transporters as tetraspanin TM4SF5 binding partners.

Authors:
Jae Woo Jung Ji Eon Kim Eunmi Kim Jung Weon Lee

Exp Mol Med 2020 01 20;52(1):7-14. Epub 2020 Jan 20.

Interdisciplinary Program in Genetic Engineering, Seoul National University, Seoul, 08826, Republic of Korea.

View Article and Find Full Text PDF
January 2020

Overproduction of inter-α-trypsin inhibitor heavy chain 1 after loss of Gα in liver exacerbates systemic insulin resistance in mice.

Authors:
Tae Hyun Kim Ja Hyun Koo Mi Jeong Heo Chang Yeob Han Yong-In Kim Shi-Young Park Il Je Cho Chang Ho Lee Cheol Soo Choi Jung Weon Lee Won Kim Je-Yoel Cho Sang Geon Kim

Sci Transl Med 2019 10;11(513)

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea.

View Article and Find Full Text PDF
October 2019

TM4SF5-mediated CD44v8-10 splicing variant promotes survival of type II alveolar epithelial cells during idiopathic pulmonary fibrosis.

Authors:
Ji Eon Kim Hye-Jin Kim Jae Woo Jung Dae-Geun Song Dasomi Park Haesong Lee Hyejin Um Jinsoo Park Seo Hee Nam Moonjae Cho Jung Weon Lee

Cell Death Dis 2019 09 9;10(9):645. Epub 2019 Sep 9.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.

View Article and Find Full Text PDF
September 2019

Nanoadjuvant-Assembled Tumor Vaccine for Preventing Long-Term Recurrence.

Authors:
Quoc-Viet Le Juhan Suh Jin Joo Choi Gyu Thae Park Jung Weon Lee Gayong Shim Yu-Kyoung Oh

ACS Nano 2019 07 14;13(7):7442-7462. Epub 2019 Jun 14.

View Article and Find Full Text PDF
July 2019

Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling.

Authors:
Jae Woo Jung Stephani Joy Y Macalino Minghua Cui Ji Eon Kim Hye-Jin Kim Dae-Geun Song Seo Hee Nam Semi Kim Sun Choi Jung Weon Lee

Cell Metab 2019 06 4;29(6):1306-1319.e7. Epub 2019 Apr 4.

Interdisciplinary Program in Genetic Engineering, Seoul National University, Seoul 08826, South Korea; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, South Korea. Electronic address:

View Article and Find Full Text PDF
June 2019

Glutamyl-prolyl-tRNA synthetase induces fibrotic extracellular matrix via both transcriptional and translational mechanisms.

Authors:
Dae-Geun Song Doyeun Kim Jae Woo Jung Seo Hee Nam Ji Eon Kim Hye-Jin Kim Jong Hyun Kim Seo-Jin Lee Cheol-Ho Pan Sunghoon Kim Jung Weon Lee

FASEB J 2019 03 28;33(3):4341-4354. Epub 2018 Dec 28.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea.

View Article and Find Full Text PDF
March 2019

Glutamyl-Prolyl-tRNA Synthetase Regulates Epithelial Expression of Mesenchymal Markers and Extracellular Matrix Proteins: Implications for Idiopathic Pulmonary Fibrosis.

Authors:
Dae-Geun Song Doyeun Kim Jae Woo Jung Seo Hee Nam Ji Eon Kim Hye-Jin Kim Jong Hyun Kim Cheol-Ho Pan Sunghoon Kim Jung Weon Lee

Front Pharmacol 2018 20;9:1337. Epub 2018 Nov 20.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea.

View Article and Find Full Text PDF
November 2018

CD133-induced TM4SF5 expression promotes sphere growth via recruitment and blocking of protein tyrosine phosphatase receptor type F (PTPRF).

Authors:
Somi Kim Chang Yun Cho Doohyung Lee Dae-Geun Song Hye-Jin Kim Jae Woo Jung Ji Eon Kim Dasomi Park Haesong Lee Hyejin Um Jinsoo Park Yoonjeong Choi Yoomin Kim Seo Hee Nam Jung Weon Lee

Cancer Lett 2018 12 11;438:219-231. Epub 2018 Sep 11.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea; Interdisciplinary Program in Genetic Engineering, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:

View Article and Find Full Text PDF
December 2018

Lysyl-tRNA synthetase-expressing colon spheroids induce M2 macrophage polarization to promote metastasis.

Authors:
Seo Hee Nam Doyeun Kim Doohyung Lee Hye-Mi Lee Dae-Geun Song Jae Woo Jung Ji Eon Kim Hye-Jin Kim Nam Hoon Kwon Eun-Kyeong Jo Sunghoon Kim Jung Weon Lee

J Clin Invest 2018 11 8;128(11):5034-5055. Epub 2018 Oct 8.

Interdisciplinary Program in Genetic Engineering.

View Article and Find Full Text PDF
November 2018

Cytostatic hydroxycoumarin OT52 induces ER/Golgi stress and STAT3 inhibition triggering non-canonical cell death and synergy with BH3 mimetics in lung cancer.

Authors:
Jin-Young Lee Oualid Talhi Dongman Jang Claudia Cerella Anthoula Gaigneaux Kyu-Won Kim Jung Weon Lee Mario Dicato Khaldoun Bachari Byung Woo Han Artur M S Silva Barbora Orlikova Marc Diederich

Cancer Lett 2018 03 13;416:94-108. Epub 2017 Dec 13.

Department of Pharmacy, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08626, Republic of Korea. Electronic address:

View Article and Find Full Text PDF
March 2018

Liver-specific deletion of RORα aggravates diet-induced nonalcoholic steatohepatitis by inducing mitochondrial dysfunction.

Authors:
Hyeon-Ji Kim Yong-Hyun Han Hyelin Na Ju-Yeon Kim Taewook Kim Hye-Jin Kim Chanseok Shin Jung Weon Lee Mi-Ock Lee

Sci Rep 2017 11 22;7(1):16041. Epub 2017 Nov 22.

College of Pharmacy, Seoul National University, Seoul, Korea.

View Article and Find Full Text PDF
November 2017

TM4SF5 promotes metastatic behavior of cells in 3D extracellular matrix gels by reducing dependency on environmental cues.

Authors:
Dae-Geun Song Gyu-Ho Lee Seo Hee Nam Jin-Gyu Cheong Doyoung Jeong Seo-Jin Lee Cheol-Ho Pan Jae Woo Jung Hye-Jin Kim Jihye Ryu Ji Eon Kim Somi Kim Chang Yun Cho Min-Kyung Kang Kyung-Min Lee Jung Weon Lee

Oncotarget 2017 Oct 7;8(48):83480-83494. Epub 2017 May 7.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, 08826 Seoul, Korea.

View Article and Find Full Text PDF
October 2017

TM4SF5-Mediated Roles in the Development of Fibrotic Phenotypes.

Authors:
Jihye Ryu Jung Weon Lee

Mediators Inflamm 2017 26;2017:5108525. Epub 2017 Mar 26.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Tumor Microenvironment Global Core Research Center, Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.

View Article and Find Full Text PDF
March 2018

Anti-cancer Activity of Novel TM4SF5-Targeting Antibodies through TM4SF5 Neutralization and Immune Cell-Mediated Cytotoxicity.

Authors:
Hye-Mi Ahn Jihye Ryu Jin Myeong Song Yunhee Lee Hye-Jin Kim Dongjoon Ko Inpyo Choi Sang Jick Kim Jung Weon Lee Semi Kim

Theranostics 2017 11;7(3):594-613. Epub 2017 Jan 11.

Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejon, Korea;; Department of Functional Genomics, Korea University of Science and Technology, Daejon, Korea.

View Article and Find Full Text PDF
October 2017

Differential regulation of cellular functions by the C-termini of transmembrane 4 L six family proteins in 2- or 3-dimensional environment.

Authors:
Jin-Gyu Cheong Dae-Geun Song Haeng Eun Song Fedor Berditchevski Seo Hee Nam Jae Woo Jung Hye-Jin Kim Ji Eon Kim Somi Kim Jihye Ryu Chang Yun Cho Kyung-Min Lee Jung Weon Lee

Oncotarget 2017 Feb;8(8):13277-13292

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.

View Article and Find Full Text PDF
February 2017

Dynamic and coordinated single-molecular interactions at TM4SF5-enriched microdomains guide invasive behaviors in 2- and 3-dimensional environments.

Authors:
Hye-Jin Kim Sojung Kwon Seo Hee Nam Jae Woo Jung Minkyung Kang Jihye Ryu Ji Eon Kim Jin-Gyu Cheong Chang Yun Cho Somi Kim Dae-Geun Song Yong-Nyun Kim Tai Young Kim Min-Kyo Jung Kyung-Min Lee Chan-Gi Pack Jung Weon Lee

FASEB J 2017 04 10;31(4):1461-1481. Epub 2017 Jan 10.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea;

View Article and Find Full Text PDF
April 2017

Function of membranous lysyl-tRNA synthetase and its implication for tumorigenesis.

Authors:
Ho Jeon Young Jung Weon Lee Sunghoon Kim

Biochim Biophys Acta 2016 12 20;1864(12):1707-1713. Epub 2016 Sep 20.

Medicinal Bioconvergence Research Center, Seoul National University, Seoul 08826, Republic of Korea; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.

View Article and Find Full Text PDF
December 2016

Erratum: Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels.

Authors:
Seo Hee Nam Doyeun Kim Mi-Sook Lee Doohyung Lee Tae Kyoung Kwak Minkyung Kang Jihye Ryu Hye-Jin Kim Haeng Eun Song Jungeun Choi Gyu-Ho Lee Sang-Yeob Kim Song Hwa Park Dae Gyu Kim Nam Hoon Kwon Tai Young Kim Jean Paul Thiery Sunghoon Kim Jung Weon Lee

Oncotarget 2016 Feb;7(6):7367

View Article and Find Full Text PDF
February 2016

Suppression of lysyl-tRNA synthetase, KRS, causes incomplete epithelial-mesenchymal transition and ineffective cell‑extracellular matrix adhesion for migration.

Authors:
Seo Hee Nam Minkyung Kang Jihye Ryu Hye-Jin Kim Doyeun Kim Dae Gyu Kim Nam Hoon Kwon Sunghoon Kim Jung Weon Lee

Int J Oncol 2016 Apr 8;48(4):1553-60. Epub 2016 Feb 8.

Interdisciplinary Program in Genetic Engineering, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.

View Article and Find Full Text PDF
April 2016

Potential role of 8-oxoguanine DNA glycosylase 1 as a STAT1 coactivator in endotoxin-induced inflammatory response.

Authors:
Hong Sook Kim Byung-Hak Kim Joo Eun Jung Chang Seok Lee Hyun Gyu Lee Jung Weon Lee Kun Ho Lee Ho Jin You Myung-Hee Chung Sang-Kyu Ye

Free Radic Biol Med 2016 Apr 11;93:12-22. Epub 2015 Nov 11.

Department of Pharmacology, Seoul National University College of Medicine, Seoul, Republic of Korea; Biomedical Science Project (BK21PLUS), Seoul National University College of Medicine, Seoul, Republic of Korea; Neuro-Immune Information Storage Network Research Center, Seoul National University College of Medicine, Republic of Korea; Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

View Article and Find Full Text PDF
April 2016

Transmembrane 4 L Six Family Member 5 (TM4SF5)-Mediated Epithelial-Mesenchymal Transition in Liver Diseases.

Authors:
Jung Weon Lee

Int Rev Cell Mol Biol 2015 20;319:141-63. Epub 2015 Jul 20.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Tumor Microenvironment Global Core Research Center, Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Seoul, Korea. Electronic address:

View Article and Find Full Text PDF
April 2016

Bidirectional signaling between TM4SF5 and IGF1R promotes resistance to EGFR kinase inhibitors.

Authors:
Jungeun Choi Minkyung Kang Seo Hee Nam Gyu-Ho Lee Hye-Jin Kim Jihye Ryu Jin Gyu Cheong Jae Woo Jung Tai Young Kim Ho-Young Lee Jung Weon Lee

Lung Cancer 2015 Oct 2;90(1):22-31. Epub 2015 Jul 2.

Interdisciplinary Program in Genetic Engineering, Seoul National University, Seoul 151-742, Republic of Korea; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea. Electronic address:

View Article and Find Full Text PDF
October 2015

Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels.

Authors:
Seo Hee Nam Doyeun Kim Mi-Sook Lee Doohyung Lee Tae Kyoung Kwak Minkyung Kang Jihye Ryu Hye-Jin Kim Haeng Eun Song Jungeun Choi Gyu-Ho Lee Sang-Yeob Kim Song Hwa Park Dae Gyu Kim Nam Hoon Kwon Tai Young Kim Jean Paul Thiery Sunghoon Kim Jung Weon Lee

Oncotarget 2015 Aug;6(25):21655-74

Interdisciplinary Program in Genetic Engineering, Seoul National University, Seoul, Republic of Korea.

View Article and Find Full Text PDF
August 2015

Self-renewal and circulating capacities of metastatic hepatocarcinoma cells required for collaboration between TM4SF5 and CD44.

Authors:
Doohyung Lee Jung Weon Lee

BMB Rep 2015 Mar;48(3):127-8

Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 151-742, Korea.

View Article and Find Full Text PDF
March 2015

Interaction of tetraspan(in) TM4SF5 with CD44 promotes self-renewal and circulating capacities of hepatocarcinoma cells.

Authors:
Doohyung Lee Juri Na Jihye Ryu Hye-Jin Kim Seo Hee Nam Minkyung Kang Jae Woo Jung Mi-Sook Lee Haeng Eun Song Jungeun Choi Gyu-Ho Lee Tai Young Kim June-Key Chung Ki Hun Park Sung-Hak Kim Hyunggee Kim Howon Seo Pilhan Kim Hyewon Youn Jung Weon Lee

Hepatology 2015 Jun 18;61(6):1978-97. Epub 2015 Mar 18.

Department of Pharmacy, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea.

View Article and Find Full Text PDF
June 2015

Twist1 and AP-1 cooperatively upregulate integrin α5 expression to induce invasion and the epithelial-mesenchymal transition.

Authors:
Eun-Hee Nam Yunhee Lee Byul Moon Jung Weon Lee Semi Kim

Carcinogenesis 2015 Mar 18;36(3):327-37. Epub 2015 Jan 18.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejon, Korea, Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejon, Korea, Department of Functional Genomics, Korea University of Science and Technology, Daejon, Korea and

View Article and Find Full Text PDF
March 2015

Correlations between transmembrane 4 L6 family member 5 (TM4SF5), CD151, and CD63 in liver fibrotic phenotypes and hepatic migration and invasive capacities.

Authors:
Minkyung Kang Jihye Ryu Doohyung Lee Mi-Sook Lee Hye-Jin Kim Seo Hee Nam Haeng Eun Song Jungeun Choi Gyu-Ho Lee Tai Young Kim Hansoo Lee Sang Jick Kim Sang-Kyu Ye Semi Kim Jung Weon Lee

PLoS One 2014 17;9(7):e102817. Epub 2014 Jul 17.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Medicinal Bioconvergence Research Center, Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul, Republic of Korea; Interdisciplinary Program in Genetic Engineering, Seoul National University, Seoul, Republic of Korea.

View Article and Find Full Text PDF
November 2015

TM4SF5-mediated protein-protein networks and tumorigenic roles.

Authors:
Jung Weon Lee

BMB Rep 2014 Sep;47(9):483-7

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Tumor Microenvironment Global Core Research Center, Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Seoul 151-742, Korea.

View Article and Find Full Text PDF
September 2014

Cross talk between the TM4SF5/focal adhesion kinase and the interleukin-6/STAT3 pathways promotes immune escape of human liver cancer cells.

Authors:
Jihye Ryu Minkyung Kang Mi-Sook Lee Hye-Jin Kim Seo Hee Nam Haeng Eun Song Doohyung Lee Jung Weon Lee

Mol Cell Biol 2014 Aug 9;34(16):2946-60. Epub 2014 Jun 9.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Tumor Microenvironment Global Core Research Center, Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Seoul, Republic of Korea Interdisciplinary Program in Genetic Engineering, Seoul National University, Seoul, Republic of Korea

View Article and Find Full Text PDF
August 2014

TM4SF5 suppression disturbs integrin α5-related signalling and muscle development in zebrafish.

Authors:
Yoon-Ju Choi Hyun Ho Kim Jeong-Gyun Kim Hye-Jin Kim Minkyung Kang Mi-Sook Lee Jihye Ryu Haeng Eun Song Seo Hee Nam Doohyung Lee Kyu-Won Kim Jung Weon Lee

Biochem J 2014 Aug;462(1):89-101

*Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Tumor Microenvironment Global Core Research Center, Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea.

View Article and Find Full Text PDF
August 2014

Snail1 induced in breast cancer cells in 3D collagen I gel environment suppresses cortactin and impairs effective invadopodia formation.

Authors:
Mi-Sook Lee Sudong Kim Baek Gil Kim Cheolhee Won Seo Hee Nam Suki Kang Hye-Jin Kim Minkyung Kang Jihye Ryu Haeng Eun Song Doohyung Lee Sang-Kyu Ye Noo Li Jeon Tai Young Kim Nam Hoon Cho Jung Weon Lee

Biochim Biophys Acta 2014 Sep 24;1843(9):2037-54. Epub 2014 May 24.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Tumor Microenvironment Global Core Research Center, Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Republic of Korea; Interdisciplinary Program in Genetic Engineering, Seoul National University, Republic of Korea. Electronic address:

View Article and Find Full Text PDF
September 2014

Membrane Proteins Involved in Epithelial-Mesenchymal Transition and Tumor Invasion: Studies on TMPRSS4 and TM4SF5.

Authors:
Semi Kim Jung Weon Lee

Genomics Inform 2014 Mar 31;12(1):12-20. Epub 2014 Mar 31.

Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 151-742, Korea.

View Article and Find Full Text PDF
March 2014

TMPRSS4 induces cancer cell invasion through pro-uPA processing.

Authors:
Hye-Jin Min Myung Kyu Lee Jung Weon Lee Semi Kim

Biochem Biophys Res Commun 2014 Mar 14;446(1):1-7. Epub 2014 Jan 14.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejon, Republic of Korea. Electronic address:

View Article and Find Full Text PDF
March 2014

Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction.

Authors:
Dae Gyu Kim Jin Young Lee Nam Hoon Kwon Pengfei Fang Qian Zhang Jing Wang Nicolas L Young Min Guo Hye Young Cho Ameeq Ul Mushtaq Young Ho Jeon Jin Woo Choi Jung Min Han Ho Woong Kang Jae Eun Joo Youn Hur Wonyoung Kang Heekyoung Yang Do-Hyun Nam Mi-Sook Lee Jung Weon Lee Eun-Sook Kim Aree Moon Kibom Kim Doyeun Kim Eun Joo Kang Youngji Moon Kyung Hee Rhee Byung Woo Han Jee Sun Yang Gyoonhee Han Won Suk Yang Cheolju Lee Ming-Wei Wang Sunghoon Kim

Nat Chem Biol 2014 Jan 10;10(1):29-34. Epub 2013 Nov 10.

1] Medicinal Bioconvergence Research Center, Seoul National University, Seoul, Korea. [2] Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Korea. [3] World Class University Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Korea.

View Article and Find Full Text PDF
January 2014

ZEB2-Sp1 cooperation induces invasion by upregulating cadherin-11 and integrin α5 expression.

Authors:
Eun-Hee Nam Yunhee Lee Xue-Feng Zhao Young-Kyu Park Jung Weon Lee Semi Kim

Carcinogenesis 2014 Feb 15;35(2):302-14. Epub 2013 Oct 15.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejon 305-806, Korea.

View Article and Find Full Text PDF
February 2014

Combating resistance to anti-IGFR antibody by targeting the integrin β3-Src pathway.

Authors:
Dong Hoon Shin Hyo-Jong Lee Hye-Young Min Sun Phil Choi Mi-Sook Lee Jung Weon Lee Faye M Johnson Kapil Mehta Scott M Lippman Bonnie S Glisson Ho-Young Lee

J Natl Cancer Inst 2013 Oct 3;105(20):1558-70. Epub 2013 Oct 3.

Affiliations of authors: Department of Thoracic/Head and Neck Medical Oncology (DHS, SPC, FMJ, SML, BSG) and Department of Experimental Therapeutics (KM), The University of Texas MD Anderson Cancer Center, Houston, TX; College of Pharmacy, Inje University, Gimhae, Gyungnam, Republic of Korea (H-JL); College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea (H-YM, M-SL, JWL, H-YL).

View Article and Find Full Text PDF
October 2013

TMPRSS4 upregulates uPA gene expression through JNK signaling activation to induce cancer cell invasion.

Authors:
Hye-Jin Min Yunhee Lee Xue-Feng Zhao Young-Kyu Park Myung Kyu Lee Jung Weon Lee Semi Kim

Cell Signal 2014 Feb 24;26(2):398-408. Epub 2013 Aug 24.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Republic of Korea; Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea. Electronic address:

View Article and Find Full Text PDF
February 2014

The COOH-terminus of TM4SF5 in hepatoma cell lines regulates c-Src to form invasive protrusions via EGFR Tyr845 phosphorylation.

Authors:
Oisun Jung Yoon-Ju Choi Tae Kyoung Kwak Minkyung Kang Mi-Sook Lee Jihye Ryu Hye-Jin Kim Jung Weon Lee

Biochim Biophys Acta 2013 Mar 6;1833(3):629-42. Epub 2012 Dec 6.

Interdisciplinary Program in Genetic Engineering, Seoul National University, Seoul 151-742, Republic of Korea.

View Article and Find Full Text PDF
March 2013

Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells.

Authors:
Oisun Jung Suyong Choi Sun-Bok Jang Sin-Ae Lee Ssang-Taek Lim Yoon-Ju Choi Hye-Jin Kim Do-Hee Kim Tae Kyoung Kwak Hyeonjung Kim Minkyung Kang Mi-Sook Lee Sook Young Park Jihye Ryu Doyoung Jeong Hae-Kap Cheong Hyun Jeong Kim Ki Hun Park Bong-Jin Lee David D Schlaepfer Jung Weon Lee

J Cell Sci 2012 Dec 17;125(Pt 24):5960-73. Epub 2012 Oct 17.

Interdisciplinary Program in Genetic Engineering, Research Institute of Pharmaceutical Sciences, Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Seoul 151-742, Korea (Republic of).

View Article and Find Full Text PDF
December 2012

STAT3-RANTES autocrine signaling is essential for tamoxifen resistance in human breast cancer cells.

Authors:
Eun Hee Yi Chang Seok Lee Jin-Ku Lee Young Ju Lee Min Kyung Shin Chung-Hyun Cho Keon Wook Kang Jung Weon Lee Wonshik Han Dong-Young Noh Yong-Nyun Kim Ik-Hyun Cho Sang-Kyu Ye

Mol Cancer Res 2013 Jan 16;11(1):31-42. Epub 2012 Oct 16.

Department of Pharmacology, Seoul National University College of Medicine, 103 Daehangno, Jongno-gu, Seoul 110-799, Korea.

View Article and Find Full Text PDF
January 2013

Simvastatin suppresses RANTES-mediated neutrophilia in polyinosinic-polycytidylic acid-induced pneumonia.

Authors:
Chang Seok Lee Eun Hee Yi Jin-Ku Lee Cheolhee Won Young Ju Lee Min Kyung Shin Young Mok Yang Myung-Hee Chung Jung Weon Lee Sang-Hyun Sung Sang-Kyu Ye

Eur Respir J 2013 May 26;41(5):1147-56. Epub 2012 Jul 26.

Dept of Pharmacology, Seoul National University College of Medicine, Seoul, Korea.

View Article and Find Full Text PDF
May 2013

A Co(III) complex cleaving soluble oligomers of h-IAPP in the presence of polymeric aggregates of h-IAPP.

Authors:
Tae Yeon Lee Woo Suk Chei Heeyeon Ju Mi-Sook Lee Jung Weon Lee Junghun Suh

Bioorg Med Chem Lett 2012 Sep 3;22(17):5689-93. Epub 2012 Jul 3.

Department of Chemistry, Seoul National University, Seoul 151-742, Republic of Korea.

View Article and Find Full Text PDF
September 2012

Cell adhesion-dependent serine 85 phosphorylation of paxillin modulates focal adhesion formation and haptotactic migration via association with the C-terminal tail domain of talin.

Authors:
Tae Kyoung Kwak Mi-Sook Lee Jihye Ryu Yoon-Ju Choi Minkyung Kang Doyoung Jeong Jung Weon Lee

J Biol Chem 2012 Aug 2;287(33):27499-509. Epub 2012 Jul 2.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Medicinal Bioconvergence Research Center, College of Pharmacy, College of Medicine, Seoul National University, Seoul 151-742, Korea.

View Article and Find Full Text PDF
August 2012

Interaction of two translational components, lysyl-tRNA synthetase and p40/37LRP, in plasma membrane promotes laminin-dependent cell migration.

Authors:
Dae Gyu Kim Jin Woo Choi Jin Young Lee Hyerim Kim Young Sun Oh Jung Weon Lee Yu Kyung Tak Joon Myong Song Ehud Razin Seok-Hyun Yun Sunghoon Kim

FASEB J 2012 Oct 2;26(10):4142-59. Epub 2012 Jul 2.

Medicinal Bioconvergence Research Center, College of Pharmacy, World Class University Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul 151-742, Korea.

View Article and Find Full Text PDF
October 2012

Functional regulation of Slug/Snail2 is dependent on GSK-3β-mediated phosphorylation.

Authors:
Jin Young Kim Young Mee Kim Chang Hee Yang Somi K Cho Jung Weon Lee Moonjae Cho

FEBS J 2012 Aug 12;279(16):2929-39. Epub 2012 Jul 12.

Department of Biochemistry, School of Medicine, Jeju National University, South Korea.

View Article and Find Full Text PDF
August 2012

Cross-talk between TGFβ1 and EGFR signalling pathways induces TM4SF5 expression and epithelial-mesenchymal transition.

Authors:
Minkyung Kang Suyong Choi Soo-Jin Jeong Sin-Ae Lee Tae Kyoung Kwak Hyeonjung Kim Oisun Jung Mi-Sook Lee Youra Ko Jihye Ryu Yoon-Ju Choi Doyoung Jeong Hyo Jeong Lee Sang-Kyu Ye Sung-Hoon Kim Jung Weon Lee

Biochem J 2012 May;443(3):691-700

Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 110-799, Republic of Korea.

View Article and Find Full Text PDF
May 2012

ZEB2 upregulates integrin α5 expression through cooperation with Sp1 to induce invasion during epithelial-mesenchymal transition of human cancer cells.

Authors:
Eun-Hee Nam Yunhee Lee Young-Kyu Park Jung Weon Lee Semi Kim

Carcinogenesis 2012 Mar 6;33(3):563-71. Epub 2012 Jan 6.

Therapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejon 305-806, Korea.

View Article and Find Full Text PDF
March 2012

Gefitinib resistance of cancer cells correlated with TM4SF5-mediated epithelial-mesenchymal transition.

Authors:
Mi-Sook Lee Hwang-Phill Kim Tae-You Kim Jung Weon Lee

Biochim Biophys Acta 2012 Feb 9;1823(2):514-23. Epub 2011 Dec 9.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Cell Dynamics Research Center, College of Pharmacy, Seoul National University, 599, Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.

View Article and Find Full Text PDF
February 2012

Antagonistic regulation of transmembrane 4 L6 family member 5 attenuates fibrotic phenotypes in CCl(4) -treated mice.

Authors:
Minkyung Kang Soo-Jin Jeong Sook Young Park Hyo Jeong Lee Hyun Jeong Kim Ki Hun Park Sang-Kyu Ye Sung-Hoon Kim Jung Weon Lee

FEBS J 2012 Feb 9;279(4):625-35. Epub 2012 Jan 9.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Cell Dynamics Research Center, College of Pharmacy, Seoul National University, Korea.

View Article and Find Full Text PDF
February 2012

JNK signaling activity regulates cell-cell adhesions via TM4SF5-mediated p27(Kip1) phosphorylation.

Authors:
Hyeonjung Kim Oisun Jung Minkyung Kang Mi-Sook Lee Doyoung Jeong Jihye Ryu Youra Ko Yoon-Ju Choi Jung Weon Lee

Cancer Lett 2012 Jan 19;314(2):198-205. Epub 2011 Oct 19.

Department of Pharmacy, College of Pharmacy, Cell Dynamics Research Center, Seoul National University, Seoul 151-742, Republic of Korea.

View Article and Find Full Text PDF
January 2012

Proteasome inhibition causes epithelial-mesenchymal transition upon TM4SF5 expression.

Authors:
Jin Young Kim Jae Kook Nam Sin-Ae Lee Mi-Sook Lee Somi K Cho Zee-Yong Park Jung Weon Lee Moonjae Cho

J Cell Biochem 2011 Mar;112(3):782-92

Department of Biochemistry, School of Medicine, Cheju National University, Jeju 690-756, Korea.

View Article and Find Full Text PDF
March 2011

Modulation of signaling between TM4SF5 and integrins in tumor microenvironment.

Authors:
Sin-Ae Lee Ki Hun Park Jung Weon Lee

Front Biosci (Landmark Ed) 2011 Jan 1;16:1752-8. Epub 2011 Jan 1.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Korea.

View Article and Find Full Text PDF
January 2011

Janus activated kinase 2/signal transducer and activator of transcription 3 pathway mediates icariside II-induced apoptosis in U266 multiple myeloma cells.

Authors:
Sun-Hee Kim Kwang Seok Ahn Soo-Jin Jeong Tae-Rin Kwon Ji Hoon Jung Sun-Mi Yun Ihn Han Seok-Geun Lee Dae Keun Kim Minkyung Kang Chang-Yan Chen Jung Weon Lee Sung-Hoon Kim

Eur J Pharmacol 2011 Mar 21;654(1):10-6. Epub 2010 Dec 21.

Cancer Preventive Material, Development Research Center, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul, South Korea.

View Article and Find Full Text PDF
March 2011

Differential inhibition of transmembrane 4 L six family member 5 (TM4SF5)-mediated tumorigenesis by TSAHC and sorafenib.

Authors:
Sin-Ae Lee Mi-Sook Lee Hyung Won Ryu Tae Kyoung Kwak Hyeonjung Kim Minkyung Kang Oisun Jung Hyun Jeong Kim Ki Hun Park Jung Weon Lee

Cancer Biol Ther 2011 Feb 1;11(3):330-6. Epub 2011 Feb 1.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Medicine, Seoul National University, Seoul, Korea.

View Article and Find Full Text PDF
February 2011

Glucosamine treatment-mediated O-GlcNAc modification of paxillin depends on adhesion state of rat insulinoma INS-1 cells.

Authors:
Tae Kyoung Kwak Hyeonjung Kim Oisun Jung Sin-Ae Lee Minkyung Kang Hyun Jeong Kim Ji-Min Park Sung-Hoon Kim Jung Weon Lee

J Biol Chem 2010 Nov 9;285(46):36021-31. Epub 2010 Sep 9.

Cancer Research Institute, Department of Tumor Biology, School of Dentistry, Seoul National University, Seoul 110-799.

View Article and Find Full Text PDF
November 2010

Transmembrane 4 L six family member 5 (TM4SF5) enhances migration and invasion of hepatocytes for effective metastasis.

Authors:
Sin-Ae Lee Tae You Kim Tae Kyoung Kwak Hyeonjung Kim Semi Kim Hyo Jeong Lee Sung-Hoon Kim Ki Hun Park Hyun Jeong Kim Moonjae Cho Jung Weon Lee

J Cell Biochem 2010 Sep;111(1):59-66

Cancer Research Institute, Seoul National University, Seoul 110-799, Korea.

View Article and Find Full Text PDF
September 2010

TM4SF5 accelerates G1/S phase progression via cytosolic p27Kip1 expression and RhoA activity.

Authors:
Hyeonjung Kim Minkyung Kang Sin-Ae Lee Tae Kyoung Kwak Oisun Jung Hyo Jeong Lee Sung-Hoon Kim Jung Weon Lee

Biochim Biophys Acta 2010 Aug 22;1803(8):975-82. Epub 2010 Apr 22.

Department of Tumor Biology, Cancer Research Institute, Cell Dynamics Research Center, College of Medicine, Seoul National University, Seoul 151-742, Republic of Korea.

View Article and Find Full Text PDF
August 2010

TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin alpha5 and its signaling pathways.

Authors:
Semi Kim Hee Young Kang Eun-Hee Nam Myung-Sook Choi Xue-Feng Zhao Chang Soo Hong Jung Weon Lee Jae Hyuk Lee Young-Kyu Park

Carcinogenesis 2010 Apr 29;31(4):597-606. Epub 2010 Jan 29.

Therapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejon 305-806, Korea.

View Article and Find Full Text PDF
April 2010

The extracellular loop 2 of TM4SF5 inhibits integrin alpha2 on hepatocytes under collagen type I environment.

Authors:
Sin-Ae Lee Young Mee Kim Tae Kyoung Kwak Hyeon Jung Kim Semi Kim Wonil Ko Sung-Hoon Kim Ki Hun Park Hyun Jeong Kim Moonjae Cho Jung Weon Lee

Carcinogenesis 2009 Nov 29;30(11):1872-9. Epub 2009 Sep 29.

Cancer Research Institute, College of Medicine, Cell Dynamics Research Center, Seoul, Korea.

View Article and Find Full Text PDF
November 2009

Syndecan-2 overexpression regulates adhesion and migration through cooperation with integrin alpha2.

Authors:
Sojoong Choi Yeonhee Kim Haein Park Inn-Oc Han Eunkyung Chung Sung-Yul Lee Yong-Bae Kim Jung Weon Lee Eok-Soo Oh Jae Youn Yi

Biochem Biophys Res Commun 2009 Jun 24;384(2):231-5. Epub 2009 Apr 24.

Department of Life Sciences, Division of Life and Pharmaceutical Sciences and the Center for Cell Signaling & Drug Discovery Research, Ewha Womans University, Seoul 120-750, Republic of Korea.

View Article and Find Full Text PDF
June 2009

Specific tyrosine phosphorylation of focal adhesion kinase mediated by Fer tyrosine kinase in suspended hepatocytes.

Authors:
Min-A Oh Suyong Choi Mi Ji Lee Moon-Chang Choi Sin-Ae Lee Wonil Ko William G Cance Eok-Soo Oh Laszlo Buday Sung-Hoon Kim Jung Weon Lee

Biochim Biophys Acta 2009 May 5;1793(5):781-91. Epub 2009 Feb 5.

Cancer Research Institute, Cell Dynamics Research Center, Department of Tumor Biology, College of Medicine, Seoul National University, 101, Daehangro, Jongno-gu, Seoul 110-799, Republic of Korea.

View Article and Find Full Text PDF
May 2009

Cholesterol depletion induces anoikis-like apoptosis via FAK down-regulation and caveolae internalization.

Authors:
Eun-Kyung Park Mi Jung Park Seong-Hee Lee Ying Chun Li Jungeun Kim Jae-Seon Lee Jung Weon Lee Sang-Kyu Ye Jong-Wan Park Chul-Woo Kim Byung-Kiu Park Yong-Nyun Kim

J Pathol 2009 Jul;218(3):337-49

National Cancer Centre, Madu 1-dong, Ilsan-gu Goyang-si, Gyeonggi-do, Korea.

View Article and Find Full Text PDF
July 2009

Blockade of four-transmembrane L6 family member 5 (TM4SF5)-mediated tumorigenicity in hepatocytes by a synthetic chalcone derivative.

Authors:
Sin-Ae Lee Hyung Won Ryu Young Mee Kim Suyong Choi Mi Ji Lee Tae Kyoung Kwak Hyeon Jung Kim Moonjae Cho Ki Hun Park Jung Weon Lee

Hepatology 2009 Apr;49(4):1316-25

Cancer Research Institute, College of Medicine, Cell Dynamics Research Center, Seoul National University, Seoul, Korea.

View Article and Find Full Text PDF
April 2009

Transcriptional induction of DLC-1 gene through Sp1 sites by histone deacetylase inhibitors in gastric cancer cells.

Authors:
Tai Young Kim In Sook Kim Hyun Soon Jong Jung Weon Lee Tae You Kim Mira Jung Yung Jue Bang

Exp Mol Med 2008 Dec;40(6):639-46

National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Seoul National University College of MedicineSeoul 110-744, Korea.

View Article and Find Full Text PDF
December 2008

Cooperation between integrin alpha5 and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity.

Authors:
Suyong Choi Sin-Ae Lee Tae Kyoung Kwak Hyeon Jung Kim Mi Ji Lee Sang-Kyu Ye Sung-Hoon Kim Semi Kim Jung Weon Lee

Blood 2009 Feb 25;113(8):1845-55. Epub 2008 Nov 25.

Cancer Research Institute, Cell Dynamics Research Center, College of Medicine, Seoul National University, Seoul, South Korea.

View Article and Find Full Text PDF
February 2009

LYR71, a derivative of trimeric resveratrol, inhibits tumorigenesis by blocking STAT3-mediated matrix metalloproteinase 9 expression.

Authors:
Ja Eun Kim Hong Sook Kim Yong Jae Shin Chang Seok Lee Cheolhee Won Sin Ae Lee Jung Weon Lee Youngsoo Kim Jae Seung Kang Sang Kyu Ye Myung Hee Chung

Exp Mol Med 2008 Oct;40(5):514-22

Department of Pharmacology, Seoul National University College of Medicine, Seoul 110-799, Korea.

View Article and Find Full Text PDF
October 2008

Ethyl pyruvate has an anti-inflammatory effect by inhibiting ROS-dependent STAT signaling in activated microglia.

Authors:
Hong Sook Kim Ik Hyun Cho Ja Eun Kim Yong Jae Shin Ju-Hong Jeon Youngsoo Kim Young Mok Yang Kwang-Ho Lee Jung Weon Lee Wang-Jae Lee Sang-Kyu Ye Myung-Hee Chung

Free Radic Biol Med 2008 Oct 16;45(7):950-63. Epub 2008 Jun 16.

Department of Pharmacology, Seoul National University College of Medicine, Yongon-dong 28, Chungno-gu, Seoul 110-799, Korea.

View Article and Find Full Text PDF
October 2008

O-GlcNAc modulation at Akt1 Ser473 correlates with apoptosis of murine pancreatic beta cells.

Authors:
Eun-Sil Kang Dohyun Han Jungeun Park Tae Kyoung Kwak Min-A Oh Sin-Ae Lee Suyong Choi Zee Yong Park Youngsoo Kim Jung Weon Lee

Exp Cell Res 2008 Jul 9;314(11-12):2238-48. Epub 2008 May 9.

Cancer Research Institute, College of Medicine, Seoul National University, 103, Daehangno, Jongno-gu, Seoul 110-799, Korea.

View Article and Find Full Text PDF
July 2008

Regulation of TM4SF5-mediated tumorigenesis through induction of cell detachment and death by tiarellic acid.

Authors:
Suyong Choi Sei-Ryang Oh Sin-Ae Lee Sung-Yul Lee Kyungseop Ahn Hyeong-Kyu Lee Jung Weon Lee

Biochim Biophys Acta 2008 Sep 30;1783(9):1632-41. Epub 2008 Apr 30.

Cancer Research Institute, College of Medicine, Seoul National University, Seoul 110-799, Korea.

View Article and Find Full Text PDF
September 2008

HSP27 regulates cell adhesion and invasion via modulation of focal adhesion kinase and MMP-2 expression.

Authors:
Joong-Won Lee Hee-Jin Kwak Je-Jung Lee Yong-Nyun Kim Jung Weon Lee Myung-Jin Park Seung Eun Jung Seok-Il Hong Jeong-Hwa Lee Jae-Seon Lee

Eur J Cell Biol 2008 Jun 9;87(6):377-87. Epub 2008 May 9.

Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.

View Article and Find Full Text PDF
June 2008

Tetraspanin TM4SF5 mediates loss of contact inhibition through epithelial-mesenchymal transition in human hepatocarcinoma.

Authors:
Sin-Ae Lee Sung-Yul Lee Ik-Hyun Cho Min-A Oh Eun-Sil Kang Yong-Bae Kim Woo Duck Seo Suyong Choi Ju-Ock Nam Mimi Tamamori-Adachi Shigetaka Kitajima Sang-Kyu Ye Semi Kim Yoon-Jin Hwang In-San Kim Ki Hun Park Jung Weon Lee

J Clin Invest 2008 Apr;118(4):1354-66

Cancer Research Institute, College of Medicine, Seoul National University, Jongno-gu, Seoul, Republic of Korea.

View Article and Find Full Text PDF
April 2008

Cell adhesion-dependent cofilin serine 3 phosphorylation by the integrin-linked kinase.c-Src complex.

Authors:
Yong-Bae Kim Suyong Choi Moon-Chang Choi Min-A Oh Sin-Ae Lee Moonjae Cho Kensaku Mizuno Sung-Hoon Kim Jung Weon Lee

J Biol Chem 2008 Apr 5;283(15):10089-96. Epub 2008 Feb 5.

Department of Tumor Biology, Cancer Research Institute, Cell Dynamics Research Center, College of Medicine, Seoul National University, Seoul 110-799, Korea.

View Article and Find Full Text PDF
April 2008

C6 glioma cell insoluble matrix components enhance interferon-gamma-stimulated inducible nitric-oxide synthase/nitric oxide production in BV2 microglial cells.

Authors:
Yoon-Jung Kim So-Young Hwang Ji-Sun Hwang Jung-Weon Lee Eok-Soo Oh Inn-Oc Han

J Biol Chem 2008 Feb 2;283(5):2526-33. Epub 2007 Nov 2.

Department of Physiology and Biophysics, Inha University, College of Medicine, 253 Yonghyun-Dong, Nam-Ku, Incheon, Republic of Korea.

View Article and Find Full Text PDF
February 2008

Development of 3-D nanofibrous fibroin scaffold with high porosity by electrospinning: implications for bone regeneration.

Authors:
Chang Seok Ki Sook Young Park Hyun Jeong Kim Hong-Moon Jung Kyung Mi Woo Jung Weon Lee Young Hwan Park

Biotechnol Lett 2008 Mar 1;30(3):405-10. Epub 2007 Nov 1.

Department of Biosystems and Biomaterials Science and Engineering, Seoul National University, Seoul, Republic of Korea.

View Article and Find Full Text PDF
March 2008

PKCdelta and cofilin activation affects peripheral actin reorganization and cell-cell contact in cells expressing integrin alpha5 but not its tailless mutant.

Authors:
Min-A Oh Eun-Sil Kang Sin-Ae Lee Eun-Ok Lee Yong-Bae Kim Sung-Hoon Kim Jung Weon Lee

J Cell Sci 2007 Aug;120(Pt 15):2717-30

Cancer Research Institute, College of Medicine, Seoul National University, 28, Yeongeon-dong, Jongno-gu, Seoul 110-799, Korea.

View Article and Find Full Text PDF
August 2007

Caffeic acid and its synthetic derivative CADPE suppress tumor angiogenesis by blocking STAT3-mediated VEGF expression in human renal carcinoma cells.

Authors:
Joo Eun Jung Hong Sook Kim Chang Seok Lee Dae-Hun Park Yong-Nyun Kim Min-Jae Lee Jung Weon Lee Jong-Wan Park Myung-Suk Kim Sang Kyu Ye Myung-Hee Chung

Carcinogenesis 2007 Aug 8;28(8):1780-7. Epub 2007 Jun 8.

Department of Pharmacology, College of Medicine, Seoul National University, Seoul 110-799, Korea.

View Article and Find Full Text PDF
August 2007

EGFR phosphorylation-dependent formation of cell-cell contacts by Ras/Erks cascade inhibition.

Authors:
Eun-Sil Kang Min-A Oh Sin-Ae Lee Tae Young Kim Sung-Hoon Kim Noriko Gotoh Yong-Nyun Kim Jung Weon Lee

Biochim Biophys Acta 2007 Jun 17;1773(6):833-43. Epub 2007 Feb 17.

Cancer Research Institute, Department of Molecular and Clinical Oncology, College of Medicine, Seoul National University, 28, Yeongeon-dong, Jongno-gu, Seoul 110-799, South Korea.

View Article and Find Full Text PDF
June 2007

DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma.

Authors:
Tai Young Kim Jung Weon Lee Hwang-Phill Kim Hyun-Soon Jong Tae-You Kim Mira Jung Yung-Jue Bang

Biochem Biophys Res Commun 2007 Mar 30;355(1):72-7. Epub 2007 Jan 30.

National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-744, Republic of Korea.

View Article and Find Full Text PDF
March 2007

8-hydroxydeoxyguanosine suppresses NO production and COX-2 activity via Rac1/STATs signaling in LPS-induced brain microglia.

Authors:
Hong Sook Kim Sang-Kyu Ye Ik Hyun Cho Joo Eun Jung Dong-Hyun Kim Seongwon Choi Yong-Sik Kim Chung-Gyu Park Tae-Yoon Kim Jung Weon Lee Myung-Hee Chung

Free Radic Biol Med 2006 Nov 27;41(9):1392-403. Epub 2006 Jul 27.

Department of Pharmacology, Seoul National University College of Medicine, Chungno-gu, Seoul 110-799, Korea.

View Article and Find Full Text PDF
November 2006

Epigenetic regulation of integrin-linked kinase expression depending on adhesion of gastric carcinoma cells.

Authors:
Yong-Bae Kim Sung-Yul Lee Sang-Kyu Ye Jung Weon Lee

Am J Physiol Cell Physiol 2007 Feb 20;292(2):C857-66. Epub 2006 Sep 20.

Cancer Research Institute, Depts. of Tumor Biology and Molecular and Clinical Oncology, College of Medicine, Seoul National Univ., Seoul 110-799, Korea.

View Article and Find Full Text PDF
February 2007

Focal adhesion and actin organization by a cross-talk of TM4SF5 with integrin alpha2 are regulated by serum treatment.

Authors:
Sung-Yul Lee Young Tai Kim Mi-Sook Lee Yong-Bae Kim Eunji Chung Semi Kim Jung Weon Lee

Exp Cell Res 2006 Oct 7;312(16):2983-99. Epub 2006 Jun 7.

Cancer Research Institute, Department of Molecular and Clinical Oncology, College of Medicine, Seoul National University, 28, Yeongeon-dong, Jongno-gu, Seoul 110-799, Korea.

View Article and Find Full Text PDF
October 2006

Integrin signaling and cell spreading mediated by phorbol 12-myristate 13-acetate treatment.

Authors:
Mi-Sook Lee Yong-Bae Kim Sung-Yul Lee Jeong-Geun Kim Sung-Hoon Kim Sang-Kyu Ye Jung Weon Lee

J Cell Biochem 2006 Sep;99(1):88-95

Department of Molecular and Clinical Oncology, Cancer Research Institute, College of Medicine, Seoul National University, 28 Yeongeon-dong, Jongno-gu, Seoul 110-799, Korea.

View Article and Find Full Text PDF
September 2006

The signaling network of transforming growth factor beta1, protein kinase Cdelta, and integrin underlies the spreading and invasiveness of gastric carcinoma cells.

Authors:
Mi-Sook Lee Tae Young Kim Yong-Bae Kim Sung-Yul Lee Seong-Gyu Ko Hyun-Soon Jong Tae-You Kim Yung-Jue Bang Jung Weon Lee

Mol Cell Biol 2005 Aug;25(16):6921-36

Cancer Research Institute, College of Medicine, Seoul National University, Republic of Korea.

View Article and Find Full Text PDF
August 2005

Cell adhesion status-dependent histone acetylation is regulated through intracellular contractility-related signaling activities.

Authors:
Yong-Bae Kim Jiyon Yu Sung-Yul Lee Mi-Sook Lee Seong-Gyu Ko Sang-Kyu Ye Hyun-Soon Jong Tae-You Kim Yung-Jue Bang Jung Weon Lee

J Biol Chem 2005 Aug 16;280(31):28357-64. Epub 2005 Jun 16.

Cancer Research Institute, Department of Tumor Biology, College of Medicine, Seoul National University, 28, Yeongeon-dong, Jongno-gu, Seoul 110-799, Korea.

View Article and Find Full Text PDF
August 2005

STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells.

Authors:
Joo Eun Jung Hyun Gyu Lee Ik Hyun Cho Doo Hyun Chung Sun-Hee Yoon Young Mok Yang Jung Weon Lee Seongwon Choi Jong-Wan Park Sang-Kyu Ye Myung-Hee Chung

FASEB J 2005 Aug 26;19(10):1296-8. Epub 2005 May 26.

Department of Pharmacology, Seoul National University College of Medicine, Chongno-gu, Seoul, Korea.

View Article and Find Full Text PDF
August 2005

TGF-beta1-mediated activations of c-Src and Rac1 modulate levels of cyclins and p27(Kip1) CDK inhibitor in hepatoma cells replated on fibronectin.

Authors:
Hwang-Phill Kim Tai-Young Kim Mi-Sook Lee Hyun-Soon Jong Tae-You Kim Jung Weon Lee Yung-Jue Bang

Biochim Biophys Acta 2005 Mar;1743(1-2):151-61

National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Department of Tumor Biology, College of Medicine, Seoul National University, Seoul 110-799, South Korea.

View Article and Find Full Text PDF
March 2005

Cyclooxygenase-2 inhibits novel ginseng metabolite-mediated apoptosis.

Authors:
Hyung Woo Yim Hyun-Soon Jong Tai Young Kim Hyun Ho Choi Sang Gyun Kim Sang Hyun Song Juyong Kim Seong-Gyu Ko Jung Weon Lee Tae-You Kim Yung-Jue Bang

Cancer Res 2005 Mar;65(5):1952-60

National Research Laboratory for Cancer Epigenetics, Cancer Research Institute and Department of Internal Medicine, Seoul National University College of Medicine, Chongno, Seoul, Republic of Korea.

View Article and Find Full Text PDF
March 2005

Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells.

Authors:
Seong Gyu Ko Hwang-Phill Kim Dong-Hoon Jin Hyun-Su Bae Sung Hoon Kim Chong-Hyeong Park Jung Weon Lee

Cancer Lett 2005 Mar;220(1):11-9

Cancer Research Institute, Department of Tumor Biology, College of Medicine, Seoul National University, Seoul 110-799, South Korea.

View Article and Find Full Text PDF
March 2005

Ras-dependent induction of HIF-1alpha785 via the Raf/MEK/ERK pathway: a novel mechanism of Ras-mediated tumor promotion.

Authors:
Ji-Hong Lim Eun-Seo Lee Ho-Jin You Jung Weon Lee Jong-Wan Park Yang-Sook Chun

Oncogene 2004 Dec;23(58):9427-31

Human Genome Research Institute and Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-799, Korea.

View Article and Find Full Text PDF
December 2004

Class I histone deacetylase-selective novel synthetic inhibitors potently inhibit human tumor proliferation.

Authors:
Jung-Hyun Park Yeonjoo Jung Tai Young Kim Sang Gyun Kim Hyun-Soon Jong Jung Weon Lee Dae-Kee Kim Jong-Soo Lee Noe Kyeong Kim Tae-You Kim Yung-Jue Bang

Clin Cancer Res 2004 Aug;10(15):5271-81

National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.

View Article and Find Full Text PDF
August 2004

Morphological adjustment of senescent cells by modulating caveolin-1 status.

Authors:
Kyung A Cho Sung Jin Ryu Yoon Sin Oh Ji Hyeun Park Jung Weon Lee Hwang-Phill Kim Kyung Tae Kim Ik Soon Jang Sang Chul Park

J Biol Chem 2004 Oct 19;279(40):42270-8. Epub 2004 Jul 19.

Department of Biochemistry and Molecular Biology, Aging and Apoptosis Research Center, National University College of Medicine, Seoul, Korea.

View Article and Find Full Text PDF
October 2004

AKAP12/Gravin is inactivated by epigenetic mechanism in human gastric carcinoma and shows growth suppressor activity.

Authors:
Moon-Chang Choi Hyun-Soon Jong Tai Young Kim Sang-Hyun Song Dong Soon Lee Jung Weon Lee Tae-You Kim Noe Kyeong Kim Yung-Jue Bang

Oncogene 2004 Sep;23(42):7095-103

National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon-dong, Chongro-gu, Seoul 110-799, Korea.

View Article and Find Full Text PDF
September 2004

Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.

Authors:
Jung Weon Lee Rudy Juliano

Mol Cells 2004 Apr;17(2):188-202

Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

View Article and Find Full Text PDF
April 2004

Smad2 mediates Erk1/2 activation by TGF-beta1 in suspended, but not in adherent, gastric carcinoma cells.

Authors:
Mi-Sook Lee Seong-Gyu Ko Hwang-Phill Kim Yong-Bae Kim Sung-Yul Lee Sang-Gyun Kim Hyun-Soon Jong Tae-You Kim Jung Weon Lee Yung-Jue Bang

Int J Oncol 2004 May;24(5):1229-34

National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Department of Tumor Biology, College of Medicine, Seoul National University, Seoul 110-799, Korea.

View Article and Find Full Text PDF
May 2004

Aberrant methylation of integrin alpha4 gene in human gastric cancer cells.

Authors:
Jinah Park Sang-Hyun Song Tai Young Kim Moon-Chang Choi Hyun-Soon Jong Tae-You Kim Jung Weon Lee Noe Kyeong Kim Woo-Ho Kim Yung-Jue Bang

Oncogene 2004 Apr;23(19):3474-80

National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-744, Korea.

View Article and Find Full Text PDF
April 2004

Cdc42-dependent mediation of UV-induced p38 activation by G protein betagamma subunits.

Authors:
MiRan Seo Chin-Ho Cho Yun-Il Lee Eun-Young Shin Dongeun Park Chang-Dae Bae Jung Weon Lee Eun-So Lee Yong-Sung Juhnn

J Biol Chem 2004 Apr 17;279(17):17366-75. Epub 2004 Feb 17.

Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 110-799, Korea.

View Article and Find Full Text PDF
April 2004