Publications by authors named "Jung Weon Lee"

100Publications

Metastatic behavior analyses of tetraspanin TM4SF5-expressing spheres in three-dimensional (3D) cell culture environment.

Arch Pharm Res 2020 Nov 21;43(11):1162-1172. Epub 2020 Nov 21.

Department of Pharmacy, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 08826, Korea.

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November 2020

Differential TM4SF5-mediated SIRT1 modulation and metabolic signaling in nonalcoholic steatohepatitis progression.

J Pathol 2021 Jan 22;253(1):55-67. Epub 2020 Oct 22.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Republic of Korea.

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January 2021

Amino acid transporters as tetraspanin TM4SF5 binding partners.

Exp Mol Med 2020 01 20;52(1):7-14. Epub 2020 Jan 20.

Interdisciplinary Program in Genetic Engineering, Seoul National University, Seoul, 08826, Republic of Korea.

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January 2020

TM4SF5-mediated CD44v8-10 splicing variant promotes survival of type II alveolar epithelial cells during idiopathic pulmonary fibrosis.

Cell Death Dis 2019 09 9;10(9):645. Epub 2019 Sep 9.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.

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September 2019

Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling.

Cell Metab 2019 06 4;29(6):1306-1319.e7. Epub 2019 Apr 4.

Interdisciplinary Program in Genetic Engineering, Seoul National University, Seoul 08826, South Korea; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, South Korea. Electronic address:

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June 2019

Glutamyl-prolyl-tRNA synthetase induces fibrotic extracellular matrix via both transcriptional and translational mechanisms.

FASEB J 2019 03 28;33(3):4341-4354. Epub 2018 Dec 28.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea.

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March 2019

Glutamyl-Prolyl-tRNA Synthetase Regulates Epithelial Expression of Mesenchymal Markers and Extracellular Matrix Proteins: Implications for Idiopathic Pulmonary Fibrosis.

Front Pharmacol 2018 20;9:1337. Epub 2018 Nov 20.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea.

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November 2018

CD133-induced TM4SF5 expression promotes sphere growth via recruitment and blocking of protein tyrosine phosphatase receptor type F (PTPRF).

Cancer Lett 2018 12 11;438:219-231. Epub 2018 Sep 11.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea; Interdisciplinary Program in Genetic Engineering, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:

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December 2018

TM4SF5 promotes metastatic behavior of cells in 3D extracellular matrix gels by reducing dependency on environmental cues.

Oncotarget 2017 Oct 7;8(48):83480-83494. Epub 2017 May 7.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, 08826 Seoul, Korea.

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October 2017

TM4SF5-Mediated Roles in the Development of Fibrotic Phenotypes.

Mediators Inflamm 2017 26;2017:5108525. Epub 2017 Mar 26.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Tumor Microenvironment Global Core Research Center, Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.

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March 2018

Anti-cancer Activity of Novel TM4SF5-Targeting Antibodies through TM4SF5 Neutralization and Immune Cell-Mediated Cytotoxicity.

Theranostics 2017 11;7(3):594-613. Epub 2017 Jan 11.

Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejon, Korea;; Department of Functional Genomics, Korea University of Science and Technology, Daejon, Korea.

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October 2017

Differential regulation of cellular functions by the C-termini of transmembrane 4 L six family proteins in 2- or 3-dimensional environment.

Oncotarget 2017 Feb;8(8):13277-13292

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.

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February 2017

Function of membranous lysyl-tRNA synthetase and its implication for tumorigenesis.

Biochim Biophys Acta 2016 12 20;1864(12):1707-1713. Epub 2016 Sep 20.

Medicinal Bioconvergence Research Center, Seoul National University, Seoul 08826, Republic of Korea; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.

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December 2016

Suppression of lysyl-tRNA synthetase, KRS, causes incomplete epithelial-mesenchymal transition and ineffective cell‑extracellular matrix adhesion for migration.

Int J Oncol 2016 Apr 8;48(4):1553-60. Epub 2016 Feb 8.

Interdisciplinary Program in Genetic Engineering, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.

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April 2016

Potential role of 8-oxoguanine DNA glycosylase 1 as a STAT1 coactivator in endotoxin-induced inflammatory response.

Free Radic Biol Med 2016 Apr 11;93:12-22. Epub 2015 Nov 11.

Department of Pharmacology, Seoul National University College of Medicine, Seoul, Republic of Korea; Biomedical Science Project (BK21PLUS), Seoul National University College of Medicine, Seoul, Republic of Korea; Neuro-Immune Information Storage Network Research Center, Seoul National University College of Medicine, Republic of Korea; Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

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April 2016

Transmembrane 4 L Six Family Member 5 (TM4SF5)-Mediated Epithelial-Mesenchymal Transition in Liver Diseases.

Authors:
Jung Weon Lee

Int Rev Cell Mol Biol 2015 20;319:141-63. Epub 2015 Jul 20.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Tumor Microenvironment Global Core Research Center, Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Seoul, Korea. Electronic address:

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April 2016

Bidirectional signaling between TM4SF5 and IGF1R promotes resistance to EGFR kinase inhibitors.

Lung Cancer 2015 Oct 2;90(1):22-31. Epub 2015 Jul 2.

Interdisciplinary Program in Genetic Engineering, Seoul National University, Seoul 151-742, Republic of Korea; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea. Electronic address:

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October 2015

Self-renewal and circulating capacities of metastatic hepatocarcinoma cells required for collaboration between TM4SF5 and CD44.

BMB Rep 2015 Mar;48(3):127-8

Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 151-742, Korea.

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March 2015

Twist1 and AP-1 cooperatively upregulate integrin α5 expression to induce invasion and the epithelial-mesenchymal transition.

Carcinogenesis 2015 Mar 18;36(3):327-37. Epub 2015 Jan 18.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejon, Korea, Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejon, Korea, Department of Functional Genomics, Korea University of Science and Technology, Daejon, Korea and

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March 2015

Correlations between transmembrane 4 L6 family member 5 (TM4SF5), CD151, and CD63 in liver fibrotic phenotypes and hepatic migration and invasive capacities.

PLoS One 2014 17;9(7):e102817. Epub 2014 Jul 17.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Medicinal Bioconvergence Research Center, Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul, Republic of Korea; Interdisciplinary Program in Genetic Engineering, Seoul National University, Seoul, Republic of Korea.

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November 2015

TM4SF5-mediated protein-protein networks and tumorigenic roles.

Authors:
Jung Weon Lee

BMB Rep 2014 Sep;47(9):483-7

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Tumor Microenvironment Global Core Research Center, Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Seoul 151-742, Korea.

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September 2014

Cross talk between the TM4SF5/focal adhesion kinase and the interleukin-6/STAT3 pathways promotes immune escape of human liver cancer cells.

Mol Cell Biol 2014 Aug 9;34(16):2946-60. Epub 2014 Jun 9.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Tumor Microenvironment Global Core Research Center, Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Seoul, Republic of Korea Interdisciplinary Program in Genetic Engineering, Seoul National University, Seoul, Republic of Korea

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August 2014

TM4SF5 suppression disturbs integrin α5-related signalling and muscle development in zebrafish.

Biochem J 2014 Aug;462(1):89-101

*Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Tumor Microenvironment Global Core Research Center, Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea.

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August 2014

Snail1 induced in breast cancer cells in 3D collagen I gel environment suppresses cortactin and impairs effective invadopodia formation.

Biochim Biophys Acta 2014 Sep 24;1843(9):2037-54. Epub 2014 May 24.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Tumor Microenvironment Global Core Research Center, Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Republic of Korea; Interdisciplinary Program in Genetic Engineering, Seoul National University, Republic of Korea. Electronic address:

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September 2014

Membrane Proteins Involved in Epithelial-Mesenchymal Transition and Tumor Invasion: Studies on TMPRSS4 and TM4SF5.

Genomics Inform 2014 Mar 31;12(1):12-20. Epub 2014 Mar 31.

Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 151-742, Korea.

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March 2014

TMPRSS4 induces cancer cell invasion through pro-uPA processing.

Biochem Biophys Res Commun 2014 Mar 14;446(1):1-7. Epub 2014 Jan 14.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejon, Republic of Korea. Electronic address:

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March 2014

Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction.

Nat Chem Biol 2014 Jan 10;10(1):29-34. Epub 2013 Nov 10.

1] Medicinal Bioconvergence Research Center, Seoul National University, Seoul, Korea. [2] Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Korea. [3] World Class University Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Korea.

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January 2014

ZEB2-Sp1 cooperation induces invasion by upregulating cadherin-11 and integrin α5 expression.

Carcinogenesis 2014 Feb 15;35(2):302-14. Epub 2013 Oct 15.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejon 305-806, Korea.

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February 2014

Combating resistance to anti-IGFR antibody by targeting the integrin β3-Src pathway.

J Natl Cancer Inst 2013 Oct 3;105(20):1558-70. Epub 2013 Oct 3.

Affiliations of authors: Department of Thoracic/Head and Neck Medical Oncology (DHS, SPC, FMJ, SML, BSG) and Department of Experimental Therapeutics (KM), The University of Texas MD Anderson Cancer Center, Houston, TX; College of Pharmacy, Inje University, Gimhae, Gyungnam, Republic of Korea (H-JL); College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea (H-YM, M-SL, JWL, H-YL).

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October 2013

TMPRSS4 upregulates uPA gene expression through JNK signaling activation to induce cancer cell invasion.

Cell Signal 2014 Feb 24;26(2):398-408. Epub 2013 Aug 24.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Republic of Korea; Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea. Electronic address:

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February 2014

The COOH-terminus of TM4SF5 in hepatoma cell lines regulates c-Src to form invasive protrusions via EGFR Tyr845 phosphorylation.

Biochim Biophys Acta 2013 Mar 6;1833(3):629-42. Epub 2012 Dec 6.

Interdisciplinary Program in Genetic Engineering, Seoul National University, Seoul 151-742, Republic of Korea.

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March 2013

Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells.

J Cell Sci 2012 Dec 17;125(Pt 24):5960-73. Epub 2012 Oct 17.

Interdisciplinary Program in Genetic Engineering, Research Institute of Pharmaceutical Sciences, Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Seoul 151-742, Korea (Republic of).

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December 2012

STAT3-RANTES autocrine signaling is essential for tamoxifen resistance in human breast cancer cells.

Mol Cancer Res 2013 Jan 16;11(1):31-42. Epub 2012 Oct 16.

Department of Pharmacology, Seoul National University College of Medicine, 103 Daehangno, Jongno-gu, Seoul 110-799, Korea.

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January 2013

A Co(III) complex cleaving soluble oligomers of h-IAPP in the presence of polymeric aggregates of h-IAPP.

Bioorg Med Chem Lett 2012 Sep 3;22(17):5689-93. Epub 2012 Jul 3.

Department of Chemistry, Seoul National University, Seoul 151-742, Republic of Korea.

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September 2012

Cell adhesion-dependent serine 85 phosphorylation of paxillin modulates focal adhesion formation and haptotactic migration via association with the C-terminal tail domain of talin.

J Biol Chem 2012 Aug 2;287(33):27499-509. Epub 2012 Jul 2.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Medicinal Bioconvergence Research Center, College of Pharmacy, College of Medicine, Seoul National University, Seoul 151-742, Korea.

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August 2012

Interaction of two translational components, lysyl-tRNA synthetase and p40/37LRP, in plasma membrane promotes laminin-dependent cell migration.

FASEB J 2012 Oct 2;26(10):4142-59. Epub 2012 Jul 2.

Medicinal Bioconvergence Research Center, College of Pharmacy, World Class University Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul 151-742, Korea.

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October 2012

Functional regulation of Slug/Snail2 is dependent on GSK-3β-mediated phosphorylation.

FEBS J 2012 Aug 12;279(16):2929-39. Epub 2012 Jul 12.

Department of Biochemistry, School of Medicine, Jeju National University, South Korea.

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August 2012

ZEB2 upregulates integrin α5 expression through cooperation with Sp1 to induce invasion during epithelial-mesenchymal transition of human cancer cells.

Carcinogenesis 2012 Mar 6;33(3):563-71. Epub 2012 Jan 6.

Therapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejon 305-806, Korea.

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March 2012

Gefitinib resistance of cancer cells correlated with TM4SF5-mediated epithelial-mesenchymal transition.

Biochim Biophys Acta 2012 Feb 9;1823(2):514-23. Epub 2011 Dec 9.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Cell Dynamics Research Center, College of Pharmacy, Seoul National University, 599, Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.

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February 2012

Antagonistic regulation of transmembrane 4 L6 family member 5 attenuates fibrotic phenotypes in CCl(4) -treated mice.

FEBS J 2012 Feb 9;279(4):625-35. Epub 2012 Jan 9.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Cell Dynamics Research Center, College of Pharmacy, Seoul National University, Korea.

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February 2012

JNK signaling activity regulates cell-cell adhesions via TM4SF5-mediated p27(Kip1) phosphorylation.

Cancer Lett 2012 Jan 19;314(2):198-205. Epub 2011 Oct 19.

Department of Pharmacy, College of Pharmacy, Cell Dynamics Research Center, Seoul National University, Seoul 151-742, Republic of Korea.

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January 2012

Proteasome inhibition causes epithelial-mesenchymal transition upon TM4SF5 expression.

J Cell Biochem 2011 Mar;112(3):782-92

Department of Biochemistry, School of Medicine, Cheju National University, Jeju 690-756, Korea.

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March 2011

Modulation of signaling between TM4SF5 and integrins in tumor microenvironment.

Front Biosci (Landmark Ed) 2011 Jan 1;16:1752-8. Epub 2011 Jan 1.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Korea.

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January 2011

Janus activated kinase 2/signal transducer and activator of transcription 3 pathway mediates icariside II-induced apoptosis in U266 multiple myeloma cells.

Eur J Pharmacol 2011 Mar 21;654(1):10-6. Epub 2010 Dec 21.

Cancer Preventive Material, Development Research Center, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul, South Korea.

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March 2011

Differential inhibition of transmembrane 4 L six family member 5 (TM4SF5)-mediated tumorigenesis by TSAHC and sorafenib.

Cancer Biol Ther 2011 Feb 1;11(3):330-6. Epub 2011 Feb 1.

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Medicine, Seoul National University, Seoul, Korea.

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February 2011

Glucosamine treatment-mediated O-GlcNAc modification of paxillin depends on adhesion state of rat insulinoma INS-1 cells.

J Biol Chem 2010 Nov 9;285(46):36021-31. Epub 2010 Sep 9.

Cancer Research Institute, Department of Tumor Biology, School of Dentistry, Seoul National University, Seoul 110-799.

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November 2010

TM4SF5 accelerates G1/S phase progression via cytosolic p27Kip1 expression and RhoA activity.

Biochim Biophys Acta 2010 Aug 22;1803(8):975-82. Epub 2010 Apr 22.

Department of Tumor Biology, Cancer Research Institute, Cell Dynamics Research Center, College of Medicine, Seoul National University, Seoul 151-742, Republic of Korea.

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August 2010

TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin alpha5 and its signaling pathways.

Carcinogenesis 2010 Apr 29;31(4):597-606. Epub 2010 Jan 29.

Therapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejon 305-806, Korea.

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April 2010

The extracellular loop 2 of TM4SF5 inhibits integrin alpha2 on hepatocytes under collagen type I environment.

Carcinogenesis 2009 Nov 29;30(11):1872-9. Epub 2009 Sep 29.

Cancer Research Institute, College of Medicine, Cell Dynamics Research Center, Seoul, Korea.

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November 2009

Syndecan-2 overexpression regulates adhesion and migration through cooperation with integrin alpha2.

Biochem Biophys Res Commun 2009 Jun 24;384(2):231-5. Epub 2009 Apr 24.

Department of Life Sciences, Division of Life and Pharmaceutical Sciences and the Center for Cell Signaling & Drug Discovery Research, Ewha Womans University, Seoul 120-750, Republic of Korea.

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June 2009

Specific tyrosine phosphorylation of focal adhesion kinase mediated by Fer tyrosine kinase in suspended hepatocytes.

Biochim Biophys Acta 2009 May 5;1793(5):781-91. Epub 2009 Feb 5.

Cancer Research Institute, Cell Dynamics Research Center, Department of Tumor Biology, College of Medicine, Seoul National University, 101, Daehangro, Jongno-gu, Seoul 110-799, Republic of Korea.

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May 2009

Transcriptional induction of DLC-1 gene through Sp1 sites by histone deacetylase inhibitors in gastric cancer cells.

Exp Mol Med 2008 Dec;40(6):639-46

National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Seoul National University College of MedicineSeoul 110-744, Korea.

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December 2008

Cooperation between integrin alpha5 and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity.

Blood 2009 Feb 25;113(8):1845-55. Epub 2008 Nov 25.

Cancer Research Institute, Cell Dynamics Research Center, College of Medicine, Seoul National University, Seoul, South Korea.

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February 2009

Ethyl pyruvate has an anti-inflammatory effect by inhibiting ROS-dependent STAT signaling in activated microglia.

Free Radic Biol Med 2008 Oct 16;45(7):950-63. Epub 2008 Jun 16.

Department of Pharmacology, Seoul National University College of Medicine, Yongon-dong 28, Chungno-gu, Seoul 110-799, Korea.

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October 2008

O-GlcNAc modulation at Akt1 Ser473 correlates with apoptosis of murine pancreatic beta cells.

Exp Cell Res 2008 Jul 9;314(11-12):2238-48. Epub 2008 May 9.

Cancer Research Institute, College of Medicine, Seoul National University, 103, Daehangno, Jongno-gu, Seoul 110-799, Korea.

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July 2008

Regulation of TM4SF5-mediated tumorigenesis through induction of cell detachment and death by tiarellic acid.

Biochim Biophys Acta 2008 Sep 30;1783(9):1632-41. Epub 2008 Apr 30.

Cancer Research Institute, College of Medicine, Seoul National University, Seoul 110-799, Korea.

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September 2008

HSP27 regulates cell adhesion and invasion via modulation of focal adhesion kinase and MMP-2 expression.

Eur J Cell Biol 2008 Jun 9;87(6):377-87. Epub 2008 May 9.

Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.

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June 2008

Cell adhesion-dependent cofilin serine 3 phosphorylation by the integrin-linked kinase.c-Src complex.

J Biol Chem 2008 Apr 5;283(15):10089-96. Epub 2008 Feb 5.

Department of Tumor Biology, Cancer Research Institute, Cell Dynamics Research Center, College of Medicine, Seoul National University, Seoul 110-799, Korea.

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April 2008

C6 glioma cell insoluble matrix components enhance interferon-gamma-stimulated inducible nitric-oxide synthase/nitric oxide production in BV2 microglial cells.

J Biol Chem 2008 Feb 2;283(5):2526-33. Epub 2007 Nov 2.

Department of Physiology and Biophysics, Inha University, College of Medicine, 253 Yonghyun-Dong, Nam-Ku, Incheon, Republic of Korea.

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February 2008

Development of 3-D nanofibrous fibroin scaffold with high porosity by electrospinning: implications for bone regeneration.

Biotechnol Lett 2008 Mar 1;30(3):405-10. Epub 2007 Nov 1.

Department of Biosystems and Biomaterials Science and Engineering, Seoul National University, Seoul, Republic of Korea.

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March 2008

PKCdelta and cofilin activation affects peripheral actin reorganization and cell-cell contact in cells expressing integrin alpha5 but not its tailless mutant.

J Cell Sci 2007 Aug;120(Pt 15):2717-30

Cancer Research Institute, College of Medicine, Seoul National University, 28, Yeongeon-dong, Jongno-gu, Seoul 110-799, Korea.

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August 2007

EGFR phosphorylation-dependent formation of cell-cell contacts by Ras/Erks cascade inhibition.

Biochim Biophys Acta 2007 Jun 17;1773(6):833-43. Epub 2007 Feb 17.

Cancer Research Institute, Department of Molecular and Clinical Oncology, College of Medicine, Seoul National University, 28, Yeongeon-dong, Jongno-gu, Seoul 110-799, South Korea.

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June 2007

DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma.

Biochem Biophys Res Commun 2007 Mar 30;355(1):72-7. Epub 2007 Jan 30.

National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-744, Republic of Korea.

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March 2007

8-hydroxydeoxyguanosine suppresses NO production and COX-2 activity via Rac1/STATs signaling in LPS-induced brain microglia.

Free Radic Biol Med 2006 Nov 27;41(9):1392-403. Epub 2006 Jul 27.

Department of Pharmacology, Seoul National University College of Medicine, Chungno-gu, Seoul 110-799, Korea.

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November 2006

Epigenetic regulation of integrin-linked kinase expression depending on adhesion of gastric carcinoma cells.

Am J Physiol Cell Physiol 2007 Feb 20;292(2):C857-66. Epub 2006 Sep 20.

Cancer Research Institute, Depts. of Tumor Biology and Molecular and Clinical Oncology, College of Medicine, Seoul National Univ., Seoul 110-799, Korea.

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February 2007

Focal adhesion and actin organization by a cross-talk of TM4SF5 with integrin alpha2 are regulated by serum treatment.

Exp Cell Res 2006 Oct 7;312(16):2983-99. Epub 2006 Jun 7.

Cancer Research Institute, Department of Molecular and Clinical Oncology, College of Medicine, Seoul National University, 28, Yeongeon-dong, Jongno-gu, Seoul 110-799, Korea.

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October 2006

Integrin signaling and cell spreading mediated by phorbol 12-myristate 13-acetate treatment.

J Cell Biochem 2006 Sep;99(1):88-95

Department of Molecular and Clinical Oncology, Cancer Research Institute, College of Medicine, Seoul National University, 28 Yeongeon-dong, Jongno-gu, Seoul 110-799, Korea.

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September 2006

Cell adhesion status-dependent histone acetylation is regulated through intracellular contractility-related signaling activities.

J Biol Chem 2005 Aug 16;280(31):28357-64. Epub 2005 Jun 16.

Cancer Research Institute, Department of Tumor Biology, College of Medicine, Seoul National University, 28, Yeongeon-dong, Jongno-gu, Seoul 110-799, Korea.

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August 2005

STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells.

FASEB J 2005 Aug 26;19(10):1296-8. Epub 2005 May 26.

Department of Pharmacology, Seoul National University College of Medicine, Chongno-gu, Seoul, Korea.

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August 2005

TGF-beta1-mediated activations of c-Src and Rac1 modulate levels of cyclins and p27(Kip1) CDK inhibitor in hepatoma cells replated on fibronectin.

Biochim Biophys Acta 2005 Mar;1743(1-2):151-61

National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Department of Tumor Biology, College of Medicine, Seoul National University, Seoul 110-799, South Korea.

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March 2005

Cyclooxygenase-2 inhibits novel ginseng metabolite-mediated apoptosis.

Cancer Res 2005 Mar;65(5):1952-60

National Research Laboratory for Cancer Epigenetics, Cancer Research Institute and Department of Internal Medicine, Seoul National University College of Medicine, Chongno, Seoul, Republic of Korea.

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March 2005

Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells.

Cancer Lett 2005 Mar;220(1):11-9

Cancer Research Institute, Department of Tumor Biology, College of Medicine, Seoul National University, Seoul 110-799, South Korea.

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March 2005

Ras-dependent induction of HIF-1alpha785 via the Raf/MEK/ERK pathway: a novel mechanism of Ras-mediated tumor promotion.

Oncogene 2004 Dec;23(58):9427-31

Human Genome Research Institute and Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-799, Korea.

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December 2004

Class I histone deacetylase-selective novel synthetic inhibitors potently inhibit human tumor proliferation.

Clin Cancer Res 2004 Aug;10(15):5271-81

National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.

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August 2004

Morphological adjustment of senescent cells by modulating caveolin-1 status.

J Biol Chem 2004 Oct 19;279(40):42270-8. Epub 2004 Jul 19.

Department of Biochemistry and Molecular Biology, Aging and Apoptosis Research Center, National University College of Medicine, Seoul, Korea.

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October 2004

AKAP12/Gravin is inactivated by epigenetic mechanism in human gastric carcinoma and shows growth suppressor activity.

Oncogene 2004 Sep;23(42):7095-103

National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon-dong, Chongro-gu, Seoul 110-799, Korea.

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September 2004

Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.

Mol Cells 2004 Apr;17(2):188-202

Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

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April 2004

Smad2 mediates Erk1/2 activation by TGF-beta1 in suspended, but not in adherent, gastric carcinoma cells.

Int J Oncol 2004 May;24(5):1229-34

National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Department of Tumor Biology, College of Medicine, Seoul National University, Seoul 110-799, Korea.

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May 2004

Aberrant methylation of integrin alpha4 gene in human gastric cancer cells.

Oncogene 2004 Apr;23(19):3474-80

National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-744, Korea.

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April 2004

Cdc42-dependent mediation of UV-induced p38 activation by G protein betagamma subunits.

J Biol Chem 2004 Apr 17;279(17):17366-75. Epub 2004 Feb 17.

Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 110-799, Korea.

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April 2004