Publications by authors named "Jun Zhong"

343 Publications

Treatment of Trigeminal Neuralgia with "Microvascular Decompression Plus" Technique.

J Neurol Surg B Skull Base 2021 Jul 19;82(Suppl 3):e295-e299. Epub 2020 May 19.

Department of Pathology, Tongji Hospital, Shanghai Tongji University, Shanghai, People's Republic of China.

 Although microvascular decompression (MVD) has been widely accepted as an effective treatment of trigeminal neuralgia (TN), some patients have not been cured. To improve the postoperative outcome, the surgical procedure should be further refined.  This is a retrospective study.  Present study conducted at a cranial nerve disorder center.  Clinical data were collected from patients with TN who had undergone surgery in our center, including 685 who had undergone traditional MVD and 576 who had undergone the "MVD plus" procedure, in which any vessel attached to the trigeminal nerve was freed away ("nerve-combing"), which was followed by intraoperative neurolysis.  Postoperative outcomes and complications in the two groups were compared.  Among patients who underwent traditional MVD, the rates of immediate relief and 1-year relief were 89.9 and 86.9%, respectively; among patients who underwent MVD plus group, these rates were 95.1 and 94.6%, respectively (  = 0.05). Patients who underwent MVD plus initially exhibited a higher rate of facial numbness (  < 0.05), but this finding decreased over time and reached the same level as that in the traditional MVD group within 3 months (  > 0.05).  Sufficient MVD with nerve-combing for the treatment of TN may produce a high rate of cure with less recurrence.
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http://dx.doi.org/10.1055/s-0040-1710520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289490PMC
July 2021

Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: a pathway analysis of genome-wide association studies.

Am J Clin Nutr 2021 Jul 13. Epub 2021 Jul 13.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Background: Epidemiological studies have suggested positive associations for iron and red meat intake with risk of pancreatic ductal adenocarcinoma (PDAC). Inherited pathogenic variants in genes involved in the hepcidin-regulating iron metabolism pathway are known to cause iron overload and hemochromatosis.

Objectives: The objective of this study was to determine whether common genetic variation in the hepcidin-regulating iron metabolism pathway is associated with PDAC.

Methods: We conducted a pathway analysis of the hepcidin-regulating genes using single nucleotide polymorphism (SNP) summary statistics generated from 4 genome-wide association studies in 2 large consortium studies using the summary data-based adaptive rank truncated product method. Our population consisted of 9253 PDAC cases and 12,525 controls of European descent. Our analysis included 11 hepcidin-regulating genes [bone morphogenetic protein 2 (BMP2), bone morphogenetic protein 6 (BMP6), ferritin heavy chain 1 (FTH1), ferritin light chain (FTL), hepcidin (HAMP), homeostatic iron regulator (HFE), hemojuvelin (HJV), nuclear factor erythroid 2-related factor 2 (NRF2), ferroportin 1 (SLC40A1), transferrin receptor 1 (TFR1), and transferrin receptor 2 (TFR2)] and their surrounding genomic regions (±20 kb) for a total of 412 SNPs.

Results: The hepcidin-regulating gene pathway was significantly associated with PDAC (P = 0.002), with the HJV, TFR2, TFR1, BMP6, and HAMP genes contributing the most to the association.

Conclusions: Our results support that genetic susceptibility related to the hepcidin-regulating gene pathway is associated with PDAC risk and suggest a potential role of iron metabolism in pancreatic carcinogenesis. Further studies are needed to evaluate effect modification by intake of iron-rich foods on this association.
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http://dx.doi.org/10.1093/ajcn/nqab217DOI Listing
July 2021

Climate warming will increase chances of hybridization and introgression between two lizards (Lacertidae).

Ecol Evol 2021 Jul 11;11(13):8573-8584. Epub 2021 May 11.

Jiangsu Key Laboratory for Biodiversity and Biotechnology College of Life Sciences Nanjing Normal University Nanjing China.

Coexisting species may experience population and range changes alone or jointly in response to environmental change. Here, we used six climate variables and ten modeling algorithms to predict the distribution of two species (.  and . ) in China. We identified the sympatric and allopatric areas by comparing projections between the two species based on habitat suitability under present and future climate scenarios. We constructed the hypervolumes of six climate variables for the two species and then evaluated overlaps between hypervolumes. From this study, we know the following. First, minimum temperature of coldest month contributes the most to the prediction of habitat suitability. Second, habitats suitable for the two species will shift northward in response to climate warming. Third, the range of will expand across the four future time intervals before 2,100, namely the 2021-2040, 2041-2060, 2061-2080, and 2081-2100 intervals, under both Shared socioeconomic pathway (SSP) 245 and SSP585 scenarios, and the range of will also expand in the future except at the 2081-2100 interval under the SSP585 scenario. Fourth, the sympatric areas will contract or expand under the SSP245 scenario and expand across the four future time intervals before 2,100 under the SSP585 scenario. Fifth, the niche hypervolumes of the two species partially overlapped, and the differences in niche centroid show some degree of niche differentiation between the two species. These results allow to conclude that climate warming will not only drive the northward drift of sympatric areas but also increase the size of these areas if nothing is done to limit the emission of greenhouse gases. Given the existence of hybridization and introgression between and in the field where they coexist, we also conclude that climate warming will increase chances of hybridization and introgression between the two species.
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http://dx.doi.org/10.1002/ece3.7671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258214PMC
July 2021

Highly active and selective oxygen reduction to HO on boron-doped carbon for high production rates.

Nat Commun 2021 Jul 9;12(1):4225. Epub 2021 Jul 9.

Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX, USA.

Oxygen reduction reaction towards hydrogen peroxide (HO) provides a green alternative route for HO production, but it lacks efficient catalysts to achieve high selectivity and activity simultaneously under industrial-relevant production rates. Here we report a boron-doped carbon (B-C) catalyst which can overcome this activity-selectivity dilemma. Compared to the state-of-the-art oxidized carbon catalyst, B-C catalyst presents enhanced activity (saving more than 210 mV overpotential) under industrial-relevant currents (up to 300 mA cm) while maintaining high HO selectivity (85-90%). Density-functional theory calculations reveal that the boron dopant site is responsible for high HO activity and selectivity due to low thermodynamic and kinetic barriers. Employed in our porous solid electrolyte reactor, the B-C catalyst demonstrates a direct and continuous generation of pure HO solutions with high selectivity (up to 95%) and high HO partial currents (up to ~400 mA cm), illustrating the catalyst's great potential for practical applications in the future.
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http://dx.doi.org/10.1038/s41467-021-24329-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270976PMC
July 2021

Geometric Modulation of Local CO Flux in [email protected] O Nanoreactors for Steering the CO RR Pathway toward High-Efficacy Methane Production.

Adv Mater 2021 Jul 5:e2101741. Epub 2021 Jul 5.

Soochow Institute of Energy and Material Innovations, College of Energy, Jiangsu Key Laboratory for Advanced Carbon Materials and Wearable Energy Technologies, Soochow University, Suzhou, 215006, China.

The electroreduction of carbon dioxide (CO RR) to CH stands as one of the promising paths for resourceful CO utilization in meeting the imminent "carbon-neutral" goal of the near future. Yet, limited success has been witnessed in the development of high-efficiency catalysts imparting satisfactory methane selectivity at a commercially viable current density. Herein, a unique category of CO RR catalysts is fabricated with the yolk-shell nanocell structure, comprising an Ag core and a Cu O shell that resembles the tandem nanoreactor. By fixing the Ag core and tuning the Cu O envelope size, the CO flux arriving at the oxide-derived Cu shell can be regulated, which further modulates the *CO coverage and *H adsorption at the Cu surface, consequently steering the CO RR pathway. Density functional theory simulations show that lower CO coverage favors methane formation via stabilizing the intermediate *CHO. As a result, the best catalyst in the flow cell shows a high CH Faraday efficiency of 74 ± 2% and partial current density of 178 ± 5 mA cm at -1.2 V , ranking above the state-of-the-art catalysts reported today for methane production. These findings mark the significance of precision synthesis in tailoring the catalyst geometry for achieving desired CO RR performance.
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http://dx.doi.org/10.1002/adma.202101741DOI Listing
July 2021

Protective effect of plastrum testudinis extract on dopaminergic neurons in a Parkinson's disease model through DNMT1 nuclear translocation and SNCA's methylation.

Biomed Pharmacother 2021 Jun 18;141:111832. Epub 2021 Jun 18.

School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, PR China; Department of Human Anatomy, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, PR China; Research Center of Integrative Medicine (Key Laboratory of Chinese Medicine Pathogenesis and Therapy Research), School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 510006, PR China. Electronic address:

The pathological characteristics of Parkinson's disease (PD) include dopaminergic neuron damage, specifically disorders caused by dopamine synthesis, in vivo. Plastrum testudinis extract (PTE) and its bioactive ingredient ethyl stearate (PubChem CID: 8122) were reported to be correlated with tyrosine hydroxylase (TH), which is a biomarker of dopaminergic neurons. This suggests that PTE and its small-molecule active ingredient ethyl stearate have potential for development as a therapeutic drug for PD. In this study, we treated 6-hydroxydopamine (6-OHDA)-induced model rats and PC12 cells with PTE. The mechanism of action of PTE and ethyl stearate was investigated by western blotting, bisulfite sequencing PCR (BSP), real-time PCR, immunofluorescence and siRNA transfection. PTE effectively upregulated the TH expression and downregulated the alpha-synuclein expression in both the substantia nigra and the striatum of the midbrain in a PD model rat. The PC12 cell model showed that both PTE and its active monomer ethyl stearate significantly promoted TH expression and blocked alpha-synuclein, agreeing with the in vivo results. BSP showed that PTE and ethyl stearate increased the methylation level of the Snca intron 1 region. These findings suggest that some of the protective effects of PTE on dopaminergic neurons are mediated by ethyl stearate. The mechanism of ethyl stearate may involve disrupting the abnormal aggregation of DNA (cytosine-5)-methyltransferase 1 (DNMT1) with alpha-synuclein by releasing DNMT1, upregulating Snca intron 1 CpG island methylation, and ultimately, reducing the expression of alpha-synuclein.
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http://dx.doi.org/10.1016/j.biopha.2021.111832DOI Listing
June 2021

Multiple controls on carbon dynamics in mixed karst and non-karst mountainous rivers, Southwest China, revealed by carbon isotopes (δC and ΔC).

Sci Total Environ 2021 Jun 8;791:148347. Epub 2021 Jun 8.

Institute of Surface-Earth System Science, School of Earth System Science, Tianjin University, Tianjin 300072, China. Electronic address:

Riverine transport of carbon from the land to the oceans plays a significant role in global carbon cycle. However, multiple processes can affect aquatic carbon cycling, and the carbon sources and processing in river systems are still elusive. Here, we analysed the water chemistry and dual carbon isotopes (δC and ΔC) of dissolved inorganic carbon (DIC) and particulate organic carbon (POC) from mixed karst and non-karst subtropical monsoonal catchments, southwest China. The water chemistry of the river water showed that DIC concentrations were mainly controlled by carbonate weathering and modulated by agricultural activities and geomorphic characteristics (i.e. elevation and slope), but the stable isotope of DIC (δC) was highly affected by CO outgassing and in-stream photosynthesis. The C/N ratios and stable isotope of POC (δC) indicated that the composition of riverine POC derived from a mixture of terrestrial sources and algae/microbial sources. Based on the δC and ΔC of POC, we used a Bayesian mixing model to constrain the POC sources, which showed that aquatic photosynthesis was the main source for POC. Our findings suggest that carbon dynamics in subtropical rivers are highly affected by aquatic photosynthesis, which has significant implications on carbon cycling within river systems.
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http://dx.doi.org/10.1016/j.scitotenv.2021.148347DOI Listing
June 2021

Synchronous evaporation and aquatic primary production in tropical river networks.

Water Res 2021 Jul 22;200:117272. Epub 2021 May 22.

Institute of Surface-Earth System Science, School of Earth System Science, Tianjin University, Tianjin 300072, China. Electronic address:

Rivers play an important role in global water and carbon cycling, but there are still large uncertainties concerning evaporation and aquatic photosynthesis. Here we combined measurements of water chemistry, isotopic compositions (i.e., δD, δO, δC and ▵C) and geographic characteristics (i.e., river width) to elucidate in-stream hydrological and biogeochemical processes across rivers in Hainan Island, China. The results showed that dissolved inorganic carbon (DIC) in river waters was largely of modern origin, with about 95% from contemporary biogenic sources based on an isotopic mass balance of ▵C. Significant evaporation and aquatic primary production co-occurred in these tropical rivers with large amounts of water and DIC being rapidly turned over in the water column, altering the water cycle and the carbon balance. High rates of evaporation and aquatic primary production were observed in the headwater segments, with narrow river width but broad available reactive surface area at the air-water interface. The asymmetric aquatic photosynthesis at different river segments caused the spatial heterogeneities of dissolved solutes. The results suggest that the available reactive area at the water-air interface is responsible for synchronous water loss and dissolved carbon evolution in flat tropical rivers. This study provides evidence that intense evaporation and aquatic photosynthesis mainly occurred in headwater segments, which has implications for understanding global carbon cycling.
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http://dx.doi.org/10.1016/j.watres.2021.117272DOI Listing
July 2021

Differential proteomics of tobacco seedling roots at high and low potassium concentrations.

Sci Rep 2021 Apr 28;11(1):9194. Epub 2021 Apr 28.

College of agriculture of Hunan Agriculture University, Changsha, 410128, Hunan, People's Republic of China.

The effects of high potassium and normal potassium treatments on protein expression in roots of flue-cured tobacco plant HKDN-5 at the seedling stage were analyzed by an unlabeled protein quantification technique. The results showed that 555 proteins were differentially expressed (245 proteins were down-regulated and 310 proteins were up-regulated) in high potassium treatment compared with normal potassium treatment. Differentially expressed proteins were involved in 96 metabolic pathways (42 metabolic pathways, 21 synthetic pathways as well as catabolic pathways, including fatty acid metabolism, phenylpropane biosynthesis, ketone body synthesis and degradation, and butyric acid metabolism. Root processing of high potassium concentrations leads to increases in the synthesis of peroxidase, superoxide dismutase and acyl-coenzyme-A synthetase. Additional proteomic differences observed in tobacco roots grown in high potassium include proteins involved with genetic information processing as well as environmental sensing. Examples include RNA helicase, ABC transporters and large subunit GTPases. These up-regulated differentially expressed proteins function mainly in protein translation, ribosome structure and protein synthesis. This indicates that under high potassium treatment, root protein synthetic processes are accelerated and substance metabolism pathways are enhanced; thus, providing the material and energetic basis for root growth.
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http://dx.doi.org/10.1038/s41598-021-88689-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080629PMC
April 2021

The effect of IL-6/Piezo2 on the trigeminal neuropathic pain.

Aging (Albany NY) 2021 04 23;13(10):13615-13625. Epub 2021 Apr 23.

Department of Neurosurgery, XinHua Hospital, The Cranial Nerve Disease Center of Shanghai, Shanghai JiaoTong University School of Medicine, Shanghai 200092, China.

The nature of trigeminal neuropathic pain (TN) attacks is regarded as the ignition of ectopic action potentials from the trigeminal root following vascular compression, which seemed to be related to transmembrane proteins and inflammation factors. This study focused on the mechanosensitive channel Piezo2 and cytokine IL-6. The chronic constriction injury of infraorbital nerve in SD rats was used to establish the TN model. The trigeminal ganglion was then achieved to perform immunocytochemistry studies. A significant upregulation of Piezo2 and IL-6 was showed in the TN model rats. The Piezo2 positive accounted for 72.3±9.5% in those IL-6 positive neurons. The Piezo2 co-localized with CGRP, IB4 and NF-200 but not with GFAP, which implied that it was expressed in both the C-type and the A-type neurons. After administration of GsMTx4 or anti-rat IL-6 antibody in the TN model, the dynamic allodynia and pinprick hyperalgesia scores as well as the mechanical threshold changed significantly. In the sham-operation rates, with local administration of IL-6, an upregulation of Piezo2 was also exhibited. Our study demonstrated that the up-regulation of Piezo2 in the pain afferent neurons following trigeminal nerve injury may play a role in the development of the neuralgia. Meanwhile, the expression of Piezo2 may be modulated by inflammatory cytokines, such as IL-6.
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http://dx.doi.org/10.18632/aging.202887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202871PMC
April 2021

A novel method to reduce false alarms in ECG diagnostic systems: capture and quantification of noisy signals.

Physiol Meas 2021 Jul 28;42(7). Epub 2021 Jul 28.

Suzhou Institute of Biomedical Engineering and Technology, China Academy of Sciences, People's Republic of China.

. Muscle artifacts (MA) and electrode motion artifacts (EMA) in electrocardiogram (ECG) signals lead to a large number of false alarms from cardiac diagnostic systems. To reduce false alarms, it is necessary to improve the performance of the diagnostic algorithm in noisy environments by removing excessively noisy signals. However, existing methods focus on signal quality assessment and contain too many artificial features. Here, we present a novel method to flexibly eliminate noisy signals without any artificial features.. Our method contains an improved lightweight deep neural network (DNN) to capture the signal portions damaged by EMA and MA, uses the sample entropy to quantize noisy portions, and discards those portions that exceed a defined threshold. Our method was tested in conjunction with Pan-Tompkins (PT), Filter Bank (FB), and 'UNSW' R-peak detection algorithms along with two heartbeat classification algorithms on datasets synthesized from the MIT-BIH Noise Stress Test Database, the China Physiological Signal Challenge 2018 Database and the MIT-BIH Arrhythmia Database.. For PT R-peak detection algorithms, the sensitivity (Se) increased noticeably from 89.01% to 99.42% in the synthesized datasets with a signal-to-noise ratio of 6 dB. With the same datasets, the Se of the FB algorithm increased about 9.29%, and a 3.64% increase occurred in the Se of the 'UNSW' algorithm. For heartbeat classification algorithms, the overall F1-score increased about 6% in the synthesized one-heartbeat datasets. It is the first study to utilize a DNN to capture noisy segments of the ECG signal.. Too many false alarms can cause alarm fatigue. Our method can be utilized as the preprocessing before signal analysis, thereby reducing false alarms from the ECG diagnostic systems.
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http://dx.doi.org/10.1088/1361-6579/abf9f4DOI Listing
July 2021

Mechanism of separation and removal of water from oily sludge using liquid dimethyl ether to dissolve hydrocarbons.

Chemosphere 2021 Sep 31;279:130452. Epub 2021 Mar 31.

College of Environment, Hohai University, Nanjing, 210098, PR China.

The effective disposal of oily sludge generated from the petroleum industry has received increasing concern. The primary difficulty for the reduction and resource utilization of oily sludge is dewatering. Therefore, finding an efficient and energy-saving dewatering technology is an urgent need for the treatment of oily sludge. In this study, an innovative developed method using liquefied dimethyl ether (L-DME) for dewatering is employed to deal with oily sludge for the first time. Oily sludge from a refinery was used to conduct experiments in sequencing dissolution-separation reactors. Changes in the dehydration rate, oil recovery, group components (hydrocarbon series of petroleum, including saturates, aromatics, resins and asphaltenes) at different extraction time, temperatures and L-DME additions were measured. The results revealed that L-DME removed 90% of the water and recovered 40% of the oil, which was an amazing dehydration effect for oily sludge. The water-binding form of oily sludge is different from sewage sludge and other biomass and the water in oily sludge is in a stable water-in-oil (W/O) suspension emulsified state. L-DME was mixed with semi-colloidal like oily sludge to break the structure of the water-in-oil emulsion, making the mixture into a solid-liquid two phase substances that were easy to separate, thus achieving a high degree of separation of water. The dissolution of saturated hydrocarbons, aromatic hydrocarbons, and small amounts of colloid by L-DME played an important auxiliary role in water removal.
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http://dx.doi.org/10.1016/j.chemosphere.2021.130452DOI Listing
September 2021

Serum creatinine as a predictor of mortality in patients readmitted to the intensive care unit after cardiac surgery: a retrospective cohort study in China.

J Thorac Dis 2021 Mar;13(3):1728-1736

Department of Nursing, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: Patients readmitted to the intensive care unit (ICU) after cardiac surgery have a high mortality rate. The relationship between renal function and in-hospital mortality in readmitted patients has not been well demonstrated.

Methods: We retrospectively evaluated cardiac surgery patients who were readmitted to the ICU at least once. Data on serum creatinine levels before surgery and on the day of ICU readmission were collected. The estimated glomerular filtration rate (eGFR) was calculated according to the creatinine-based Chronic Kidney Disease-Epidemiology Collaboration equation. We used logistic regression models and restricted cubic spline curves with four knots (5%, 35%, 65%, 95%) to investigate the relationship between renal function indicators and mortality.

Results: Of the 184 patients evaluated, 30 patients died during hospitalization, yielding a mortality rate of 16.30%. Cardiac dysfunction (n=84, 45.65%) and respiration disorder (n=51, 27.72%) were the most common reasons for ICU readmission. Creatinine [odds ratio (OR): 1.14, 95% confidence interval (CI): 1.07-1.25] and eGFR (OR: 0.95, 95% CI: 0.93-0.98) were independently associated with in-hospital mortality after adjusting for various confounders. Both creatinine level and eGFR had a linear association with in-hospital mortality (P for non-linearity ˃0.05).

Conclusion: Renal function is significantly associated with the in-hospital mortality of patients readmitted to the ICU after cardiac surgery, as evidenced by the independent correlation of both creatinine and eGFR with in-hospital mortality.
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http://dx.doi.org/10.21037/jtd-20-3205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024843PMC
March 2021

Cortical Thickness Changes in Chronic Ketamine Users.

Front Psychiatry 2021 25;12:645471. Epub 2021 Mar 25.

The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou, China.

Previous studies have examined the effects of long-term ketamine use on gray matter volume. But it is unclear whether chronic ketamine use alters cortical thickness and whether cortical thickness changes in chronic ketamine users are associated with cognitive deficits observed in chronic ketamine users. Here, 28 chronic ketamine users and 30 healthy controls (HCs) were recruited. Cortical morphometry based on Computational Anatomy Toolbox (CAT12) was used to measure cortical thickness. Cognitive performance was measured by MATRICS Consensus Cognitive Battery (MCCB). Two-sample -test was used to assess differences in cortical thickness and cognitive performance between the two groups. Partial correlation analysis was used for assessing correlations between cortical thickness changes and clinical characteristics, cognitive performance in chronic ketamine users. Chronic ketamine users exhibited significantly reduced cortical thickness in frontal, parietal, temporal, and occipital lobes compared to HC [false discovery rate (FDR) corrected at < 0.05]. In chronic ketamine users, the average quantity (g) of ketamine use/day was negatively correlated with cortical thickness in the left superior frontal gyrus (SFG), right caudal middle frontal gyrus (MFG), and right paracentral lobule. The frequency of ketamine use (days per week) was negatively correlated with cortical thickness in the left isthmus cingulate cortex. Duration of ketamine use (month) was negatively correlated with cortical thickness in the left precentral gyrus. The chronic ketamine users showed significantly poorer cognitive performance on the working memory ( = 0.009), visual learning ( = 0.009), speed of processing ( < 0.000), and Matrics composite ( = 0.01). There was no correlation between scores of domains of MCCB and reduced cortical thickness. The present study observed reduced cortical thickness in multiple brain areas, especially in the prefrontal cortex (PFC) in chronic ketamine users. Dose, frequency, and duration of ketamine use was negatively correlated with cortical thickness of some brain areas. Our results suggest that chronic ketamine use may lead to a decrease of cortical thickness. But the present study did not observe any correlation between reduced cortical thickness and decreased cognitive performance in chronic ketamine users.
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http://dx.doi.org/10.3389/fpsyt.2021.645471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026883PMC
March 2021

Oxidation of pyrite and reducing nitrogen fertilizer enhanced the carbon cycle by driving terrestrial chemical weathering.

Sci Total Environ 2021 May 30;768:144343. Epub 2020 Dec 30.

Institute of Surface-Earth System Science, School of Earth System Science, Tianjin University, Tianjin 300072, China.

Sulfuric acid formed by pyrite oxidation and nitric acid formed by oxidation of reducing nitrogen fertilizer through neutralization with carbonate minerals can rapidly perturb the carbon cycle. However, these processes and corresponding mechanisms have not been well documented due to the lack of information about both the sources of acids and the processes of oxidative weathering. Here, multiple isotopes (C-DIC, S and O-SO, N and O-NO, and O and D-HO), hydrochemistry and historical monitoring data were used to assess the roles of strong acids in chemical weathering and the carbon cycle in a karst river system. The variations in alkalinity and the δC-DIC signals, along with theoretical mixing models, indicated that strong acids were involved in carbonate weathering. However, the contribution of weathering driven by strong acids to the total weathering budget determined by mixing models was lower than that determined by assuming that all protons were neutralized by minerals. These protons were liberated from oxidation of pyrite and reducing nitrogen fertilizers constrained by isotope techniques and hydrochemistry with the use of a Bayesian isotope mixing model. The strong acid weathering could account for 66% of total weathering if all of the protons were neutralized by carbonate and silicate, which was not consistent with the result provided by mixing models. These results indicated that in addition to being neutralized by minerals, the protons might be largely neutralized by HCO derived from rock weathering driven by both carbonic and strong acids. The coupling cycles of carbon, nitrogen and sulfur would be boosted due to oxidation of pyrite and reducing nitrogen fertilizers. This study suggests that the CO uptake by terrestrial chemical weathering should be re-evaluated after adequately considering the effects of strong acids liberated by natural processes and anthropogenic activities.
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http://dx.doi.org/10.1016/j.scitotenv.2020.144343DOI Listing
May 2021

Long-Term Mortality Related to Acute Kidney Injury Following Intracerebral Hemorrhage: A 10-Year (2010-2019) Retrospective Study.

J Stroke Cerebrovasc Dis 2021 May 6;30(5):105688. Epub 2021 Mar 6.

Department of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China, 400038. Electronic address:

Objectives: Acute kidney injury (AKI) following intracerebral hemorrhage (ICH) is an intractable medical complication and an independent predictor of short-term mortality. However, the correlation between AKI and long-term mortality has not been fully investigated. The aim of the present study was to determine the relationship between AKI following ICH and long-term mortality in a 10-year (2010-2019) retrospective cohort.

Materials And Methods: A total of 1449 ICH patients were screened and enrolled at the Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University) from January 2010 to December 2016. The endpoint for follow-up was May 31, 2019. The estimated all-cause mortality was determined using Cox proportional hazard regression models.

Results: Among 1449 ICH patients, 136 (9.4%) suffered from AKI, and the duration of follow-up was a median of 5.1 years (IQR 3.2-7.2). The results indicated that the risk factors for AKI without preexisting chronic kidney disease (CKD) in the multivariable analysis were age (p = 0.002), nephrotoxic antibiotics (p = 0.000), diabetes mellitus (p = 0.005), sepsis (p = 0.000), antiplatelet therapy (p = 0.002), infratentorial hemorrhage (p = 0.000) and ICH volume (p = 0.003). Age (p = 0.008), ACEIs/ARBs (p = 0.010), nephrotoxic antibiotics (p = 0.014), coronary artery disease (p = 0.009), diabetes mellitus (p = 0.014), hypertension (p = 0.000) and anticoagulant therapy (p = 0.000) were independent predictors of AKI with preexisting CKD. Meanwhile, the data demonstrated that the estimated all-cause mortality was significantly higher in ICH patients with AKI without preexisting CKD (HR 4.208, 95% CI 2.946-6.011; p = 0.000) and in ICH patients with AKI with preexisting CKD (HR 2.470, 95% CI 1.747-3.492; p = 0.000) than in those without AKI.

Conclusions: AKI is a long-term independent predictor of mortality in ICH patients. Thus, renal function needs to be routinely determined in ICH patients during clinical practice.
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2021.105688DOI Listing
May 2021

Whole-Voltage-Range Oxygen Redox in P2-Layered Cathode Materials for Sodium-Ion Batteries.

Adv Mater 2021 Apr 1;33(13):e2008194. Epub 2021 Mar 1.

Chemical Sciences and Engineering Division, Argonne National Laboratory, Lemont, IL, 60439, USA.

Oxygen-redox of layer-structured metal-oxide cathodes has drawn great attention as an effective approach to break through the bottleneck of their capacity limit. However, reversible oxygen-redox can only be obtained in the high-voltage region (usually over 3.5 V) in current metal-oxide cathodes. Here, we realize reversible oxygen-redox in a wide voltage range of 1.5-4.5 V in a P2-layered Na Mg [Fe Mn □ ]O cathode material, where intrinsic vacancies are located in transition-metal (TM) sites and Mg-ions are located in Na sites. Mg-ions in the Na layer serve as "pillars" to stabilize the layered structure during electrochemical cycling, especially in the high-voltage region. Intrinsic vacancies in the TM layer create the local configurations of "□-O-□", "Na-O-□" and "Mg-O-□" to trigger oxygen-redox in the whole voltage range of charge-discharge. Time-resolved techniques demonstrate that the P2 phase is well maintained in a wide potential window range of 1.5-4.5 V even at 10 C. It is revealed that charge compensation from Mn- and O-ions contributes to the whole voltage range of 1.5-4.5 V, while the redox of Fe-ions only contributes to the high-voltage region of 3.0-4.5 V. The orphaned electrons in the nonbonding 2p orbitals of O that point toward TM-vacancy sites are responsible for reversible oxygen-redox, and Mg-ions in Na sites suppress oxygen release effectively.
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http://dx.doi.org/10.1002/adma.202008194DOI Listing
April 2021

First record of mitochondrial genome of (Squamata: Scincidae) and phylogenetic analysis.

Mitochondrial DNA B Resour 2021 Feb 15;6(2):564-565. Epub 2021 Feb 15.

College of Life Sciences, Jiangsu Key Laboratory for Biodiversity and Biotechnology, Nanjing Normal University, Nanjing, Jiangsu, China.

We sequenced and annotated the nearly complete mitochondrial genome (mitogenome) of (Squamata: Scincidae). This mitogenome was 14,106 bp in size and encoded 13 protein-coding genes, two ribosomal RNA genes, and 22 transfer RNA genes. The most common start codon is ATG, the most common termination codon is TAA and five genes have incomplete termination codon T. The overall nucleotide composition was 32.0% of A, 14.3% of G, 26.1% of T, and 27.6% of C. The data will increase the basic information of Scincidae phylogenetic research and can help to better understand the phylogenetic status of in Squamata.
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http://dx.doi.org/10.1080/23802359.2021.1875903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889270PMC
February 2021

The impacts of reservoirs on the sources and transport of riverine organic carbon in the karst area: A multi-tracer study.

Water Res 2021 Apr 14;194:116933. Epub 2021 Feb 14.

Institute of Surface-Earth System Science, School of Earth System Science, Tianjin University, Tianjin 300072, China; State Key laboratory of Hydraulic Engineering Simulation and Safety, Tianjin University, Tianjin 300072, China. Electronic address:

Reservoirs have been constructed as clean energy sources in recent decades with various environmental impacts. Karst rivers typically exhibit high dissolved inorganic carbon (DIC) concentrations, whether and how reservoirs affect carbon cycling, especially organic carbon (OC)-related biogeochemical processes in karst rivers, are unclear. To fill this knowledge gap, multiple tracer methods (including fluorescence excitation-emission matrix (EEM), ultraviolet (UV) absorption, and stable carbon (δC) and radiocarbon (ΔC) isotopes) were utilized to track composition and property changes of both particulate OC (POC) and dissolved OC (DOC) along river-transition-reservoir transects in the Southwest China karst area. The changes in chemical properties indicated that from the river to the reservoir, terrestrial POC is largely replaced by phytoplankton-derived OC, while gradual coloured dissolved organic matter (CDOM) removal and addition of phytoplankton-derived OC to the DOC pool occurred as water flowed to the reservoir. Higher primary production in the transition area than that in the reservoir area was observed, which may be caused by nutrient released from suspended particles. Within the reservoir, the production surpassed degradation in the upper 5 m, resulting in a net DIC transformation into DOC and POC and terrestrial DOM degradation. The primary production was then gradually weakened and microbial degradation became more important down the profile. It is estimated that ~3.1-6.3 mg L (~15.5-31.5 mg-C m (~10-21%)) DIC was integrated into the OC pool through the biological carbon pump (BCP) process in the upper 5 m in the transition and reservoir areas. Our results emphasize the reservoir impact on riverine OC transport, and due to their characteristics, karst areas exhibit a higher BCP potential which is sensitive to human activities (more nutrient are provided) than non-karst areas.
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http://dx.doi.org/10.1016/j.watres.2021.116933DOI Listing
April 2021

The simpler the better: a personal philosophy of microvascular decompression surgery.

Authors:
Jun Zhong

Chin Med J (Engl) 2021 Feb 15;134(4):410-412. Epub 2021 Feb 15.

Department of Neurosurgery, Xinhua Hospital (The Cranial Nerve Disorder Center of Shanghai), Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.

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http://dx.doi.org/10.1097/CM9.0000000000001233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909433PMC
February 2021

Usage of Angiotensin-Converting Enzyme Inhibitor or Angiotensin II Receptor Blocker in Hypertension Intracerebral Hemorrhage.

Neuropsychiatr Dis Treat 2021 9;17:355-363. Epub 2021 Feb 9.

Department of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, People's Republic of China.

Background: Inflammation plays an essential role in secondary brain injury after intracerebral hemorrhage (ICH). Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) have been suggested to suppress neuroinflammation after central nervous system (CNS) damage in animal models. However, the role of ACEIs and ARBs in ICH patients with hypertension remains unresolved in clinic. The aim of the present study is to evaluate the effect of ACEIs/ARBs on ICH patients with hypertension using a retrospective, single-center data analysis.

Methods: ICH patients diagnosed by computerized tomographic (CT) at Southwest Hospital, Third Military Medical University were included in the present research from January 2015 to December 2019. According to the medical history for the usage of antihypertensive drugs, patients were assigned into either ACEIs/ARBs group or non-ACEIs/ARBs group. Demographics, clinical baseline, radiological documents and treatments were collected and these data were statistically analyzed between the two groups.

Results: A total of 635 ICH patients with hypertension were included and allocated into 2 groups according to the usage of antihypertensive drugs: 281 in the ACEIs/ARBs group and 354 in the non-ACEIs/ARBs group. The results presented that the 3-months mortality and prevalence of ICH-associated pneumonia were lower in ACEIs/ARBs group than that in non-ACEIs/ARBs group (5.0% vs 11.9%, p=0.002; 58.4% vs 66.7%, p=0.031). While, there was no significant difference in favorable outcome (40.2% vs 33.9%, p=0.101) between the two groups. Furthermore, patients in ACEIs/ARBs group exhibited significantly less perihematomal edema volume on days 3 (23.5 ± 14.4 versus 28.7 ± 20.1 mL, p=0.045) and 7 (21.0 ± 13.7 versus 25.7 ± 17.6 mL, p=0.044), compared to that in non- ACEIs/ARBs group.

Conclusion: The usage of ACEIs/ARBs helps decrease mortality, perihematomal edema volume, and prevalence of ICH-associated pneumonia in ICH patients with hypertension.
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http://dx.doi.org/10.2147/NDT.S291624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881796PMC
February 2021

The thermal dependence and molecular basis of physiological color change in (Lacertidae).

Biol Open 2021 Mar 26;10(3). Epub 2021 Mar 26.

Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, Jiangsu, China

One of the main functions of physiological color change is thermoregulation. This change occurs much more rapidly than morphological color change, but the underlying mechanism remains poorly understood. Here, we studied the thermal dependence and molecular basis of physiological color change in lizards using (Lacertidae) as the model system. Body color was thermally sensitive, becoming increasingly light as body temperatures deviated from the level (∼30°C) preferred by this species. We identified 3389 differentially expressed genes (DEGs) between lizards at 24°C and 30°C, and 1,097 DEGs between lizards at 36°C and 30°C. Temperature affected the cAMP signal pathway, motor proteins, cytoskeleton, and the expression of genes related to melanocyte-stimulating hormone (MSH) and melanocyte-concentrating hormone (MCH). Our data suggest that the role of physiological color change in thermoregulation is achieved in by altering the arrangement of pigments and thus the amount of solar radiation absorbed and reflected. G protein-coupling system inhibits adenylate cyclase activity to transform ATP into cAMP and thereby causes rapid pigment aggregation. MCH deactivates the G proteins and thereby initiates pigment dispersion. This mechanism differs from that reported for teleost fish where MCH activates the G proteins and thereby causes pigment aggregation.This article has an associated First Person interview with the first author of the paper.
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http://dx.doi.org/10.1242/bio.058503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015239PMC
March 2021

Why do selfies increase young women's willingness to consider cosmetic surgery in China? The mediating roles of body surveillance and body shame.

J Health Psychol 2021 Feb 15:1359105321990802. Epub 2021 Feb 15.

Xinyang Normal University, Xinyang, Henan, China.

The present study was designed to examine a possible two mediator model with both body surveillance and body shame mediating the association of selfie behavior with cosmetic surgery consideration in young adult women. A sample of 588 young adult women participated in this study and completed questionnaires regarding selfie behavior, body surveillance, body shame, and cosmetic surgery consideration. Results indicated that selfie behavior was positively related to cosmetic surgery consideration. In addition, the mediation analysis by PROCESS revealed that body surveillance and body shame mediated the relation between selfie behavior and cosmetic surgery consideration. These findings add to the extant literature by suggesting that selfie behavior may be a new experience of self-objectification, which provide new insights into the relation between selfie activities and cosmetic surgery consideration in young women.
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http://dx.doi.org/10.1177/1359105321990802DOI Listing
February 2021

Ambroxol Upregulates Glucocerebrosidase Expression to Promote Neural Stem Cells Differentiation Into Neurons Through Wnt/β-Catenin Pathway After Ischemic Stroke.

Front Mol Neurosci 2020 20;13:596039. Epub 2021 Jan 20.

Department of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.

Ischemic stroke has been becoming one of the leading causes resulting in mortality and adult long-term disability worldwide. Post-stroke pneumonia is a common complication in patients with ischemic stroke and always associated with 1-year mortality. Though ambroxol therapy often serves as a supplementary treatment for post-stroke pneumonia in ischemic stroke patients, its effect on functional recovery and potential mechanism after ischemic stroke remain elusive. In the present study, the results indicated that administration of 70 mg/kg and 100 mg/kg enhanced functional recovery by virtue of decreasing infarct volume. The potential mechanism, to some extent, was due to promoting NSCs differentiation into neurons and interfering NSCs differentiation into astrocytes through increasing GCase expression to activate Wnt/β-catenin signaling pathway in penumbra after ischemic stroke, which advanced basic knowledge of ambroxol in regulating NSCs differentiation and provided a feasible therapy for ischemic stroke treatment, even in other brain disorders in clinic.
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http://dx.doi.org/10.3389/fnmol.2020.596039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7855720PMC
January 2021

A FOD Detection Approach on Millimeter-Wave Radar Sensors Based on Optimal VMD and SVDD.

Sensors (Basel) 2021 Feb 2;21(3). Epub 2021 Feb 2.

School of Electrical Engineering, Sichuan University, Chengdu 610000, China.

Foreign object debris (FOD) on airport runways can cause serious accidents and huge economic losses. FOD detection systems based on millimeter-wave (MMW) radar sensors have the advantages of higher range resolution and lower power consumption. However, it is difficult for traditional FOD detection methods to detect and distinguish weak signals of targets from strong ground clutter. To solve this problem, this paper proposes a new FOD detection approach based on optimized variational mode decomposition (VMD) and support vector data description (SVDD). This approach utilizes SVDD as a classifier to distinguish FOD signals from clutter signals. More importantly, the VMD optimized by whale optimization algorithm (WOA) is used to improve the accuracy and stability of the classifier. The results from both the simulation and field case show the excellent FOD detection performance of the proposed VMD-SVDD method.
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http://dx.doi.org/10.3390/s21030997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867293PMC
February 2021

Paeonol attenuates inflammation by confining HMGB1 to the nucleus.

J Cell Mol Med 2021 Mar 3;25(6):2885-2899. Epub 2021 Feb 3.

Research Center of Integrative Medicine, School Basic Medical Sciences, University of Chinese Medicine, Guangzhou, China.

Inflammation is a biological process that exists in a large number of diseases. If the magnitude or duration of inflammation becomes uncontrolled, inflammation may cause pathological damage to the host. HMGB1 and NF-κB have been shown to play pivotal roles in inflammation-related diseases. New drugs aimed at inhibiting HMGB1 expression have become a key research focus. In the present study, we showed that paeonol (Pae), the main active component of Paeonia suffruticosa, decreases the expression of inflammatory cytokines and inhibits the translocation of HMGB1 induced by lipopolysaccharide (LPS). By constructing HMGB1-overexpressing (HMGB1 ) and HMGB1-mutant (HMGB1 ) RAW264.7 cells, we found that the nuclear HMGB1 could induce an LPS-tolerant state in RAW264.7 cells and that paeonol had no influence on the expression of inflammatory cytokines in HMGB1 RAW264.7 cells. In addition, the anti-inflammatory property of paeonol was lost in HMGB1 conditional knockout mice, indicating that HMGB1 is a target of paeonol and a mediator through which paeonol exerts its anti-inflammatory function. Additionally, we also found that HMGB1 and P50 competitively bound with P65, thus inactivating the NF-κB pathway. Our research confirmed the anti-inflammation property of paeonol and suggests that inhibiting the translocation of HMGB1 could be a new strategy for treating inflammation.
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http://dx.doi.org/10.1111/jcmm.16319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957162PMC
March 2021

Seasonal variation of nitrogen biogeochemical processes constrained by nitrate dual isotopes in cascade reservoirs, Southwestern China.

Environ Sci Pollut Res Int 2021 Jun 25;28(21):26617-26627. Epub 2021 Jan 25.

Institute of Surface-Earth System Science, School of Earth System Science, Tianjin University, Tianjin, 300072, China.

The increase of affected river reaches by reservoirs has drastically disturbed the original hydrological conditions, and subsequently influenced the nutrient biogeochemistry in the aquatic system, particularly in the cascade reservoir system. To understand the seasonal variation of nitrogen (N) behaviors in cascade reservoirs, hydrochemistry and nitrate dual isotopes (δN-NO and δO-NO) were conducted in a karst watershed (Wujiang River) in southwest China. The results showed that NO-N accounted for almost 90% of the total dissolved nitrogen (TDN) concentration with high average concentration 3.8 ± 0.4 mg/L among four cascade reservoirs. Higher N concentration (4.0 ± 0.8 mg/L) and larger longitudinal variation were observed in summer than in other seasons. The relationship between the variation of NO-N and dual isotopes in the profiles demonstrated that nitrification was dominated transformation, while assimilation contributed significantly in the epilimnion during spring and summer. The high dissolved oxygen concentration in the present cascade reservoirs system prevented the occurrence of N depletion processes in most of the reservoirs. Denitrification occurred in the oldest reservoir during winter with a rate ranging from 18 to 28%. The long-term record of surface water TDN concentration in reservoirs demonstrated an increase from 2.0 to 3.6 mg/L during the past two decades (~ 0.1 mg/L per year). The seasonal nitrate isotopic signature and continuously increased fertilizer application demonstrated that chemical fertilizer contribution significantly influenced NO-N concentration in the karst cascade reservoirs. The research highlighted that the notable N increase in karst cascade reservoirs could influence the aquatic health in the region and further investigations were required.
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http://dx.doi.org/10.1007/s11356-021-12505-9DOI Listing
June 2021

Effects of treatment status and life quality on anxiety in MMT patients.

Subst Abuse Treat Prev Policy 2021 Jan 13;16(1). Epub 2021 Jan 13.

The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), 36 Mingxin Road, Liwan District, Guangzhou, 510370, Guangdong Province, China.

Background: Anxiety, an important factor that affects the therapeutic effect and preservation rate of methadone maintenance treatment, has a high prevalence among MMT patients. This study aims to investigate the effects of treatment status and life quality on anxiety in MMT patients.

Methods: One hundred and Seventy-seven methadone maintenance treatment users in Guangzhou, China were evaluated. The socio-demographic, duration and MMT-related characteristics were documented. Anxiety level and quality of life were evaluated by Beck Anxiety inventory (BAI) and the Quality of Life-Drug Addiction (QOL-DA) respectively. The correlation between different factors and BAI score was also analyzed.

Results: The BAI total score and the QOL-DA score were 7.1±8.2, 163.5±21.4 respectively. 30.5% of the subjects showed mild to severe anxiety. Treatment interruption and QOL-DA score had strong correlations with the score of BAI, with correlation coefficients of 0.17 and - 0.08 respectively.

Conclusions: Anxiety symptoms were commonly presented in MMT patients. Treatment interruption and quality of life are two major factors affecting anxiety of MMT patients.
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http://dx.doi.org/10.1186/s13011-021-00343-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805232PMC
January 2021

Early risk stratification of acute type A aortic dissection: development and validation of a predictive score.

Cardiovasc Diagn Ther 2020 Dec;10(6):1827-1838

Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: The performance of published preoperative risk scores for acute type A aortic dissection (aTAAD) is suboptimal. So, the predictive power of these scores were externally validated in order to develop and validate a more reliable preoperative score for identification of patients at high risk of mortality.

Methods: Potential preoperative risk variables of consecutively admitted patients with aTAAD were prospectively collected. Seven published risk scores were validated with our dataset. For derivation and internal validation, the original population was divided at a ratio of 7:3. Logistic regression was used to identify variables for the new score. A 50-patient retrospective dataset was used for external validation. The predictive accuracy for post-operative mortality was evaluated using the area under the receiver operating characteristic (AUROC) curve.

Results: During the study period, 225 patients with aTAAD were admitted preoperatively. Of these, 209 underwent surgical repair and 29 died postoperatively. The AUROCs of the seven published pre-operative risk scores for post-operative mortality ranged from 0.57 to 0.77. Four variables were derived for the new score system, i.e., Acute myocardial ischemia, Lactate, Iliac arteries involved, and CreatininE (the ALICE score). The AUROCs for post-operative mortality in the derivation, internal and external validation populations were 0.85, 0.88 and 0.83, respectively. At a cutoff value of 3, the ALICE score for post-operative mortality had a sensitivity of 71% to 88% and specificity of 78% to 86%.

Conclusions: The ALICE score comprising four components might help bedside clinicians in early detection of the most severe aTAAD patients.
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http://dx.doi.org/10.21037/cdt-20-730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758751PMC
December 2020

Complete mitochondrial genome of (Squamata: Scincidae) and phylogenetic analysis.

Mitochondrial DNA B Resour 2020 Jan 7;5(1):373-374. Epub 2020 Jan 7.

College of Life Sciences, Jiangsu Key Laboratory for Biodiversity and Biotechnology, Nanjing Normal University, Nanjing, P. R. China.

We sequenced and annotated the complete mitochondrial genome (mitogenome) of (Squamata: Scincidae). This mitogenome was 17,466 bp long and encoded 13 protein-coding genes (PCGs), 22 transfer RNA genes, 2 ribosomal RNA genes, and 2 non-coding regions. The overall nucleotide composition was 31.8% of A, 14.5% of G, 27.2% of T, and 26.5% of C. Phylogenetic analysis using Bayesian Inference (BI) validated the taxonomic status of , exhibiting the close relationship with the other two species from the genus .
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http://dx.doi.org/10.1080/23802359.2019.1703579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748710PMC
January 2020
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