Publications by authors named "Jun Yan"

1,663 Publications

  • Page 1 of 1

Differential metabolic requirement governed by transcription factor c-Maf dictates innate γδT17 effector functionality in mice and humans.

Sci Adv 2022 May 25;8(21):eabm9120. Epub 2022 May 25.

Division of Immunotherapy, The Hiram C. Polk, Jr., MD Department of Surgery, Immuno-Oncology Program, Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY, USA.

Cellular metabolism has been proposed to govern distinct γδ T cell effector functions, but the underlying molecular mechanisms remain unclear. We show that interleukin-17 (IL-17)-producing γδ T (γδT17) and interferon-γ (IFN-γ)-producing γδ T (γδT1) cells have differential metabolic requirements and that the rate-limiting enzyme isocitrate dehydrogenase 2 (IDH2) acts as a metabolic checkpoint for their effector functions. Intriguingly, the transcription factor c-Maf regulates γδT17 effector function through direct regulation of IDH2 promoter activity. Moreover, mTORC2 affects the expression of c-Maf and IDH2 and subsequent IL-17 production in γδ T cells. Deletion of c-Maf in γδ T cells reduces metastatic lung cancer development, suggesting c-Maf as a potential target for cancer immune therapy. We show that c-Maf also controls IL-17 production in human γδ T cells from peripheral blood and in oral cancers. These results demonstrate a critical role of the transcription factor c-Maf in regulating γδT17 effector function through IDH2-mediated metabolic reprogramming.
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http://dx.doi.org/10.1126/sciadv.abm9120DOI Listing
May 2022

Ankylosing spondylitis complicated with andersson lesion in the lower cervical spine: A case report.

World J Clin Cases 2022 Apr;10(11):3533-3540

Department of Orthopedics, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China.

Background: Andersson lesion (AL) is an uncommon complication in ankylosing spondylitis (AS), which is characterized by nonneoplastic bone destruction and often appears as bone destruction and sclerosis in the vertebral body and/or the area involving the intervertebral disc. According to the literature, Andersson lesion commonly occur in the thoracic and lumbar spine and rarely in the cervical spine.

Case Summary: This case involved a 78-year-old man with a long history of AS who developed AL in the cervical spine (C5/6 and C6/7). One-stage anterior-posterior approach surgery was successfully performed. At the 6-month follow-up, the pain was significantly reduced, and the limb function was gradually improved.

Conclusion: AL uncharacteristically appears in the cervical spine and tends to be misdiagnosed as vertebral metastases or spinal tuberculosis. Posterior combined with anterior surgery achieves solid biological stabilization in the treatment of AL bone destruction.
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http://dx.doi.org/10.12998/wjcc.v10.i11.3533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048539PMC
April 2022

Echocardiography in the diagnosis of Shone's complex and analysis of the causes for missed diagnosis and misdiagnosis.

World J Clin Cases 2022 Apr;10(11):3369-3378

Department of Cardiovascular Surgery, Fuwai Hospital, Beijing 100037, China.

Background: Shone's complex is a rare syndrome characterized by congenital left heart defects that can differ among the patients.

Aim: To use echocardiography in the diagnosis of Shone's complex and analyze the causes of missed diagnosis and misdiagnosis.

Methods: This was a retrospective study of patients who underwent echocardiography and repair surgery from February 14, 2008, to November 22, 2019. The patients were followed once a year at the outpatient clinic after surgery.

Results: Sixty-six patients were included. The patients were 2.7 (0.8-5.6) years of age, and 54.5% were male. Ten (15.2%) had a history of heart surgery. The most common heart defect was the Annulo-Leaflet mitral ring (ALMR) (50/66, 75.8%), followed by coarctation of the aorta (CoA) (43/66, 65.2%). The patients had a variety of combinations of defects. Only two (3.0%) patients had all four defects. None of the patients had a family history of congenital heart disease. The preoperative echocardiographic findings were examined against the intraoperative findings. Echocardiography missed an ALMR in 31 patients (47.0%), a parachute mitral valve (PMV) in one patient (1.5%), subaortic stenosis in one patient (1.5%), and CoA in two patients (3.0%).

Conclusion: Echocardiography is an effective method to diagnose the Shone's complex. Due to this disease's complexity and interindividual variability, Improving the understanding of the disease can reduce misdiagnosis and missed diagnosis.
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http://dx.doi.org/10.12998/wjcc.v10.i11.3369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048561PMC
April 2022

Genome-wide identification and characterization of the SPL gene family and its expression in the various developmental stages and stress conditions in foxtail millet (Setaria italica).

BMC Genomics 2022 May 20;23(1):389. Epub 2022 May 20.

College of Agriculture, Guizhou University, Huaxi District, Guiyang, 550025, Guizhou Province, People's Republic of China.

Background: Among the major transcription factors, SPL plays a crucial role in plant growth, development, and stress response. Foxtail millet (Setaria italica), as a C4 crop, is rich in nutrients and is beneficial to human health. However, research on the foxtail millet SPL (SQUAMOSA PROMOTER BINDING-LIKE) gene family is limited.  RESULTS: In this study, a total of 18 SPL genes were identified for the comprehensive analysis of the whole genome of foxtail millet. These SiSPL genes were divided into seven subfamilies (I, II, III, V, VI, VII, and VIII) according to the classification of the Arabidopsis thaliana SPL gene family. Structural analysis of the SiSPL genes showed that the number of introns in subfamilies I and II were much larger than others, and the promoter regions of SiSPL genes were rich in different cis-acting elements. Among the 18 SiSPL genes, nine genes had putative binding sites with foxtail millet miR156. No tandem duplication events were found between the SiSPL genes, but four pairs of segmental duplications were detected. The SiSPL genes expression were detected in different tissues, which was generally highly expressed in seeds development process, especially SiSPL6 and SiSPL16, which deserve further study. The results of the expression levels of SiSPL genes under eight types of abiotic stresses showed that many stress responsive genes, especially SiSPL9, SiSPL10, and SiSPL16, were highly expressed under multiple stresses, which deserves further attention.

Conclusions: In this research, 18 SPL genes were identified in foxtail millet, and their phylogenetic relationships, gene structural features, duplication events, gene expression and potential roles in foxtail millet development were studied. The findings provide a new perspective for the mining of the excellent SiSPL gene and the molecular breeding of foxtail millet.
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http://dx.doi.org/10.1186/s12864-022-08633-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122484PMC
May 2022

Acacia Fiber Protects the Gut from Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli Colonization Enabled by Antibiotics.

mSphere 2022 May 18:e0007122. Epub 2022 May 18.

Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA.

Novel approaches to combating antibiotic resistance are needed given the ever-continuing rise of antibiotic resistance and the scarce discovery of new antibiotics. Little is known about the colonization dynamics and the role of intrinsic plant-food characteristics in this process. We sought to determine whether plant fiber could alter colonization dynamics by antibiotic-resistant bacteria in the gut. We determined that ingestion of antibiotics in mice markedly enhanced gut colonization by a pathogenic extended-spectrum beta-lactamase-producing Escherichia coli strain of human origin, E. coli JJ1886 (ST131-30Rx). Furthermore, ingestion of soluble acacia fiber before and after antibiotic exposure significantly reduced pathogenic E. coli colonization. 16S rRNA analysis and cocultures demonstrated that fiber protected the microbiome by serving as a prebiotic, which induced native gut E. coli to inhibit pathogenic E. coli via colicin M. Fiber may be a useful prebiotic with which to administer antibiotics to protect human and livestock gut microbiomes against colonization from antibiotic-resistant, pathogenic bacteria. A One Health-based strategy-the concept that human health and animal health are interconnected with the environment-is necessary to determine the drivers of antibiotic resistance from food to the clinic. Moreover, humans can ingest antibiotic-resistant bacteria on food and asymptomatically, or "silently," carry such bacteria in the gut long before they develop an opportunistic extraintestinal infection. Here, we determined that fiber-rich foods, in particular acacia fiber, may be a new, promising, and inexpensive prebiotic to administer with antibiotics to protect the mammalian (i.e., human and livestock) gut against such colonization by antibiotic-resistant, pathogenic bacteria.
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http://dx.doi.org/10.1128/msphere.00071-22DOI Listing
May 2022

Effect of stem cell treatment on burn wounds: A systemic review and a meta-analysis.

Int Wound J 2022 May 13. Epub 2022 May 13.

Department of Burn and Plastic Surgery, Affiliated Hospital of Nantong University, Nantong, China.

A meta-analysis was performed to evaluate the effect of stem cells treatment in managing burn wounds. A systematic literature search up to March 2022 incorporated 24 studies reported between 2013 and 2021 including 400 animals with burn wounds at the beginning of the study; 211 were using stem cells treatment, and 189 controlled. Statistical tools like the contentious method were used within a random or fixed-influence model to establish the mean difference (MD) with 95% confidence intervals (CIs) to evaluate the influence of stem cells treatment in managing burn wounds. Stem cells treatment had a significantly higher burn wound healing rate (MD, 15.18; 95% CI, 11.29-19.07, P < .001), higher blood vessel number (MD, 12.28; 95% CI, 10.06-14.51, P < .001), higher vascular endothelial growth factor (MD, 10.24; 95% CI, 7.19-13.29, P < .001), lower interleukin-1 level (MD, -98.48; 95% CI, -155.33 to -41.63, P < .001), and lower tumour necrosis factor α level (MD, -28.71; 95% CI, -46.65 to -10.76, P < .002) compared with control in animals' models with burn wounds. Stem cells treatment had a significantly higher burn wound healing rate, higher blood vessel number, higher vascular endothelial growth factor, lower interleukin-1 level, and lower tumour necrosis factor α level compared with control in animals' models with burn wounds. Further studies are required to validate these findings.
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http://dx.doi.org/10.1111/iwj.13831DOI Listing
May 2022

Similarities and Differences in Brain Activation Between Patients With Schizophrenia and Obsessive-Compulsive Disorder: A Near-Infrared Spectroscopy Study.

Front Psychiatry 2022 26;13:853428. Epub 2022 Apr 26.

Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China.

Schizophrenia (SZ) and obsessive-compulsive disorder (OCD) share several epidemiological and clinical features, but the neurobiological substrates shared by these two diseases remain unclear. This study aimed to explore the similarities and differences in brain function between them using near-infrared spectroscopy (NIRS). Eventually, 130 SZ patients, 70 OCD and 75 normal controls (NCs) were enrolled. A 52-channel NIRS instrument was used to detect the concentration changes in oxygenated hemoglobin ([oxy-Hb]) during the verbal fluency task. Ten regions of interests (ROIs) were defined: the bilateral dorsolateral prefrontal cortex (DLPFC), frontopolar cortex (FPC), orbitofrontal cortex (OFC), inferior prefrontal gyrus (IFG) and temporal gyrus (TG). Through two different analysis strategies based on channels or ROIs, we compared the [oxy-Hb] changes in three groups by one-way analysis of variance (ANOVA) and tests. Across 52 channels, compared to the NC group, both SZ and OCD groups exhibited reduced activity in 17 channels, including left FPC, left DLPFC, bilateral OFC, IFG, middle TG, supplementary motor cortex and Broca's area, while SZ showed lower activity in channel 35 (right OFC) than OCD patients. Across all ROIs, compared to the NC group, both SZ and OCD groups showed reduced activity in 7 ROIs, including left FPC, bilateral OFC, IFG and TG, while SZ showed lower activity in the right OFC than OCD group, which were almost consistent with the results based on channels. This study suggests SZ and OCD present with some similar neuropathological changes, while SZ shows more severe impairment in the right OFC than OCD.
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http://dx.doi.org/10.3389/fpsyt.2022.853428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086627PMC
April 2022

The Power of Affection: Exploring the Key Drivers of Customer Loyalty in Virtual Reality-Enabled Services.

Front Psychol 2022 25;13:850896. Epub 2022 Apr 25.

School of Management, Huazhong University of Science and Technology, Wuhan, China.

The accelerating growth of virtual reality (VR) technology and evolving customer needs make multifarious challenges and opportunities for service industries. Based on the Technology Acceptance Model (TAM) and Theory of Affection Responses, we explored the key drivers of customer loyalty in virtual reality-enabled services through a large-scaled survey data collected from VR users in four major cities of Pakistan. The study employs the partial least squares structural equation modeling (PLS-SEM). We verified that the authenticity of the VR experience and TAM dimensions (ease of use, usefulness of VR) are the key drivers of customer loyalty béhavioral in VR-enabled services. Furthermore, results revealed that Affective responses (i.e., enjoyment, emotional involvement, and flow state) significantly mediated the relationships between the drivers and customer loyalty (continued use, recommendation, and willingness to pay premium). Implications for researchers and VR practitioners were also provided.
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http://dx.doi.org/10.3389/fpsyg.2022.850896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085384PMC
April 2022

Comparative outcomes of cortical bone trajectory screw fixation and traditional pedicle screws in lumbar fusion: A meta-analysis.

World Neurosurg 2022 May 6. Epub 2022 May 6.

Hubei University of Chinese Medicine, 188 Tan Hua-lin Road, Wuhan 430065, P.R. China. Electronic address:

Background: Pedicular screws (PS) is often used in lumbar fusion. Cortical bone trajectory (CBT) is a novel technology in lumbar fusion with less clinical outcomes evidence. So we conduct a meta-analysis to compare the efficacy and safety between cortical bone trajectory screw fixation and traditional pedicle screws in lumbar fusion surgery.

Methods: Multiple databases were searched for the articles about comparison of cortical bone trajectory (CBT) and traditional pedicle screws (PS) in lumbar fusion surgeries. The Meta-analysis was conducted by Revman 5.3 software. The following indicators were abstracted: visual analog scale (VAS) scores for back and leg pain, Oswestry Disability Index (ODI), Japanese Orthopedic Association (JOA), surgical duration, complications, and blood loss. The quality of the articles was assessed by the Newcastle-Ottawa Scale or Cochrane Handbook.

Results: 25 studies were included involving a total of 1735 patients. There is no difference in preoperative VAS scores, JOA, ODI, postoperative VAS scores and fusion rates. Besides, postoperative JOA(MD = 0.78, P = 0.02), ODI (MD = -2.09, P=0.03), surgical duration(MD = -26.90, P = 0.02), complications(MD = 0.70, P = 0.03), and blood loss(MD = -85.27, P=0.0009) showed greater improvement trends in CBT group than PS group with significant difference.

Conclusion: CBT reduced the rate of complications, surgical duration, blood loss, postoperative ODI and JOA scores. CBT technique with better postoperative outcomes achieved similar fusion rates compared with PS technique.
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http://dx.doi.org/10.1016/j.wneu.2022.04.129DOI Listing
May 2022

Comprehensive lipidomic analysis reveals regulation of glyceride metabolism in rat visceral adipose tissue by high-altitude chronic hypoxia.

PLoS One 2022 6;17(5):e0267513. Epub 2022 May 6.

Endocrinology Department, Qinghai Provincial People's Hospital, Xining, PR, China.

Adipose tissue plays a central role in energy substrate homeostasis and is a key regulator of lipid flow throughout these processes. As hypoxia affects lipid metabolism in adipose tissue, we aimed to investigate the effects of high-altitude chronic hypoxia on lipid metabolism in the adipose tissue of rats using a lipidomic analysis approach. Visceral adipose tissues from rats housed in a high-altitude hypoxia environment representing 4,300 m with 14.07% oxygen (hypoxia group) and from rats housed in a low-altitude normoxia environment representing 41 m with 20.95% oxygen (normoxia group) for 8 weeks were analyzed using an ultra-performance liquid chromatography-Orbitrap mass spectrometry system. After 8 weeks, the body weight and visceral adipose tissue weight of the hypoxia group were significantly decreased compared to those of the normoxia group (p < 0.05). The area and diameter of visceral adipose cells in the hypoxia group were significantly smaller than those of visceral adipose cells in the normoxia group (p < 0.05). The results of lipidomic analysis showed a total of 21 lipid classes and 819 lipid species. The total lipid concentration of the hypoxia group was lower than that in the normoxia group (p < 0.05). Concentrations of diacylglycerols and triacylglycerols in the hypoxia group were significantly lower than those in the normoxia group (p < 0.05). Using univariate and multivariate analyses, we identified 74 lipids that were significantly altered between the normoxia and hypoxia groups. These results demonstrate that high-altitude chronic hypoxia changes the metabolism of visceral adipose glycerides, which may potentially modulate other metabolic processes.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0267513PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075645PMC
May 2022

Rauwolfia vomitoria extract suppresses benign prostatic hyperplasia by inducing autophagic apoptosis through endoplasmic reticulum stress.

BMC Complement Med Ther 2022 May 5;22(1):125. Epub 2022 May 5.

Department of Laboratory Animal Science, Fudan University, 130 Dong'an Road, Shanghai, 200032, China.

Background: The current drug treatments for benign prostatic hyperplasia (BPH) have negative side effects. Therefore, it is important to find effective alternative therapies with significantly fewer side effects. Our previous study revealed that Rauwolfia vomitoria (RWF) root bark extract reversed BPH development in a rat model. However, the molecular mechanism of its inhibitory effects on BPH remains largely unknown.

Methods: BPH-1 and WPMY-1 cell lines derived from BPH epithelial and prostatic stromal compartments were selected to investigate how RWF extract inhibits BPH in vitro by MTT and flow cytometry assays. Microarray, quantitative real-time PCR, immunoblotting, and GFP-LC3 immunofluorescence assays were performed to evaluate the effects of RWF extract on endoplasmic reticulum stress (ER stress) and autophagic apoptosis pathways in two cell lines. A human BPH ex vivo explant assay was also employed for validation.

Results: RWF extract treatment decreased cell viability and induced apoptotic cell death in both BPH-1 and WPMY-1 cells in a concentration-dependent manner with the increase of pro-apoptotic PCDC4 protein. RWF extract induced autophagy by enhancing the levels of autophagic genes (ULK2 and SQSTM1/p62) and the LC3II:LC3I ratio, with the increase of GFP-LC3 puncta. Moreover, RWF extract activated PERK- and ATF6-associated ER stress pathways by inducing the transcriptional levels of EIF2AK3/PERK, DDIT3/CHOP and ATF6, accompanied by the reduction of BiP protein level, but not its mRNA level. Another ER stress pathway was not induced by RWF extract, as manifested by the lack of XBP1 splicing. Pharmacological inhibition of autophagy by 3-methyladenine abrogated apoptosis but not ER stress; while inhibition of ER stress by 4-phenylbutyrate alleviated the induction of autophagy and apoptosis. In addition, pretreatments with either 3-methyladenine or 4-phenylbutyrate suppressed RWF extract-induced cytotoxicity. Notably, the inductions of PERK- and ATF6-related stress pathways and autophagic apoptosis were confirmed in a human BPH ex vivo explant.

Conclusions: Our data have demonstrated that RWF extract significantly suppressed the viabilities of BPH epithelial cells and BPH myofibroblasts by inducing apoptosis via upregulating ER stress and autophagy. These data indicate that RWF extract is a potential novel alternative therapeutic approach for BPH.
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http://dx.doi.org/10.1186/s12906-022-03610-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074266PMC
May 2022

Single-junction organic solar cells with over 19% efficiency enabled by a refined double-fibril network morphology.

Nat Mater 2022 May 5. Epub 2022 May 5.

Frontiers Science Center for Transformative Molecules, In-situ Center for Physical Science, and Center of Hydrogen Science, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.

In organic photovoltaics, morphological control of donor and acceptor domains on the nanoscale is the key for enabling efficient exciton diffusion and dissociation, carrier transport and suppression of recombination losses. To realize this, here, we demonstrated a double-fibril network based on a ternary donor-acceptor morphology with multi-length scales constructed by combining ancillary conjugated polymer crystallizers and a non-fullerene acceptor filament assembly. Using this approach, we achieved an average power conversion efficiency of 19.3% (certified 19.2%). The success lies in the good match between the photoelectric parameters and the morphological characteristic lengths, which utilizes the excitons and free charges efficiently. This strategy leads to an enhanced exciton diffusion length and a reduced recombination rate, hence minimizing photon-to-electron losses in the ternary devices as compared to their binary counterparts. The double-fibril network morphology strategy minimizes losses and maximizes the power output, offering the possibility of 20% power conversion efficiencies in single-junction organic photovoltaics.
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http://dx.doi.org/10.1038/s41563-022-01244-yDOI Listing
May 2022

Observation of Ultrastrong Coupling between Substrate and the Magnetic Topological Insulator MnBiTe.

Nano Lett 2022 May 3;22(10):3856-3864. Epub 2022 May 3.

Department of Physics, Southern University of Science and Technology, Shenzhen, Guangdong 518055, People's Republic of China.

The intrinsic magnetic topological insulator MnBiTe has attracted significant interest recently as a promising platform for exploring exotic quantum phenomena. Here we report that, when atomically thin MnBiTe is deposited on a substrate such as silicon oxide or gold, there is a very strong mechanical coupling between the atomic layer and the supporting substrate. This is manifested as an intense low-frequency breathing Raman mode that is present even for monolayer MnBiTe. Interestingly, this coupling turns out to be stronger than the interlayer coupling between the MnBiTe atomic layers. We further found that these low-energy breathing modes are highly sensitive to sample degradation, and they become drastically weaker upon ambient air exposure. This is in contrast to the higher energy optical phonon modes which are much more robust, suggesting that the low-energy Raman modes found here can be an effective indicator of sample quality.
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http://dx.doi.org/10.1021/acs.nanolett.1c04194DOI Listing
May 2022

An ultrastable Ti-based metallocalixarene nanocage cluster with photocatalytic amine oxidation activity.

Chem Commun (Camb) 2022 May 17;58(40):6028-6031. Epub 2022 May 17.

College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, Hunan, P. R. China.

Polyhedral metallocalixarene nanocage clusters based on pure Ti(IV) ions are to our knowledge unknown hitherto. Herein we report the first Ti(IV)-based metallocalixarene nanocage cluster by assembling a [TiO] cage with six -butylcalix[4]arene molecules. Notably, the cluster exhibits extraordinary stability in high-concentration acid/alkali solutions and can act as a stable photocatalyst to catalyze the oxidation of ammonia to imines.
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http://dx.doi.org/10.1039/d2cc01740gDOI Listing
May 2022

The Effect of Smoking Habits on Blood Cadmium and Lead Levels in Residents Living Near a Mining and Smelting Area in Northwest China: a Cross-Sectional Study.

Biol Trace Elem Res 2022 May 2. Epub 2022 May 2.

The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.

Few studies have focused on environmental cadmium (Cd) and lead (Pb) exposure while exploring the effect of smoking on blood Cd (BCd) and blood Pb (BPb) levels. Moreover, essential trace elements affect the absorption, accumulation, and toxicity of Cd and Pb. To investigate the effect of smoking on BCd and BPb levels under high Cd and Pb exposure and the influence of essential trace elements on the effect, 301 residents living near a mining and smelting area in Northwest China were included in our study. After collecting health information and measuring BCd, BPb, serum iron, magnesium, and total calcium levels, we analyzed the association between smoking and BCd and BPb levels and the influence of the essential trace elements on the association. The results showed that BCd and BPb levels in smokers were significantly higher than those in non-smokers. There was a dose-response association between pack-years and the odds ratios (ORs) of high BCd and BPb levels in all participants compared with non-smokers. Serum iron, magnesium, and calcium had a negative effect on the elevations of the ORs of high BCd and BPb levels. In addition, smoking-related elevations of BCd and BPb levels vary by sex, age, BMI, and age of smoking initiation. Our findings present evidence for the effect of smoking on BCd and BPb levels under high Cd and Pb exposure and may provide guidance for the prevention and control of BCd and BPb elevations in residents living in Cd- and Pb-polluted areas.
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http://dx.doi.org/10.1007/s12011-022-03248-wDOI Listing
May 2022

Chitosan assisted MXene decoration onto polymer fabric for high efficiency solar driven interfacial evaporation of oil contaminated seawater.

J Colloid Interface Sci 2022 Apr 15;622:169-180. Epub 2022 Apr 15.

School of Chemistry and Chemical Engineering, Yangzhou University, No 180, Road Siwangting, Yangzhou, Jiangsu 225002, China. Electronic address:

The solar-driven interfacial evaporation (SDIE) is now a promising way to solve the shortage of fresh water. However, high performance SDIE for the oil contaminated seawater remains challenging. Here, we propose a facile "chitosan assisted MXene decoration" strategy to prepare a superhydrophilic and underwater superoleophobic Chitosan/MXene/fabric (CMF) for highly efficient SDIE. Benefiting from the superhydrophilicity and excellent photo-thermal conversion performance, the CMF is served as both the solar absorber and the water transportation path. Under the light illumination with one sun intensity (1 kW·m), a high evaporation rate of 1.50 kg·m·h and efficiency of 88.05% are achieved. The strong interfacial interaction and outstanding salt rejection behavior of the CMF ensure the SDIE long-term stability and durability. In addition, the underwater superoleophobic CMF can effectively and quickly repel different oils and is hence suitable for high performance SDIE of the oil-in-water emulsion and the crude oil contaminated seawater. This work provides a rational design and optimization for the SDIE system, which holds great potential in practical desalination applications.
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http://dx.doi.org/10.1016/j.jcis.2022.04.074DOI Listing
April 2022

Illness perceptions and adherence to breast cancer-related lymphedema risk management behaviours among breast cancer survivors.

Eur J Oncol Nurs 2022 Apr 18;58:102144. Epub 2022 Apr 18.

School of Nursing, Sun Yat-Sen University, Guangzhou, Guangdong Province, China. Electronic address:

Purpose: To describe illness perceptions of breast cancer-related lymphedema (BCRL) and adherence to BCRL risk management behaviours and analyse the relationship between these factors in postoperative breast cancer survivors in China.

Methods: A cross-sectional study was conducted in the first half of 2019 using 281 breast cancer survivors. Participants' illness perceptions and adherence to BCRL risk management behaviours at the 3rd month after surgery were investigated using the Revised Illness Perception Questionnaire for BCRL (IPQ-R [BCRL]), Lymphedema Risk Management Behaviour Questionnaire (LRMBQ), and Functional Exercise Adherence Scale (FEAS). The relationship between these variables was studied using correlation analysis and multiple linear regression analysis.

Results: Among the four dimensions of the LRMBQ, the mean score of our respondents received in "skin care" was 3.63 (S.D. 0.67), which was the lowest on the dimension, demonstrating the worst performance in this aspect. Regarding the FEAS results, better functional exercise adherence was observed in our sample compared to previous Chinese research. The results also showed that adherence to BCRL risk management behaviours was related to patient age and degree of education. Furthermore, other dimensions of illness perceptions, such as consequence, timeline acute/chronic, illness coherence and identity, follow their multiple linear regression equations with their corresponding BCRL risk management behaviour adherence.

Conclusions: Our findings confirmed the importance of illness perceptions for adherence to BCRL risk management behaviours, suggesting that we need to pay attention to patients' cognition in this respect and supply necessary interventions.
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http://dx.doi.org/10.1016/j.ejon.2022.102144DOI Listing
April 2022

Association of the collagen signature with pathological complete response in rectal cancer patients.

Cancer Sci 2022 Apr 29. Epub 2022 Apr 29.

Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, China.

Collagen in the tumor microenvironment is recognized as a potential biomarker for predicting treatment response. This study investigated whether the collagen features are associated with pathological complete response (pCR) in locally advanced rectal cancer (LARC) patients receiving neoadjuvant chemoradiotherapy (nCRT) and develop and validate a prediction model for individualized prediction of pCR. The prediction model was developed in a primary cohort (353 consecutive patients). In total, 142 collagen features were extracted from the multiphoton image of pretreatment biopsy, and the least absolute shrinkage and selection operator (Lasso) regression was applied for feature selection and collagen signature building. A nomogram was developed using multivariable analysis. The performance of the nomogram was assessed with respect to its discrimination, calibration, and clinical utility. An independent cohort (163 consecutive patients) was used to validate the model. The collagen signature comprised four collagen features significantly associated with pCR both in the primary and validation cohorts (p < 0.001). Predictors in the individualized prediction nomogram included the collagen signature and clinicopathological predictors. The nomogram showed good discrimination with area under the ROC curve (AUC) of 0.891 in the primary cohort and good calibration. Application of the nomogram in the validation cohort still gave good discrimination (AUC = 0.908) and good calibration. Decision curve analysis demonstrated that the nomogram was clinically useful. In conclusion, the collagen signature in the tumor microenvironment of pretreatment biopsy is significantly associated with pCR. The nomogram based on the collagen signature and clinicopathological predictors could be used for individualized prediction of pCR in LARC patients before nCRT.
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http://dx.doi.org/10.1111/cas.15385DOI Listing
April 2022

Mechanism of lncRNA-H19 in Intestinal Injury of Mice with Ulcerative Colitis.

Int Arch Allergy Immunol 2022 Apr 28:1-12. Epub 2022 Apr 28.

Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Introduction: Ulcerative colitis (UC) is a debilitating condition of the gastrointestinal system, and long non-coding RNA (lncRNA)-H19 emerges as a crucial player in inflammatory diseases. This study is designed to evaluate the mechanism of H19 in intestinal injury of UC mice and hint at a novel target for UC treatment.

Methods: UC mouse model was established, followed by injection of shH19, antagomir-331-3p, and tumor necrosis factor receptor-associated factor 4 (TRAF4) overexpression vector. H19, miR-331-3p, and TRAF4 expressions were detected via reverse transcription quantitative polymerase chain reaction. Intestinal injury was appraised via disease activity index (DAI), hematoxylin-eosin staining, and histopathological scoring. Interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and IL-10 levels were detected via enzyme-linked immunosorbent assay. Binding relationships of H19 and miR-331-3p and TRAF4 were verified.

Results: H19 was highly expressed in colon tissues. Silencing H19 attenuated intestinal injury of UC mice, manifested by reductions in weight loss, DAI, histopathological scores, IL-1β and TNF-α, and increases in colon length and IL-10. Mechanically, lncRNA-H19 is bound to miR-331-3p to inhibit its expression. TRAF4 is a target of miR-331-3p. Inhibition of miR-331-3p or overexpression of TRAF4 could reverse the alleviating role of lncRNA-H19 in intestinal injury of UC mice.

Conclusion: LncRNA-H19 was highly expressed in UC mice and bound to miR-331-3p to promote TRAF4 transcription, thereby aggravating intestinal injury.
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http://dx.doi.org/10.1159/000524156DOI Listing
April 2022

Preparation and characterization of polydopamine/melamine microencapsulated red phosphorus and its flame retardance in epoxy resin.

RSC Adv 2021 Jun 7;11(33):20391-20402. Epub 2021 Jun 7.

Army Engineering University of PLA-Shijiazhuang Campus Shijiazhuang Hebei 050003 P. R. China

Polydopamine/melamine composite microencapsulated red phosphorus ([email protected]/MA) was prepared and applied as the flame retardant for epoxy resin (EP) in this work. For comparison, polydopamine (PDA) coated red phosphorus ([email protected]) was also prepared. The microstructure, chemical composition and thermal decomposition of the as prepared samples were systematically characterized. The results showed that PDA and PDA/MA shell structures were fabricated successfully convenient water-based processes at room temperature. The flame retardance of red phosphorus (RP), [email protected], and [email protected]/MA on EP was evaluated. The results showed that EP blending with 7 wt% [email protected]/MA passed V-0 degree in the vertical burning test (UL-94), reached a limited oxygen index (LOI) of 30.9% and decreased the peak heat release rate of EP by 65.1% in the cone calorimeter test. The satisfactory flame retardance can be attributed to the intumescent flame retardant system consisting of [email protected]/MA. The PDA and PDA/MA shell structures also improved the compatibility between RP and EP, thus [email protected] and [email protected]/MA had less significant impact on the tensile-strain properties of EP.
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http://dx.doi.org/10.1039/d1ra03164cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034026PMC
June 2021

Probabilistic Prediction of Nonadherence to Psychiatric Disorder Medication from Mental Health Forum Data: Developing and Validating Bayesian Machine Learning Classifiers.

Comput Intell Neurosci 2022 15;2022:6722321. Epub 2022 Apr 15.

School of Computer Science, South China Normal University, Guangzhou, Guangdong, China.

Background: Medication nonadherence represents a major burden on national health systems. According to the World Health Organization, increasing medication adherence may have a greater impact on public health than any improvement in specific medical treatments. More research is needed to better predict populations at risk of medication nonadherence.

Objective: To develop clinically informative, easy-to-interpret machine learning classifiers to predict people with psychiatric disorders at risk of medication nonadherence based on the syntactic and structural features of written posts on health forums.

Methods: All data were collected from posts between 2016 and 2021 on mental health forum, administered by Together 4 Change, a long-running not-for-profit organisation based in Oxford, UK. The original social media data were annotated using the Tool for the Automatic Analysis of Syntactic Sophistication and Complexity (TAASSC) system. Through applying multiple feature optimisation techniques, we developed a best-performing model using relevance vector machine (RVM) for the probabilistic prediction of medication nonadherence among online mental health forum discussants.

Results: The best-performing RVM model reached a mean AUC of 0.762, accuracy of 0.763, sensitivity of 0.779, and specificity of 0.742 on the testing dataset. It outperformed competing classifiers with more complex feature sets with statistically significant improvement in sensitivity and specificity, after adjusting the alpha levels with Benjamini-Hochberg correction procedure. . We used the forest plot of multiple logistic regression to explore the association between written post features in the best-performing RVM model and the binary outcome of medication adherence among online post contributors with psychiatric disorders. We found that increased quantities of 3 syntactic complexity features were negatively associated with psychiatric medication adherence: "dobj_stdev" (standard deviation of dependents per direct object of nonpronouns) (OR, 1.486, 95% CI, 1.202-1.838, < 0.001), "cl_av_deps" (dependents per clause) (OR, 1.597, 95% CI, 1.202-2.122, , 0.001), and "VP_T" (verb phrases per T-unit) (OR, 2.23, 95% CI, 1.211-4.104, , 0.010). Finally, we illustrated the clinical use of the classifier with Bayes' monograph which gives the posterior odds and their 95% CI of positive (nonadherence) versus negative (adherence) cases as predicted by the best-performing classifier. The odds ratio of the posterior probability of positive cases was 3.9, which means that around 10 in every 13 psychiatric patients with a positive result as predicted by our model were following their medication regime. The odds ratio of the posterior probability of true negative cases was 0.4, meaning that around 10 in every 14 psychiatric patients with a negative test result after screening by our classifier were not adhering to their medications.

Conclusion: Psychiatric medication nonadherence is a large and increasing burden on national health systems. Using Bayesian machine learning techniques and publicly accessible online health forum data, our study illustrates the viability of developing cost-effective, informative decision aids to support the monitoring and prediction of patients at risk of medication nonadherence.
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http://dx.doi.org/10.1155/2022/6722321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033323PMC
April 2022

Association among Infection, Tooth Loss, and Heavy Medal Exposure in a Chinese Rural Population.

Int J Environ Res Public Health 2022 04 11;19(8). Epub 2022 Apr 11.

Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, China.

Previous research suggests that heavy metals may be associated with increased susceptibility to infection. This study investigated the effect of heavy metal exposure (Pb and Cd) on tooth loss and infection in a Chinese rural population, who live near a mining and smelting area. Blood samples were collected from the study participants to estimate the lead (Pb) and cadmium (Cd) exposure levels. infection was analyzed using the C-urea breath test, and the number of missing teeth (MT), filled teeth (FT), and missing or filled teeth (MFT) were counted by conducting a physical examination. Regression analysis was used to assess the difference between -positive and -negative individuals in the MT, FT, and MFT groups, adjusting for confounders. The infection prevalence was higher in individuals in the high Cd or high Pb groups than that in the low Cd or low Pb groups ( < 0.05). In addition, greater numbers of FT and MFT were observed in individuals in the high Pb group than those in the low Pb group ( < 0.05). We further found 8.7% (95% CI, 2.8-23.8%, = 0.017) of the effect of the high BPb level on infection risk could be statistically explained by FT using amediation analyses in adjusted models, and 6.8% (95% CI, 1.6-24.8%, = 0.066) by MFT. Furthermore, FT and MFT were significantly associated with increased risk for infection (odds ratio (OR) = 4.938, 95% confidence interval (CI): 1.125-21.671; OR = 3.602, 95% CI: 1.218-10.648, respectively). Pb and Cd exposure may be associated with tooth loss and increased susceptibility to infection, and tooth loss may be an independent risk factor for infection.
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http://dx.doi.org/10.3390/ijerph19084569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025748PMC
April 2022

The relationship of marital adjustment and posttraumatic growth in female breast cancer patients and their husbands.

Psychol Health Med 2022 Apr 19:1-7. Epub 2022 Apr 19.

School of Nursing, Sun Yat-Sen University, Guangzhou, GD, China.

Posttraumatic growth (PTG) is very important for breast cancer couples to cope with cancer. Individual marital adjustment can affect PTG, however, it is still unknown that the effect of marital adjustment on one's own and their spouses' PTG in breast cancer couples. To investigate the status of PTG and marital adjustment and explore the relation between PTG and marital adjustment in breast cancer patient-husband dyads. General data, marital adjustment and PTG scores of breast cancer patients ( = 206) and their husbands ( = 206) were collected through a general information questionnaire, the Post-traumatic Growth Inventory (PTGI) and Marital Adjustment Test (MAT). T-tests and structural equation models were applied to explore the relations between marital adjustment and PTG among breast cancer patients and their husbands. The PTG among breast cancer patients was significantly higher than among their husbands ( < 0.05); the score of patients' marital adjustment was 96.18 ± 22.08, and that of their husbands was 96.22 ± 22.27. The participants' marital adjustment had a positive predictive effect on their own PTG ( < 0.05), and patients' marital adjustment also had a positive predictive effect on their husbands' PTG ( < 0.05). Breast cancer patients experienced more PTG than their husbands; patients' PTG was promoted by their own marital adjustment, while husbands' PTG was promoted by both their own and the patient's marital adjustment. In order to improve breast cancer patients' and their husbands' PTG, it is essential to promote their marital adjustment.
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http://dx.doi.org/10.1080/13548506.2022.2067339DOI Listing
April 2022

Altered Interhemispheric Functional Connectivity Associated With Early Verbal Fluency Decline After Deep Brain Stimulation in Parkinson's Disease.

Front Aging Neurosci 2022 1;14:799545. Epub 2022 Apr 1.

Department of Geriatric Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.

Background: Patients with Parkinson's disease (PD) experience a decline in verbal fluency (VF) immediately after undergoing deep brain stimulation (DBS) of the subthalamic nucleus (STN). This phenomenon is thought to be related to surgical microlesions.

Purpose: We investigated the alterations in interhemispheric functional connectivity after STN-DBS in PD patients. We also evaluated the correlation between these changes and decreased VF scores.

Method: Overall, 30 patients with PD were enrolled in the study. Resting-state functional magnetic resonance imaging scans were performed twice, once before and once after DBS, in PD patients. Voxel-mirrored homotopic connectivity (VMHC) was applied in order to evaluate the synchronicity of functional connectivity between the hemispheres.

Result: After undergoing STN-DBS, PD patients demonstrated reduced VMHC value in the posterior cerebellum lobe, angular gyrus, precuneus/posterior cingulate gyrus (PCC), supramarginal gyrus, superior frontal gyrus (SFG) (medial and dorsolateral) and middle frontal gyrus (MFG). In addition, we observed a significant positive correlation between the altered VMHC value in the SFG and MFG and the change of phonemic VF scores.

Conclusion: PD patients demonstrated an interhemispheric coordination disorder in the prefrontal cortex, cerebellum, supramarginal gyrus and DMN after undergoing STN-DBS. The positive correlation between reduced VMHC value in the SFG and MFG and the changes of VF scores provides a novel understanding with regard to the decline of VF after DBS.
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http://dx.doi.org/10.3389/fnagi.2022.799545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011328PMC
April 2022

Bio-based arginine surface-modified ammonium polyphosphate: an efficient intumescent flame retardant for epoxy resin.

RSC Adv 2022 Mar 23;12(15):9223-9237. Epub 2022 Mar 23.

Army Engineering University of PLA-Shijiazhuang Campus Shijiazhuang Hebei 050003 P. R. China

In this work, ammonium polyphosphate (APP) was surface-modified by bio-based arginine (Arg) for the first time to enhance its flame retardance for fire-safety epoxy resin (EP). The structure of Arg modified APP (Arg-APP) was characterized by Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), H nuclear magnetic resonance (H-NMR), and scanning electron microscopy (SEM). The results illustrated that Arg was attached on the surface of APP through a cation exchange reaction. With Arg acting as the efficient carbon source, the char-forming ability of Arg-APP was significantly improved as illustrated by thermogravimetric analysis (TGA). The flame retardance of EP/APP and EP/Arg-APP composites was evaluated using the limit oxygen index (LOI), vertical burning tests (UL-94), and cone calorimeter tests (CCT). The results showed that at the same weight loading (15 wt%), Arg-APP had better flame retardance and smoke suppression performance compared with pristine APP, which can be attributed to Arg-APP constituting an integrated intumescent flame retardant (IFR) and facilitating formation of char residues with significantly expanded structures and higher carbonization degrees. When the weight loading of Arg-APP reached 25 wt%, the EP/Arg-APP composite could achieve an LOI value as high as 34.7%, pass V-0 requirements in UL-94 tests, and decrease the peak heat release rate and total smoke production by 83.5% and 61.1% compared with neat EP in CCT, respectively, indicating the superior flame retardance performance of Arg-APP. Finally, the effects of the flame retardant additives on the mechanical properties of EP were evaluated by the differential scanning calorimetry (DSC) tests and tensile-strain tests. At the same additive weight loading (15 wt%), the EP/Arg-APP composite showed higher glass-transition temperature and better tensile-strain properties compared with EP/APP composite, which can be attributed to the Arg shell structure improving the compatibility between APP and the organic substrate. In conclusion, this work presents a convenient and environmentally friendly method to improve the practical performance of APP.
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http://dx.doi.org/10.1039/d1ra09459aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985179PMC
March 2022

Age-related changes in neuronal receptive fields of primary auditory cortex in frequency, amplitude, and temporal domains.

Hear Res 2022 Apr 6;420:108504. Epub 2022 Apr 6.

Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada. Electronic address:

Aging populations often experience difficulties hearing. This phenomenon, known as age-related hearing loss, is associated with decreases in hearing sensitivity and pathophysiological changes in the central auditory system, including the primary auditory cortex (AI). To better understand changes in the central auditory system, this study is designed to compare the receptive fields of AI neurons of young and old C57 mice in frequency, amplitude, and temporal domains by using random-delivery (various interval) of multi-frequency gamma-shaped tone pips and a novel data processing approach known as the intensity-stacked spectrotemporal receptive field (iSTRF). We show that the fundamental changes in the response properties of AI neurons in old mice were in line with the literature. Compared to young mice, AI neurons in old mice tuned to lower frequency and higher amplitude of tones with broader frequency tuning, shorter dB (dynamic) range, longer response duration, as well as a higher firing rate. We further compared the entire iSTRF and core iSTRF (above 50% maximal firing rate) between young and old mice; the core iSTRF represented the AI neuronal responses to sound that fall into the central frequency and amplitude ranges from the auditory periphery. It is remarkable that the difference was significant in the entire iSTRF while little difference was observed in the core iSTRFs between young and old mice. However, the lower best frequency and higher best amplitude were obvious in both iSTRFs that were mostly determined by the deficits in the inner ears of old mice. In the frequency domain, the tuning quality factor of entire iSTRFs was significantly greater in old mice, while that of core iSTRFs was not compared to young mice. In the amplitude domain, significantly shorter dB range in old mice were observed in the entire iSTRF, but not in the core iSTRF. In the temporal domain, the response duration of old AI neurons was significantly longer in entire iSTRFs, but not in core iSTRFs, when compared to young AI neurons. Furthermore, the average firing rate of old AI neurons was significantly higher in entire iSTRF, but not in core iSTRF. It is also interesting that the ratio of the firing rate to background firing rate (signal-noise ratio) were similar between young and old AI neurons. Our data suggests that age-related hearing loss has relatively less impact on auditory information processing when sounds fall into the optimal frequency and amplitude ranges of given AI neurons.
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http://dx.doi.org/10.1016/j.heares.2022.108504DOI Listing
April 2022

Reconciling models of interfacial state kinetics and device performance in organic solar cells: impact of the energy offsets on the power conversion efficiency.

Energy Environ Sci 2022 Mar 7;15(3):1256-1270. Epub 2022 Feb 7.

Department of Physics and Centre for Plastic Electronics, Imperial College London London SW7 2AZ UK

Achieving the simultaneous increases in the open circuit voltage ( ), short circuit current ( ) and fill factor (FF) necessary to further increase the power conversion efficiency (PCE) of organic photovoltaics (OPV) requires a unified understanding of how molecular and device parameters affect all three characteristics. In this contribution, we introduce a framework that for the first time combines different models that have been used separately to describe the different steps of the charge generation and collection processes in OPV devices: a semi-classical rate model for charge recombination processes in OPV devices, zero-dimensional kinetic models for the photogeneration process and exciton dissociation and one-dimensional semiconductor device models. Using this unified multi-scale model in conjunction with experimental techniques (time-resolved absorption spectroscopy, steady-state and transient optoelectronic measurements) that probe the various steps involved in charge generation we can shed light on how the energy offsets in a series of polymer: non-fullerene devices affect the charge carrier generation, collection, and recombination properties of the devices. We find that changing the energy levels of the donor significantly affects not only the transition rates between local-exciton (LE) and charge-transfer (CT) states, but also significantly changes the transition rates between CT and charge-separated (CS) states, challenging the commonly accepted picture of charge generation and recombination. These results show that in order to obtain an accurate picture of charge generation in OPV devices, a variety of different experimental techniques under different conditions in conjunction with a comprehensive model of processes occurring at different time-scales are required.
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http://dx.doi.org/10.1039/d1ee02788cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924960PMC
March 2022

High altitude Relieves transmission risks of COVID-19 through meteorological and environmental factors: Evidence from China.

Environ Res 2022 Apr 9;212(Pt B):113214. Epub 2022 Apr 9.

Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, School of Life Sciences, Lanzhou University, Tianshui South Road #222, Lanzhou, Gansu, 730000, PR China. Electronic address:

Existing studies reported higher altitudes reduce the COVID-19 infection rate in the United States, Colombia, and Peru. However, the underlying reasons for this phenomenon remain unclear. In this study, regression analysis and mediating effect model were used in a combination to explore the altitudes relation with the pattern of transmission under their correlation factors. The preliminary linear regression analysis indicated a negative correlation between altitudes and COVID-19 infection in China. In contrast to environmental factors from low-altitude regions (<1500 m), high-altitude regions (>1500 m) exhibited lower PM2.5, average temperature (AT), and mobility, accompanied by high SO and absolute humidity (AH). Non-linear regression analysis further revealed that COVID-19 confirmed cases had a positive correlation with mobility, AH, and AT, whereas negatively correlated with SO, CO, and DTR. Subsequent mediating effect model with altitude-correlated factors, such as mobility, AT, AH, DTR and SO, suffice to discriminate the COVID-19 infection rate between low- and high-altitude regions. The mentioned evidence advance our understanding of the altitude-mediated COVID-19 transmission mechanism.
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http://dx.doi.org/10.1016/j.envres.2022.113214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993487PMC
April 2022

MM-associated circular RNA downregulates microRNA-19a through methylation to suppress proliferation of pancreatic adenocarcinoma cells.

Bioengineered 2022 Apr;13(4):9294-9300

Department of Anaesthesiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai City, PR. China.

Opposite roles of circular RNA MM-associated circular RNA (circ-MYBL2) have been observed in different malignancies, and its role in pancreatic adenocarcinoma (PA) is unknown. Our preliminary sequencing data revealed its inverse correlation with microRNA-19a (miR-19a). This study was performed to explore the role of circ-MYBL2 in PA and its crosstalk with miR-19a. The accumulation of circ-MYBL2 and miR-19a in PA was detected by RT-qPCR. Participation of circ-MYBL2 in the regulation of miR-19a and its RNA gene methylation was studied with an overexpression assay, followed by RT-qPCR and MSP analyses. The role of miR-19a and circ-MYBL2 in PA cell proliferation and movement was evaluated using the BrdU assay and the Transwell assay, respectively. Downregulation of circ-MYBL2 and upregulation of miR-19a were observed in PA. In PA cells, circ-MYBL2 decreased the accumulation of miR-19a but increased its RNA gene methylation. Overexpression of circ-MYBL2 decreased PA cell proliferation and movement, while overexpression of miR-19a showed an opposite effect. In addition, circ-MYBL2 suppressed the role of miR-19a in cell proliferation, migration, and invasion. In conclusion, circ-MYBL2 was downregulated in PA and it downregulated miR-19a through methylation to suppress PA cell proliferation.
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http://dx.doi.org/10.1080/21655979.2022.2051815DOI Listing
April 2022

Breast Cancer-Related Lymphedema Risk-Management Behaviors Among Chinese Breast Cancer Survivors and Relationships with Socio-Demographic and Clinical Characteristics: A Longitudinal Study.

Patient Prefer Adherence 2022 25;16:797-808. Epub 2022 Mar 25.

School of Nursing, Sun Yat-sen University, Guangzhou, Guangdong Province, People's Republic of China.

Purpose: We sought to determine changes in breast cancer-related lymphedema (BCRL) risk-management behaviors in the six-month period after surgery among Chinese breast cancer survivors and to explore the relationship between their socio-demographic and clinical characteristics and these behaviors.

Patients And Methods: A longitudinal study design was adopted. Females aged ≥18 years with a first breast cancer diagnosis and who had undergone modified radical mastectomy were recruited from a cancer hospital in China. Respondents with a history of other malignant tumors, mental illness, or cognitive impairment were excluded from the study. Socio-demographic and clinical factors were assessed at baseline. BCRL risk-management behaviors were assessed with the Lymphedema Risk-Management Behavior Questionnaire (LRMBQ) and Functional Exercise Adherence Scale (FEAS) in the first, third, and sixth months after surgery. Repeated-measures analysis of variance was used to examine changes in BCRL risk-management behaviors over the three study time periods, and a generalized linear mixed model was used to determine socio-demographic and clinical factors associated with BCRL risk-management behaviors.

Results: A total of 166 participants completed all three assessments. The scores of the total LRMBQ and its "Skin care" and "Lifestyle" subscales did not change significantly, but those of the "Avoidance of limb compression and injury" and "Other matters requiring attention" subscales changed over the three study time periods. Additionally, scores of the total FEAS and most of its subscales changed over the three study time periods. Furthermore, BCRL risk-management behaviors were significantly related to patients' geographic residence, education level, and tumor stage.

Conclusion: Some dimensions of BCRL risk-management behaviors changed over time, and several socio-demographic and clinical factors are related to BCRL risk-management behaviors. It is recommended that health care professionals consider the dynamic nature of BCRL risk-management behaviors and related factors when planning health education and promotion interventions.
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http://dx.doi.org/10.2147/PPA.S356750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965334PMC
March 2022
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