Publications by authors named "Jun Wu"

3,042 Publications

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mBrainAligner-Web: A Web Server for Cross-Modal Coherent Registration of Whole Mouse Brains.

Bioinformatics 2022 Aug 11. Epub 2022 Aug 11.

Ministry of Education Key Laboratory of Intelligent Computation and Signal Processing, Information Materials and Intelligent Sensing Laboratory of Anhui Province, School of Electronics and Information Engineering, Anhui University, Hefei, Anhui, China.

Summary: Recent whole-brain mapping projects are collecting increasingly larger sets of high-resolution brain images using a variety of imaging, labeling and sample preparation techniques. Both mining and analysis of these data require reliable and robust cross-modal registration tools. We recently developed the mBrainAligner, a pipeline for performing cross-modal registration of the whole-mouse brain. However, using this tool requires scripting or command-line skills to assemble and configure the different modules of mBrainAligner for accommodating different registration requirements and platform settings. In this application note, we present mBrainAligner-Web, a web server with a user-friendly interface that allows to configure and run mBrainAligner locally or remotely across platforms.

Availability And Implementation: mBrainAligner-Web is available at http://mbrainaligner.ahu.edu.cn/ with source code at https://github.com/reaneyli/mBrainAligner-web.
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http://dx.doi.org/10.1093/bioinformatics/btac549DOI Listing
August 2022

First report of Colletotrichum godetiae causing anthracnose fruit rot on Prunus pseudocerasus in Zhejiang province, China.

Plant Dis 2022 Aug 10. Epub 2022 Aug 10.

Zhejiang Academy of Agricultural Sciences, Institute of Plant Protection and Microbiology, Hangzhou, Zhejiang, China;

Prunus pseudocerasus (L.) G. Don is an economically important crop, with 8,420 hm2 of harvested area and 35,000 tons in 2020 (https://www.fao.org/faostat/zh/#data/QCL), and is one of the favorite fruits among consumers. A severe fruit rot disease of P. pseudocerasus cultivar "HeiZhenZhu" was observed in an orchard in Pujiang county (119°42'E, 29°21'N), Zhejiang province in April 2022. Sixty-three plants from a survey of about 200 plants showed anthracnose symptoms, with a disease incidence of more than 30%. Ten diseased fruits were collected from eight different trees. The naturally affected fruits during color changing stage showed initial light brown necrotic lesions, later, the lesions were depressed, and dark brown, the fruits were rotten, and pink conidial masses were produced (Fig. 1 A-F). Conidia were transferred using a sterilized needle into sterile water, diluted to approx. 10 conidia/µL, and spread onto potato dextrose agar (PDA) (Thermo Scientific™) (containing cephalosporin 50 µg/mL). After 24 h, single colonies were transferred, and six single-spore isolates were obtained from different plants. When the strains were grown at 26°C for 7 days, the colonies on PDA were flat with entire margin, surface medium gray-green to white, reverse salmon, light gray-green to white (Fig. 1 G). The conidia of the representative strain YTTJ-JHGS5 were unicellular, hyaline, smooth-walled, cylindrical to fusiform with one end round and one end acute, or both acute ends, 14.4 to 18.9 µm (mean = 16.4 ± 0.9 µm, n = 30) × 4.4 to 5.8 µm (mean = 5.1 ± 0.3 µm, n = 30) (Fig. 1 I). Conidiogenous cells were hyaline, smooth-walled, cylindrical to clavate, 6.5-16.8 µm × 2.6-5.3 µm (n = 30), opening 1.1-2.0 µm (Fig. 1 H). Appressoria were single, light brown to medium brown, elliptical or irregular in shape, the outline entire or undulate, 9.2 to 12.1 µm (mean = 9.2 ± 1.1 µm, n = 30) × 4.6 to 6.7 µm (mean = 5.6 ± 0.4 µm, n = 30) (Fig. 1 J). The morphological characteristics of YTTJ-JHGS5 were consistent with the Colletotrichum acutatum species complex (Damm et al. 2012). To further identify the species, the internal transcribed spacer (ITS), actin (ACT), beta-tubulin (TUB), chitin synthase (CHS-1), calmodulin (CAL) and glyceraldehyde-3-phosphate dehydrogenase (GPD) genes were sequenced (Weir et al. 2012; O'Donnell et al. 2000). The thirty-six sequences had been deposited in GenBank (ITS: ON155427-ON155432; ACT: ON191542-ON191547; CAL: ON191548-ON191553; CHS-1: ON167522-ON167527; GPD: ON191554-ON191559; TUB2: ON191560-ON191565, respectively). A BLAST search of these sequences (ITS, ACT, CHS-1, GPD, and TUB2) showed 99% identity with the sequences of ex-holotype C. godetiae CBS133.44 (ITS: JQ948402; ACT: JQ949723; CHS-1: JQ949063; GPD: JQ948733; TUB2: JQ950053) (Damm et al. 2012); the sequences of CAL genes of these strains showed 99% identity with the sequence of C. godetiae VV-087 (CAL: MK416001) (Varjas et al. 2020). The Bayes phylogenesis showed that six strains and C. godetiae CBS133.44 were clustered in a robust branch (Bayesian posterior probability = 1). Based on the morphological characteristics and phylogenesis, these strains were identified as C. godetiae. To fulfill Koch's postulates, in April 2022, live plant pathogenicity tests were performed in the field, and color-changing-stage fruits of five-year-old trees were disinfected with 75% alcohol and air-dried for 10 min to volatilize excess alcohol. A conidial suspension (50 mL of 1 × 106 conidia/mL) was sprayed on fifteen fruits for each plant, fifteen fruits sprayed with sterilized water served as control. The experiment was repeated four times, each repeat contained ten trees. The daily average temperature and daily average RH in the orchard were 22°C and 67%, respectively. After 6 days, the fruit surfaces were depressed, dark brown, later, the lesions were expanded, and pink conidial masses were observed (Fig. 1, L). Control fruits remain healthy (Fig. 1, K). C. godetiae was re-isolated from the lesions of inoculated fruits. C. godetiae has been reported on Ceanothus sp., Fragaria × ananassa and so on worldwide (Farr and Rossman 2022), in addition, C. fructicola infected cherry (Zhao et al. 2022). To our knowledge, this is the first report of C. godetiae causing anthracnose fruit rot on Prunus pseudocerasus in China. This disease occurs mainly on immature fruits and leads to yield loss in the field, therefore it is necessary to take preventive measures in advance.
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http://dx.doi.org/10.1094/PDIS-04-22-0862-PDNDOI Listing
August 2022

High plasma soluble thrombomodulin levels indicated poor prognosis of decompensated liver cirrhosis: a prospective cohort study.

Eur J Gastroenterol Hepatol 2022 Aug 5. Epub 2022 Aug 5.

The Third Unit, Department of Hepatology, Beijing Youan Hospital, Capital Medical University.

Objective: Hepatic sinusoidal endothelial injury is a prominent characteristic of liver cirrhosis. We determined plasma soluble thrombomodulin (sTM) levels in cirrhosis patients to evaluate the relationship between vascular injury and long-term prognosis.

Methods: A prospective single-center study was performed. The participants were followed up for every 6 months or until death or transplantation. A chemiluminescent enzyme immunoassay was used to establish a baseline sTM.

Results: Among the 219 patients with decompensated liver cirrhosis, 53.42% were caused by hepatitis B and hepatitis C. Plasma sTM levels were much higher in cirrhosis than in healthy controls and increased parallel with Child-Pugh classification (P < 0.01) and the amount of ascites (P = 0.04). After adjusting for sex, age, international normalized ratio, bilirubin, and other potential factors, multivariate Cox regression revealed that per TU/ml elevation of plasma sTM causes an increase of 8% in mortality, and per-SD elevation of thrombomodulin causes a 53% increase in mortality. As the mortality rates in low (5.90-12.60 TU/ml) and medium (12.70-18.00 TU/ml) sTM levels were similar, so we chose the cutoff of 18.00 TU/ml to divide into two groups, and K-M analysis indicated that patients with sTM >18.0 TU/ml demonstrated an additional 2.01 times death risk (95% CI, 1.13-7.93; P = 0.01) than those with sTM ≤18.0 TU/ml.

Conclusion: Plasma sTM in cirrhosis was significantly increased in parallel with the severity of liver dysfunction. sTM elevation than 18 TU/ml indicated a poor prognosis of decompensated liver cirrhosis.
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http://dx.doi.org/10.1097/MEG.0000000000002428DOI Listing
August 2022

Oxidation and Reduction Dual-Responsive Polymeric Prodrug Micelles Co-delivery Precisely Prescribed Paclitaxel and Honokiol for Laryngeal Carcinoma Combination Therapy.

Front Pharmacol 2022 22;13:934632. Epub 2022 Jul 22.

Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.

Laryngeal carcinoma is the most common head and neck malignancy globally, and chemotherapy is still the most common treatment for this type of carcinoma. Monotherapy has become powerless because of the lack of drugs in the anticancer agent library, the difficult process of new drug discovery, and the widespread drug resistance. Combination therapy with two agents, in particular Chinese herbal medicines with chemotherapy drugs, is a potential alternative to chemotherapy alone. However, combination therapy faces difficulties in delivering multiple drugs to tumor tissue in a precise ratio. Here, a cocktail polymeric prodrug micelle (PHPPM) was developed using an oxidation and reduction dual-responsive polymeric paclitaxel (PTX) and polymeric honokiol (HK) prodrugs. Both of them were obtained by covalently conjugating the drug to dextran diselenium bonds. Following optimization and characterization, the PHPPM with the precise mass ratio of PTX and HK was obtained, enabling ratiometric drug loading, synchronized drug release in response to tumor high-level reactive oxygen species and glutathione environment, long blood circulation, and high tumor accumulation. This co-delivery system can effectively inhibit laryngeal carcinoma growth and . Codelivery of chemotherapy agents and Chinese herbal medicine with a precise ratio and controlled release of the two drugs at the tumor site provides an effective approach to clinical therapy for other laryngeal carcinomas.
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http://dx.doi.org/10.3389/fphar.2022.934632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354237PMC
July 2022

Immune cell cholinergic signaling in adipose thermoregulation and immunometabolism.

Trends Immunol 2022 Aug 3. Epub 2022 Aug 3.

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address:

Research focusing on adipose immunometabolism has been expanded from inflammation in white fat during obesity development to immune cell function regulating thermogenic fat, energy expenditure, and systemic metabolism. This opinion discusses our current understanding of how resident immune cells within the thermogenic fat niche may regulate whole-body energy homeostasis. Furthermore, various types of immune cells can synthesize acetylcholine (ACh) and regulate important physiological functions. We highlight a unique subset of cholinergic macrophages within subcutaneous adipose tissue, termed cholinergic adipose macrophages (ChAMs); these macrophages interact with beige adipocytes through cholinergic receptor nicotinic alpha 2 subunit (CHRNA2) signaling to induce adaptive thermogenesis. We posit that these newly identified thermoregulatory macrophages may broaden our view of immune system functions for maintaining metabolic homeostasis and potentially treating obesity and metabolic disorders.
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http://dx.doi.org/10.1016/j.it.2022.07.006DOI Listing
August 2022

Psychological coherence, inclusive leadership and implicit absenteeism in obstetrics and gynecology nurses: a multi-site survey.

BMC Psychiatry 2022 08 3;22(1):525. Epub 2022 Aug 3.

Department of Education, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.

Background: Implicit absenteeism is very common among clinical nurses. We aimed to evaluate the role of psychological coherence in the inclusive leadership and implicit absenteeism among obstetrics and gynecology nurses, to provide evidence to the clinical management of nurses.

Methods: Through the convenience sampling method, a survey of gynecology nurses in tertiary hospitals in 16 cities of Anhui Province, China was conducted using the General Information Questionnaire, the Stanford Implicit Absence Scale, the Inclusive Leadership Scale and the Sense of Coherence Scale. Statistical analysis was performed by SPSS 20.

Results: A total of 1080 nurses were included with an effective response rate of 93.5%. The average score of nurses' recessive absenteeism in this study was (16.8 ± 0.15). The average of inclusive leadership score was (34.25 ± 7.23). The average score of psychological coherence score of obstetrics and gynecology nurses was (55.79 ± 8.28). Pearson correlation analysis showed that there was a relationship between implicit absenteeism behavior, inclusive leadership, and the level of psychological coherence in obstetrics and gynecology nurses (all P < 0.05). Linear regression analysis indicated that psychological coherence played a partial mediating role between inclusive leadership and obstetrics and gynecology nurses' implicit absenteeism (all P < 0.05).

Conclusions: Obstetrics and gynecology nurses have serious recessive absenteeism with low sense of psychological coherence and inclusive leadership. Nursing managers should improve the psychological coherence through effective interventions, thereby reducing the incidence of implicit absenteeism.
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http://dx.doi.org/10.1186/s12888-022-04137-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351111PMC
August 2022

Extremely broadband light absorption by bismuth-based metamaterials involving hybrid resonances.

Phys Chem Chem Phys 2022 Aug 3. Epub 2022 Aug 3.

Shandong Institute of Advanced Technology, Jinan 250100, China.

An ultra-broadband polarization-insensitive perfect absorber for the 400-4000 nm spectral range is proposed and studied. The absorber is composed of a dielectric film and a phase change material film sandwiched between a bismuth square ring array and a continuous bismuth mirror. Greater than 94% absorptivity across the wavelength range of 400-4000 nm and an averaged absorptivity of about 97% can be achieved. The physical origin results from the mixed effect of guided mode resonance (GMR), cavity resonance (CR) and surface plasmon resonance (SPR). In addition, such a property is maintained excellent in a very large viewing angle range. Furthermore, the proposed scheme exhibits certain geometrical parameter tolerance, which is beneficial for practical fabrication with low cost. Finally, the potential application of the solar cells is investigated as an illustration. The designed metamaterial absorber will find promising applications in solar cells, thermo-photovoltaics and detection.
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http://dx.doi.org/10.1039/d2cp02869gDOI Listing
August 2022

Treatment of efferent loop syndrome after pancreatoduodenectomy with a fully covered self-expandable metal stent: A case report.

DEN open 2023 Apr 29;3(1):e156. Epub 2022 Jul 29.

Department of Gastroenterology, Eastern Hepatobiliary Hospital Naval Military Medical University Shanghai China.

Efferent loop syndrome is a very rare complication following pancreatoduodenectomy. The treatment of efferent loop syndrome varies depending on the cause of the syndrome. Conservative treatment methods, including nasogastric drainage and enteral nutrition, are adopted that are effective in most of patients; however, surgical treatment is usually required in patients with complete loop obstruction. Herein, we report a case of severe efferent loop obstruction that occurred after pancreatoduodenectomy, which was refractory to conservative treatment and successfully resolved by insertion of a fully covered self-expandable metal stent.
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http://dx.doi.org/10.1002/deo2.156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338343PMC
April 2023

Efficacy of Respiratory Training in Relieving Postoperative Pain in Patients with Spinal Nerve Root Entrapment Syndrome.

Comput Math Methods Med 2022 22;2022:7703835. Epub 2022 Jul 22.

Department of Neurosurgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan City, Hubei Province 430014, China.

Background: Breathing exercise can help patients with dyspnea to change the wrong breathing pattern, improve the degree of freedom of respiratory muscles, increase alveolar ventilation, promote breathing, and relieve the symptoms of dyspnea patients. Therefore, this study is aimed at investigating the role of breathing training in alleviating postoperative pain in patients with spinal nerve root entrapment syndrome.

Objective: To explore the effect of respiratory training in relieving postoperative pain in patients with spinal nerve root entrapment syndrome.

Methods: Fifty-eight patients with spinal nerve root entrapment syndrome treated in our hospital from May 2020 to May 2021 were analyzed retrospectively. The patients were randomly divided into a control group ( = 29) and an observation group ( = 29). The control group was given routine postoperative pain nursing, and the observation group was given respiratory training on the basis of the control group. The scores of visual analogue scale (VAS), self-rating anxiety scale (SAS), Oswestry dysfunction index questionnaire (ODI), the dosage of postoperative analgesics, and the time of first out-of-bed activity were recorded before pain nursing intervention and 3 days and 7 days after intervention.

Results: The VAS, SAS, and ODI scores of the observation group after 3 d and 7 d of intervention were lower than those of the control group. Compared with the same group, the scores of VAS, SAS, and ODI after 3 d and 7 d of intervention were lower than those before intervention, and those after 7 d of intervention were lower than those after 3 d of intervention ( < 0.05). The dosage of postoperative analgesics and the time of first out-of-bed activity in the observation group were lower than those in the control group ( < 0.05).

Conclusion: Respiratory training can effectively relieve postoperative pain, reduce anxiety, and improve spinal function in patients with spinal nerve root entrapment syndrome, which is beneficial to the prognosis of patients and is worthy of promotion.
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http://dx.doi.org/10.1155/2022/7703835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337933PMC
August 2022

Blood-based tumour mutation index act as prognostic predictor for immunotherapy and chemotherapy in non-small cell lung cancer patients.

Biomark Res 2022 Jul 29;10(1):55. Epub 2022 Jul 29.

Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.

Background: Circulating tumour DNA (ctDNA)-based sequencing might provide a simple test for the stratified model of non-small cell lung cancer (NSCLC). Here, we aimed to assess the ctDNA sequencing-based tumour mutation index (TMI) model for screening responders (from non-responders) among NSCLC patients who received monotherapy with docetaxel or atezolizumab.

Methods: We performed a retrospective analysis of the POPLAR (NCT01903993) and OAK (NCT02008227) trials. We identified three biomarkers, blood tumour mutation burden (bTMB), sensitive blood tumour mutation burden (sbTMB) and unfavourable mutation score (UMS), of the ctDNA profiles. After integrating the advantages and disadvantages of the three independent biomarkers, we developed the TMI model and identified NSCLC patients who may benefit from monotherapy with docetaxel or atezolizumab in terms of overall survival (OS).

Results: The TMI model as a stratified biomarker for docetaxel responders provided a median OS duration of 5.55 months longer than non-responders in the OAK cohort, with a significantly decreased hazard ratio (HR). Moreover, atezolizumab responders had a 10.21-month OS advantage over atezolizumab non-responders in the OAK cohort via TMI stratification, and the HR was also decreased significantly. The TMI demonstrated effectiveness for stratifying responders in the POPLAR cohort. Importantly, we found that the TMI model could screen additional responders upon combining the cohorts from the POPLAR and OAK trials after adjustment.

Conclusion: In the present study, we provide a novel TMI model for screening responders (from non-responders) among NSCLC patients who received the 2nd-line monotherapy with docetaxel or atezolizumab. We believe that the biomarker TMI will potentially be effective for the clinical treatment of NSCLC in the future.
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http://dx.doi.org/10.1186/s40364-022-00400-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9336041PMC
July 2022

Assessing sediment organic pollution via machine learning models and resource performance.

Bioresour Technol 2022 Jul 26;361:127710. Epub 2022 Jul 26.

Institute of Ecological and Environmental Sciences, Sichuan Agricultural University, Sichuan 611130, China. Electronic address:

Due to the potential ecological risks of organic pollution in sediments, aquatic ecosystems are currently facing substantial environmental threats. Assessing and controlling sediment pollution has become a huge challenge. Therefore, this study proposes a novel strategy for predicting organic pollution indicators for sediment, as well as an effective resource-utilization method. Contaminated sediments were converted into catalysts for sulfate radical advanced oxidation technologies by a one-step calcination method. The results revealed that the catalyst excelled in activating peroxymonosulfate to degrade tetracycline via a non-radical pathway. Most importantly, a predictive model of organic pollution indicators was established by machine learning. This study provides a novel approach for resource utilization and a strategy for assessing organic pollution in sediments.
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http://dx.doi.org/10.1016/j.biortech.2022.127710DOI Listing
July 2022

RNA viromes from terrestrial sites across China expand environmental viral diversity.

Nat Microbiol 2022 Aug 28;7(8):1312-1323. Epub 2022 Jul 28.

Shanghai Public Health Clinical Center, Shanghai Key Laboratory of Organ Transplantation of Zhongshan Hospital, State Key Laboratory of Genetic Engineering, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, China.

Environmental RNA viruses are ubiquitous and diverse, and probably have important ecological and biogeochemical impacts. Understanding the global diversity of RNA viruses is limited by sampling biases, dependence on cell culture and PCR for virus discovery, and a focus on viruses pathogenic to humans or economically important animals and plants. To address this knowledge gap, we generated metatranscriptomic sequence data from 32 diverse environments in 16 provinces and regions of China. We identified 6,624 putatively novel virus operational taxonomic units from soil, sediment and faecal samples, greatly expanding known diversity of the RNA virosphere. These newly identified viruses included positive-sense, negative-sense and double-strand RNA viruses from at least 62 families. Sediments and animal faeces were rich sources of viruses. Virome compositions were affected by local environmental factors, including organic content and eukaryote species abundance. Notably, environmental factors had a greater impact on the abundance and diversity of plant, fungal and bacterial viruses than of animal viromes. Our data confirm that RNA viruses are an integral part of both terrestrial and aquatic ecosystems.
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http://dx.doi.org/10.1038/s41564-022-01180-2DOI Listing
August 2022

Preparation of the 1-Methylimidazole Borane/Tetrazole System for Hypergolic Fuels.

Molecules 2022 Jul 13;27(14). Epub 2022 Jul 13.

State Key Laboratory of Materials-Oriented Chemical Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, College of Chemical Engineering, Nanjing Tech University, Nanjing 210009, China.

Based on the acid-base neutralization, the (1-methylimidazolium)(tetrazol-1-yl)borane was successfully synthesized by taking advantage of the acidity of the tetrazole and the basicity of the 1-methylimidazole borane complex. Through HRMS, NMR, and FT-IR, the structure of synthetic compounds was characterized in detail. Concerning about the (1-methylimidazolium)(tetrazol-1-yl)borane, it had an ignition-delay time of about 25 ms and a density specific impulse over 351 s·g/cm, making it a suitable candidate for green hypergolic fuels. Moreover, it also demonstrated that introducing tetrazole into the borane could be an appropriate strategy to adjust the performance of the energy of those borane compounds.
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http://dx.doi.org/10.3390/molecules27144466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323667PMC
July 2022

Remote C-H Glycosylation by Ruthenium(II) Catalysis: Modular Assembly of meta-C-Aryl Glycosides.

Angew Chem Int Ed Engl 2022 Jul 25. Epub 2022 Jul 25.

Georg-August-Universitaet Goettingen, Institut fuer Organische und Biomolekulare Chemie, Tammannstr. 2, 37077, Goettingen, GERMANY.

The prevalence of C -aryl glycosides in biologically active natural products and approved drugs has long motivated the development of efficient strategies for their selective synthesis. Cross-couplings have been frequently used, but largely relied on palladium catalyst with prefunctionalized substrates, while ruthenium-catalyzed C -aryl glycoside preparation has thus far proven elusive. Herein, we disclose a versatile ruthenium(II)-catalyzed meta- C-H glycosylation to access meta-C -aryl glycosides from readily available glycosyl halide donors. The robustness of the ruthenium catalysis was reflected by mild reaction conditions, outstanding levels of anomeric selectivity and exclusive meta- site-selectivity.
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http://dx.doi.org/10.1002/anie.202208620DOI Listing
July 2022

A commentary on "Radiofrequency ablation reduces pain for knee osteoarthritis: A meta-analysis of randomized controlled trials" [Int. J. Surg. 91 (2021) 105951].

Int J Surg 2022 Jul 20:106772. Epub 2022 Jul 20.

Department of Orthopaedic Surgery, The Hangzhou Medical College Affiliated Lin'an People's Hospital and The First People's Hospital of Hangzhou Lin'an District, No. 548 Yijing Street, Lin'an District, Hangzhou, Zhejiang, China. Electronic address:

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http://dx.doi.org/10.1016/j.ijsu.2022.106772DOI Listing
July 2022

Effects of Thoracic Paravertebral Blockon Inflammatory Response, Stress Response, Hemodynamics and Anesthesia Resuscitation inGallbladder Carcinoma.

Cell Mol Biol (Noisy-le-grand) 2022 Feb 28;68(2):171-177. Epub 2022 Feb 28.

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The study aimed to explore the effects of the ultrasound-guided thoracic paravertebral block (TPVB) on the inflammatory response, stress response, hemodynamics and anesthesia resuscitation in gallbladder carcinoma. Eighty gallbladder carcinoma patients undergoing open cholecystectomy in Heilongjiang Provincial Hospital from February 2016 to April 2019 were selected and divided into observation group (n=40) and control group (n=40) using a random number table. All patients underwent open cholecystectomy under general anesthesia and tracheal intubation. Patient-controlled intravenous analgesia was adopted after the operation in the control group, while right TPVB was performed before general anesthesia in the observation group. The changes in inflammatory factors and oxidative stress factors were compared between the two groups, the anesthesia resuscitation indexes, and the changes in the bispectral index (BIS) and Ramsay score during anesthesia resuscitation were recorded, and the changes in the hemodynamic indexes in perianesthesia and anesthesia resuscitation-related complications were analyzed. At 15 min after anesthesia, the observation group had lower levels of inflammatory factors high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) (p<0.05), malondialdehyde (MDA) (p<0.05) and a higher level of superoxide dismutase (SOD) (p<0.05) than the control group. The anesthesia resuscitation time was shorter in the observation group than that in the control group (p<0.05). At 10 min, 20 min and 30 min after anesthesia, both BIS and Ramsay scores were significantly higher in the observation group than those in the control group (p<0.05). Moreover, the proportion of circulatory function-related complications and anesthesia resuscitation-related complications were lower in the observation group than that in the control group (p<0.05). The NRS score in the observation group was lower than that in the control group after anesthesia (p<0.05). TPVB in perianesthesia for gallbladder carcinoma patients can effectively lower the body's inflammatory and stress responses, promote anesthesia resuscitation, reduce complications in perianesthesia, and relieve postoperative pain.
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http://dx.doi.org/10.14715/cmb/2022.68.2.24DOI Listing
February 2022

A innovative stepwise strategy using magnetic FeO-co-graft tannin/polyethyleneimine composites in a coupled process of sulfate radical-advanced oxidation processes to control harmful algal blooms.

J Hazard Mater 2022 Jun 28;439:129485. Epub 2022 Jun 28.

Key Laboratory of Integrated Regulation and Resources Development on Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing 210098, China.

A novel co-graft tannin and polyethyleneimine co-coating magnetic composite ([email protected]) was prepared in the study. On this premise, an unique stepwise efficient strategy based on magnetic flocculation and Sulfate radical (SO)-advanced oxidation processes (S-AOPs) for eliminating Microcystis aeruginosa (M. aeruginosa) and algal organic matters (AOMs) was presented. Due to the high positive charge of [email protected], a > 99 % high algae removal rate was obtained at a modest [email protected] dosage of 100 mg/L at pH = 8.0 with a short separation time of 5 min. Further, peroxymonosulfate (PMS) treatment was employed as a pre-oxidation method to lower cell stability and promote M. aeruginosa removal by subsequent [email protected] flocculation. The PMS/[email protected] system successfully cuts the optimum dose of [email protected] in half (50 mg/L) without causing obvious cell damage. Following algal fast magnetic separation, ultraviolet (UV) was introduced to activate PMS to totally degrade AOM and microcystin. Response surface methodology (RSM) demonstrated that UV/PMS oxidation removed > 80 % of DOC and > 94 % of microcystin under optimal conditions. SO was the main radical species that aided in the elimination of AOM. This is the first study to use magnetic flocculation in conjunction with AOPs to mitigate harmful algal blooms, which can enable the non-destructive eradication of M. aeruginosa while also efficiently degrading AOMs.
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http://dx.doi.org/10.1016/j.jhazmat.2022.129485DOI Listing
June 2022

Riemannian Manifold-Based Feature Space and Corresponding Image Clustering Algorithms.

IEEE Trans Neural Netw Learn Syst 2022 Jul 22;PP. Epub 2022 Jul 22.

Image feature representation is a key factor influencing the accuracy of clustering. Traditional point-based feature spaces represent spectral features of an image independently and introduce spatial relationships of pixels in the image domain to enhance the contextual information expression ability. Mapping-based feature spaces aim to preserve the structure information, but the complex computation and the unexplainability of image features have a great impact on their applications. To this end, we propose an explicit feature space called Riemannian manifold feature space (RMFS) to present the contextual information in a unified way. First, the Gaussian probability distribution function (pdf) is introduced to characterize the features of a pixel in its neighborhood system in the image domain. Then, the feature-related pdfs are mapped to a Riemannian manifold, which constructs the proposed RMFS. In RMFS, a point can express the complex contextual information of corresponding pixel in the image domain, and pixels representing the same object are linearly distributed. This gives us a chance to convert nonlinear image segmentation problems to linear computation. To verify the superiority of the expression ability of the proposed RMFS, a linear clustering algorithm and a fuzzy linear clustering algorithm are proposed. Experimental results show that the proposed RMFS-based algorithms outperform their counterparts in the spectral feature space and the RMFS-based ones without the linear distribution characteristics. This indicates that the RMFS can better express features of an image than spectral feature space, and the expressed features can be easily used to construct linear segmentation models.
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http://dx.doi.org/10.1109/TNNLS.2022.3190836DOI Listing
July 2022

Enhanced visible light photocatalytic hydrogen production over poly(dibenzothiophene-,-dioxide)-based heterostructures decorated by Earth-abundant layered double hydroxides.

Dalton Trans 2022 Aug 9;51(31):11768-11775. Epub 2022 Aug 9.

School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430205, P. R. China.

Layered double hydroxides (LDHs) have emerged as one of the promising catalyst substitutes to noble metals in photocatalytic water splitting due to their unique optoelectronic properties. Herein, a series of novel [email protected] composites have been designed and synthesized to investigate photocatalytic performance. Various physicochemical techniques characterized their structural, nanomorphological, and optical properties. These results demonstrated the existence of NiFeLDH particles on the surface of PSO and the strong interaction between NiFeLDH and PSO. The photocatalytic performance was much increased in the case of [email protected] as compared to that of Pt-modified PSO because of the synergistic effect between PSO and NiFeLDH. Remarkably, [email protected] exhibits the highest photocatalytic activity with a rate of 52.8 mmol h g at an optimal content without a Pt cocatalyst under visible light irradiation.
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http://dx.doi.org/10.1039/d2dt01465cDOI Listing
August 2022

Natural Soybean Milk-Derived Bioactive Coatings for Enhanced Wound Healing.

ACS Appl Mater Interfaces 2022 Aug 20;14(30):34480-34487. Epub 2022 Jul 20.

School of Biomedical Engineering, State Key Laboratory of Oncology in South China, Sun Yat-Sen University, Guangzhou 510006, China.

Foodborne biomaterials, derived from diets, comprise selfassembled collections of many micro- or nanoscale units with abundant nutrients and active substances. In this study, soybean milk (SBM) was selected as a tissue engineering product for simple and feasible wound repair. SBM is a common drink prepared from soybeans and is rich in soy protein, soy isoflavones, and other bioactive components. Thus, SBM has substantial potential for antioxidation and tissue remodeling. Here, the multifunctional effect of SBM as a bioactive coating for promoting wound healing was studied. The results showed that SBM has good biocompatibility and biological activity. It efficiently scavenges intracellular reactive oxygen species, significantly enhances epithelial cell migration, and improves angiogenesis, thereby accelerating tissue remodeling. The results of animal experiments further confirmed that the SBM-bioinspired coating has promising applications for cutaneous wound regeneration.
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http://dx.doi.org/10.1021/acsami.2c09689DOI Listing
August 2022

The amount of membrane cholesterol required for robust cell adhesion and proliferation in serum-free condition.

PLoS One 2022 20;17(7):e0259482. Epub 2022 Jul 20.

Department of Advanced Bioscience, Graduate School of Agriculture, Kindai University, Nara, Japan.

Serum-containing medium is widely used to support cell attachment, stable growth and serial passaging of various cancer cell lines. However, the presence of cholesterols and lipids in serum greatly hinders the analysis of the effects of cholesterol depletion on cells in culture. In this study, we developed a defined serum-free culture condition accessible to a variety of different types of adherent cancer cells. We tested different factors that are considered essential for cell culture and various extracellular matrix for plate coating, and found cells cultured in Dulbecco's Modified Eagle's Medium (DMEM) basal media supplemented with Albumin (BSA) and insulin-transferrin-selenium-ethanolamine (ITS-X) on fibronectin-precoated plate (called as "DA-X condition") showed comparable proliferation and survival to those in a serum-containing medium. Interestingly, we observed that DA-X condition could be adapted to a wide variety of adherent cancer cell lines, which enabled the analysis of how cholesterol depletion affected cancer cells in culture. Mechanistically, we found the beneficial effects of the DA-X condition in part can be attributed to the appropriate level of membrane cholesterol, and fibronectin-mediated signaling plays an important role in the suppression of cholesterol production.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0259482PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299302PMC
July 2022

The early association of water irrigation with negative pressure wound therapy does not more efficiently reduce the depth of the alkali infiltration progress into the burn.

Int Wound J 2022 Jul 19. Epub 2022 Jul 19.

Department of Burn and Plastic Surgery, Shenzhen Institute of Translational Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, People's Republic of China.

Water irrigation is an efficacious decontaminating method for dermis exposures to corrosive agents and hence has been widely applied to treat especially alkali burns. Nevertheless, once alkali has infiltrated the deep subcutaneous tissue, washing the tissue surface with water irrigation does not attenuate the damage progress. Therefore, significant efforts have been devoted to promising strategies aimed at removing the deeply infiltrated lye. According to a recent report, the negative pressure wound therapy (NPWT) reduces the pH value of the exudate from alkali-provoked burns thus accelerating wound healing. However, it remains to be ascertained whether or not NPWT coupled with water irrigation, that is, iNPWT, more effectively hinders the alkali injury deepening. In this study, we compared the effectiveness of an early application of water irrigation with or without NPWT in preventing the progressive deepening of the alkali burn in an animal model. Our histological examination results showed no appreciable difference in tissue injury depth, dermal retention, inflammatory cell infiltration, re-epithelization, and cellular function between iNPWT and water irrigation alone treatments. Thus, our results prove that the more expensive NPWT coupled with water irrigation does not more effectively hinder the alkali's injury deepening. Hence, iNPWT use should be more cautious in clinical practice.
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http://dx.doi.org/10.1111/iwj.13883DOI Listing
July 2022

Diagnostic performance of urine analysis based on flow microimaging and artificial intelligence recognition technology in suspected urinary tract infection patients.

Scand J Clin Lab Invest 2022 Jul 19:1-6. Epub 2022 Jul 19.

Department of Laboratory, Beijing Jishuitan Hospital, Beijing, China.

To investigate the diagnostic performance and clinical value of flow microimaging and artificial intelligence recognition technology for rapid screening of suspected urinary tract infection (UTI). Standard strains of bacteria responsible for UTIs, ATCC25922 and ATCC25923 were prepared and used to evaluate the accuracy of classifying and counting bacteria. A total of 146 specimens of clean, midstream urine were collected from adults with suspected UTI (excluding pregnant women, and patients with urethral catheterization) and analyzed by urinary culture and assay using a MUS-3600 analyzer. Fourfold tables were used to evaluate the diagnostic performance in measurements of nitrite and leukocyte esterase. ROC curves were generated to identify cutoff values for bacillus, coccus, leukocyte, and leukocyte cluster counts. Of the samples cultured, 85 (58%) were negative and 61 (42%) were positive. and showed good linear relationships between measured and theoretical values in a series of standard strains samples (>0.95). The sensitivity of the nitrite parameter for diagnosis of suspected UTI was 37.7% and the specificity was 100%. Cutoff values obtained from ROC analysis were 50 μl for bacillus (sensitivity: 69.5%; specificity: 96.5%) with positive predictive value of 93.2% and negative predictive value of 82%. WBC ≥ 23 μl or bacillus ≥50 μl gave the highest sensitivity of 81% and NPV of 86%. MUS-3600 demonstrated sufficient specificity for UTIs to have utility in reducing needless urinary culture. Accuracy in classifying bacillus shows great potential for the rapid identification of pathogens for clinical purposes.
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http://dx.doi.org/10.1080/00365513.2022.2100273DOI Listing
July 2022

Compatibility and function of human induced pluripotent stem cell derived cardiomyocytes on an electrospun nanofibrous scaffold, generated from an ionomeric polyurethane composite.

J Biomed Mater Res A 2022 Jul 19. Epub 2022 Jul 19.

Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.

Synthetic scaffolds are needed for generating organized neo-myocardium constructs to promote functional tissue repair. This study investigated the biocompatibility of an elastomeric electrospun degradable polar/hydrophobic/ionic polyurethane (D-PHI) composite scaffold with human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). The composite material was electrospun to generate scaffolds, with nanofibres oriented in aligned or random directions. These features enabled the authors to evaluate the effect of characteristic elements which mimic that of the native extracellular matrix (alignment, chemical heterogeneity, and fiber topography) on hiPSC-CMs activity. The functional nature of the hiPSC-CM cultured on gelatin and Matrigel-coated scaffolds were assessed, investigating the influence of protein interactions with the synthetic substrate on subsequent cell phenotype. After 7 days of culture, high hiPSC-CM viability was observed on the scaffolds. The cells on the aligned scaffold were elongated and demonstrated aligned sarcomeres that oriented parallel to the direction of the fibers, while the cells on random scaffolds and a tissue culture polystyrene (TCPS) control did not exhibit such an organized morphology. The hiPSC-CMs cultured on the scaffolds and TCPS expressed similar levels of cardiac troponin-T, but there was a higher expression of ventricular myosin light chain-2 on the D-PHI composite scaffolds versus TCPS, indicating a higher proportion of hiPSC-CM exhibiting a ventricular cardiomyocyte like phenotype. Within 7 days, the hiPSC-CMs on aligned scaffolds and TCPS beat synchronously and had similar conductive velocities. These preliminary results show that aligned D-PHI elastomeric scaffolds allow hiPSC-CMs to demonstrate important cardiomyocytes characteristics, critical to enabling their future potential use for cardiac tissue regeneration.
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http://dx.doi.org/10.1002/jbm.a.37428DOI Listing
July 2022

Deletion of SM22α disrupts the structure and function of caveolae and T-tubules in cardiomyocytes, contributing to heart failure.

PLoS One 2022 18;17(7):e0271578. Epub 2022 Jul 18.

Department of Biochemistry and Molecular Biology, College of Basic Medicine, Key Laboratory of Medical Biotechnology of Hebei Province, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China.

Aims: Smooth muscle 22-alpha (SM22α) is an actin-binding protein that plays critical roles in mediating polymerization of actin filaments and stretch sensitivity of cytoskeleton in vascular smooth muscle cells (VSMCs). Multiple lines of evidence indicate the existence of SM22α in cardiomyocytes. Here, we investigated the effect of cardiac SM22α on the membrane architecture and functions of cardiomyocytes to pressure overload.

Methods: SM22α knock-out (KO) mice were utilized to assess the role of SM22α in the heart. Echocardiography was used to evaluate cardiac function, transverse aortic constriction (TAC) was used to induce heart failure, cell shortening properties were measured by IonOptix devices in intact cardiomyocytes, Ca2+ sensitivity of myofilaments was measured in permeabilized cardiomyocytes. Confocal microscopy, electron microscopy, western blotting, co-immunoprecipitation (co-IP), Real-Time Quantitative Reverse Transcription PCR (qRT-PCR) techniques were used to perform functional and structural analysis.

Results: SM22α ablation did not alter cardiac function at baseline, but mRNA levels of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and β-myosin heavy chain (β-MHC) were increased significantly compared with wild type (WT) controls. The membrane architecture was severely disrupted in SM22α KO cardiomyocytes, with disassembly and flattening of caveolae and disrupted T-tubules. Furthermore, SM22α was co-immunoprecipitated with caveolin-3 (Cav3), and the interaction between Cav3 and actin was significantly reduced in SM22α KO cells. SM22α KO cardiomyocytes displayed asynchronized SR Ca2+ release, significantly increased Ca2+ spark frequency. Additionally, the kinetics of sarcomere shortening was abnormal, accompanied with increased sensitivity and reduced maximum response of myofilaments to Ca2+ in SM22α KO cardiomyocytes. SM22α KO mice were more prone to heart failure after TAC.

Conclusions: Our findings identified that SM22α may be required for the architecture and function of caveolae and T-tubules in cardiomyocytes.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0271578PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292107PMC
July 2022

Effects of Salinity Stress at Reproductive Growth Stage on Rice ( L.) Composition, Starch Structure, and Physicochemical Properties.

Front Nutr 2022 29;9:926217. Epub 2022 Jun 29.

State Key Laboratory of Hybrid Rice, Hunan Hybrid Rice Research Center, Changsha, China.

This study aimed to investigate the changes in polished rice composition, starch structure, and physicochemical properties from three rice cultivars treated with medium and high salinity stress at the reproductive growth stage. The results showed that salt stress led to poor milling and appearance quality, higher total starch content, protein content, higher proportion of the medium, and long chains of amylopectin, as well as gelatinization temperature (GT) but lower amylose content and lower proportion of the short chain of amylopectin. Compared with salt-sensitive cultivars, the salt-tolerant cultivars exhibited lower GT and gelatinization enthalpy, better pasting properties, and more stable crystal structure; therefore, their eating and cooking quality (ECQ) was less affected. The above results imply that salt stress at the reproductive growth stage can degrade ECQ and can slightly increase the pasting property of starch from salt-tolerant rice cultivar.
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http://dx.doi.org/10.3389/fnut.2022.926217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277441PMC
June 2022

Nitrite accumulation, denitrification kinetic and microbial evolution in the partial denitrification process: The combined effects of carbon source and nitrate concentration.

Bioresour Technol 2022 Jul 11;361:127604. Epub 2022 Jul 11.

College of Environmental Science and Engineering, Yangzhou University, Yangzhou 225127, PR China.

The combined effects of carbon source (HAc, HPr, Glu, Glu + HAc) and nitrate concentration (40, 80 mg/L labeling as R, R) on partial denitrification (PD) were discussed at C/N ratio of 2.5 (COD = 100, 200 mg/L). The optimal NO-N and NTR reached to 67.03 mg/L, 99.14% in HAc-R system, and denitrification kinetics revealed the same conclusion, corresponding to higher COD utilization rate (CUR: 58.46 mgCOD/(gVSS·h)), nitrate reduction rate (NRR: 29.94 mgN/(gVSS·h)) and nitrite accumulation rate (NAR: 29.68 mgN/(gVSS·h)). The preference order was HAc > HPr > Glu + HAc > Glu in both R and R systems due to different metabolic pathways, however, the NO-N accumulation and kinetic parameters of R group were dramatically higher than those in R for the same carbon source. The R group facilitated more concentrated biodiversity (607-808 OTUs) with Terrimonas and norank_f_Saprospiraceae responsible for high NO-N accumulation in HAc and HPr served systems, while norank_f_norank_o_Saccharimonadales and OLB13 dominated the Glu containing systems.
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http://dx.doi.org/10.1016/j.biortech.2022.127604DOI Listing
July 2022

A commentary on "Comparing intramedullary nailing and plate fixation for treating distal tibial fractures: A meta-analysis of randomized controlled trials" [Int. J. Surg. 53 (2018) 5-11].

Int J Surg 2022 Jul 12:106757. Epub 2022 Jul 12.

Department of Orthopaedic Surgery, The Hangzhou Medical College Affiliated Lin'an People's Hospital and the First People's Hospital of Hangzhou Lin'an District, No. 548 Yijing Street, Lin'an District, Hangzhou, Zhejiang, China. Electronic address:

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http://dx.doi.org/10.1016/j.ijsu.2022.106757DOI Listing
July 2022

Delivery of enzalutamide nanoparticles for effectively inhibiting prostate cancer progression.

Biomater Sci 2022 Jul 14. Epub 2022 Jul 14.

Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Androgen deprivation therapy has been used as a standard clinical treatment for prostate cancer, but the disease generally progresses to castration-resistant prostate cancer in a very short time. Enzalutamide (ENZ) is an emerging second-generation androgen receptor (AR) antagonist used for the treatment of patients with nonmetastatic castration-resistant prostate cancer (CRPC). However, due to the rapid onset of drug resistance, it provides only a modest increase in survival. Here, we propose a convenient and effective androgen receptor antagonist drug delivery strategy, that is, the use of a biocompatible nanoparticle (NP) drug delivery system for drug delivery to improve its bioavailability and therapeutic performance. Although the particle size of the phenylpropyl polymer (8P4) nanoparticles is small, it has a high drug-carrying capacity. ENZ-8P4 NPs can increase drug delivery efficiency, enhance drug cytotoxicity, and reduce the half-inhibitory concentration (IC50) of the drug. In addition, experiments confirmed that ENZ-8P4 preferentially accumulates in the tumor and significantly inhibits tumor growth. Hence, the 8P4 drug delivery system loaded with enzalutamide has excellent potential for the treatment of prostate cancer.
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http://dx.doi.org/10.1039/d2bm00697aDOI Listing
July 2022

Diffusion-Weighted Imaging Image Combined with Transcranial Doppler Ultrasound in the Diagnosis of Patients with Cerebral Infarction and Vertigo.

Contrast Media Mol Imaging 2022 30;2022:5313238. Epub 2022 Jun 30.

Department of Community Medical Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.

This study aimed at exploring the application value of diffusion-weighted imaging (DWI) combined with transcranial Doppler (TCD) in the diagnosis of patients with cerebral infarction and vertigo (CI + V). In this article, using a retrospective case-control study, 100 CI + V patients (CI + V group) were examined by DWI combined with TCD. Seventy cases of noncerebral infarction with vertigo (control group) who were hospitalized at the same time were collected for clinical data analysis and comprehensive evaluation of each index. The results showed that in patients with CI + V, the abnormal rate of blood vessels was proportional to the size of the lesion, and the abnormal rate of blood vessels in the large-area infarction group (97%) was much higher than that of the small-area infarct group (62%) and the lacunar infarction group (51%). The overall abnormal rate of blood vessels in the CI + V group (71%) was greatly higher than that in the control group (15%), showing a statistically and extremely great difference ( < 0.01). In short, DWI can effectively extract lesion-related data, and combined with TCD examination, the clinical diagnosis of CI + V can be more accurately performed, which had a positive impact on the clinical work of CI + V. This work provided some reference for the clinical effective diagnosis method of CI + V.
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http://dx.doi.org/10.1155/2022/5313238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262581PMC
July 2022
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