Jun Takayama

Jun Takayama

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Jun Takayama

Jun Takayama

Publications by authors named "Jun Takayama"

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Characterization of 6-bromoferulic acid as a novel common-use matrix for MALDI-TOF-MS.

Rapid Commun Mass Spectrom 2019 Oct 28. Epub 2019 Oct 28.

Biomedical Research Center, Saitama Medical University, 38 Moro-Hongo, Moroyama, Iruma-gun, Saitama, 350-0495, Japan.

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http://dx.doi.org/10.1002/rcm.8636DOI Listing
October 2019

Potent HIV-1 protease inhibitors incorporating squaramide-derived P2 ligands: Design, synthesis, and biological evaluation.

Bioorg Med Chem Lett 2019 Sep 5;29(18):2565-2570. Epub 2019 Aug 5.

Department of Refractory Viral Infections, National Center for Global Health and Medicine, Shinjuku, Tokyo 162-8655, Japan; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch National Cancer Institute, Bethesda, MD 20892, USA; Division of Clinical Sciences, Kumamoto University Hospital, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2019.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711809PMC
September 2019

Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.

Bioorg Med Chem 2017 10 9;25(19):5114-5127. Epub 2017 Apr 9.

Department of Hematology, Kumamoto University of Medicine, Kumamoto 860-8556, Japan; Department of Infectious Diseases, Kumamoto University of Medicine, Kumamoto 860-8556, Japan; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch National Cancer Institute, Bethesda, MD 20892, USA; Department of Refractory Viral Infection, National Center for Global Health and Medicine Research Institute, Shinjuku, Tokyo 162-8655, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S09680896173073
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http://dx.doi.org/10.1016/j.bmc.2017.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617771PMC
October 2017

A fission yeast cell-based system for multidrug resistant HIV-1 proteases.

Cell Biosci 2017 11;7. Epub 2017 Jan 11.

Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201 USA ; Department of Microbiology-Immunology, University of Maryland School of Medicine, Baltimore, MD 21201 USA ; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201 USA ; Children's Memorial Institute for Education and Research, Northwestern University Feinberg School of Medicine, Chicago, IL 10164 USA.

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http://cellandbioscience.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s13578-016-0131-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225522PMC
January 2017

Systematic evaluation of methyl ester bioisosteres in the context of developing alkenyldiarylmethanes (ADAMs) as non-nucleoside reverse transcriptase inhibitors (NNRTIs) for anti-HIV-1 chemotherapy.

Bioorg Med Chem 2016 07 24;24(13):3006-3022. Epub 2016 May 24.

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and The Purdue University Center for Cancer Research, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.05.010DOI Listing
July 2016

The Sperm TRP-3 Channel Mediates the Onset of a Ca(2+) Wave in the Fertilized C. elegans Oocyte.

Cell Rep 2016 Apr 7;15(3):625-637. Epub 2016 Apr 7.

Laboratory for Developmental Dynamics, RIKEN Quantitative Biology Center, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.03.040DOI Listing
April 2016

Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands.

Bioorg Med Chem Lett 2015 Nov 30;25(21):4903-4909. Epub 2015 May 30.

Departments of Hematology and Infectious Diseases, Kumamoto University of Medicine, Kumamoto 860-8556, Japan; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD 20892, USA; Center for Clinical Sciences, National Center for Global Health and Medicine, Shinjuku, Tokyo 162-8655, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2015.05.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607586PMC
November 2015

Environmental alkalinity sensing mediated by the transmembrane guanylyl cyclase GCY-14 in C. elegans.

Curr Biol 2013 Jun 9;23(11):1007-12. Epub 2013 May 9.

Okinawa Institute of Science and Technology Graduate University, Okinawa 904-0495, Japan.

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http://dx.doi.org/10.1016/j.cub.2013.04.052DOI Listing
June 2013

Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases.

J Virol 2010 May 24;84(9):4619-29. Epub 2010 Feb 24.

Department of Microbiology and Immunology, Loyola University Medical Center, Bldg. 105, Rm. 3929, 2160 South First Avenue, Maywood, IL 60153, USA.

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http://dx.doi.org/10.1128/JVI.02406-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863753PMC
May 2010

Single-cell transcriptional analysis of taste sensory neuron pair in Caenorhabditis elegans.

Nucleic Acids Res 2010 Jan 29;38(1):131-42. Epub 2009 Oct 29.

Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1093/nar/gkp868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800226PMC
January 2010

Lateralized gustatory behavior of C. elegans is controlled by specific receptor-type guanylyl cyclases.

Curr Biol 2009 Jun 11;19(12):996-1004. Epub 2009 Jun 11.

Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.cub.2009.05.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730525PMC
June 2009

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication.

Proc Natl Acad Sci U S A 2008 Oct 13;105(42):16119-24. Epub 2008 Oct 13.

Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago, IL 60607, USA.

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http://dx.doi.org/10.1073/pnas.0805240105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571001PMC
October 2008

Enantioselective Synthesis of Cyclopentyltetrahydrofuran (Cp-THF), an Important High-Affinity P2-Ligand for HIV-1 Protease Inhibitors.

Tetrahedron Lett 2008 May;49(21):3409-3412

Departments of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, IN 47907, USA.

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http://dx.doi.org/10.1016/j.tetlet.2008.03.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2424253PMC
May 2008

Time course of changes in optic nerve head circulation after acute reduction in intraocular pressure.

Invest Ophthalmol Vis Sci 2005 Apr;46(4):1409-19

Eye Clinic, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1167/iovs.04-1082DOI Listing
April 2005

Effects of topical phenylephrine on blood flow in the posterior segments of monkey and aged human eyes.

Jpn J Ophthalmol 2004 May-Jun;48(3):243-8

Department of Ophthalmology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1007/s10384-004-0051-5DOI Listing
July 2004

Time course of the change in optic nerve head circulation after an acute increase in intraocular pressure.

Invest Ophthalmol Vis Sci 2003 Sep;44(9):3977-85

Eye Clinic, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1167/iovs.03-0024DOI Listing
September 2003

Pi-face-selective Diels-Alder reactions of 3,4-di-tert-butylthiophene 1-oxide and 1-imide and formation of 1,2-thiazetidines.

J Am Chem Soc 2003 Jul;125(27):8255-63

Department of Chemistry, Faculty of Science, Saitama University, Saitama 338-8570, Japan.

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http://dx.doi.org/10.1021/ja029867iDOI Listing
July 2003

Electrophoretic variant of a lactate dehydrogenase isoenzyme and selective promoter methylation of the LDHA gene in a human retinoblastoma cell line.

Clin Chem 2002 Nov;48(11):1938-45

Department of Laboratory Medicine,Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.

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November 2002