Jun O Liu

Jun O Liu

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Pharmacologic Activation of Lytic Epstein-Barr Virus Gene Expression without Virion Production.

J Virol 2019 Oct 30;93(20). Epub 2019 Sep 30.

Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/JVI.00998-19DOI Listing
October 2019

Pharmacophore-Directed Retrosynthesis Applied to Rameswaralide: Synthesis and Bioactivity of Natural Product Tricyclic Cores.

Org Lett 2019 Sep 9;21(18):7394-7399. Epub 2019 Sep 9.

Department of Chemistry & Biochemistry , Baylor University , Waco , Texas 76710 , United States.

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http://dx.doi.org/10.1021/acs.orglett.9b02713DOI Listing
September 2019

One-step Heck Reaction Generates Nonimmunosuppressive FK506 Analogs for Pharmacological BMP Activation.

ACS Med Chem Lett 2019 Sep 19;10(9):1279-1283. Epub 2019 Aug 19.

Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine and the SJ Yan and HJ Mao Laboratory of Chemical Biology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.9b00144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746090PMC
September 2019

Activation of BMP Signaling by FKBP12 Ligands Synergizes with Inhibition of CXCR4 to Accelerate Wound Healing.

Cell Chem Biol 2019 May 28;26(5):652-661.e4. Epub 2019 Feb 28.

Department of Pharmacology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; The SJ Yan and HJ Mao Laboratory of Chemical Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.01.011DOI Listing
May 2019

Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP).

Antiviral Res 2018 08 26;156:55-63. Epub 2018 May 26.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584CL Utrecht, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01663542183002
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http://dx.doi.org/10.1016/j.antiviral.2018.05.010DOI Listing
August 2018

Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of Carabin.

Blood 2018 03 1;131(12):1325-1336. Epub 2018 Feb 1.

Key Laboratory of Metabolism and Molecular Medicine, The Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, China.

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http://dx.doi.org/10.1182/blood-2017-07-794875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865229PMC
March 2018

USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1.

Nucleic Acids Res 2018 01;46(2):823-839

Key Laboratory of Molecular Medicine, Ministry of Education and Department of Biochemistry and Molecular Biology, Shanghai Medical College & Department of Pulmonary and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai 200032, China.

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http://dx.doi.org/10.1093/nar/gkx1226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778534PMC
January 2018

Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth.

Cancer Lett 2017 11 18;409:91-103. Epub 2017 Sep 18.

Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; The SJ Yan and HJ Mao Laboratory of Chemical Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634947PMC
November 2017

Drug Modulators of B Cell Signaling Pathways and Epstein-Barr Virus Lytic Activation.

J Virol 2017 08 27;91(16). Epub 2017 Jul 27.

Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/JVI.00747-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533897PMC
August 2017

Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A.

Cell Chem Biol 2017 May 27;24(5):605-613.e5. Epub 2017 Apr 27.

Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; The SJ Yan and HJ Mao Laboratory of Chemical Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://www.cell.com/cms/attachment/2092097339/2076394873/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S245194561730106
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http://dx.doi.org/10.1016/j.chembiol.2017.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562292PMC
May 2017

Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis.

ACS Chem Biol 2017 01 2;12(1):174-182. Epub 2016 Dec 2.

Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine , Baltimore, Maryland 21205, United States.

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http://pubs.acs.org/doi/10.1021/acschembio.6b00849
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http://dx.doi.org/10.1021/acschembio.6b00849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791891PMC
January 2017

Characterization of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone as a novel inhibitor of methionine aminopeptidases from Mycobacterium tuberculosis.

Tuberculosis (Edinb) 2016 12 28;101S:S73-S77. Epub 2016 Sep 28.

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14729792163041
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http://dx.doi.org/10.1016/j.tube.2016.09.025DOI Listing
December 2016

Insights into the structure-activity relationship of the anticancer compound ZJ-101, a derivative of marine natural product superstolide A: A role played by the lactone moiety.

Bioorg Med Chem Lett 2016 10 20;26(19):4702-4704. Epub 2016 Aug 20.

Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.08.046DOI Listing
October 2016

Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway.

Sci Rep 2016 10 3;6:34655. Epub 2016 Oct 3.

Chemical Genomics Global Research Laboratory, Department of Biotechnology, Translational Research Center for Protein Function Control, College of Life Science &Biotechnology, Yonsei University, Seoul 120-749, Republic of Korea.

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http://dx.doi.org/10.1038/srep34655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046148PMC
October 2016

Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier.

PLoS Pathog 2016 Oct 6;12(10):e1005926. Epub 2016 Oct 6.

Department of Pediatrics, Division of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053521PMC
October 2016

Regulation of mTORC1 by lysosomal calcium and calmodulin.

Elife 2016 10 27;5. Epub 2016 Oct 27.

Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, United States.

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http://dx.doi.org/10.7554/eLife.19360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106211PMC
October 2016

Targeted Delivery and Sustained Antitumor Activity of Triptolide through Glucose Conjugation.

Angew Chem Int Ed Engl 2016 09 30;55(39):12035-9. Epub 2016 Aug 30.

Department of Pharmacology, SJ Yan and HJ Mao Laboratory of Chemical Biology, Johns Hopkins School of Medicine, 725 North Wolfe Street, Hunterian Building, Room 516, Baltimore, MD, 21205, USA.

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http://dx.doi.org/10.1002/anie.201606121DOI Listing
September 2016

Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling.

J Vis Exp 2016 09 20(115). Epub 2016 Sep 20.

Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine; Department of Oncology, Johns Hopkins University School of Medicine;

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http://dx.doi.org/10.3791/54529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5092040PMC
September 2016

Insights into the structure-activity relationship of the anticancer compound ZJ-101, a derivative of marine natural product superstolide A: A critical role played by the conjugated trienyl lactone moiety.

Bioorg Med Chem Lett 2016 08 22;26(15):3411-3. Epub 2016 Jun 22.

Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.06.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013146PMC
August 2016

Divergence of Antiangiogenic Activity and Hepatotoxicity of Different Stereoisomers of Itraconazole.

Clin Cancer Res 2016 06 22;22(11):2709-20. Epub 2016 Jan 22.

Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1888DOI Listing
June 2016

Insights into the structure-activity relationship of the anticancer compound ZJ-101: A critical role played by the cyclohexene ring.

Bioorg Med Chem Lett 2016 06 19;26(12):2890-2892. Epub 2016 Apr 19.

Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.04.044DOI Listing
June 2016

Artemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs.

Oncotarget 2016 Feb;7(6):7268-79

Center for Stem Cell Biology & Regenerative Medicine, Departments of Pediatrics and Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.18632/oncotarget.6896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872784PMC
February 2016

A gating mechanism for Pi release governs the mRNA unwinding by eIF4AI during translation initiation.

Nucleic Acids Res 2015 Dec 12;43(21):10157-67. Epub 2015 Oct 12.

Key Laboratory of Metabolism and Molecular Medicine, the Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China

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http://dx.doi.org/10.1093/nar/gkv1033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666354PMC
December 2015

Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells.

Proc Natl Acad Sci U S A 2015 Dec 10;112(52):E7276-85. Epub 2015 Dec 10.

Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD 21205

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http://dx.doi.org/10.1073/pnas.1512867112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703001PMC
December 2015

Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors.

ACS Med Chem Lett 2015 Jul 8;6(7):782-6. Epub 2015 Jun 8.

Department of Biochemistry and Molecular Biology and Chemical Genomics Core Facility, Indiana University School of Medicine , 635 Barnhill Drive, Indianapolis, Indiana 46202, United States ; Department of Biochemistry and Molecular Biology and Chemical Genomics Core Facility, Indiana University School of Medicine , 635 Barnhill Drive, Indianapolis, Indiana 46202, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.5b00118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499873PMC
July 2015

Identification of novel vascular projections with cellular trafficking abilities on the microvasculature of pancreatic ductal adenocarcinoma.

J Pathol 2015 Jun 17;236(2):142-154. Epub 2015 Feb 17.

State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, 200433, People's Republic of China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089710PMC
http://dx.doi.org/10.1002/path.4506DOI Listing
June 2015

Inhibition of angiogenesis by selective estrogen receptor modulators through blockade of cholesterol trafficking rather than estrogen receptor antagonism.

Cancer Lett 2015 Jun 20;362(1):106-15. Epub 2015 Mar 20.

Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, 725 N Wolfe St, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469646PMC
June 2015

Recent advances in drug repositioning for the discovery of new anticancer drugs.

Int J Biol Sci 2014 10;10(7):654-63. Epub 2014 Jun 10.

2. Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, 725 N Wolfe St, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.7150/ijbs.9224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081601PMC
March 2015

Covalent modification of a cysteine residue in the XPB subunit of the general transcription factor TFIIH through single epoxide cleavage of the transcription inhibitor triptolide.

Angew Chem Int Ed Engl 2015 Feb 12;54(6):1859-63. Epub 2014 Dec 12.

Department of Pharmacology, Johns Hopkins School of Medicine, 725 North Wolfe Street, Hunterian Building, Room 516, Baltimore, MD 21205 (USA).

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http://dx.doi.org/10.1002/anie.201408817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314353PMC
February 2015

Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein.

Cell Rep 2015 Feb 29;10(4):600-15. Epub 2015 Jan 29.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584CL Utrecht, the Netherlands; Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, 6525GA Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.12.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383725PMC
February 2015

Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer.

Br J Pharmacol 2014 Oct 5;171(19):4478-89. Epub 2014 Sep 5.

Department of Biochemistry and Molecular Biology, Medical College, Soochow University, Suzhou, China; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://doi.wiley.com/10.1111/bph.12800
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http://dx.doi.org/10.1111/bph.12800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209153PMC
October 2014

Second-generation derivatives of the eukaryotic translation initiation inhibitor pateamine A targeting eIF4A as potential anticancer agents.

Bioorg Med Chem 2014 Jan 4;22(1):116-25. Epub 2013 Dec 4.

Natural Product LINCHPIN Laboratory, Department of Chemistry, Texas A&M University, P.O. Box 300012, College Station, TX 77842-3012, USA; Department of Chemistry, Texas A&M University, P.O. Box 300012, College Station, TX 77842-3012, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896130098
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http://dx.doi.org/10.1016/j.bmc.2013.11.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958936PMC
January 2014

p53 Represses transcription of RING finger LIM domain-binding protein RLIM through Sp1.

PLoS One 2013 1;8(5):e62832. Epub 2013 May 1.

State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, PR China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062832PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641103PMC
November 2013

Identification, biochemical and structural evaluation of species-specific inhibitors against type I methionine aminopeptidases.

J Med Chem 2013 Jul 27;56(13):5295-305. Epub 2013 Jun 27.

Center for Chemical Biology, CSIR-Indian Institute of Chemical Technology , Tarnaka, Hyderabad AP-500 007, India.

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http://dx.doi.org/10.1021/jm400395pDOI Listing
July 2013

Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells.

Hepatology 2013 Jun;57(6):2458-68

Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://doi.wiley.com/10.1002/hep.26237
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http://dx.doi.org/10.1002/hep.26237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633649PMC
June 2013

Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1.

Bioorg Med Chem 2013 May 21;21(9):2600-17. Epub 2013 Feb 21.

State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China.

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http://dx.doi.org/10.1016/j.bmc.2013.02.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688283PMC
May 2013

Tricyclic thiazoles are a new class of angiogenesis inhibitors.

Bioorg Med Chem Lett 2013 May 24;23(9):2733-7. Epub 2013 Feb 24.

Department of Pharmacology & Molecular Sciences, 725 North Wolfe Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.bmcl.2013.02.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670749PMC
May 2013

Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.

J Med Chem 2013 May 1;56(10):3996-4016. Epub 2013 May 1.

Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1021/jm400227zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714011PMC
May 2013

Arginine68 is an essential residue for the C-terminal cleavage of human Atg8 family proteins.

BMC Cell Biol 2013 May 30;14:27. Epub 2013 May 30.

State Key Laboratory of Genetic Engineering; Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China.

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http://dx.doi.org/10.1186/1471-2121-14-27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686597PMC
May 2013

Possible steps of complete disassembly of post-termination complex by yeast eEF3 deduced from inhibition by translocation inhibitors.

Nucleic Acids Res 2013 Jan 18;41(1):264-76. Epub 2012 Oct 18.

Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1093/nar/gks958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592416PMC
January 2013

Polycomb group protein PHF1 regulates p53-dependent cell growth arrest and apoptosis.

J Biol Chem 2013 Jan 13;288(1):529-39. Epub 2012 Nov 13.

State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, China.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.338996
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http://dx.doi.org/10.1074/jbc.M111.338996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537050PMC
January 2013

Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir.

J Natl Cancer Inst 2012 Oct 5;104(20):1576-90. Epub 2012 Oct 5.

Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

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http://www.oxfordjournals.org/our_journals/jnci/press_releas
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http://jnci.oxfordjournals.org/cgi/doi/10.1093/jnci/djs396
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http://dx.doi.org/10.1093/jnci/djs396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472971PMC
October 2012

Salicylanilide derivatives block Mycobacterium tuberculosis through inhibition of isocitrate lyase and methionine aminopeptidase.

Tuberculosis (Edinb) 2012 Sep 4;92(5):434-9. Epub 2012 Jul 4.

Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.

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http://dx.doi.org/10.1016/j.tube.2012.06.001DOI Listing
September 2012

Analogs of N'-hydroxy-N-(4H,5H-naphtho[1,2-d]thiazol-2-yl)methanimidamide inhibit Mycobacterium tuberculosis methionine aminopeptidases.

Bioorg Med Chem 2012 Jul 17;20(14):4507-13. Epub 2012 May 17.

Department of Pharmacology & Molecular Sciences, 725 North Wolfe Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.bmc.2012.05.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495175PMC
July 2012

The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation.

Biochem J 2012 Jun;444(2):279-89

State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, PR China.

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http://dx.doi.org/10.1042/BJ20111983DOI Listing
June 2012

Synergistic inhibition of endothelial cell proliferation, tube formation, and sprouting by cyclosporin A and itraconazole.

PLoS One 2011 28;6(9):e24793. Epub 2011 Sep 28.

Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024793PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182171PMC
April 2012

Substituted oxines inhibit endothelial cell proliferation and angiogenesis.

Org Biomol Chem 2012 Apr 6;10(15):2979-92. Epub 2012 Mar 6.

Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1039/c2ob06978dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767132PMC
April 2012

Stereospecific metabolism of itraconazole by CYP3A4: dioxolane ring scission of azole antifungals.

Drug Metab Dispos 2012 Mar 21;40(3):426-35. Epub 2011 Nov 21.

Department of Pharmaceutics, University of Washington, P.O. Box 357610, Seattle, Washington 98103, USA.

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http://dx.doi.org/10.1124/dmd.111.042739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286268PMC
March 2012

Identification and validation of protein targets of bioactive small molecules.

Bioorg Med Chem 2012 Mar 20;20(6):1902-9. Epub 2011 Dec 20.

Department of Pharmacology, Johns Hopkins University School of Medicine, MD, USA.

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http://dx.doi.org/10.1016/j.bmc.2011.11.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714012PMC
March 2012

The antifungal drug itraconazole inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells.

J Biol Chem 2011 Dec 24;286(51):44045-56. Epub 2011 Oct 24.

Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1074/jbc.M111.278754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243534PMC
December 2011

Characterization of clioquinol and analogues as novel inhibitors of methionine aminopeptidases from Mycobacterium tuberculosis.

Tuberculosis (Edinb) 2011 Dec 23;91 Suppl 1:S61-5. Epub 2011 Nov 23.

Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.tube.2011.10.012DOI Listing
December 2011

Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer.

Cancer Res 2011 Nov 6;71(21):6764-72. Epub 2011 Sep 6.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-0691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206167PMC
November 2011

Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation.

Proc Natl Acad Sci U S A 2011 Nov 14;108(48):19264-9. Epub 2011 Nov 14.

Department of Surgery, and McKusick-Nathans Institute for Genetic Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1073/pnas.1113081108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228434PMC
November 2011

Itraconazole side chain analogues: structure-activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, and hedgehog signaling.

J Med Chem 2011 Oct 5;54(20):7363-74. Epub 2011 Oct 5.

Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, United States.

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http://pubs.acs.org/doi/abs/10.1021/jm200944b
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http://dx.doi.org/10.1021/jm200944bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307530PMC
October 2011

A simple and efficient route to the FKBP-binding domain from rapamycin.

Tetrahedron Lett 2011 Sep;52(39):5070-5072

Department of Pharmacology, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205.

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https://linkinghub.elsevier.com/retrieve/pii/S00404039110122
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http://dx.doi.org/10.1016/j.tetlet.2011.07.094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165043PMC
September 2011

A calcineurin-independent mechanism of angiogenesis inhibition by a nonimmunosuppressive cyclosporin A analog.

J Pharmacol Exp Ther 2011 Aug 11;338(2):466-75. Epub 2011 May 11.

Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 N. Wolfe St., Baltimore, MD 21205, USA.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.111.18085
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http://dx.doi.org/10.1124/jpet.111.180851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141903PMC
August 2011

Inhibition of eukaryotic translation elongation by the antitumor natural product Mycalamide B.

RNA 2011 Aug 21;17(8):1578-88. Epub 2011 Jun 21.

Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1261/rna.2624511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153980PMC
August 2011

Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly.

Nucleic Acids Res 2011 May 29;39(10):4464-74. Epub 2011 Jan 29.

MOE Key Laboratory for Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.

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http://dx.doi.org/10.1093/nar/gkr030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105382PMC
May 2011

High-throughput screen identifies novel inhibitors of cancer biomarker α-methylacyl coenzyme A racemase (AMACR/P504S).

Mol Cancer Ther 2011 May 25;10(5):825-38. Epub 2011 Mar 25.

Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-10-0902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423201PMC
May 2011

Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth.

Prostate 2011 Mar 31;71(4):333-43. Epub 2010 Aug 31.

Chemical Therapeutics Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1002/pros.21247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043358PMC
March 2011

XPB, a subunit of TFIIH, is a target of the natural product triptolide.

Nat Chem Biol 2011 Mar 30;7(3):182-8. Epub 2011 Jan 30.

Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/nchembio.522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622543PMC
March 2011

Regulator of Ras depalmitoylation and retrograde trafficking: a new hat for FKBP.

Mol Cell 2011 Jan;41(2):131-3

Department of Pharmacology, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.molcel.2011.01.009DOI Listing
January 2011

Effect of nitroxoline on angiogenesis and growth of human bladder cancer.

J Natl Cancer Inst 2010 Dec 18;102(24):1855-73. Epub 2010 Nov 18.

Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1093/jnci/djq457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001967PMC
December 2010

IL-2 mRNA stabilization upon PMA stimulation is dependent on NF90-Ser647 phosphorylation by protein kinase CbetaI.

J Immunol 2010 Nov 24;185(9):5140-9. Epub 2010 Sep 24.

State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1000849
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November 2010

Carbonyl reductase 1 as a novel target of (-)-epigallocatechin gallate against hepatocellular carcinoma.

Hepatology 2010 Aug;52(2):703-14

State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.

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http://doi.wiley.com/10.1002/hep.23723
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August 2010

Protein N-terminal processing: substrate specificity of Escherichia coli and human methionine aminopeptidases.

Biochemistry 2010 Jul;49(26):5588-99

Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1021/bi1005464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906754PMC
July 2010

Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity.

Bioorg Med Chem Lett 2010 May 30;20(10):3112-5. Epub 2010 Mar 30.

State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 200032 Shanghai, China.

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http://dx.doi.org/10.1016/j.bmcl.2010.03.093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165038PMC
May 2010

The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation.

J Biol Chem 2010 Mar 12;285(12):8869-79. Epub 2010 Jan 12.

State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China.

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http://dx.doi.org/10.1074/jbc.M109.063321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838308PMC
March 2010

Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin.

Nat Chem Biol 2010 Mar 31;6(3):209-217. Epub 2010 Jan 31.

Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/nchembio.304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831214PMC
March 2010

Cholesterol trafficking is required for mTOR activation in endothelial cells.

Proc Natl Acad Sci U S A 2010 Mar 22;107(10):4764-9. Epub 2010 Feb 22.

Department of Pharmacology and Oncology, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1073/pnas.0910872107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842052PMC
March 2010

Impact of Absolute Stereochemistry on the Antiangiogenic and Antifungal Activities of Itraconazole.

ACS Med Chem Lett 2010;1(4):155-159

Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1021/ml1000068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165044PMC
January 2010

Malaria-infected mice live until at least day 30 after a new monomeric trioxane combined with mefloquine are administered together in a single low oral dose.

J Med Chem 2009 Dec;52(23):7458-62

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218-2685, USA.

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http://dx.doi.org/10.1021/jm9005934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788671PMC
December 2009

Targeting the role of N-terminal methionine processing enzymes in Mycobacterium tuberculosis.

Tuberculosis (Edinb) 2009 Dec;89 Suppl 1:S55-9

College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA.

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http://dx.doi.org/10.1016/S1472-9792(09)70013-7DOI Listing
December 2009

Expeditious synthesis of hippuristanol and congeners with potent antiproliferative activities.

Chemistry 2009 Oct;15(40):10356-9

State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, 200032 Shanghai, China.

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http://dx.doi.org/10.1002/chem.200901732DOI Listing
October 2009

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization.

Proc Natl Acad Sci U S A 2009 Oct 1;106(42):17910-5. Epub 2009 Oct 1.

Vascular Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1073/pnas.0909353106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764905PMC
October 2009

Inhibition of nonsense-mediated mRNA decay by the natural product pateamine A through eukaryotic initiation factor 4AIII.

J Biol Chem 2009 Aug 1;284(35):23613-21. Epub 2009 Jul 1.

Department of Pharmacology, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1074/jbc.M109.009985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749136PMC
August 2009

Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells.

Science 2009 Aug 20;325(5944):1142-6. Epub 2009 Aug 20.

Immunology and Hematopoiesis Division, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1126/science.1176077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859703PMC
August 2009

Identification of inhibitors of ABCG2 by a bioluminescence imaging-based high-throughput assay.

Cancer Res 2009 Jul 30;69(14):5867-75. Epub 2009 Jun 30.

Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-4866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711991PMC
July 2009