Publications by authors named "Jun Ma"

2,905 Publications

  • Page 1 of 1

Effect of Swelling by Organic Solvent on Structure, Pyrolysis, and Methanol Extraction Performance of Hefeng Bituminous Coal.

ACS Omega 2021 Jun 3;6(23):14765-14773. Epub 2021 Jun 3.

Key Laboratory of Coal Clean Conversion & Chemical Engineering Process (Xinjiang Uyghur Autonomous Region), College of Chemical Engineering, Xinjiang University, Urumqi 830046, Xinjiang, China.

-methyl-2-pyrrolidone (NMP), pyridine (Py), tetrahydrofuran (THF), and tetralin (THN) were used to swell Hefeng acid-washed bituminous coal (HBC). The swelling effect on HBC by each solvent is different, among which NMP presented well swelling performance, with a swelling degree of 2.11. FTIR results showed that acid washing and swelling processes presented a marginal effect on HBC, and there was no damage to the macromolecule structure of the coal. TG-DTG profiles of the swollen coals illustrated that the total weight loss of each sample was lower than that of the acid-washing one, while the temperature of the maximum weight loss rate peak was almost unchanged, around 445 °C. Extract yield by methanol followed the order of HBC > HBC > HBC (swelled by NMP), showing that acid washing promoted the methanol extraction process, with a higher extract yield of 3.21%, which is twice that of HBC (1.66%).
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http://dx.doi.org/10.1021/acsomega.0c06105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209798PMC
June 2021

Accelerated catalytic oxidation of dissolved manganese(II) by chlorine in the presence of in situ-growing 3D manganese(III)/(IV) oxide nanosheet assembly in zeolite filter.

Water Res 2021 May 9;201:117223. Epub 2021 May 9.

State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China. Electronic address:

Manganese contamination is ubiquitous in ground water. Water eutrophication also exaggerates manganese release and contamination in surface water. However, conventional manganese(II) removal process through sand filter is low-efficiency and long-term ripening. Manganese exceeding standard is still a bottleneck issue for drinking water plants. To provide a quick-setup and low-cost means, we invented an accelerated catalytic oxidation filtration process through porous zeolite filter with dynamically coating of manganese oxide nanocatalysts. In dynamic filtration process, the addition of chlorine less than redox stoichiometric consumption can efficiently remove dissolved manganese(II) from contaminated tap water, ground water and Songhua river water. Characterization results showed that a continuous manganese(III)/(IV) oxide nanosheet catalyst was dynamically in situ-growing and assembled into 3D porous superstructure in the reactive [email protected](s) filter. Active Mn(III) species on the edges of MnO(s) nanosheets were dynamically generated and transferred into stable Mn(IV) species on the layer-structured surface. The cycling transformation of manganese(III)/(IV) species was responsible for the accelerated catalytic oxidation of dissolved manganese(II) by chlorine. Without process changes in drinking water plant, the porous [email protected](s) media could be feasibly integrated onto the existing sand filtration tanks for emergence handling of manganese(II) contamination. This novel reactive [email protected](s) filter with higher hydraulic conductivity provides a high-efficiency, scalable and low-cost technique for the manganese(II) removal from various of water environments.
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http://dx.doi.org/10.1016/j.watres.2021.117223DOI Listing
May 2021

Identifying the Persistent Free Radicals (PFRs) Formed as Crucial Metastable Intermediates during Peroxymonosulfate (PMS) Activation by N-Doped Carbonaceous Materials.

Environ Sci Technol 2021 Jun 17. Epub 2021 Jun 17.

State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin 150090, P. R. China.

A nonradical mechanism involved in peroxymonosulfate (PMS) activation in carbonaceous materials (CMs) is still controversial. In this study, we prepared N-doped CMs, including hollow carbon spheres (NHCSs) and carbon nanotubes (N-CNTs), to probe the crucial intermediates during PMS activation. The results suggested that the higher efficiency and lower activation energy (13.72 kJ mol) toward phenol (PN) degradation in an NHCS/PMS system than PMS alone (∼24.07 kJ mol) depended on a typical nonradical reaction. Persistent free radicals (PFRs) with a factor of 2.0033-2.0045, formed as crucial metastable intermediates on NHCS or N-CNT in the presence of PMS, contribute largely to the organic degradation (∼73.4%). Solid evidence suggested that the formation of PFRs relied on the attack of surface-bonded OH and SO or peroxides in PMS, among which surface-bonded SO was most thermodynamically favorable based on theoretical calculations. Electron holes within PFRs on NHCSs shifted the Fermi level to the positive energy with the valance band increasing from 1.18 to 1.98 eV, promoting the reactivity toward nucleophilic substances. The degradation intermediates of aromatic compounds (e.g., PN) and electron rearrangement triggered the evolution of PFRs from oxygen-centered to carbon-centered radicals. Moreover, due to the specific electron configuration, graphitic N on NHCS was critical for stabilizing the PFRs. This study provides insightful understanding of the fate of organic contaminants and the structure-activity relationship of reactivity of CMs toward PMS activation.
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http://dx.doi.org/10.1021/acs.est.1c01974DOI Listing
June 2021

Multi-Centre, Multi-Vendor and Multi-Disease Cardiac Segmentation: The M&Ms Challenge.

IEEE Trans Med Imaging 2021 Jun 17;PP. Epub 2021 Jun 17.

The emergence of deep learning has considerably advanced the state-of-the-art in cardiac magnetic resonance (CMR) segmentation. Many techniques have been proposed over the last few years, bringing the accuracy of automated segmentation close to human performance. However, these models have been all too often trained and validated using cardiac imaging samples from single clinical centres or homogeneous imaging protocols. This has prevented the development and validation of models that are generalizable across different clinical centres, imaging conditions or scanner vendors. To promote further research and scientific benchmarking in the field of generalizable deep learning for cardiac segmentation, this paper presents the results of the Multi-Centre, Multi-Vendor and Multi-Disease Cardiac Segmentation (M&Ms) Challenge, which was recently organized as part of the MICCAI 2020 Conference. A total of 14 teams submitted different solutions to the problem, combining various baseline models, data augmentation strategies, and domain adaptation techniques. The obtained results indicate the importance of intensity-driven data augmentation, as well as the need for further research to improve generalizability towards unseen scanner vendors or new imaging protocols. Furthermore, we present a new resource of 375 heterogeneous CMR datasets acquired by using four different scanner vendors in six hospitals and three different countries (Spain, Canada and Germany), which we provide as open-access for the community to enable future research in the field.
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http://dx.doi.org/10.1109/TMI.2021.3090082DOI Listing
June 2021

Corrigendum to "Robust Diffeomorphic Mapping via Geodesically Controlled Active Shapes".

Int J Biomed Imaging 2021 26;2021:9780202. Epub 2021 May 26.

Center for Imaging Science, Johns Hopkins University, Baltimore, MD 21218, USA.

[This corrects the article DOI: 10.1155/2013/205494.].
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http://dx.doi.org/10.1155/2021/9780202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179761PMC
May 2021

HKUST-1-derived highly ordered Cu nanosheets with enriched edge sites, stepped (211) surfaces and (200) facets for effective electrochemical CO reduction.

Chemosphere 2021 Sep 29;278:130408. Epub 2021 Mar 29.

College of Environment, Zhejiang University of Technology, Hangzhou, 310032, China. Electronic address:

A novel electrode composed of Cu nanosheets constructed from nanoparticles was synthesized by in situ electrochemical derivation from the metal-organic framework (MOF) HKUST-1. The prepared derivative electrode (HE-Cu) exhibited higher Faradaic efficiency (FE, 56.0%) of electrochemical CO reduction (COR) compared with that of pristine Cu foil (p-Cu, 32.3%) at an overpotential of -1.03 V vs. a reversible hydrogen electrode (RHE). HE-Cu also exhibited lower onset potential of COR as well as inhibiting the H evolution reaction. Electrochemical measurements revealed that HE-Cu exhibited higher CO adsorption (1.58-fold) and a larger electrochemical active surface area (1.24-fold) compared with p-Cu. Physicochemical characterization and Tafel analysis showed that stepped Cu (211) surfaces, (200) facets and Cu edge atoms on HE-Cu contributed significantly to the enhanced COR activity and/or HCOOH and/or C2 product selectivity. The FEs of HCOOH and C2 products for HE-Cu increased 1.57-fold and 10.6-fold at an overpotential of -1.19 V vs. RHE compared with p-Cu. Although CH was produced on p-Cu, its formation was totally suppressed on HE-Cu due to the increase of edge sites and (200) facets. Our study demonstrates that electroreduction of MOFs is a promising method to prepare novel and stable electrochemical catalysts with unique surface structures. The fabricated derivative electrode not only promoted electrochemical COR activity but also exhibited high C2 product selectivity.
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http://dx.doi.org/10.1016/j.chemosphere.2021.130408DOI Listing
September 2021

A variable parabolic reaction coefficient model for chlorine decay in bulk water.

Water Res 2021 May 28;201:117302. Epub 2021 May 28.

State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin, 150090, China.

The first-order model is the most widely utilized model for chlorine decay due to its having only one parameter and an analytical solution. While variable reaction coefficient type models have higher accuracy and wider application range, their widespread uses are hindered by their complexity and the non-existence of an analytical solution. The objective of this study was to develop a variable parabolic reaction coefficient model to simulate and predict chlorine decay in bulk water. The decreasing reactivity of the reacting agents is included in a variable coefficient, which decreases with increasing consumption of the chlorine-reactive species concentration. The model includes minimal parameters that must be calculated, and an analytical solution was derived. Experimental data, including chlorination with different initial chlorine concentrations or temperatures, rechlorination, and water mixing, were utilized to evaluate the accuracy of the variable parabolic reaction coefficient model under different conditions. The relationship between the parameters and temperature was established utilizing the Arrhenius equation. On the basis of assumptions that the chlorine consumed by reactions with the pipe wall does not decrease the variable rate coefficient, this study subtracted the instantaneous aggregate chlorine wall consumption from the total chlorine consumption, so that the parameter values in the VPRC model (derived from laboratory decay tests) can be used in the system model. For output water at the entrance of the WDN with unknown initial chlorine concentration and unknown decay duration from disinfection to entry into the water distribution network, an effective method to determine the model parameter is proposed.
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http://dx.doi.org/10.1016/j.watres.2021.117302DOI Listing
May 2021

National School-Based Health Lifestyles Intervention in Chinese Children and Adolescents on Obesity and Hypertension.

Front Pediatr 2021 28;9:615283. Epub 2021 May 28.

School of Public Health, Institute of Child and Adolescent Health, Peking University, Beijing, China.

This study aimed to examine the effectiveness of the national school-based intervention on both obesity and high blood pressure in Chinese children and adolescents aged 6-18 years. The national school-based cluster non-randomized controlled trial was done in seven provinces from September 2013 to February 2014. A total of 23,175 children and adolescents in the control group and 25,702 in the intervention group were included in this trial with a mean follow-up of 6.7 ± 0.9 months. Mixed-effects regression models were used to evaluate the effect of the interventions on body weight and blood pressure (BP). A significant upward in the body mass index (BMI) levels but downward in systolic BP (SBP), diastolic BP (DBP), BMI -scores, SBP Z-scores, and DBP -scores were witnessed in the intervention group compared to those in the control group (<0.001). Subgroup analyses presented significant intervention effects in children aged 6-12 years for BMI, SBP, DBP, and their standardized values -scores, but no effective results were found in adolescents aged 13-18 years. Stratification analyses based on the dynamic weight changes presented non-differential HBP, SHBP, and DHBP prevalence gaps between the control and intervention groups. Children aged 6-12 years with higher BMI percentiles at baseline presented obvious declines in SBP and DBP standardized values -scores. A mean 6-month multi-centered school-based comprehensive obesity intervention in China yields a small to null effect on obesity and hypertension with increasing age; the early age before 12 years may be the key period for interventions, and the younger, the better. Precise and high-intensity interventions targeting the population at different stages of childhood and adolescence are urgently needed to be developed. https://www.clinicaltrials.gov/, identifier: NCT02343588.
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http://dx.doi.org/10.3389/fped.2021.615283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192970PMC
May 2021

Numerical study of acoustophoretic manipulation of particles in microfluidic channels.

Proc Inst Mech Eng H 2021 Jun 11:9544119211024775. Epub 2021 Jun 11.

State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering, Hohai University, Nanjing, P.R. China.

The microfluidic technology based on surface acoustic waves (SAW) has been developing rapidly, as it can precisely manipulate fluid flow and particle motion at microscales. We hereby present a numerical study of the transient motion of suspended particles in a microchannel. In conventional studies, only the microchannel's bottom surface generates SAW and only the final positions of the particles are analyzed. In our study, the microchannel is sandwiched by two identical SAW transducers at both the bottom and top surfaces while the channel's sidewalls are made of poly-dimethylsiloxane (PDMS). Based on the perturbation theory, the suspended particles are subject to two types of forces, namely the Acoustic Radiation Force (ARF) and the Stokes Drag Force (SDF), which correspond to the first-order acoustic field and the second-order streaming field, respectively. We use the Finite Element Method (FEM) to compute the fluid responses and particle trajectories. Our numerical model is shown to be accurate by verifying against previous experimental and numerical results. We have determined the threshold particle size that divides the SDF-dominated regime and the ARF-dominated regime. By examining the time scale of the particle movement, we provide guidelines on the device design and operation.
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http://dx.doi.org/10.1177/09544119211024775DOI Listing
June 2021

Metronomic capecitabine as adjuvant therapy in locoregionally advanced nasopharyngeal carcinoma: a multicentre, open-label, parallel-group, randomised, controlled, phase 3 trial.

Lancet 2021 Jun 4. Epub 2021 Jun 4.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, China.

Background: Patients with locoregionally advanced nasopharyngeal carcinoma have a high risk of disease relapse, despite a high proportion of patients attaining complete clinical remission after receiving standard-of-care treatment (ie, definitive concurrent chemoradiotherapy with or without induction chemotherapy). Additional adjuvant therapies are needed to further reduce the risk of recurrence and death. However, the benefit of adjuvant chemotherapy for nasopharyngeal carcinoma remains controversial, highlighting the need for more effective adjuvant treatment options.

Methods: This multicentre, open-label, parallel-group, randomised, controlled, phase 3 trial was done at 14 hospitals in China. Patients (aged 18-65 years) with histologically confirmed, high-risk locoregionally advanced nasopharyngeal carcinoma (stage III-IVA, excluding T3-4N0 and T3N1 disease), no locoregional disease or distant metastasis after definitive chemoradiotherapy, an Eastern Cooperative Oncology Group performance status of 0 or 1, sufficient haematological, renal, and hepatic function, and who had received their final radiotherapy dose 12-16 weeks before randomisation, were randomly assigned (1:1) to receive either oral metronomic capecitabine (650 mg/m body surface area twice daily for 1 year; metronomic capecitabine group) or observation (standard therapy group). Randomisation was done with a computer-generated sequence (block size of four), stratified by trial centre and receipt of induction chemotherapy (yes or no). The primary endpoint was failure-free survival, defined as the time from randomisation to disease recurrence (distant metastasis or locoregional recurrence) or death due to any cause, in the intention-to-treat population. Safety was assessed in all patients who received at least one dose of capecitabine or who had commenced observation. This trial is registered with ClinicalTrials.gov, NCT02958111.

Findings: Between Jan 25, 2017, and Oct 25, 2018, 675 patients were screened, of whom 406 were enrolled and randomly assigned to the metronomic capecitabine group (n=204) or to the standard therapy group (n=202). After a median follow-up of 38 months (IQR 33-42), there were 29 (14%) events of recurrence or death in the metronomic capecitabine group and 53 (26%) events of recurrence or death in the standard therapy group. Failure-free survival at 3 years was significantly higher in the metronomic capecitabine group (85·3% [95% CI 80·4-90·6]) than in the standard therapy group (75·7% [69·9-81·9]), with a stratified hazard ratio of 0·50 (95% CI 0·32-0·79; p=0·0023). Grade 3 adverse events were reported in 35 (17%) of 201 patients in the metronomic capecitabine group and in 11 (6%) of 200 patients in the standard therapy group; hand-foot syndrome was the most common adverse event related to capecitabine (18 [9%] patients had grade 3 hand-foot syndrome). One (<1%) patient in the metronomic capecitabine group had grade 4 neutropenia. No treatment-related deaths were reported in either group.

Interpretation: The addition of metronomic adjuvant capecitabine to chemoradiotherapy significantly improved failure-free survival in patients with high-risk locoregionally advanced nasopharyngeal carcinoma, with a manageable safety profile. These results support a potential role for metronomic chemotherapy as an adjuvant therapy in the treatment of nasopharyngeal carcinoma.

Funding: The National Natural Science Foundation of China, the Key-Area Research and Development Program of Guangdong Province, the Natural Science Foundation of Guangdong Province, the Innovation Team Development Plan of the Ministry of Education, and the Overseas Expertise Introduction Project for Discipline Innovation.

Translation: For the Chinese translation of the abstract see Supplementary Materials section.
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http://dx.doi.org/10.1016/S0140-6736(21)01123-5DOI Listing
June 2021

Molybdenum disulfide (MoS): A novel activator of peracetic acid for the degradation of sulfonamide antibiotics.

Water Res 2021 May 26;201:117291. Epub 2021 May 26.

State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China.

Sulfonamide antibiotics (SAs) are typical antibiotics and have attracted increasing concerns about their wide occurrence in environment as well as potential risk for human health. In this study, we applied a novel advanced oxidation process in SAs degradation by combining molybdenum sulfide and peracetic acid (MoS/PAA). Reactive oxygen species (ROS) including HO, CHC(O)O, CHC(O)OO, and O were generated from PAA by MoS activation and contributed to SAs degradation. The effects of initial pH, the dosages of PAA and MoS, and humic acid for SAs degradation were further evaluated by selecting sulfamethoxazole (SMX) as a target SA in the MoS/PAA process. Results suggested that the optimum pH for SMX removal was 3, where the degradation efficiency of SMX was higher than 80% after reaction for 15 min. Increasing PAA (0.075-0.45 mM) or MoS (0.1-0.4 g/L) dosages facilitated the SMX degradation, while the presence of humic acids retarded the SMX removal. This MoS/PAA process also showed good efficiencies in removing other SAs including sulfaguanidine, sulfamonomethoxine and sulfamerazine. Their possible degradation pathways were proposed based on the products identification and DFT calculation, showing that apart from the oxidation of amine groups to nitro groups in SAs, MoS/PAA induced SO extrusion reaction for SAs that contained six-membered heterocyclic moieties.
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http://dx.doi.org/10.1016/j.watres.2021.117291DOI Listing
May 2021

Frequency-specific alterations of the resting-state BOLD signals in nocturnal enuresis: an fMRI Study.

Sci Rep 2021 Jun 8;11(1):12042. Epub 2021 Jun 8.

Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dong-Fang Road, Shanghai, 200127, China.

Resting state functional magnetic resonance imaging studies of nocturnal enuresis have focused primarily on regional metrics in the blood oxygen level dependent (BOLD) signal ranging from 0.01 to 0.08 Hz. However, it remains unclear how local metrics show in sub-frequency band. 129 children with nocturnal enuresis (NE) and 37 healthy controls were included in this study. The patients were diagnosed by the pediatricians in Shanghai Children's Medical Center affiliated to Shanghai Jiao Tong University School of Medicine, according to the criteria from International Children's Continence Society (ICCS). Questionnaires were used to evaluate the symptoms of enuresis and completed by the participants. In this study, fALFF, ReHo and PerAF were calculated within five different frequency bands: typical band (0.01-0.08 Hz), slow-5 (0.01-0.027 Hz), slow-4 (0.027-0.073 Hz), slow-3 (0.073-0.198 Hz), and slow-2 (0.198-0.25 Hz). In the typical band, ReHo increased in the left insula and the right thalamus, while fALFF decreased in the right insula in children with NE. Besides, PerAF was increased in the right middle temporal gyrus in these children. The results regarding ReHo, fALFF and PerAF in the typical band was similar to those in slow-5 band, respectively. A correlation was found between the PerAF value of the right middle temporal gyrus and scores of the urinary intention-related wakefulness. Results in other bands were either negative or in white matter. NE children might have abnormal intrinsic neural oscillations mainly on slow-5 bands.
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http://dx.doi.org/10.1038/s41598-021-90546-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187680PMC
June 2021

Oxygen defective titanate nanotubes induced by iron deposition for enhanced peroxymonosulfate activation and acetaminophen degradation: Mechanisms, water chemistry effects, and theoretical calculation.

J Hazard Mater 2021 May 27;418:126180. Epub 2021 May 27.

The Key Laboratory of Water and Sediment Sciences, Ministry of Education, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China; State Environmental Protection Key Laboratory of All Material Fluxes in River Ecosystems, Peking University, Beijing 100871, China.

The large consumption of acetaminophen (APAP) worldwide and unsatisfactory treatment efficiencies by conventional wastewater treatment processes give rise to the seeking of new technology for its effective removal. Herein, we proposed a facile one-step hydrothermal method to synthesize defective iron deposited titanate nanotubes (Fe/TNTs) for peroxymonosulfate (PMS) activation and APAP degradation. The retarded first-order reaction rate of APAP degradation by Fe/TNTs was 5.1 times higher than that of neat TNTs. Characterizations indicated iron deposition effectively induced oxygen vacancies and Ti, facilitating the electrical conductivity and PMS binding affinity of Fe/TNTs. Besides, oxygen vacancies could act as an electron mediator through PMS activation by iron. Moreover, the formation of Fe-O-Ti bond facilitated the synergistic redox coupling between Fe and Ti, further enhancing the PMS activation. SO was the major radical, causing C-N bond cleavage and decreasing the overall toxicity. In contrast, APAP degradation by neat TNTs-PMS system mainly works through nonradical reaction. The Fe/TNTs activated PMS showed desired APAP removal under mild water chemistry conditions and good reusability. This work is expected to expand the potential application of titanate nanomaterials for PMS activation, and shed light on facile synthesis of oxygen defective materials for sulfate-radical-based advanced oxidation processes.
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http://dx.doi.org/10.1016/j.jhazmat.2021.126180DOI Listing
May 2021

The combination of CUDC-907 and gilteritinib shows promising in vitro and in vivo antileukemic activity against FLT3-ITD AML.

Blood Cancer J 2021 Jun 7;11(6):111. Epub 2021 Jun 7.

Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.

About 25% of patients with acute myeloid leukemia (AML) harbor FMS-like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) mutations and their prognosis remains poor. Gilteritinib is a FLT3 inhibitor approved by the US FDA for use in adult FLT3-mutated relapsed or refractory AML patients. Monotherapy, while efficacious, shows short-lived responses, highlighting the need for combination therapies. Here we show that gilteritinib and CUDC-907, a dual inhibitor of PI3K and histone deacetylases, synergistically induce apoptosis in FLT3-ITD AML cell lines and primary patient samples and have striking in vivo efficacy. Upregulation of FLT3 and activation of ERK are mechanisms of resistance to gilteritinib, while activation of JAK2/STAT5 is a mechanism of resistance to CUDC-907. Gilteritinib and CUDC-907 reciprocally overcome these mechanisms of resistance. In addition, the combined treatment results in cooperative downregulation of cellular metabolites and persisting antileukemic effects. CUDC-907 plus gilteritinib shows synergistic antileukemic activity against FLT3-ITD AML in vitro and in vivo, demonstrating strong translational therapeutic potential.
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http://dx.doi.org/10.1038/s41408-021-00502-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184771PMC
June 2021

Comparison of the clinical effect between the lower sternal incision and the left parasternal fourth intercostal incision in the transthoracic closure of ventricular septal defect.

J Cardiothorac Surg 2021 Jun 7;16(1):165. Epub 2021 Jun 7.

Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fuzhou, 350001, China.

Background: To analyze the clinical effect of two different ways of minimally invasive transthoracic closure in children with ventricular septal defect (VSD).

Methods: From January 2015 to July 2019, 294 children with VSD were enrolled in the Fujian Medical University Union Hospital. Patients were divided into two groups - those who underwent VSD closure through the left sternal fourth intercostal incision (group A: n = 95) and the lower sternal incision (group B: n = 129).

Results: The operation time, bleeding volume, postoperative mechanical ventilation time, postoperative intensive care unit (ICU) monitoring time, postoperative hospitalization time and complication rate in group A were significantly lower than those in group B (P < 0.05). There was no significant difference between the two groups in the operation success rate, mechanical ventilation time and total hospitalization cost (P > 0.05).

Conclusion: The transthoracic closure of ventricular septal defect through the left sternal fourth intercostal incision is feasible, safe, cosmetic, and worth popularizing.
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http://dx.doi.org/10.1186/s13019-021-01543-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186159PMC
June 2021

Associations Between Single-Child Status and Metabolic Syndrome in Children and Adolescents in China.

Front Pediatr 2021 20;9:661164. Epub 2021 May 20.

Menzies Health Institute Queensland, Griffith University, Brisbane, QLD, Australia.

To evaluate the associations between single-child status and metabolic syndrome (MS) and to identify the highest risk group of MS among single children. Differences in participants' characteristics by sex were examined by Student's -test for continuous variables and Pearson's chi-squared test for categorical variables. Multivariate logistic regression analysis was performed to estimate the odds ratios () and 95% confidence intervals () for MS and its components according to the single-child status. Radar maps were used to compare the composition of different components in MS. In total, 11,784 (5,880 boys) children and adolescents were included in this study, with a mean age of (11.3 ± 3.1) years. MS was observed in 7.1% of participants, with a higher prevalence in boys (8.2%) than girls (5.9%) ( < 0.05). The prevalence of MS, elevated blood pressure and abdominal obesity in single children were higher than that in children with siblings, particularly in boys ( < 0.001). Elevated risk of abdominal obesity was observed in single children [boys (1.56, 95% CI: 1.31, 1.85), girls (1.40, 95% CI: 1.19, 1.63)], however, increased ORs of elevated blood pressure and metabolic syndrome were observed in single-child boys only (1.19, 95% CI: 1.01, 1.40 and 1.76, 95% CI: 1.34, 2.31, respectively). Results showed that a statistically significant association between single child status and MS was mainly observed in urban boys (2.04, 95% CI: 1.33, 3.12) and rural boys (1.50, 95% CI: 1.05, 2.15), but not in girls. Among all the combinations of MS, two combinations were significantly associated with the single-child status, including the combination of elevated blood pressure, abdominal and low HDL-C (1.45, 1.04, 2.04) and the combination of elevated blood pressure, abdominal obesity, low HDL-C and hypertriglyceridemia (2.04, 1.40, 3.06) ( < 0.05). The present study found that single children and adolescents had a higher risk of MS, elevated blood pressure and abdominal obesity. The associations were stronger in urban boys. Further attention should be directed to the prevention and control strategies targeting the high-risk population of MS.
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http://dx.doi.org/10.3389/fped.2021.661164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173115PMC
May 2021

A new modified Gant-Miwa-Thiersch combined with submucosal and perirectal sclerosant injection procedure for full-thickness rectal prolapse in elderly women: clinical analysis of 34 cases.

BMC Surg 2021 Jun 5;21(1):284. Epub 2021 Jun 5.

Shanxi Bethune Hospital, Taiyuan, 030012, People's Republic of China.

Background: Full-thickness rectal prolapse (FTRP) frequently occurs in elderly women, and more than 100 surgical procedures have been proposed to restore FTRP. The Gant-Miwa-Thiersch (GMT) procedure is the most used treatment in China. However, the recurrence rate of FTRP post-GMT, which is as high as 23.8%, is concerning. We described a new modified GMT combined with internal and external rectal sclerosant injection (nmGMTSI) procedure to address this problem.

Methods: The nmGMTSI was performed under spinal anesthesia in 34 frail, elderly female patients with FTRP. The surgical results of FTRP were assessed. Fecal incontinence and constipation were evaluated using the Wexner score, and anal canal rest pressure (ACRP), maximum anal systolic pressure (MASP), anorectal sensation thresholds (AST), and maximum rectal tolerance (MRT) using anorectal manometry preoperatively and postoperatively. The causes of recurrence and complications were analyzed.

Results: All patients were cured according to the clinical cure standard. The perioperative Wexner fecal incontinence score (WFIS) was 10.3 ± 3.31, which became 3.7 ± 2.43 (P < 0.0001) postoperatively. The perioperative ACRP was 2.0 ± 0.56 kPa, which became 8.5 ± 2.25 kPa (P < 0.0001) postoperatively. The perioperative MASP was 4.5 ± 1.16 kPa, which became 18.6 ± 2.50 kPa (P < 0.0001) postoperatively. However, no significant difference was observed between the preoperative and postoperative Wexner constipation scores (WCS) (17.3 ± 2.25 vs. 15.4 ± 2.89, P = 0.1047). The perioperative and postoperative AST were 38.1 ± 5.34 mL and 23.5 ± 3.61 mL, respectively (P = 0.0002). The maximum rectal tolerance (MRT) was 157.1 ± 16.73 mL, which became 121.2 ± 12.45 mL postoperatively (P = 0.0009). The patients developed no serious postoperative complications. The total relapse rate after nmGMTSI was 2.9% in the median two years follow-up period. The most common cause of relapse after nmGMTSI was the removal of infected threads used in the Thiersch procedure.

Conclusion: The benefits of nmGMTSI include low rates of recurrence, complications, and mortality, cost-effectiveness, wide adaptation, minimal invasiveness, and technical simplicity. Hence, it should be considered the first option for the treatment of FTRP in frail elderly women.
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http://dx.doi.org/10.1186/s12893-021-01284-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180061PMC
June 2021

Induced pluripotent stem cells derived from one 70-years-old male donor with the APOE-ε4/ε4 alleles.

Stem Cell Res 2021 May 13;53:102395. Epub 2021 May 13.

Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China; Human Anatomy Department, Hebei Medical University, Hebei Province 050017, China. Electronic address:

Apolipoprotein E (ApoE) is a lipid-binding protein with ε2, ε3, and ε4 allelic variants in human. The ε4 isoform (ApoE4) is the strongest genetic risk factor for the late-onset form of Alzheimer's disease (AD), and is also associated with multiple neurological disorders, multiple sclerosis, and cerebrovascular disease. Here, induced pluripotent stem cells were derived from the peripheral blood mononuclear cells of a 70-year-old male donor with APOE-ε4/ε4 alleles background to explore pathogenesis and screen potential treatment methods in neurodegenerative diseases. In the newly-developed induced pluripotent stem cell line, the pluripotent markers were well expressed. In addition, the generated cells displayed a normal karyotype and have differentiation potential.
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http://dx.doi.org/10.1016/j.scr.2021.102395DOI Listing
May 2021

Tuning the Chemical Properties of Co-Ti C T MXene Materials for Catalytic CO Reduction.

Small 2021 Jun 4:e2007509. Epub 2021 Jun 4.

Dalian National Laboratory for Clean Energy (DNL), Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, China.

MXenes, a novel family of 2D materials, are energy materials that have gained considerable attention, particularly for their catalytic applications in emerging areas such as CO and N hydrogenation. Herein, for the first time, it is shown that the surface reducibility of Ti C T MXene can be tuned by N doping, which induces a change in the catalytic properties of supported Co nanoparticles. Pristine Co-Ti C T MXene favors CO production during CO hydrogenation, whereas CH production is favored when the MXene is subjected to simple N doping. X-ray photoelectron spectroscopy and transmission electron microscopy (TEM) reveal that surface rutile TiO nanoparticles appear on the Ti C T support upon N doping, which interact strongly with the supported Co nanoparticles. This interaction alters the reducibility of the supported Co nanoparticles at the interface with the TiO nanoparticles, shifting the product selectivity from CO to CH . This study successfully showcases a practical strategy, based on surface chemistry modulation of 2D MXenes, for regulating product distribution in CO hydrogenation.
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http://dx.doi.org/10.1002/smll.202007509DOI Listing
June 2021

Wax-Transferred Hydrophobic CVD Graphene Enables Water-Resistant and Dendrite-Free Lithium Anode toward Long Cycle Li-Air Battery.

Adv Sci (Weinh) 2021 Jun 3:e2100488. Epub 2021 Jun 3.

Center for Nanochemistry (CNC), Beijing Science and Engineering Center for Nanocarbons, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.

One of the key challenges in achieving practical lithium-air battery is the poor moisture tolerance of the lithium metal anode. Herein, guided by theoretical modeling, an effective tactic for realizing water-resistant Li anode by implementing a wax-assisted transfer protocol is reported to passivate the Li surface with an inert high-quality chemical vapor deposition (CVD) graphene layer. This electrically conductive and mechanically robust graphene coating enables serving as an artificial solid/electrolyte interphase (SEI), guiding homogeneous Li plating/stripping, suppressing dendrite and "dead" Li formation, as well as passivating the Li surface from moisture erosion and side reactions. Consequently, lithium-air batteries fabricated with the passivated Li anodes demonstrate a superb cycling performance up to 2300 h (230 cycles at 1000 mAh g , 200 mA g ). More strikingly, the anode recycled thereafter can be recoupled with a fresh cathode to continuously run for 400 extended hours. Comprehensive time-lapse and ex situ microscopic and spectroscopic investigations are further carried out for elucidating the fundamentals behind the extraordinary air and electrochemical stability.
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http://dx.doi.org/10.1002/advs.202100488DOI Listing
June 2021

Macrophages/Microglia in the Glioblastoma Tumor Microenvironment.

Int J Mol Sci 2021 May 28;22(11). Epub 2021 May 28.

Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA.

The complex interaction between glioblastoma and its microenvironment has been recognized for decades. Among various immune profiles, the major population is tumor-associated macrophage, with microglia as its localized homolog. The present definition of such myeloid cells is based on a series of cell markers. These good sentinel cells experience significant changes, facilitating glioblastoma development and protecting it from therapeutic treatments. Huge, complicated mechanisms are involved during the overall processes. A lot of effort has been dedicated to crack the mysterious codes in macrophage/microglia recruiting, activating, reprogramming, and functioning. We have made our path. With more and more key factors identified, a lot of new therapeutic methods could be explored to break the ominous loop, to enhance tumor sensitivity to treatments, and to improve the prognosis of glioblastoma patients. However, it might be a synergistic system rather than a series of clear, stepwise events. There are still significant challenges before the light of truth can shine onto the field. Here, we summarize recent advances in this field, reviewing the path we have been on and where we are now.
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http://dx.doi.org/10.3390/ijms22115775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198046PMC
May 2021

Dietary Inflammatory Index and Ovarian Cancer Risk: A Meta-Analysis.

Nutr Cancer 2021 Jun 1:1-10. Epub 2021 Jun 1.

Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Existing evidence suggests diet and chronic inflammation as risk factors in ovarian cancer (OC) development. We aim to conduct a meta-analysis exploring possible associations between dietary inflammatory potential and OC. A systematic search was conducted through PubMed, Scopus, Embase, and PMC databases for studies reporting relationships between dietary inflammatory potential and OC risk published up to September 2020. We included six studies for stepwise analysis, of which 5,468 among 197,086 individuals developed OC. Pooled odds ratios (ORs) were calculated by fixed-effects models, while heterogeneity was assessed by Q test and I statistic. The results revealed a positive association between dietary inflammatory potential measured by the Dietary Inflammatory Index (DII) and OC( < 0.05). Individuals with higher DII scores had a 42% increased risk of OC incidence [OR = 1.42, 95% confidence interval (CI): 1.19-1.65]. The analysis considering DII as a continuous variable showed an increased risk of 10% for 1-point increase of DII(OR = 1.10, 95% CI: 1.06-1.14). Subgroup analysis revealed that increased risk of OC in individuals with higher DII scores vs. those with lower DII was only significant among post-menopausal women(OR = 1.72, 95% CI: 1.26-2.21) rather than those pre/peri-menopausal(OR = 1.21, 95% CI: 0.63-1.79). Pro-inflammatory diets with higher DII score were significantly related to increased OC risk among post-menopausal women.
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http://dx.doi.org/10.1080/01635581.2021.1931366DOI Listing
June 2021

Lappaconitine hydrochloride inhibits proliferation and induces apoptosis in human colon cancer HCT-116 cells via mitochondrial and MAPK pathway.

Acta Histochem 2021 May 29;123(5):151736. Epub 2021 May 29.

Key Laboratory of Stem Cells and Gene Drug of Gansu Provincial, The 940(th) Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou, Gansu, 730070, China.

Lappaconitine hydrochloride (LH), as a new synthetic alkaloid, exhibits antitumor activity, whereas its antitumor effect on colorectal cancer (CRC) has not been investigated. In this study, the effect of LH on HCT-116 cell proliferation and apoptosis in vivo and in vitro and underlying molecular mechanism were explored. The Cell Counting Kit-8 (CCK-8) was used to assess cell viability. Morphological change was observed by Hoechst 33342 staining. Cell cycle and apoptosis were performed using a flow cytometer. The western blot method was used to screen for related protein expression. The mitochondrial membrane potential (MMP) was confirmed using the 5, 5, 6, 6'-tetrachloro-1, 1', 3, 3'-tetraethylbenzimi-dazolyl carbo cyanine iodide (JC-1) staining assay. Reactive oxygen species (ROS) was evaluated by a 20-70-dichlorofluorescein diacetate (DCFH-DA) staining assay. The antitumor effect was evaluated in vivo by the xenograft HCT-116 model. The results showed that LH significantly inhibited cell viability in a time- and concentration-dependent manner. LH induced apoptosis and S phase cell cycle arrest. LH promoted the reduction of MMP and ROS accumulation. Moreover, LH activated the mitochondrial and MAPK pathway. The experiments in vivo showed that LH had significant antitumor effect in tumor-bearing mice, and had virtually no effect on the weight and internal organs of the mice. In conclusion, LH could induce apoptosis in HCT-116 cells through mitochondrial and MAPK signaling pathways. LH may be a promising treatment for CRC.
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http://dx.doi.org/10.1016/j.acthis.2021.151736DOI Listing
May 2021

Comparing methods of detecting and segmenting unruptured intracranial aneurysms on TOF-MRAS: The ADAM challenge.

Neuroimage 2021 May 27;238:118216. Epub 2021 May 27.

Department of Informatics, Technische Universität München, Munich, Germany.

Accurate detection and quantification of unruptured intracranial aneurysms (UIAs) is important for rupture risk assessment and to allow an informed treatment decision to be made. Currently, 2D manual measures used to assess UIAs on Time-of-Flight magnetic resonance angiographies (TOF-MRAs) lack 3D information and there is substantial inter-observer variability for both aneurysm detection and assessment of aneurysm size and growth. 3D measures could be helpful to improve aneurysm detection and quantification but are time-consuming and would therefore benefit from a reliable automatic UIA detection and segmentation method. The Aneurysm Detection and segMentation (ADAM) challenge was organised in which methods for automatic UIA detection and segmentation were developed and submitted to be evaluated on a diverse clinical TOF-MRA dataset. A training set (113 cases with a total of 129 UIAs) was released, each case including a TOF-MRA, a structural MR image (T1, T2 or FLAIR), annotation of any present UIA(s) and the centre voxel of the UIA(s). A test set of 141 cases (with 153 UIAs) was used for evaluation. Two tasks were proposed: (1) detection and (2) segmentation of UIAs on TOF-MRAs. Teams developed and submitted containerised methods to be evaluated on the test set. Task 1 was evaluated using metrics of sensitivity and false positive count. Task 2 was evaluated using dice similarity coefficient, modified hausdorff distance (95 percentile) and volumetric similarity. For each task, a ranking was made based on the average of the metrics. In total, eleven teams participated in task 1 and nine of those teams participated in task 2. Task 1 was won by a method specifically designed for the detection task (i.e. not participating in task 2). Based on segmentation metrics, the top two methods for task 2 performed statistically significantly better than all other methods. The detection performance of the top-ranking methods was comparable to visual inspection for larger aneurysms. Segmentation performance of the top ranking method, after selection of true UIAs, was similar to interobserver performance. The ADAM challenge remains open for future submissions and improved submissions, with a live leaderboard to provide benchmarking for method developments at https://adam.isi.uu.nl/.
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http://dx.doi.org/10.1016/j.neuroimage.2021.118216DOI Listing
May 2021

Assessment of Modifiable Factors for the Association of Marital Status With Cancer-Specific Survival.

JAMA Netw Open 2021 May 3;4(5):e2111813. Epub 2021 May 3.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, People's Republic of China.

Importance: Married patients with cancer have better cancer-specific survival than unmarried patients. Increasing the early diagnosis and definitive treatment of cancer among unmarried patients may reduce the survival gap.

Objectives: To evaluate the extent to which marriage is associated with cancer-specific survival, stage at diagnosis, and treatment among patients with 9 common solid cancers and to recommend methods for reducing the survival gap.

Design, Setting, And Participants: This retrospective, population-based cohort study included patients older than 18 years who were diagnosed with 1 of 9 common cancers between January 1, 2007, and December 31, 2016. Patient data were retrieved from the Surveillance, Epidemiology, and End Results Program. Statistical analyses were performed from August 1 to October 1, 2020.

Exposures: Marital status, classified as married and unmarried (including single, separated, divorced, widowed, and unmarried patients or domestic partners).

Main Outcomes And Measures: The primary outcome was the time ratio (TR) of cancer-specific survival (married vs unmarried). Mediation analyses were conducted to determine the extent to which the association of marriage with cancer-specific survival was mediated by stage at diagnosis and treatment.

Results: This study included 1 733 906 patients (894 379 [51.6%] women; 1 067 726 [61.6%] married; mean [SD] age, 63.76 [12.60] years). Multivariate analyses found that those who were married were associated with better cancer-specific survival than unmarried patients (TR, 1.36; 95% CI, 1.35-1.37). Early diagnosis in breast cancer, colorectal cancer, endometrial cancer, and melanoma mediated the association between marital status and cancer-specific survival (breast cancer: proportion mediated [PM], 11.4%; 95% CI, 11.2%-11.6%; colorectal cancer: PM, 10.9%; 95% CI, 10.7%-11.2%; endometrial cancer: PM, 12.9%; 95% CI, 12.5%-13.3%; melanoma: PM, 12.0%; 95% CI, 11.7-12.4%). Surgery mediated the association between marital status and cancer-specific survival in lung (PM, 52.2%; 95% CI, 51.9%-52.4%), pancreatic (PM, 28.9%; 95% CI, 28.6%-29.3%), and prostate (PM, 39.3%; 95% CI, 39.0%-39.6%) cancers. Chemotherapy mediated the association of marital status with cancer-specific survival in lung (PM, 37.7%; 95% CI, 37.6%-37.9%) and pancreatic (PM, 28.6%; 95% CI, 28.4%-28.9%) cancers. Improved cancer-specific survival associated with marriage was greater among men than women (men: TR, 1.27; 95% CI, 1.25-1.28; women: TR, 1.20; 95% CI, 1.19-1.21). The contribution of receiving an early diagnosis and treatment with surgery or chemotherapy to the association between marital status and cancer-specific survival was greater among men than women (early diagnosis: PM, 21.7% [95% CI, 21.5%-21.9%] vs PM, 20.3% [95% CI, 20.2%-20.4%]; surgery: PM, 26.6% [95% CI, 26.4%-26.7%] vs PM, 11.1% [95% CI, 11.0%-11.2%]; chemotherapy: PM, 6.8% [95% CI, 6.7%-6.8%] vs PM, 5.1% [95% CI, 5.0%-5.2%]).

Conclusions And Relevance: In this study, survival disparities associated with marital status were attributable to early diagnosis in breast, colorectal, and endometrial cancers as well as melanoma and to treatment-related variables in lung, pancreatic, and prostate cancers. The findings also suggest that marriage may play a greater protective role in the cancer-specific survival of men than of women.
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http://dx.doi.org/10.1001/jamanetworkopen.2021.11813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164101PMC
May 2021

A new nairo-like virus associated with human febrile illness in China.

Emerg Microbes Infect 2021 Dec;10(1):1200-1208

Department of Emerging Infectious Diseases, The First Hospital of Jilin University, Changchun, People's Republic of China.

Several nairo-like viruses have been discovered in ticks in recent years, but their relevance to public health remains unknown. Here, we found a patient who had a history of tick bite and suffered from a febrile illness was infected with a previously discovered RNA virus, Beiji nairovirus (BJNV), in the nairo-like virus group of the order . We isolated the virus by cell culture assay. BJNV could induce cytopathic effects in the baby hamster kidney and human hepatocellular carcinoma cells. Negative-stain electron microscopy revealed enveloped and spherical viral particles, morphologically similar to those of nairoviruses. We identified 67 patients as BJNV infection in 2017-2018. The median age of patients was 48 years (interquartile range 41-53 years); the median incubation period was 7 days (interquartile range 3-12 days). Most patients were men (70%), and a few (10%) had underlying diseases. Common symptoms of infected patients included fever (100%), headache (99%), depression (63%), coma (63%), and fatigue (54%), myalgia or arthralgia (45%); two (3%) patients became critically ill and one died. BJNV could cause growth retardation, viremia and histopathological changes in infected suckling mice. BJNV was also detected in sheep, cattle, and multiple tick species. These findings demonstrated that the newly discovered nairo-like virus may be associated with a febrile illness, with the potential vectors of ticks and reservoirs of sheep and cattle, highlighting its public health significance and necessity of further investigation in the tick-endemic areas worldwide.
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http://dx.doi.org/10.1080/22221751.2021.1936197DOI Listing
December 2021

Association between N-terminal pro-BNP and 12 months major adverse cardiac events among patients admitted with NSTEMI.

Ann Palliat Med 2021 May 12;10(5):5231-5243. Epub 2021 May 12.

Department of Cardiology, Tianjin Chest Hospital, Tianjin, China.

Background: In recent years, the hospital admission rate of non-ST-elevation myocardial infarction (NSTEMI) patients has exhibited an increasing trend, and a forthcoming transition from ST-elevation myocardial infarction (STEMI) to NSTEMI has been observed in China. The association between serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) and major adverse cardiac events (MACEs) within 12 months after discharge among patients with NSTEMI remains unclear.

Methods: A total of 1,357 consecutively admitted NSTEMI patients were from the TAMI cohort. The patients' baseline demographic and clinical information were collected, and follow-up was carried out for 12 months. The primary outcome was composite MACEs consisting of all-cause death, hospital admission for unstable angina, hospital admission for heart failure, non fatal recurrent myocardial infarction, and target lesion revascularization (TLR). We adopted a Cox proportional hazard model to analyze the effect of NT-proBNP on MACEs and quantified the added prognostic value of NT-proBNP on the Global Registry of Acute CoronaryEvents (GRACE) risk score using the Harrell C-index, NRI, and IDI.

Results: The overall average follow-up period was 313 days. In total, 211 (15.55%) patients suffered from at least one MACE, and 97 patients were lost to follow-up, with a median follow-up time of 147 days. As the NT-proBNP level increased, a significant uptrend in the incidence of composite MACEs, all-cause death, and heart failure was observed. The multivariable Cox model revealed that NT-proBNP was an independent risk factor for composite MACEs [medium- vs. low-, HR: 2.19 (1.45-3.32), P=0.0002]; [high- vs. low-, HR: 3.07 (1.78-5.29), P<0.0001], as well as for all-cause death and heart failure. Subgroup analysis indicated that NT-proBNP was a robust prognostic biomarker, and the prognostic value was more evident for patients older than 60 years and whose LVEF was less than 40%. NT-proBNP (log-scale) was moderately correlated with the GRACE score (r=0.58, P<0.0001). The Harrell C-index of NT-proBNP combined with the GRACE score was 0.7715, which was higher than that of the GRACE score alone (0.7149) for predicting composite MACEs, and this improvement was verified by significant IDI (0.064, 95% CI: 0.027-0.106).

Conclusions: NT-proBNP is a robust long-term prognostic biomarker for patients diagnosed with NSTEMI, especially for older patients and those with impaired cardiac ejection function. Combined usage of NT-proBNP levels with the GRACE score might help identify a subset of NSTEMI patients at a particularly high risk of MACEs 12 months after discharge.
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http://dx.doi.org/10.21037/apm-20-2538DOI Listing
May 2021

Effects of salinity on the simultaneous anammox and denitrification process: performance, sludge morphology and shifts in microbial communities.

R Soc Open Sci 2021 May 12;8(5):202099. Epub 2021 May 12.

College of Energy and Environmental Engineering, Hebei University of Engineering, Handan 056038, People's Republic of China.

In this study, the long-term effects of different salinities on the performance, sludge morphology and shifts in microbial communities were studied in a simultaneous anammox and denitrification (SAD) process at a C/N ratio of 0.5. Stable nitrogen removal efficiencies of 86.96 and 84.58% and nitrogen removal rates of 0.95 and 0.93 kg (m d) could be achieved under low (25 mmol l) and moderate (50 mmol l) salinity, respectively. However, the performance collapsed when the system was exposed to high salinity (100 mmol l). The content of extracellular polymeric substances increased as salinity increased, which resulted in larger sizes of granular sludge under low and moderate salinities. Nevertheless, high salinity shock disintegrated granular sludge, thereby decreasing the average granule size. The Illumina-Miseq sequencing results revealed that was the sole salinity-tolerant AnAOB genus during the entire operation, whereas the main denitrification bacterial genera shifted from under low salinity to , and under high salinity. The results of this study provide a comprehensive and practical evaluation of the SAD process for organic nitrogen-rich saline wastewater treatment.
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http://dx.doi.org/10.1098/rsos.202099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113906PMC
May 2021

Artificial Intelligence Based on Blood Biomarkers Including CTCs Predicts Outcomes in Epithelial Ovarian Cancer: A Prospective Study.

Onco Targets Ther 2021 18;14:3267-3280. Epub 2021 May 18.

Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.

Objective: We aimed to develop an ovarian cancer-specific predictive framework for clinical use platinum-sensitivity and prognosis using machine learning methods based on multiple biomarkers, including circulating tumor cells (CTCs).

Patients And Methods: We enrolled 156 epithelial ovarian cancer (EOC) patients, randomly assigned into the training and validation cohorts. Eight machine learning classifiers, including Random Forest (RF), Support Vector Machine, Gradient Boosting Machine, Conditional RF, Neural Network, Naive Bayes, Elastic Net, and Logistic Regression, were used to derive predictive information from 11 peripheral blood parameters, including CTCs. Through the advanced CanPatrol CTC-enrichment technique, we detect CTCs and classify them into subpopulations: epithelial, mesenchymal, and hybrids. Survival curves were generated by Kaplan-Meier method and calculated through the Log rank test.

Results: Machine learning techniques, especially the Random Forest classifier, were superior to conventional regression-based analyses in predicting multiple clinical parameters related to EOC. The values for the receiver operating characteristic (ROC) curve for segregating EOC with advanced clinical stages and platinum-sensitivity were 0.796 (95% CI, 0.727-0.866) and 0.809 (95% CI, 0.742-0.876), respectively. Stepwise, we used the unsupervised clustering analysis to identify EOC subgroups with significantly worse overall survival (OS), especially in the advanced-stage group with the p-value of 0.0018 (HR, 2.716; 95% CI, 1.602-4.605) for progression-free survival (PFS) and 0.0037 (HR, 2.359; 95% CI, 1.752-6.390) for overall survival (OS).

Conclusion: Machine learning systems could provide risk stratification for EOC patients before initial intervention through blood variables, including circulating tumor cells. The predictive algorithms could facilitate personalized treatment options through promising pre-treatment stratification of EOC patients.

Trial Registration: ChiCTR-DDD-16009601 Registered 25 October 2016.
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http://dx.doi.org/10.2147/OTT.S307546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140950PMC
May 2021