Publications


Impact of Cell Composition and Geometry on Human Induced Pluripotent Stem Cells-Derived Engineered Cardiac Tissue.
Sci Rep 2017 Apr 3;7:45641. Epub 2017 Apr 3.
Kosair Charities Pediatric Heart Research Program, Cardiovascular Innovation Institute, University of Louisville, Louisville, Kentucky, The United States of America.

In Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling.
Stem Cell Reports 2017 Mar 23;8(3):634-647. Epub 2017 Feb 23.
Laboratory of Stem Cell Differentiation, Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.



The myocardial regenerative potential of three-dimensional engineered cardiac tissues composed of multiple human iPS cell-derived cardiovascular cell lineages.
Sci Rep 2016 Jul 20;6:29933. Epub 2016 Jul 20.
Kosair Charities Pediatric Heart Research Program, Cardiovascular Innovation Institute, University of Louisville, Louisville, Kentucky, The United States of America.

Efficient long-term survival of cell grafts after myocardial infarction with thick viable cardiac tissue entirely from pluripotent stem cells.
Sci Rep 2015 Nov 20;5:16842. Epub 2015 Nov 20.
Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.

Human iPS cell-engineered cardiac tissue sheets with cardiomyocytes and vascular cells for cardiac regeneration.
Sci Rep 2014 Oct 22;4:6716. Epub 2014 Oct 22.
Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.

Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart.
Nat Commun 2014 Jul 29;5:4552. Epub 2014 Jul 29.
1] Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan [2] Core Research for Evolutional Science and Technology (CREST), Japan Science Technology Agency, 4-1-8, Honcho, Kawaguchi, Saitama 332-0012, Japan.


Single-step generation of gene knockout-rescue system in pluripotent stem cells by promoter insertion with CRISPR/Cas9.
Biochem Biophys Res Commun 2014 Feb 22;444(2):158-63. Epub 2014 Jan 22.
Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan; Department of Stem Cell Differentiation, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan. Electronic address:


к Opioids inhibit tumor angiogenesis by suppressing VEGF signaling.
Sci Rep 2013 Nov 14;3:3213. Epub 2013 Nov 14.
1] Laboratory of Stem Cell Differentiation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan [2] Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan [3] Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA [4].




PKA/CREB signaling triggers initiation of endothelial and hematopoietic cell differentiation via Etv2 induction.
Stem Cells 2012 Apr;30(4):687-96
Laboratory of Stem Cell Differentiation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.


The κ opioid system regulates endothelial cell differentiation and pathfinding in vascular development.
Blood 2011 Jul 1;118(3):775-85. Epub 2011 Apr 1.
Laboratory of Stem Cell Differentiation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, Sakyo-ku, Kyoto, Japan.


Therapeutic angiogenesis by transplantation of induced pluripotent stem cell-derived Flk-1 positive cells.
BMC Cell Biol 2010 Sep 22;11:72. Epub 2010 Sep 22.
Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8560, Japan.

Mass preparation of size-controlled mouse embryonic stem cell aggregates and induction of cardiac differentiation by cell patterning method.
Biomaterials 2009 Sep 31;30(26):4384-9. Epub 2009 May 31.
Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, TWIns, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.

Cyclosporin-A potently induces highly cardiogenic progenitors from embryonic stem cells.
Biochem Biophys Res Commun 2009 Jan 16;379(1):115-20. Epub 2008 Dec 16.
Laboratory of Stem Cell Differentiation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan.

Cyclic strain induces mouse embryonic stem cell differentiation into vascular smooth muscle cells by activating PDGF receptor beta.
J Appl Physiol (1985) 2008 Mar 10;104(3):766-72. Epub 2008 Jan 10.
Dept. of Biomedical Engineering, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.


Hyperpolarization-activated cyclic nucleotide-gated channels and T-type calcium channels confer automaticity of embryonic stem cell-derived cardiomyocytes.
Stem Cells 2007 Nov 26;25(11):2712-9. Epub 2007 Jul 26.
Laboratory of Stem Cell Differentiation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, 53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.


Differentiation of lymphatic endothelial cells from embryonic stem cells on OP9 stromal cells.
Arterioscler Thromb Vasc Biol 2006 Sep 11;26(9):2070-6. Epub 2006 May 11.
Molecular and Cancer Research Unit, HMRO, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.

Adrenomedullin/cyclic AMP pathway induces Notch activation and differentiation of arterial endothelial cells from vascular progenitors.
Arterioscler Thromb Vasc Biol 2006 Sep 29;26(9):1977-84. Epub 2006 Jun 29.
Laboratory of Stem Cell Differentiation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, 53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507 Japan.

High level of endothelial cell-specific gene expression by a combination of the 5' flanking region and the 5' half of the first intron of the VE-cadherin gene.
Blood 2005 Jun 3;105(12):4657-63. Epub 2005 Mar 3.
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Graduate School of Medicine, Stem Cell Research Center, Kyoto University, Japan.

Fluid shear stress induces differentiation of Flk-1-positive embryonic stem cells into vascular endothelial cells in vitro.
Am J Physiol Heart Circ Physiol 2005 Apr 2;288(4):H1915-24. Epub 2004 Dec 2.
Dept. of Biomedical Engineering, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.


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