Publications by authors named "Julien Lescar"

131Publications

The SiaABC threonine phosphorylation pathway controls biofilm formation in response to carbon availability in Pseudomonas aeruginosa.

Authors:
Wee-Han Poh Jianqing Lin Brendan Colley Nicolai Müller Boon Chong Goh David Schleheck Abbas El Sahili Andreas Marquardt Yang Liang Staffan Kjelleberg Julien Lescar Scott A Rice Janosch Klebensberger

PLoS One 2020 6;15(11):e0241019. Epub 2020 Nov 6.

University of Stuttgart, Institute of Biochemistry and Technical Biochemistry, Stuttgart, Germany.

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December 2020

Defining the structural basis for human leukocyte antigen reactivity in clinical transplantation.

Authors:
Yue Gu Robynne W K Koh May Ling Lai Denise Pochinco Rachel Z C Teo Marieta Chan Tanusya M Murali Chong Wai Liew Yee Hwa Wong Nicholas R J Gascoigne Kathryn J Wood Julien Lescar Peter Nickerson Paul A MacAry Anantharaman Vathsala

Sci Rep 2020 10 27;10(1):18397. Epub 2020 Oct 27.

National University Centre for Organ Transplantation (NUCOT), National University Hospital, Singapore, Singapore.

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October 2020

Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional Studies.

Authors:
Rishi Arora Chong Wai Liew Tingjin Sherryl Soh Dorcas Adobea Otoo Cheah Chen Seh Kimberley Yue Shahul Nilar Gang Wang Fumiaki Yokokawa Christian G Noble Yen Liang Chen Pei-Yong Shi Julien Lescar Thomas M Smith Timothy E Benson Siew Pheng Lim

J Virol 2020 11 23;94(24). Epub 2020 Nov 23.

Novartis Institute for Tropical Diseases, Singapore

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November 2020

Crystal structure of the periplasmic sensor domain of histidine kinase VbrK suggests indirect sensing of β-lactam antibiotics.

Authors:
Boon Chong Goh Yong Kang Chua Xinlei Qian Jianqing Lin Martin Savko Peter C Dedon Julien Lescar

J Struct Biol 2020 Nov 2;212(2):107610. Epub 2020 Sep 2.

Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Centre, 138602, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, 636921, Singapore; School of Biological Sciences, Nanyang Technological University, 637551, Singapore. Electronic address:

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November 2020

Pyruvate kinase from Plasmodium falciparum: Structural and kinetic insights into the allosteric mechanism.

Authors:
Wenhe Zhong Kuohan Li Qixu Cai Jingjing Guo Meng Yuan Yee Hwa Wong Malcolm D Walkinshaw Linda A Fothergill-Gilmore Paul A M Michels Peter C Dedon Julien Lescar

Biochem Biophys Res Commun 2020 Nov 30;532(3):370-376. Epub 2020 Aug 30.

Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, 1 CREATE Way, 138602, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, 636921, Singapore; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551, Singapore. Electronic address:

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November 2020

Modulation of Lymphocyte Potassium Channel K1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin.

Authors:
Seow Theng Ong Saumya Bajaj Mark R Tanner Shih Chieh Chang Bankala Krishnarjuna Xuan Rui Ng Rodrigo A V Morales Ming Wei Chen Dahai Luo Dharmeshkumar Patel Sabina Yasmin Jeremy Jun Heng Ng Zhong Zhuang Hai M Nguyen Abbas El Sahili Julien Lescar Rahul Patil Susan A Charman Edward G Robins Julian L Goggi Peng Wen Tan Pragalath Sadasivam Boominathan Ramasamy Siddana V Hartimath Vikas Dhawan Janna Bednenko Paul Colussi Heike Wulff Michael W Pennington Serdar Kuyucak Raymond S Norton Christine Beeton K George Chandy

ACS Pharmacol Transl Sci 2020 Aug 14;3(4):720-736. Epub 2020 May 14.

Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Experimental Medicine Building, 59 Nanyang Drive, Singapore 636921.

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August 2020

Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase.

Authors:
Aicha Gharbi-Ayachi Sridhar Santhanakrishnan Yee Hwa Wong Kitti W K Chan Siok Thing Tan Roderick W Bates Subhash G Vasudevan Abbas El Sahili Julien Lescar

J Virol 2020 10 14;94(21). Epub 2020 Oct 14.

School of Biological Sciences, Nanyang Technological University, Singapore

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October 2020

Crystal structures of full length DENV4 NS2B-NS3 reveal the dynamic interaction between NS2B and NS3.

Authors:
Wint Wint Phoo Abbas El Sahili ZhenZhen Zhang Ming Wei Chen Chong Wai Liew Julien Lescar Subhash G Vasudevan Dahai Luo

Antiviral Res 2020 10 5;182:104900. Epub 2020 Aug 5.

Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, 636921, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, 636921, Singapore; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 636921, Singapore. Electronic address:

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October 2020

Tagging Transferrin Receptor with a Disulfide FRET Probe To Gauge the Redox State in Endosomal Compartments.

Authors:
Xiaobao Bi Juan Yin Dingpeng Zhang Xiaohong Zhang Seetharamsing Balamkundu Julien Lescar Peter C Dedon James P Tam Chuan-Fa Liu

Anal Chem 2020 09 3;92(18):12460-12466. Epub 2020 Aug 3.

School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.

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September 2020

PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function.

Authors:
Sreekanth Rajan Yongwoo Jang Chun-Hyung Kim Woori Kim Hui Ting Toh Jeha Jeon Bin Song Aida Serra Julien Lescar Jun Yeob Yoo Serap Beldar Hong Ye Congbao Kang Xue-Wei Liu Melissa Feitosa Yeahan Kim Dabin Hwang Geraldine Goh Kah-Leong Lim Hye Min Park Choong Hwan Lee Sungwhan F Oh Gregory A Petsko Ho Sup Yoon Kwang-Soo Kim

Nat Chem Biol 2020 08 25;16(8):876-886. Epub 2020 May 25.

Molecular Neurobiology Laboratory, Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.

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August 2020

Temporal release of a three-component protein subunit vaccine from polymer multilayers.

Authors:
Divakara S S M Uppu Michelle E Turvey Abdul Rahim Mohammed Sharif Katell Bidet Yanpu He Victor Ho Anagha D Tambe Julien Lescar Ern Yu Tan Katja Fink Jianzhu Chen Paula T Hammond

J Control Release 2020 01 20;317:130-141. Epub 2019 Nov 20.

Interdisciplinary Research Group in Infectious Diseases, Singapore-MIT Alliance for Research and Technology, Singapore; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address:

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January 2020

Structure of the human metapneumovirus polymerase phosphoprotein complex.

Authors:
Junhua Pan Xinlei Qian Simon Lattmann Abbas El Sahili Tiong Han Yeo Huan Jia Tessa Cressey Barbara Ludeke Sarah Noton Marian Kalocsay Rachel Fearns Julien Lescar

Nature 2020 01 7;577(7789):275-279. Epub 2019 Nov 7.

School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

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January 2020

NS5 from Dengue Virus Serotype 2 Can Adopt a Conformation Analogous to That of Its Zika Virus and Japanese Encephalitis Virus Homologues.

Authors:
Abbas El Sahili Tingjin Sherryl Soh Jonas Schiltz Aïcha Gharbi-Ayachi Cheah Chen Seh Pei-Yong Shi Siew Pheng Lim Julien Lescar

J Virol 2019 12 12;94(1). Epub 2019 Dec 12.

NTU Institute of Structural Biology, School of Biological Sciences, Nanyang Technological University, Singapore

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December 2019

Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.

Authors:
Wenhe Zhong Kalyan Kumar Pasunooti Seetharamsing Balamkundu Yee Hwa Wong Qianhui Nah Vinod Gadi Shanmugavel Gnanakalai Yok Hian Chionh Megan E McBee Pooja Gopal Siau Hoi Lim Nelson Olivier Ed T Buurman Thomas Dick Chuan Fa Liu Julien Lescar Peter C Dedon

J Med Chem 2019 09 29;62(17):7788-7805. Epub 2019 Aug 29.

Infectious Disease and Antimicrobial Resistance Interdisciplinary Research Groups , Singapore-MIT Alliance for Research and Technology , 1 CREATE Way , 138602 Singapore.

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September 2019

Crystal structure and catalytic mechanism of the essential mG37 tRNA methyltransferase TrmD from .

Authors:
Juthamas Jaroensuk Yee Hwa Wong Wenhe Zhong Chong Wai Liew Somchart Maenpuen Abbas E Sahili Sopapan Atichartpongkul Yok Hian Chionh Qianhui Nah Narumon Thongdee Megan E McBee Erin G Prestwich Michael S DeMott Pimchai Chaiyen Skorn Mongkolsuk Peter C Dedon Julien Lescar Mayuree Fuangthong

RNA 2019 11 9;25(11):1481-1496. Epub 2019 Aug 9.

Applied Biological Sciences Program, Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok 10210, Thailand.

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November 2019

Pyruvate Kinase Regulates the Pentose-Phosphate Pathway in Response to Hypoxia in Mycobacterium tuberculosis.

Authors:
Wenhe Zhong Jingjing Guo Liang Cui Yok Hian Chionh Kuohan Li Abbas El Sahili Qixu Cai Meng Yuan Paul A M Michels Linda A Fothergill-Gilmore Malcolm D Walkinshaw Yuguang Mu Julien Lescar Peter C Dedon

J Mol Biol 2019 09 2;431(19):3690-3705. Epub 2019 Aug 2.

Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, 1 CREATE Way, 138602, Singapore; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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September 2019

Cell-active carbazole derivatives as inhibitors of the zika virus protease.

Authors:
Gerasimos Rassias Vasiliki Zogali Crystall M D Swarbrick Kitti Wing Ki Chan Shu Ann Chan Chin Piaw Gwee Sai Wang Entzy Kaplanai Aleksander Canko Dimitrios Kiousis Julien Lescar Dahai Luo Minos-Timotheos Matsoukas Subhash G Vasudevan

Eur J Med Chem 2019 Oct 17;180:536-545. Epub 2019 Jul 17.

Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road 169857, Singapore. Electronic address:

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October 2019

Backbone resonance assignment for the full length tRNA-(NG37) methyltransferase of Pseudomonas aeruginosa.

Authors:
Yan Li Wenhe Zhong Ann Zhufang Koay Hui Qi Ng Qianhui Nah Yee Hwa Wong Jeffrey Hill Julien Lescar Peter C Dedon CongBao Kang

Biomol NMR Assign 2019 10 7;13(2):327-332. Epub 2019 Jun 7.

Experimental Drug Development Centre, 10 Biopolis Road, #05-01, Singapore, 138670, Singapore.

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October 2019

Structural determinants for peptide-bond formation by asparaginyl ligases.

Authors:
Xinya Hemu Abbas El Sahili Side Hu Kaho Wong Yu Chen Yee Hwa Wong Xiaohong Zhang Aida Serra Boon Chong Goh Dina A Darwis Ming Wei Chen Siu Kwan Sze Chuan-Fa Liu Julien Lescar James P Tam

Proc Natl Acad Sci U S A 2019 06 23;116(24):11737-11746. Epub 2019 May 23.

School of Biological Sciences, Nanyang Technological University, 637551 Singapore;

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June 2019

Pellino1 specifically binds to phospho-Thr18 of p53 and is recruited to sites of DNA damage.

Authors:
Liang Dai Jianqing Lin Aminahtusaidah Binte Said Yin Hoe Yau Susana Geifman Shochat David Ruiz-Carrillo Kang Sun Ramya Chandrasekaran Siu Kwan Sze Julien Lescar Peter Cf Cheung

Biochem Biophys Res Commun 2019 06 12;513(3):714-720. Epub 2019 Apr 12.

School of Biological Sciences, Nanyang Technological University, Singapore. Electronic address:

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June 2019