Julie Frearson

Julie Frearson

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Julie Frearson

Julie Frearson

Publications by authors named "Julie Frearson"

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44Publications

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A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors.

J Med Chem 2018 09 12;61(18):8374-8389. Epub 2018 Sep 12.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee , DD1 5EH , United Kingdom.

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http://dx.doi.org/10.1021/acs.jmedchem.8b00884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167002PMC
September 2018

Screening a protein kinase inhibitor library against Plasmodium falciparum.

Malar J 2017 11 7;16(1):446. Epub 2017 Nov 7.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1186/s12936-017-2085-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678585PMC
November 2017

The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines.

Cell Chem Biol 2017 Aug 3;24(8):981-992.e4. Epub 2017 Aug 3.

Centre for Gene Regulation & Expression, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.06.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563080PMC
August 2017

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei.

J Med Chem 2015 Oct 29;58(19):7695-706. Epub 2015 Sep 29.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Sir James Black Centre, Dundee, DD1 5EH, U.K.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601051PMC
October 2015

The design and synthesis of potent and selective inhibitors of Trypanosoma brucei glycogen synthase kinase 3 for the treatment of human african trypanosomiasis.

J Med Chem 2014 Sep 8;57(18):7536-49. Epub 2014 Sep 8.

Drug Discovery Unit, College of Life Sciences, University of Dundee , Sir James Black Centre, Dow Street, Dundee DD1 5EH, U.K.

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http://dx.doi.org/10.1021/jm500239bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175002PMC
September 2014

A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei.

ACS Chem Biol 2013 Sep 18;8(9):1981-7. Epub 2013 Jul 18.

Division of Biological Chemistry and Drug Discovery, ‡Division of Molecular Microbiology, and §MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee , Dundee DD1 5EH, U.K.

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http://dx.doi.org/10.1021/cb400411xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780468PMC
September 2013

Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay.

Antimicrob Agents Chemother 2013 Jul 9;57(7):2913-22. Epub 2013 Apr 9.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom.

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http://dx.doi.org/10.1128/AAC.02398-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697379PMC
July 2013

From on-target to off-target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti-Trypanosoma brucei drug discovery lead molecules.

ChemMedChem 2013 Jul 14;8(7):1127-37. Epub 2013 Jun 14.

Drug Discovery Unit (DDU), Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, DD1 5EH, UK.

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http://dx.doi.org/10.1002/cmdc.201300072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728731PMC
July 2013

Optimizing the use of CROs by academia and small companies.

Nat Rev Drug Discov 2013 Jul;12(7):487-8

Alzheimer's Drug Discovery Foundation, 57 W. 57th Street, New York, New York 10019, USA.

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http://dx.doi.org/10.1038/nrd4057DOI Listing
July 2013

Chemical proteomic analysis reveals the drugability of the kinome of Trypanosoma brucei.

ACS Chem Biol 2012 Nov 23;7(11):1858-65. Epub 2012 Aug 23.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.

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http://dx.doi.org/10.1021/cb300326zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621575PMC
November 2012

IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening.

PLoS One 2012 25;7(4):e35792. Epub 2012 Apr 25.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035792PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340893PMC
September 2012

Quinol derivatives as potential trypanocidal agents.

Bioorg Med Chem 2012 Feb 27;20(4):1607-15. Epub 2011 Dec 27.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.bmc.2011.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281193PMC
February 2012

Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors.

ChemMedChem 2012 Jan 8;7(1):95-106. Epub 2011 Dec 8.

Drug Discovery Unit, Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1002/cmdc.201100420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320663PMC
January 2012

Identification of inhibitors of the Leishmania cdc2-related protein kinase CRK3.

ChemMedChem 2011 Dec 13;6(12):2214-24. Epub 2011 Sep 13.

Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1002/cmdc.201100344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272345PMC
December 2011

Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488.

ChemMedChem 2011 Oct 10;6(10):1832-40. Epub 2011 Aug 10.

Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee, Dundee, DD1 5EH, Scotland, UK.

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http://dx.doi.org/10.1002/cmdc.201100278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229842PMC
October 2011

Finding new hits in neglected disease projects: target or phenotypic based screening?

Curr Top Med Chem 2011 ;11(10):1284-91

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, Sir James Black Centre, University of Dundee, UK.

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http://dx.doi.org/10.2174/156802611795429176DOI Listing
August 2011

Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1.

ChemMedChem 2011 Feb 29;6(2):302-8. Epub 2010 Dec 29.

Drug Discovery Unit, Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, Scotland, DD1 5EH, UK.

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http://dx.doi.org/10.1002/cmdc.201000450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047710PMC
February 2011

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis.

Biochem Pharmacol 2010 Nov 7;80(10):1478-86. Epub 2010 Aug 7.

Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.bcp.2010.07.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025325PMC
November 2010

Drug Discovery in Academia- the third way?

Expert Opin Drug Discov 2010 Oct;5(10):909-19

Drug Discovery Unit, College of Life Sciences, Dundee, UK.

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http://dx.doi.org/10.1517/17460441.2010.506508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948567PMC
October 2010

Nuclear DBF-2-related kinases are essential regulators of cytokinesis in bloodstream stage Trypanosoma brucei.

J Biol Chem 2010 May 15;285(20):15356-68. Epub 2010 Mar 15.

Division of Infection & Immunity, Faculty of Biomedical and Life Sciences and Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.074591
Publisher Site
http://dx.doi.org/10.1074/jbc.M109.074591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865264PMC
May 2010

Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase.

Anal Biochem 2010 Jan 11;396(2):194-203. Epub 2009 Sep 11.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD15EH, UK.

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http://dx.doi.org/10.1016/j.ab.2009.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789237PMC
January 2010

HTS and hit finding in academia--from chemical genomics to drug discovery.

Drug Discov Today 2009 Dec 28;14(23-24):1150-8. Epub 2009 Sep 28.

Sir James Black Centre, University of Dundee, UK.

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http://dx.doi.org/10.1016/j.drudis.2009.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814004PMC
December 2009

Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis.

J Biol Chem 2009 Dec 14;284(52):36137-45. Epub 2009 Oct 14.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M109.045336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794729PMC
December 2009

Investigation of trypanothione reductase as a drug target in Trypanosoma brucei.

ChemMedChem 2009 Dec;4(12):2060-9

Drug Discovery Unit, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1002/cmdc.200900262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855869PMC
December 2009

Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase.

ChemMedChem 2009 Aug;4(8):1341-53

Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1002/cmdc.200900098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929374PMC
August 2009

Target assessment for antiparasitic drug discovery.

Trends Parasitol 2007 Dec 24;23(12):589-95. Epub 2007 Oct 24.

Drug Discovery Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.pt.2007.08.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2979298PMC
December 2007